full name
origin recognition complex subunit 1

synonyms
HSORC1, ORC1L, PARC1, ORC1, ENSG00000085840

HGNC
HGNC:8487

Entrez Gene
Gene:4998

ENSEMBL
ENSG00000085840

location
chr: 1
start: 52838501
stop: 52870143
strand: -

OMIM
OMIM:601902: ORC1 (Autosomal recessive inheritance,Heterogeneous)
OMIM:224690: Meier-Gorlin syndrome 1

transcripts
NM_001190818.1
NM_001190819.1
NM_004153.3

pathways
Activation of ATR in response to replication stress [NCBI:1269757] [REACTOME:R-HSA-176187] [PUBMED:12791985]
Activation of the pre-replicative complex [NCBI:1269773] [REACTOME:R-HSA-68962] [PUBMED:10402192] [PUBMED:10801458] [PUBMED:11323433] [PUBMED:12169736] [PUBMED:9765232] [PUBMED:9829972] [PUBMED:10970868] [PUBMED:7502077] [PUBMED:9353276] [PUBMED:11459976] [PUBMED:11395502] [PUBMED:11779870] [PUBMED:9038340]
Assembly of the ORC complex at the origin of replication [NCBI:1269834] [REACTOME:R-HSA-68616] [PUBMED:11395502] [PUBMED:11739726] [PUBMED:11278932] [PUBMED:9372948] [PUBMED:11323433] [PUBMED:1579162] [PUBMED:10438470] [PUBMED:1110244] [PUBMED:8044842]
Assembly of the pre-replicative complex [NCBI:1269833] [REACTOME:R-HSA-68867] [PUBMED:11801723] [PUBMED:9829972] [PUBMED:9288745] [PUBMED:9407030] [PUBMED:9927482] [PUBMED:9335335] [PUBMED:11046155]
Association of licensing factors with the pre-replicative complex [NCBI:1269795] [REACTOME:R-HSA-69298]
CDC6 association with the ORC:origin complex [NCBI:1269835] [REACTOME:R-HSA-68689] [PUBMED:11532947] [PUBMED:11046155] [PUBMED:9566895] [PUBMED:9312054] [PUBMED:10712901] [PUBMED:10995389] [PUBMED:9520412] [PUBMED:9889196] [PUBMED:10339564] [PUBMED:7641697] [PUBMED:10801458]
CDT1 association with the CDC6:ORC:origin complex [NCBI:1269836] [REACTOME:R-HSA-68827] [PUBMED:11125146] [PUBMED:11836525] [PUBMED:11175741] [PUBMED:10766248] [PUBMED:10766247] [PUBMED:10898791] [PUBMED:9635433] [PUBMED:9442876]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints [NCBI:219800] [WikiPathways:WP1775] [NCBI:1269742] [REACTOME:R-HSA-69620] [PUBMED:16314342] [PUBMED:10872471] [PUBMED:12773400] [PUBMED:1384126] [PUBMED:10323868] [PUBMED:10973490] [PUBMED:9278512] [PUBMED:16407120] [PUBMED:11535616] [PUBMED:15743907] [PUBMED:11331603] [PUBMED:15707391] [PUBMED:11313932] [PUBMED:15833913] [PUBMED:16931761] [PUBMED:10859164] [PUBMED:14624239] [PUBMED:9733515] [PUBMED:11804586] [PUBMED:14605214] [PUBMED:16327781] [PUBMED:12791985] [PUBMED:14500360] [PUBMED:10373362] [PUBMED:8943031] [PUBMED:12578958] [PUBMED:10051570] [PUBMED:8242752] [PUBMED:8196638] [PUBMED:16262255] [PUBMED:12049731] [PUBMED:12766774] [PUBMED:10473346] [PUBMED:10330186] [PUBMED:12006501] [PUBMED:11927569] [PUBMED:11907025] [PUBMED:15190204] [PUBMED:10777662] [PUBMED:11390642] [PUBMED:9843217] [PUBMED:11157767] [PUBMED:9733514] [PUBMED:14729973] [PUBMED:11181178] [PUBMED:16027118] [PUBMED:12399544] [PUBMED:15226314] [PUBMED:7850419]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Cell cycle [NCBI:83054] [KEGG:hsa04110] [NCBI:198811] [WikiPathways:WP179] [PUBMED:17568790] [PUBMED:7973727] [PUBMED:9832503] [PUBMED:16936746] [PUBMED:9029154] [PUBMED:12573239] [PUBMED:12809600] [PUBMED:9733515] [PUBMED:8242749] [PUBMED:9618481] [PUBMED:10385618] [PUBMED:15568976] [PUBMED:17426725] [PUBMED:17018296] [PUBMED:16212951] [PUBMED:15838516] [PUBMED:11099028] [PUBMED:15838523] [PUBMED:15876871] [PUBMED:7908906] [PUBMED:9889196] [PUBMED:19020303] [PUBMED:12925736]
