Logo
full name
transmembrane protein 173

synonyms
ERIS, MITA, MPYS, NET23, STING, TMEM173, ENSG00000184584

HGNC
HGNC:27962

Entrez Gene
Gene:340061

ENSEMBL
ENSG00000184584

location
chr: 5
start: 138855113
stop: 138862343
strand: -

OMIM
OMIM:612374: TMEM173
OMIM:615934: STING-associated vasculopathy, infantile-onset

transcripts
NM_198282.2

pathways
Cytosolic DNA-sensing pathway [NCBI:125137] [KEGG:hsa04623] [PUBMED:18573338] [PUBMED:19665965] [PUBMED:19567913] [PUBMED:18280611] [PUBMED:18724932] [PUBMED:19497760] [PUBMED:16286919] [PUBMED:19122387] [PUBMED:19590578] [PUBMED:23258413] [PUBMED:18375758] [PUBMED:19321146] [PUBMED:19362700] [PUBMED:18941233] [PUBMED:19767723]
Cytosolic sensors of pathogen-associated DNA [NCBI:1269268] [REACTOME:R-HSA-1834949] [PUBMED:23706668] [PUBMED:21533068] [PUBMED:23706667]
IRF3-mediated induction of type I IFN [NCBI:1269273] [REACTOME:R-HSA-3270619] [PUBMED:22394562]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
NOD-like receptor signaling pathway [NCBI:122191] [KEGG:hsa04621] [PUBMED:25330206] [PUBMED:21575908] [PUBMED:23846113] [PUBMED:26549800] [PUBMED:16493424] [PUBMED:23124073] [PUBMED:24840700] [PUBMED:27291964] [PUBMED:27012466] [PUBMED:24707857] [PUBMED:19767725] [PUBMED:25879280] [PUBMED:23215645] [PUBMED:22819539] [PUBMED:23702978] [PUBMED:20643110] [PUBMED:25879288] [PUBMED:26655628] [PUBMED:25145756] [PUBMED:24718315] [PUBMED:26482951] [PUBMED:25526305] [PUBMED:26121197] [PUBMED:22430786]
Neutrophil degranulation [NCBI:1457780] [REACTOME:R-HSA-6798695] [PUBMED:20338884] [PUBMED:1378856] [PUBMED:17627888] [PUBMED:23650620] [PUBMED:8692836]
RIG-I-like receptor signaling pathway [NCBI:117292] [KEGG:hsa04622] [PUBMED:19224920] [PUBMED:19076341] [PUBMED:18549796] [PUBMED:18591413] [PUBMED:19615405] [PUBMED:19120475] [PUBMED:18439848] [PUBMED:19120476] [PUBMED:15208624] [PUBMED:19539500] [PUBMED:18272355] [PUBMED:18984593]
Regulation of innate immune responses to cytosolic DNA [NCBI:1269277] [REACTOME:R-HSA-3134975] [PUBMED:23706668] [PUBMED:19362700]
STAT6-mediated induction of chemokines [NCBI:1269274] [REACTOME:R-HSA-3249367] [PUBMED:22000020]
STING mediated induction of host immune responses [NCBI:1269272] [REACTOME:R-HSA-1834941] [PUBMED:19776740] [PUBMED:22607800] [PUBMED:18724357] [PUBMED:21947006] [PUBMED:22394562] [PUBMED:23585680] [PUBMED:23478444] [PUBMED:19433799] [PUBMED:20107183] [PUBMED:21820332] [PUBMED:20871604] [PUBMED:19926846] [PUBMED:21892174] [PUBMED:22706339] [PUBMED:20890285] [PUBMED:23604073]