full name
cell division cycle 25C

synonyms
CDC25, PPP1R60, CDC25C, ENSG00000158402

HGNC
HGNC:1727

Entrez Gene
Gene:995

ENSEMBL
ENSG00000158402

location
chr: 5
start: 137620959
stop: 137674064
strand: -

transcripts
NM_022809.2
NM_001790.3

pathways
Activation of ATR in response to replication stress [NCBI:1269757] [REACTOME:R-HSA-176187] [PUBMED:12791985]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints [NCBI:1269742] [REACTOME:R-HSA-69620]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Cell cycle [NCBI:83054] [KEGG:hsa04110] [PUBMED:7973727] [PUBMED:17568790] [PUBMED:9832503] [PUBMED:16936746] [PUBMED:9029154] [PUBMED:12573239] [PUBMED:19020303] [PUBMED:9618481] [PUBMED:12809600] [PUBMED:8242749] [PUBMED:10385618] [PUBMED:17426725] [PUBMED:17018296] [PUBMED:16212951] [PUBMED:12925736] [PUBMED:11099028] [PUBMED:15568976] [PUBMED:15838516] [PUBMED:15838523] [PUBMED:15876871] [PUBMED:7908906] [PUBMED:9889196]
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex [NCBI:1269755] [REACTOME:R-HSA-75035]
Cyclin A/B1 associated events during G2/M transition [NCBI:1269800] [REACTOME:R-HSA-69273] [PUBMED:18228324]
Cyclin B2 mediated events [NCBI:1269802] [REACTOME:R-HSA-157881] [PUBMED:10395539] [PUBMED:11238451] [PUBMED:7737117] [PUBMED:17533373]
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models [NCBI:1457789] [REACTOME:R-HSA-8862803] [PUBMED:8090221] [PUBMED:12684440] [PUBMED:22899714] [PUBMED:10830966] [PUBMED:7592934] [PUBMED:19519302]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
G2/M Checkpoints [NCBI:1269753] [REACTOME:R-HSA-69481]
G2/M DNA damage checkpoint [NCBI:1269754] [REACTOME:R-HSA-69473]
G2/M Transition [NCBI:1269799] [REACTOME:R-HSA-69275]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
MicroRNAs in cancer [NCBI:852705] [KEGG:hsa05206] [PUBMED:23075324] [PUBMED:21742789] [PUBMED:22351564] [PUBMED:18817506] [PUBMED:22345301] [PUBMED:21402473] [PUBMED:22926415] [PUBMED:23165235] [PUBMED:19630570] [PUBMED:21565290] [PUBMED:23091478] [PUBMED:23462054] [PUBMED:23316212] [PUBMED:19773200] [PUBMED:22035854] [PUBMED:20221895] [PUBMED:20345848] [PUBMED:22580099] [PUBMED:20128019]
Mitotic G2-G2/M phases [NCBI:1269797] [REACTOME:R-HSA-453274]
Neurodegenerative Diseases [NCBI:1457788] [REACTOME:R-HSA-8863678] [PUBMED:26848654]
Oocyte meiosis [NCBI:126909] [KEGG:hsa04114] [PUBMED:16760654] [PUBMED:17480229] [PUBMED:15136768] [PUBMED:18946022] [PUBMED:18598214] [PUBMED:16518630] [PUBMED:18631137] [PUBMED:15182704] [PUBMED:15182701] [PUBMED:16554437] [PUBMED:14691134] [PUBMED:18550795] [PUBMED:18096427] [PUBMED:14517314] [PUBMED:18311174]
PLK1 signaling events [NCBI:138007] [Pathway Interaction Database:plk1_pathway] [PUBMED:15070733] [PUBMED:18418076] [PUBMED:15350223] [PUBMED:16885021] [PUBMED:12167714] [PUBMED:16966375] [PUBMED:18615013] [PUBMED:18662541] [PUBMED:18521620] [PUBMED:7790358] [PUBMED:8428596] [PUBMED:12852857] [PUBMED:18427546] [PUBMED:17446864] [PUBMED:16760428] [PUBMED:15148369] [PUBMED:16885022] [PUBMED:9734353] [PUBMED:18331714] [PUBMED:16980960] [PUBMED:18378770] [PUBMED:16860740] [PUBMED:15964272] [PUBMED:10980711] [PUBMED:11050165] [PUBMED:16580887] [PUBMED:17360533] [PUBMED:15678101] [PUBMED:11897663] [PUBMED:16418575] [PUBMED:17218258] [PUBMED:14734534] [PUBMED:18566290] [PUBMED:17081991] [PUBMED:15469984] [PUBMED:11447294] [PUBMED:17351640] [PUBMED:16934469] [PUBMED:18552834] [PUBMED:17488623] [PUBMED:8991084] [PUBMED:17785528] [PUBMED:18477460] [PUBMED:19351716] [PUBMED:12939256] [PUBMED:12852856] [PUBMED:15737063]
PLK3 signaling events [NCBI:138042] [Pathway Interaction Database:plk3_pathway] [PUBMED:12242661] [PUBMED:11551930] [PUBMED:17264206] [PUBMED:14968113]