DNA Replication [NCBI:198771] [WikiPathways:WP466] [NCBI:1269875] [REACTOME:R-HSA-69306] [PUBMED:11257218] [PUBMED:12045100] [PUBMED:1536007] [PUBMED:10966477] [PUBMED:1579437] [PUBMED:8223461]
DNA Replication Pre-Initiation [NCBI:1269832] [REACTOME:R-HSA-69002]
E2F mediated regulation of DNA replication [NCBI:1269774] [REACTOME:R-HSA-113510] [PUBMED:12726857] [PUBMED:12393009] [PUBMED:12473340]
E2F transcription factor network [NCBI:137934] [Pathway Interaction Database:e2f_pathway] [PUBMED:15175242] [PUBMED:8618861] [PUBMED:8832394] [PUBMED:11857079] [PUBMED:11034215] [PUBMED:7479977] [PUBMED:9704927] [PUBMED:15014447] [PUBMED:16288221] [PUBMED:11274364] [PUBMED:9192872] [PUBMED:7958837] [PUBMED:9774682] [PUBMED:9271400] [PUBMED:12766778] [PUBMED:12757710] [PUBMED:17704056] [PUBMED:10766737] [PUBMED:7705662] [PUBMED:15897886] [PUBMED:9778043] [PUBMED:8657141] [PUBMED:8552092] [PUBMED:11418595] [PUBMED:11101847] [PUBMED:11719808] [PUBMED:19491197] [PUBMED:16179649] [PUBMED:7791762] [PUBMED:12697828] [PUBMED:16357170] [PUBMED:12389032] [PUBMED:8264596] [PUBMED:12748276] [PUBMED:10454584] [PUBMED:10783242] [PUBMED:15713665] [PUBMED:2524830] [PUBMED:14633988] [PUBMED:9689056] [PUBMED:15133492] [PUBMED:9724731] [PUBMED:16892051] [PUBMED:10030670] [PUBMED:11799067] [PUBMED:8943353] [PUBMED:12101096] [PUBMED:11459832] [PUBMED:8114719] [PUBMED:9520412] [PUBMED:11389439] [PUBMED:16211008] [PUBMED:12411495] [PUBMED:7958836] [PUBMED:12909625] [PUBMED:10187822] [PUBMED:9020173] [PUBMED:18348985] [PUBMED:12611887] [PUBMED:10373518] [PUBMED:9191053] [PUBMED:10688648] [PUBMED:12077144] [PUBMED:8334989] [PUBMED:11904439] [PUBMED:15510213] [PUBMED:15306814]
E2F-enabled inhibition of pre-replication complex formation [NCBI:1269776] [REACTOME:R-HSA-113507] [PUBMED:11090133]
G1 to S cell cycle control [NCBI:198805] [WikiPathways:WP45] [PUBMED:12164919]
G1/S Transition [NCBI:1269768] [REACTOME:R-HSA-69206]
G1/S-Specific Transcription [NCBI:1269772] [REACTOME:R-HSA-69205]
G2/M Checkpoints [NCBI:1269753] [REACTOME:R-HSA-69481]
M/G1 Transition [NCBI:1269831] [REACTOME:R-HSA-68874]
Mitotic G1-G1/S phases [NCBI:1269764] [REACTOME:R-HSA-453279]
Orc1 removal from chromatin [NCBI:1269782] [REACTOME:R-HSA-68949] [PUBMED:11931757] [PUBMED:11809796] [PUBMED:11739726] [PUBMED:1110244]
RB in Cancer [NCBI:920977] [WikiPathways:WP2446] [PUBMED:7565706] [PUBMED:8242749] [PUBMED:15469821]
Regulation of DNA replication [NCBI:1269794] [REACTOME:R-HSA-69304]
Removal of licensing factors from origins [NCBI:1269796] [REACTOME:R-HSA-69300]
S Phase [NCBI:1269777] [REACTOME:R-HSA-69242]
Switching of origins to a post-replicative state [NCBI:1269781] [REACTOME:R-HSA-69052]
Synthesis of DNA [NCBI:1269779] [REACTOME:R-HSA-69239]