Logo
full name
histone deacetylase 3

synonyms
HD3, RPD3, RPD3-2, HDAC3, ENSG00000171720

HGNC
HGNC:4854

Entrez Gene
Gene:8841

ENSEMBL
ENSG00000171720

location
chr: 5
start: 141000443
stop: 141016423
strand: -

transcripts
NM_003883.3

pathways
Activation of HOX genes during differentiation [NCBI:1339139] [REACTOME:R-HSA-5619507] [PUBMED:19923920] [PUBMED:25804734] [PUBMED:23973942] [PUBMED:23650639] [PUBMED:20435029] [PUBMED:24529385]
Activation of anterior HOX genes in hindbrain development during early embryogenesis [NCBI:1339140] [REACTOME:R-HSA-5617472] [PUBMED:19575673] [PUBMED:23973942] [PUBMED:18394579] [PUBMED:24529385] [PUBMED:24115586] [PUBMED:18412118] [PUBMED:19651303] [PUBMED:25804734] [PUBMED:22770981] [PUBMED:19923920] [PUBMED:16155570] [PUBMED:18816852] [PUBMED:25560970] [PUBMED:10068641] [PUBMED:10662633] [PUBMED:20435029] [PUBMED:17368312] [PUBMED:21497760] [PUBMED:10668974]
Alcoholism [NCBI:585563] [KEGG:hsa05034] [PUBMED:16764827] [PUBMED:18616668] [PUBMED:19077056] [PUBMED:18991950] [PUBMED:19756388] [PUBMED:12068305] [PUBMED:16102840] [PUBMED:20947635] [PUBMED:20729980] [PUBMED:16278489] [PUBMED:17270154] [PUBMED:20626732] [PUBMED:18310464] [PUBMED:10774721] [PUBMED:19342616] [PUBMED:12605085] [PUBMED:15500908] [PUBMED:14729391] [PUBMED:12085089] [PUBMED:16776597]
Association of TriC/CCT with target proteins during biosynthesis [NCBI:1268699] [REACTOME:R-HSA-390471] [PUBMED:19011634]
BMAL1:CLOCK,NPAS2 activates circadian gene expression [NCBI:1269872] [REACTOME:R-HSA-1368108] [PUBMED:12868535] [PUBMED:9616112]
Chaperonin-mediated protein folding [NCBI:1268694] [REACTOME:R-HSA-390466] [PUBMED:11868281] [PUBMED:15519848]
Chromatin modifying enzymes [NCBI:1270434] [REACTOME:R-HSA-3247509]
Chromatin organization [NCBI:1270433] [REACTOME:R-HSA-4839726] [PUBMED:21342762] [PUBMED:15598472]
Circadian Clock [NCBI:1269871] [REACTOME:R-HSA-400253] [PUBMED:18775307] [PUBMED:18802415] [PUBMED:18786386] [PUBMED:16987893]
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants [NCBI:1268891] [REACTOME:R-HSA-2894862] [PUBMED:15472075] [PUBMED:17646408] [PUBMED:17646409] [PUBMED:16738328]
Constitutive Signaling by NOTCH1 PEST Domain Mutants [NCBI:1268889] [REACTOME:R-HSA-2644606] [PUBMED:15472075] [PUBMED:17646408] [PUBMED:17646409]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases of signal transduction [NCBI:1268855] [REACTOME:R-HSA-5663202] [PUBMED:12509752]
Fatty acid, triacylglycerol, and ketone body metabolism [NCBI:1270010] [REACTOME:R-HSA-535734]
HDACs deacetylate histones [NCBI:1270436] [REACTOME:R-HSA-3214815] [PUBMED:21872466] [PUBMED:12429021]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Mitochondrial biogenesis [NCBI:1268839] [REACTOME:R-HSA-1592230] [PUBMED:18430751] [PUBMED:19262508] [PUBMED:22265687] [PUBMED:20533901] [PUBMED:20933024] [PUBMED:21757760] [PUBMED:19575678] [PUBMED:19008463] [PUBMED:21629705] [PUBMED:21543634] [PUBMED:22817841] [PUBMED:20649548] [PUBMED:22146081] [PUBMED:19276888] [PUBMED:19682549] [PUBMED:15744310] [PUBMED:19076454]
NOTCH1 Intracellular Domain Regulates Transcription [NCBI:1269537] [REACTOME:R-HSA-2122947] [PUBMED:11044625] [PUBMED:8649374] [PUBMED:21737748] [PUBMED:9694793] [PUBMED:20972443] [PUBMED:11585921] [PUBMED:17114293] [PUBMED:8001118] [PUBMED:18094723] [PUBMED:8687460] [PUBMED:16256737] [PUBMED:16530044] [PUBMED:12050117] [PUBMED:10964718] [PUBMED:12391150] [PUBMED:7566092] [PUBMED:15546612] [PUBMED:15107403] [PUBMED:18374649] [PUBMED:14980219] [PUBMED:11461910] [PUBMED:10713164]
