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Genes
TCF7
Gene - TCF7
full name
transcription factor 7
synonyms
TCF-1, TCF7, ENSG00000081059
HGNC
HGNC:11639
Entrez Gene
Gene:6932
ENSEMBL
ENSG00000081059
location
chr: 5
start: 133450402
stop: 133483920
strand: +
transcripts
NM_003202.3
NM_213648.3
NM_201634.3
NM_001134851.2
NM_201632.3
NR_033449.1
pathways
Acute myeloid leukemia
[NCBI:83117]
[KEGG:hsa05221]
[PUBMED:12951584]
[PUBMED:12563308]
[PUBMED:16352814]
[PUBMED:16236521]
[PUBMED:16146838]
[PUBMED:16642045]
[PUBMED:15625120]
[PUBMED:11721960]
[PUBMED:17554387]
[PUBMED:12468433]
Adherens junction
[NCBI:83070]
[KEGG:hsa04520]
[PUBMED:11703922]
[PUBMED:10890911]
[PUBMED:15551862]
[PUBMED:15561584]
[PUBMED:10959047]
[PUBMED:11984870]
[PUBMED:10204118]
[PUBMED:15489912]
[PUBMED:14623871]
[PUBMED:15001769]
[PUBMED:12640114]
[PUBMED:12665527]
[PUBMED:11171368]
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
[NCBI:117293]
[KEGG:hsa05412]
[PUBMED:16823481]
[PUBMED:19205777]
[PUBMED:11716909]
[PUBMED:12270949]
[PUBMED:18382419]
[PUBMED:16101641]
[PUBMED:16124859]
[PUBMED:17413274]
Basal cell carcinoma
[NCBI:83113]
[KEGG:hsa05217]
[PUBMED:15948971]
[PUBMED:15978322]
[PUBMED:15468170]
[PUBMED:11276000]
[PUBMED:11130178]
[PUBMED:14737121]
[PUBMED:15270885]
[PUBMED:16306523]
[PUBMED:14556242]
[PUBMED:15656799]
[PUBMED:16054233]
[PUBMED:12588368]
[PUBMED:16881963]
[PUBMED:11736900]
Beta-catenin independent WNT signaling
[NCBI:1269610]
[REACTOME:R-HSA-3858494]
[PUBMED:22935904]
[PUBMED:21903638]
[PUBMED:23256519]
[PUBMED:8065359]
[PUBMED:7739543]
[PUBMED:23140633]
Binding of TCF/LEF:CTNNB1 to target gene promoters
[NCBI:1269603]
[REACTOME:R-HSA-4411364]
[PUBMED:17698587]
[PUBMED:18160255]
[PUBMED:15592430]
[PUBMED:11809809]
[PUBMED:10489374]
Breast cancer
[NCBI:1435207]
[KEGG:hsa05224]
[PUBMED:24649067]
[PUBMED:26040571]
[PUBMED:11879567]
[PUBMED:22722193]
[PUBMED:26028978]
[PUBMED:25013431]
[PUBMED:11737884]
[PUBMED:23702927]
[PUBMED:21076461]
[PUBMED:21898546]
[PUBMED:27390604]
[PUBMED:24291072]
[PUBMED:26968398]
[PUBMED:20087430]
[PUBMED:23000897]
[PUBMED:25544707]
[PUBMED:24596345]
[PUBMED:23988612]
[PUBMED:24111892]
[PUBMED:25907219]
[PUBMED:15343273]
[PUBMED:21965336]
[PUBMED:23881035]
[PUBMED:23196196]
[PUBMED:22178455]
[PUBMED:20436504]
[PUBMED:19088017]
[PUBMED:16113099]
[PUBMED:20971825]
Ca2+ pathway
[NCBI:1269615]
[REACTOME:R-HSA-4086398]
[PUBMED:21903638]
[PUBMED:21181886]
[PUBMED:16099039]
Colorectal cancer
[NCBI:83106]
[KEGG:hsa05210]
[PUBMED:15479695]
[PUBMED:11459867]
