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Genes
IL4
Gene - IL4
full name
interleukin 4
synonyms
BCGF-1, BCGF1, BSF-1, BSF1, IL-4, IL4, ENSG00000113520
HGNC
HGNC:6014
Entrez Gene
Gene:3565
ENSEMBL
ENSG00000113520
location
chr: 5
start: 132009678
stop: 132018370
strand: +
transcripts
NM_000589.3
NM_172348.2
pathways
Allograft rejection
[NCBI:83123]
[KEGG:hsa05330]
[PUBMED:8835634]
[PUBMED:12023610]
[PUBMED:12563298]
[PUBMED:17445565]
[PUBMED:12216939]
[PUBMED:14710779]
[PUBMED:10746853]
[PUBMED:10571983]
[PUBMED:10331992]
[PUBMED:10667806]
Asthma
[NCBI:83120]
[KEGG:hsa05310]
[PUBMED:11686879]
[PUBMED:17364144]
[PUBMED:10811837]
[PUBMED:11477111]
[PUBMED:18274559]
[PUBMED:11172168]
[PUBMED:18274560]
[PUBMED:10719286]
[PUBMED:12093011]
[PUBMED:17976144]
[PUBMED:17133123]
Autoimmune thyroid disease
[NCBI:83121]
[KEGG:hsa05320]
[PUBMED:15132715]
[PUBMED:12192541]
[PUBMED:17192582]
[PUBMED:9534029]
[PUBMED:11396701]
[PUBMED:11913070]
[PUBMED:15049952]
[PUBMED:11577986]
[PUBMED:15762980]
CD40/CD40L signaling
[NCBI:138061]
[Pathway Interaction Database:cd40_pathway]
[PUBMED:11967542]
[PUBMED:11304555]
[PUBMED:11714736]
[PUBMED:17878343]
[PUBMED:12354380]
[PUBMED:11406619]
[PUBMED:9133417]
[PUBMED:7527023]
[PUBMED:18997794]
[PUBMED:1374165]
[PUBMED:1385114]
[PUBMED:12958312]
[PUBMED:10764746]
[PUBMED:11909853]
[PUBMED:10318845]
[PUBMED:7533327]
[PUBMED:16260598]
[PUBMED:18997792]
[PUBMED:12818164]
[PUBMED:10748139]
[PUBMED:9718306]
[PUBMED:10395671]
[PUBMED:17878362]
[PUBMED:7544915]
[PUBMED:12370254]
[PUBMED:8910514]
[PUBMED:17143273]
[PUBMED:10433725]
[PUBMED:14981114]
[PUBMED:16622006]
[PUBMED:12122011]
[PUBMED:12133933]
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
[NCBI:137993]
[Pathway Interaction Database:nfat_tfpathway]
[PUBMED:11254715]
[PUBMED:11356833]
[PUBMED:12121669]
[PUBMED:10878360]
[PUBMED:11786533]
[PUBMED:8284217]
[PUBMED:10816557]
[PUBMED:11956291]
[PUBMED:7510691]
[PUBMED:9195954]
[PUBMED:8240350]
[PUBMED:12452838]
[PUBMED:8623163]
[PUBMED:15834410]
[PUBMED:10894164]
[PUBMED:10970869]
[PUBMED:10755616]
[PUBMED:14607827]
[PUBMED:12705856]
[PUBMED:12086671]
[PUBMED:7982959]
[PUBMED:9047239]
[PUBMED:12374808]
[PUBMED:14573767]
[PUBMED:12560487]
[PUBMED:10570264]
[PUBMED:8397339]
[PUBMED:12055628]
[PUBMED:15308098]
[PUBMED:12065418]
[PUBMED:7891702]
[PUBMED:7749982]
[PUBMED:14973438]
[PUBMED:8674125]
[PUBMED:16873067]
[PUBMED:12453415]
[PUBMED:8441422]
[PUBMED:1737937]
[PUBMED:10671476]
[PUBMED:8376940]
[PUBMED:9545284]
Calcium signaling in the CD4+ TCR pathway
[NCBI:137941]
[Pathway Interaction Database:tcrcalciumpathway]
[PUBMED:8284217]
[PUBMED:10816557]
[PUBMED:10970869]
[PUBMED:8240350]