Polo-like kinase mediated events [NCBI:1269804] [REACTOME:R-HSA-156711] [PUBMED:15692562] [PUBMED:22391450] [PUBMED:15654331] [PUBMED:15070733] [PUBMED:23109430] [PUBMED:19160488]
Progesterone-mediated oocyte maturation [NCBI:119304] [KEGG:hsa04914] [PUBMED:10497333] [PUBMED:12084906] [PUBMED:12045215] [PUBMED:11063930] [PUBMED:12477927] [PUBMED:11148128] [PUBMED:11730319] [PUBMED:12374568]
RHO GTPase Effectors [NCBI:1269509] [REACTOME:R-HSA-195258] [PUBMED:9694656] [PUBMED:18066052] [PUBMED:11018042] [PUBMED:10470034] [PUBMED:8702756] [PUBMED:21730051] [PUBMED:8571126] [PUBMED:19513348] [PUBMED:17244649] [PUBMED:11145705] [PUBMED:24128008] [PUBMED:23716662] [PUBMED:8617235] [PUBMED:8543060] [PUBMED:11804587] [PUBMED:24969695] [PUBMED:12635176] [PUBMED:12778124] [PUBMED:18006505] [PUBMED:1660188] [PUBMED:21351730] [PUBMED:16507994] [PUBMED:14595335] [PUBMED:10072071] [PUBMED:10591629] [PUBMED:10753910] [PUBMED:23875749] [PUBMED:17151359] [PUBMED:10652353] [PUBMED:12221077] [PUBMED:10559936] [PUBMED:12783890] [PUBMED:11948177] [PUBMED:18237546] [PUBMED:16079795] [PUBMED:10924361] [PUBMED:14514689] [PUBMED:8107774] [PUBMED:8756646] [PUBMED:16979770] [PUBMED:16636067] [PUBMED:9751706] [PUBMED:10619026] [PUBMED:23444367] [PUBMED:15546864] [PUBMED:12473120] [PUBMED:8816443] [PUBMED:9199170] [PUBMED:12514133] [PUBMED:16762923] [PUBMED:12110184] [PUBMED:16431929] [PUBMED:10975528] [PUBMED:10940294] [PUBMED:9535855] [PUBMED:7559638] [PUBMED:11162552] [PUBMED:19737400] [PUBMED:9988689] [PUBMED:12732141] [PUBMED:8798539] [PUBMED:24914801] [PUBMED:11689693] [PUBMED:8769096] [PUBMED:9368021]
RHO GTPases activate PKNs [NCBI:1269512] [REACTOME:R-HSA-5625740] [PUBMED:21351730] [PUBMED:21749319] [PUBMED:10753910] [PUBMED:18429822] [PUBMED:9175763] [PUBMED:12783890] [PUBMED:14514689] [PUBMED:10924361] [PUBMED:7673228] [PUBMED:10619026] [PUBMED:10467162] [PUBMED:11134534] [PUBMED:9030526] [PUBMED:9988689] [PUBMED:19723632] [PUBMED:24128008] [PUBMED:18006505]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Rho GTPases [NCBI:1269507] [REACTOME:R-HSA-194315] [PUBMED:16212495] [PUBMED:15630019]
TP53 Regulates Transcription of Cell Cycle Genes [NCBI:1383071] [REACTOME:R-HSA-6791312] [PUBMED:12897130] [PUBMED:11896574] [PUBMED:18337750] [PUBMED:24739573] [PUBMED:9184226] [PUBMED:8242751] [PUBMED:11812999] [PUBMED:11574543] [PUBMED:22172947] [PUBMED:17719541] [PUBMED:20460379] [PUBMED:22802529] [PUBMED:9671765] [PUBMED:11814693] [PUBMED:16160013] [PUBMED:23485469] [PUBMED:26122615] [PUBMED:23236473] [PUBMED:22802528] [PUBMED:9712883] [PUBMED:7784094] [PUBMED:20531387] [PUBMED:9780002] [PUBMED:10891498] [PUBMED:22252318] [PUBMED:19276069] [PUBMED:20817677] [PUBMED:14968113] [PUBMED:18431400] [PUBMED:20352051] [PUBMED:12692263] [PUBMED:18719709] [PUBMED:16140933] [PUBMED:7973727] [PUBMED:10524633] [PUBMED:15574328] [PUBMED:24096481] [PUBMED:15186775] [PUBMED:16772293] [PUBMED:8242752] [PUBMED:8944033] [PUBMED:17146433] [PUBMED:9659898]
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest [NCBI:1383073] [REACTOME:R-HSA-6804114] [PUBMED:7784094] [PUBMED:23485469] [PUBMED:15186775] [PUBMED:15574328] [PUBMED:16772293] [PUBMED:10524633] [PUBMED:9659898] [PUBMED:20460379] [PUBMED:11574543] [PUBMED:7973727] [PUBMED:24096481] [PUBMED:17719541]
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain [NCBI:1383074] [REACTOME:R-HSA-6804115] [PUBMED:22252318] [PUBMED:17146433] [PUBMED:8944033] [PUBMED:12897130] [PUBMED:11896574] [PUBMED:18337750] [PUBMED:9184226] [PUBMED:9671765] [PUBMED:16140933] [PUBMED:16160013] [PUBMED:20531387] [PUBMED:11814693] [PUBMED:23236473] [PUBMED:9712883] [PUBMED:19276069] [PUBMED:14968113] [PUBMED:20352051]
Transcriptional Regulation by TP53 [NCBI:1269654] [REACTOME:R-HSA-3700989] [PUBMED:26122615] [PUBMED:19410540]