[PUBMED:9196022]
[PUBMED:11170304]
[PUBMED:12951588]
[PUBMED:15349822]
[PUBMED:15711891]
[PUBMED:16042571]
[PUBMED:15000146]
[PUBMED:12737309]
[PUBMED:10505543]
[PUBMED:11078609]
[PUBMED:11223406]
[PUBMED:16326109]
[PUBMED:16699851]
[PUBMED:11477132]
[PUBMED:12621137]
[PUBMED:15573119]
[PUBMED:16555243]
[PUBMED:15310786]
Deactivation of the beta-catenin transactivating complex
[NCBI:1269604]
[REACTOME:R-HSA-3769402]
[PUBMED:18632669]
[PUBMED:12408825]
[PUBMED:18573912]
[PUBMED:11080158]
[PUBMED:15525529]
[PUBMED:16510874]
[PUBMED:12712206]
[PUBMED:18077326]
[PUBMED:19364920]
[PUBMED:12408824]
[PUBMED:10898789]
Degradation of beta-catenin by the destruction complex
[NCBI:1269596]
[REACTOME:R-HSA-195253]
[PUBMED:17143292]
Endometrial cancer
[NCBI:83109]
[KEGG:hsa05213]
[PUBMED:14747944]
[PUBMED:11431710]
[PUBMED:7585656]
[PUBMED:16508724]
[PUBMED:15284264]
[PUBMED:17028294]
[PUBMED:16248975]
[PUBMED:15947972]
Formation of the beta-catenin:TCF transactivating complex
[NCBI:1269602]
[REACTOME:R-HSA-201722]
[PUBMED:19305417]
[PUBMED:11713476]
[PUBMED:18334222]
[PUBMED:11934263]
[PUBMED:16751178]
[PUBMED:22617422]
[PUBMED:20951344]
[PUBMED:11136974]
[PUBMED:19619488]
[PUBMED:10831834]
[PUBMED:21285352]
Hippo signaling pathway
[NCBI:749777]
[KEGG:hsa04390]
[PUBMED:18955139]
[PUBMED:20439427]
[PUBMED:20951342]
[PUBMED:21138973]
[PUBMED:18328423]
[PUBMED:21324984]
[PUBMED:23034192]
[PUBMED:21808241]
[PUBMED:17975546]
[PUBMED:22750148]
[PUBMED:21084559]
[PUBMED:19846288]
[PUBMED:22895435]
[PUBMED:22683405]
[PUBMED:22658639]
[PUBMED:22153608]
[PUBMED:20945341]
[PUBMED:22830020]
[PUBMED:21874053]
[PUBMED:21376238]
Melanogenesis
[NCBI:83092]
[KEGG:hsa04916]
[PUBMED:11041354]
[PUBMED:10347209]
[PUBMED:15016298]
[PUBMED:11023702]
[PUBMED:11602344]
[PUBMED:12753399]
[PUBMED:10841026]
[PUBMED:16822996]
[PUBMED:15383650]
[PUBMED:9263329]
[PUBMED:16246839]
[PUBMED:10643996]
[PUBMED:12894244]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Prostate cancer
[NCBI:83111]
[KEGG:hsa05215]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11527574]
[PUBMED:11750244]
[PUBMED:16551847]
[PUBMED:10835690]
[PUBMED:8069858]
[PUBMED:15724144]
[PUBMED:10453277]
[PUBMED:15082523]
[PUBMED:9422516]
Regulation of Wnt-mediated beta catenin signaling and target gene transcription
[NCBI:169352]
[Pathway Interaction Database:wnt_beta_catenin_pathway]
[PUBMED:19901072]
[PUBMED:19699733]
[PUBMED:15142975]
[PUBMED:16565090]
[PUBMED:17372190]
[PUBMED:17310985]
[PUBMED:11751639]
[PUBMED:16301527]
[PUBMED:10921920]