[PUBMED:8623163]
[PUBMED:1715244]
[PUBMED:1715516]
[PUBMED:16406492]
[PUBMED:9655484]
[PUBMED:8397339]
[PUBMED:10861295]
[PUBMED:9047239]
[PUBMED:293720]
[PUBMED:7891702]
[PUBMED:12925851]
[PUBMED:9660798]
[PUBMED:1377362]
[PUBMED:12065418]
[PUBMED:8441422]
[PUBMED:7528941]
[PUBMED:1737937]
[PUBMED:12809556]
[PUBMED:9545284]
[PUBMED:11254715]
[PUBMED:10878360]
[PUBMED:10593895]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
Cytokine-cytokine receptor interaction
[NCBI:83051]
[KEGG:hsa04060]
[PUBMED:11071910]
[PUBMED:12072446]
[PUBMED:7791754]
[PUBMED:15032600]
[PUBMED:12651226]
[PUBMED:11252892]
[PUBMED:11796220]
[PUBMED:11312110]
[PUBMED:9862719]
[PUBMED:12421671]
[PUBMED:12039028]
[PUBMED:9759503]
[PUBMED:9395284]
[PUBMED:11166270]
[PUBMED:10714678]
[PUBMED:12651221]
Fc epsilon RI signaling pathway
[NCBI:83082]
[KEGG:hsa04664]
[PUBMED:16470226]
[PUBMED:12145654]
[PUBMED:11079101]
[PUBMED:10586892]
[PUBMED:14630197]
[PUBMED:12360215]
[PUBMED:11449275]
Glucocorticoid receptor regulatory network
[NCBI:138014]
[Pathway Interaction Database:reg_gr_pathway]
[PUBMED:8943293]
[PUBMED:1708774]
[PUBMED:15826950]
[PUBMED:11027313]
[PUBMED:12118039]
[PUBMED:9388207]
[PUBMED:11751894]
[PUBMED:12151000]
[PUBMED:9765258]
[PUBMED:9407028]
[PUBMED:19074285]
[PUBMED:2838908]
[PUBMED:15817653]
[PUBMED:9722596]
[PUBMED:12917342]
[PUBMED:1387550]
[PUBMED:10974006]
[PUBMED:15790729]
[PUBMED:10825196]
[PUBMED:10623828]
[PUBMED:2169352]
[PUBMED:9315653]
[PUBMED:7759501]
[PUBMED:8290595]
[PUBMED:2905764]
[PUBMED:12351702]
[PUBMED:11080152]
[PUBMED:8428574]
[PUBMED:9215863]
[PUBMED:15459252]
[PUBMED:10400612]
[PUBMED:9426156]
[PUBMED:17440046]
[PUBMED:18838540]
[PUBMED:2169353]
[PUBMED:10820245]
[PUBMED:12511605]
[PUBMED:2586521]
[PUBMED:1740658]
[PUBMED:11555652]
[PUBMED:11562347]
[PUBMED:9482836]
[PUBMED:18337589]
[PUBMED:10958685]
[PUBMED:9388192]
[PUBMED:15834420]
[PUBMED:15657031]
[PUBMED:8878484]
[PUBMED:10760263]
[PUBMED:12730237]
[PUBMED:8702844]
[PUBMED:2169351]
[PUBMED:17215482]
[PUBMED:8898375]
Hematopoietic cell lineage
[NCBI:83078]
[KEGG:hsa04640]
[PUBMED:15629410]
[PUBMED:15738953]
[PUBMED:11905810]
[PUBMED:15156179]
[PUBMED:12415312]
[PUBMED:14985712]
[PUBMED:9927518]
[PUBMED:15771582]
[PUBMED:14670296]
[PUBMED:12360214]
IL-17 signaling pathway
[NCBI:1474301]
[KEGG:hsa04657]
[PUBMED:17921324]
[PUBMED:24011563]
[PUBMED:21349428]
[PUBMED:20383173]
[PUBMED:20514051]
[PUBMED:20177959]
[PUBMED:18178098]
[PUBMED:21074482]
[PUBMED:21130872]
[PUBMED:17027518]
[PUBMED:23917206]
[PUBMED:23116200]
[PUBMED:18701318]
[PUBMED:26252407]
[PUBMED:22851696]
[PUBMED:21155836]
[PUBMED:25145755]
[PUBMED:17177681]
[PUBMED:19575028]
[PUBMED:23557798]
[PUBMED:21852080]
[PUBMED:22324470]
IL12-mediated signaling events
[NCBI:137922]
[Pathway Interaction Database:il12_2pathway]
[PUBMED:12874225]
[PUBMED:12221108]
[PUBMED:16380506]
[PUBMED:9768751]
[PUBMED:17114419]
[PUBMED:10358173]
[PUBMED:9890938]
[PUBMED:12213961]
[PUBMED:11120802]
[PUBMED:9202126]
[PUBMED:16641133]
[PUBMED:10198225]
[PUBMED:16763563]
[PUBMED:15728489]
[PUBMED:8103068]
[PUBMED:10903740]
[PUBMED:10201984]
[PUBMED:7638186]
[PUBMED:11894097]
[PUBMED:16220539]
[PUBMED:10961885]
[PUBMED:7594594]
[PUBMED:17110450]
[PUBMED:9582275]
[PUBMED:10320373]
[PUBMED:7528775]
[PUBMED:11207258]
[PUBMED:9038232]
[PUBMED:15522880]
[PUBMED:11175814]
[PUBMED:9531298]
[PUBMED:7722452]
[PUBMED:8943050]
[PUBMED:7553885]
[PUBMED:9454765]
IL2 signaling events mediated by STAT5
[NCBI:137988]
[Pathway Interaction Database:il2_stat5pathway]
[PUBMED:11160217]
[PUBMED:16645171]
[PUBMED:9121484]
[PUBMED:17182565]
[PUBMED:14607901]
[PUBMED:9104808]
[PUBMED:11485747]
[PUBMED:14614860]
[PUBMED:10679091]
[PUBMED:12196288]
[PUBMED:10072077]
[PUBMED:10544201]
[PUBMED:15004274]
[PUBMED:9390691]
[PUBMED:9395528]
[PUBMED:10514006]
[PUBMED:14500638]
[PUBMED:16757175]
[PUBMED:9541574]
[PUBMED:8617294]
IL4-mediated signaling events
[NCBI:137933]
[Pathway Interaction Database:il4_2pathway]
[PUBMED:8602263]
[PUBMED:15199062]
[PUBMED:7705411]
[PUBMED:11160325]
[PUBMED:8557643]
[PUBMED:8134361]
[PUBMED:1948049]
[PUBMED:10843732]
[PUBMED:11034397]
[PUBMED:8624802]
[PUBMED:14557412]
[PUBMED:1997653]
[PUBMED:10586089]
[PUBMED:14634100]
[PUBMED:17541284]
[PUBMED:8124718]
[PUBMED:16210622]
[PUBMED:7822337]
[PUBMED:11572871]
[PUBMED:2147202]
[PUBMED:10228008]
[PUBMED:7675087]
[PUBMED:12574343]
[PUBMED:14603527]
[PUBMED:15659391]
[PUBMED:11160269]
[PUBMED:7760829]
[PUBMED:7973658]
[PUBMED:10072514]
[PUBMED:9013879]
[PUBMED:8624803]
[PUBMED:10490661]
[PUBMED:14978013]
[PUBMED:10364072]
[PUBMED:12459556]
[PUBMED:11714803]
[PUBMED:8602264]
[PUBMED:9811885]
[PUBMED:12776189]
[PUBMED:15728454]
[PUBMED:10601358]
[PUBMED:11739727]
[PUBMED:11160275]
[PUBMED:9852037]
[PUBMED:9670964]
[PUBMED:15004182]
[PUBMED:8266078]
[PUBMED:3144043]
[PUBMED:8992992]
[PUBMED:8089482]
[PUBMED:9651359]
[PUBMED:16810739]
[PUBMED:7499365]
[PUBMED:7721786]
[PUBMED:9065461]
[PUBMED:11241672]
[PUBMED:10950967]
[PUBMED:8810328]
[PUBMED:8624821]
[PUBMED:9110977]
[PUBMED:8609418]
[PUBMED:15187136]
[PUBMED:9414268]
[PUBMED:8916957]
[PUBMED:10201892]
[PUBMED:17200144]
[PUBMED:8458387]
[PUBMED:11544308]
[PUBMED:10657944]
[PUBMED:15153491]
[PUBMED:7544011]
[PUBMED:8266076]
[PUBMED:11801631]
[PUBMED:12044779]
[PUBMED:8621475]
[PUBMED:9697832]
[PUBMED:12242343]
[PUBMED:7694370]
[PUBMED:9380721]