[PUBMED:8622675]
[PUBMED:19571879]
[PUBMED:11445543]
[PUBMED:19066453]
[PUBMED:15768032]
[PUBMED:10704849]
[PUBMED:19940019]
[PUBMED:15378020]
[PUBMED:10318916]
[PUBMED:10617567]
[PUBMED:19435523]
[PUBMED:18511409]
[PUBMED:18006687]
[PUBMED:14638683]
[PUBMED:15782138]
[PUBMED:15143193]
[PUBMED:9671490]
[PUBMED:11263497]
[PUBMED:18193033]
[PUBMED:9751710]
[PUBMED:11532957]
[PUBMED:10898789]
[PUBMED:11266540]
[PUBMED:17090534]
[PUBMED:15492215]
[PUBMED:16309666]
[PUBMED:12502739]
[PUBMED:10980707]
[PUBMED:17945188]
[PUBMED:11572874]
[PUBMED:11809808]
[PUBMED:17113388]
[PUBMED:20128690]
[PUBMED:17709391]
[PUBMED:11500377]
[PUBMED:12464179]
[PUBMED:18347071]
[PUBMED:18347094]
[PUBMED:15592430]
[PUBMED:10958684]
[PUBMED:12408825]
[PUBMED:15525529]
[PUBMED:16581771]
[PUBMED:12052822]
[PUBMED:15668231]
[PUBMED:16014379]
[PUBMED:17923689]
[PUBMED:15592505]
[PUBMED:10984057]
[PUBMED:20044351]
[PUBMED:11940574]
[PUBMED:10747853]
[PUBMED:12606575]
[PUBMED:15728254]
[PUBMED:11080158]
[PUBMED:12446687]
[PUBMED:20128911]
[PUBMED:19816403]
[PUBMED:18573912]
[PUBMED:17397822]
[PUBMED:10489374]
[PUBMED:17052462]
[PUBMED:20371816]
[PUBMED:18347063]
[PUBMED:11035805]
[PUBMED:11792709]
[PUBMED:16899215]
[PUBMED:10882123]
[PUBMED:12200448]
[PUBMED:15060161]
[PUBMED:12711682]
[PUBMED:12582159]
[PUBMED:12646922]
[PUBMED:19460168]
[PUBMED:16778892]
[PUBMED:17306568]
[PUBMED:12712206]
[PUBMED:19711354]
[PUBMED:17893322]
[PUBMED:10934025]
[PUBMED:19503085]
[PUBMED:19433865]
Repression of WNT target genes
[NCBI:1269598]
[REACTOME:R-HSA-4641265]
[PUBMED:15121853]
[PUBMED:11266540]
[PUBMED:10831834]
[PUBMED:8955148]
[PUBMED:22305159]
[PUBMED:20925119]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by Wnt
[NCBI:1269594]
[REACTOME:R-HSA-195721]
[PUBMED:19530173]
[PUBMED:23256519]
[PUBMED:22952392]
[PUBMED:19204114]
[PUBMED:19365405]
[PUBMED:19619488]
[PUBMED:17143292]
[PUBMED:17230199]
[PUBMED:18710302]
[PUBMED:16099039]
[PUBMED:20576942]
[PUBMED:10858654]
[PUBMED:12967557]
TCF dependent signaling in response to WNT
[NCBI:1269599]
[REACTOME:R-HSA-201681]
[PUBMED:19619488]
[PUBMED:23256519]
[PUBMED:23343194]
Thyroid cancer
[NCBI:83112]
[KEGG:hsa05216]
[PUBMED:16189702]
[PUBMED:17062879]
[PUBMED:16557281]
[PUBMED:16242838]
[PUBMED:12094241]
[PUBMED:16551846]
[PUBMED:16946003]
[PUBMED:11165748]
Wnt signaling pathway
[NCBI:83061]
[KEGG:hsa04310]
[PUBMED:12446114]
[PUBMED:14745971]
[PUBMED:14530294]
[PUBMED:15102436]
[PUBMED:14635791]
[PUBMED:19482104]
[PUBMED:23256519]
[PUBMED:12967557]
[PUBMED:11433294]
[PUBMED:18838381]