[PUBMED:9541585]
[PUBMED:7807002]
[PUBMED:16537510]
[PUBMED:8258319]
[PUBMED:9799097]
[PUBMED:12023955]
[PUBMED:8085155]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Inflammatory bowel disease (IBD)
[NCBI:842771]
[KEGG:hsa05321]
[PUBMED:17499605]
[PUBMED:12006974]
[PUBMED:18053739]
[PUBMED:20134493]
[PUBMED:10898785]
[PUBMED:18563156]
[PUBMED:23176791]
[PUBMED:18200661]
[PUBMED:12797537]
[PUBMED:21487504]
[PUBMED:19381306]
[PUBMED:21681604]
[PUBMED:19322214]
[PUBMED:16493424]
[PUBMED:18242222]
[PUBMED:12042806]
[PUBMED:9759857]
Interleukin-10 signaling
[NCBI:1470924]
[REACTOME:R-HSA-6783783]
[PUBMED:11244051]
Interleukin-4 and 13 signaling
[NCBI:1470923]
[REACTOME:R-HSA-6785807]
[PUBMED:12704343]
[PUBMED:10358772]
Intestinal immune network for IgA production
[NCBI:128760]
[KEGG:hsa04672]
[PUBMED:18483500]
[PUBMED:18838301]
[PUBMED:15971106]
[PUBMED:18243016]
[PUBMED:19079167]
[PUBMED:18549797]
[PUBMED:19079156]
[PUBMED:17161619]
[PUBMED:17182536]
[PUBMED:12511876]
Jak-STAT signaling pathway
[NCBI:83077]
[KEGG:hsa04630]
[PUBMED:21034406]
[PUBMED:22339650]
[PUBMED:16204702]
[PUBMED:25587654]
[PUBMED:24069565]
[PUBMED:22383755]
[PUBMED:24606160]
[PUBMED:10851053]
[PUBMED:23735217]
[PUBMED:25217450]
[PUBMED:21372217]
Leishmaniasis
[NCBI:144181]
[KEGG:hsa05140]
[PUBMED:11890722]
[PUBMED:7916951]
[PUBMED:10417174]
[PUBMED:11298294]
[PUBMED:10586030]
[PUBMED:15322192]
[PUBMED:15831826]
[PUBMED:11728310]
[PUBMED:15039466]
[PUBMED:10462516]
[PUBMED:10608501]
[PUBMED:15721837]
[PUBMED:15639739]
[PUBMED:14762510]
[PUBMED:18793215]
[PUBMED:7591091]
[PUBMED:12438359]
[PUBMED:18070909]
[PUBMED:17543969]
[PUBMED:15983048]
[PUBMED:16848789]
[PUBMED:10770277]
[PUBMED:9504340]
Measles
[NCBI:213306]
[KEGG:hsa05162]
[PUBMED:16237742]
[PUBMED:12804771]
[PUBMED:19198562]
[PUBMED:20376484]
[PUBMED:11385511]
[PUBMED:16963735]
[PUBMED:19198566]
[PUBMED:18922877]
[PUBMED:19203114]
[PUBMED:12620806]
[PUBMED:16690907]
[PUBMED:17720800]
[PUBMED:20636817]
[PUBMED:12410527]
[PUBMED:11582511]
[PUBMED:19203109]
[PUBMED:19203113]
[PUBMED:14585342]
[PUBMED:12805463]
Notch signaling pathway
[NCBI:83062]
[KEGG:hsa04330]
[NCBI:169345]
[Pathway Interaction Database:notch_pathway]
[PUBMED:11459941]
[PUBMED:12682059]
[PUBMED:11825871]
[PUBMED:17658278]
[PUBMED:15998794]
[PUBMED:11101851]
[PUBMED:19686683]
[PUBMED:18490439]
[PUBMED:11150244]
[PUBMED:9694793]
[PUBMED:10206645]
[PUBMED:19704010]
[PUBMED:16137758]
[PUBMED:15288258]
[PUBMED:17392792]
[PUBMED:8749394]
[PUBMED:15965470]
[PUBMED:14566063]
[PUBMED:19567869]
[PUBMED:11585921]
[PUBMED:18676613]
[PUBMED:12913000]
[PUBMED:10593990]
[PUBMED:15274632]
[PUBMED:11777909]
[PUBMED:12015972]
[PUBMED:10028969]
[PUBMED:18043734]
[PUBMED:17658279]
[PUBMED:17575125]
[PUBMED:10958687]
[PUBMED:15300010]
[PUBMED:10882062]
[PUBMED:12374742]
[PUBMED:11782429]
[PUBMED:9653148]
[PUBMED:9315665]
[PUBMED:8643690]
[PUBMED:17114293]
[PUBMED:10837024]
[PUBMED:15067010]
[PUBMED:17296795]
[PUBMED:10940313]
[PUBMED:18628966]
[PUBMED:12826675]
[PUBMED:12681948]
[PUBMED:16492672]
[PUBMED:12551931]
[PUBMED:15082708]
[PUBMED:12464310]
[PUBMED:12794186]
[PUBMED:16107360]
[PUBMED:19726682]
[PUBMED:11486031]
[PUBMED:16287852]
[PUBMED:12297508]
[PUBMED:16061358]
[PUBMED:17107962]
[PUBMED:9244302]
[PUBMED:11425854]
[PUBMED:9620803]
[PUBMED:15272268]
[PUBMED:18417156]
[PUBMED:16000382]
[PUBMED:11896183]
[PUBMED:11604511]
[PUBMED:16847353]
[PUBMED:11432830]
[PUBMED:15652348]
[PUBMED:12417415]
[PUBMED:14567914]
[PUBMED:11006133]
[PUBMED:18077452]
[PUBMED:16144902]
[PUBMED:15288257]
[PUBMED:15585829]
[PUBMED:12370315]
[PUBMED:15288260]
[PUBMED:17434929]
[PUBMED:12814948]
[PUBMED:10882063]
[PUBMED:11518718]
PI3K-Akt signaling pathway
[NCBI:692234]
[KEGG:hsa04151]
[PUBMED:12048182]
[PUBMED:11357143]
[PUBMED:21440011]
[PUBMED:15209374]
[PUBMED:12669022]
[PUBMED:18842113]
[PUBMED:16847462]
[PUBMED:12660731]
[PUBMED:17360849]
[PUBMED:9838078]
[PUBMED:15505410]
[PUBMED:16248975]
[PUBMED:12531180]
[PUBMED:21779440]
[PUBMED:16187290]
[PUBMED:15784165]
[PUBMED:21620960]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
T cell receptor signaling pathway
[NCBI:83080]
[KEGG:hsa04660]
[PUBMED:17395537]
[PUBMED:15308211]
[PUBMED:15928679]
[PUBMED:14656980]
[PUBMED:17187070]
[PUBMED:15084594]
[PUBMED:16799472]
[PUBMED:12669022]
[PUBMED:15286727]
[PUBMED:15122199]
[PUBMED:19132916]
[PUBMED:15489916]
[PUBMED:11905831]
[PUBMED:12195013]
[PUBMED:15343367]
[PUBMED:12133805]
[PUBMED:14647476]
[PUBMED:15771581]
[PUBMED:15099566]
[PUBMED:14617194]
[PUBMED:19290929]
[PUBMED:15345216]
Th1 and Th2 cell differentiation
[NCBI:1458885]
[KEGG:hsa04658]
[PUBMED:15819694]
[PUBMED:12171942]
[PUBMED:19165228]
[PUBMED:23336087]
[PUBMED:26044597]
[PUBMED:19151746]
[PUBMED:19362457]
[PUBMED:22044277]
[PUBMED:11752608]
[PUBMED:23405903]
[PUBMED:19375293]
[PUBMED:24113868]
[PUBMED:19151747]
[PUBMED:23624818]
[PUBMED:22566933]
[PUBMED:11121747]
[PUBMED:20969597]
[PUBMED:20065998]
Th17 cell differentiation
[NCBI:1469482]
[KEGG:hsa04659]
[PUBMED:23325835]
[PUBMED:23036716]
[PUBMED:20488727]
[PUBMED:21151104]
[PUBMED:21084214]
[PUBMED:20054607]
[PUBMED:22754770]
[PUBMED:22640807]
[PUBMED:19379825]
[PUBMED:22133865]
[PUBMED:22324470]
[PUBMED:17768419]
[PUBMED:18408735]
[PUBMED:21776333]
[PUBMED:26253381]
[PUBMED:16200068]
[PUBMED:18362914]
[PUBMED:24325586]
[PUBMED:19381306]
[PUBMED:18166487]