NR1D1 (REV-ERBA) represses gene expression [NCBI:1269874] [REACTOME:R-HSA-1368071] [PUBMED:18006707] [PUBMED:20581824] [PUBMED:20414452] [PUBMED:18037887]
Organelle biogenesis and maintenance [NCBI:1268838] [REACTOME:R-HSA-1852241] [PUBMED:8608592] [PUBMED:16103713]
PPARA activates gene expression [NCBI:1270030] [REACTOME:R-HSA-1989781] [PUBMED:10529898] [PUBMED:18288277] [PUBMED:11330046] [PUBMED:20936127] [PUBMED:14999402]
Protein folding [NCBI:1268693] [REACTOME:R-HSA-391251] [PUBMED:15459659] [PUBMED:18395510] [PUBMED:15519848]
RORA activates gene expression [NCBI:1269873] [REACTOME:R-HSA-1368082] [PUBMED:7926749]
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) [NCBI:1270029] [REACTOME:R-HSA-400206] [PUBMED:18288277] [PUBMED:10529898] [PUBMED:16476485] [PUBMED:16503871]
Regulation of retinoblastoma protein [NCBI:137916] [Pathway Interaction Database:rb_1pathway] [PUBMED:15469821] [PUBMED:11470869] [PUBMED:8493578] [PUBMED:7596417] [PUBMED:8449399] [PUBMED:9468140] [PUBMED:11596110] [PUBMED:9545246] [PUBMED:16360038] [PUBMED:14673169] [PUBMED:17991896] [PUBMED:8805225] [PUBMED:7926730] [PUBMED:10322110] [PUBMED:11533237] [PUBMED:1828393] [PUBMED:8657117] [PUBMED:9491888] [PUBMED:7877691] [PUBMED:14729964] [PUBMED:1710781] [PUBMED:10778858] [PUBMED:11566021] [PUBMED:8246996] [PUBMED:12450794] [PUBMED:16374512] [PUBMED:10783144] [PUBMED:15949438] [PUBMED:9468139] [PUBMED:8242749] [PUBMED:9464541] [PUBMED:1531329] [PUBMED:9819434] [PUBMED:12479814] [PUBMED:10888886] [PUBMED:10597288] [PUBMED:8626527] [PUBMED:7629134] [PUBMED:11545733] [PUBMED:17620057] [PUBMED:11433299] [PUBMED:9858607] [PUBMED:15716956] [PUBMED:10490602] [PUBMED:1828392] [PUBMED:15577944] [PUBMED:11484059] [PUBMED:11583618] [PUBMED:10499802]
Retinoic acid receptors-mediated signaling [NCBI:138039] [Pathway Interaction Database:retinoic_acid_pathway] [PUBMED:9192892] [PUBMED:16417524] [PUBMED:7476969] [PUBMED:12032153] [PUBMED:8145770] [PUBMED:12824162] [PUBMED:10938135] [PUBMED:9351827] [PUBMED:15608670] [PUBMED:8855229] [PUBMED:16456540] [PUBMED:16613989] [PUBMED:15688020] [PUBMED:16275922] [PUBMED:15657432] [PUBMED:11467847] [PUBMED:16038797] [PUBMED:12885766] [PUBMED:14535629] [PUBMED:10608897] [PUBMED:12110588] [PUBMED:9230306] [PUBMED:16093479] [PUBMED:16723356] [PUBMED:11955452] [PUBMED:16769902] [PUBMED:10748061] [PUBMED:8164684] [PUBMED:17088940] [PUBMED:10938283] [PUBMED:7791761] [PUBMED:12032135] [PUBMED:11006275] [PUBMED:10383391] [PUBMED:11606411]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by NOTCH [NCBI:1269530] [REACTOME:R-HSA-157118]
Signaling by NOTCH1 [NCBI:1269535] [REACTOME:R-HSA-1980143] [PUBMED:20972443] [PUBMED:8649374] [PUBMED:11740940] [PUBMED:15965470] [PUBMED:16284625] [PUBMED:9694793] [PUBMED:19567869] [PUBMED:12354787] [PUBMED:11585921] [PUBMED:20418862] [PUBMED:11226752] [PUBMED:9590294] [PUBMED:9315665] [PUBMED:17114293] [PUBMED:18094723] [PUBMED:10964718] [PUBMED:10879540] [PUBMED:8001118] [PUBMED:12050117] [PUBMED:18043734] [PUBMED:9819428] [PUBMED:15824097] [PUBMED:9244301] [PUBMED:16256737] [PUBMED:8687460] [PUBMED:19726682] [PUBMED:8313469] [PUBMED:15574878] [PUBMED:18296446] [PUBMED:16530044] [PUBMED:9620803] [PUBMED:18237417] [PUBMED:7566092] [PUBMED:18628966] [PUBMED:12391150] [PUBMED:12530964] [PUBMED:11006133] [PUBMED:18374649] [PUBMED:15107403] [PUBMED:18077452] [PUBMED:15652348] [PUBMED:15546612] [PUBMED:10882063] [PUBMED:14980219] [PUBMED:10713164] [PUBMED:9462510] [PUBMED:11461910] [PUBMED:14567914] [PUBMED:17003037] [PUBMED:17028573] [PUBMED:11044625] [PUBMED:10206645] [PUBMED:19524514]
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer [NCBI:1268890] [REACTOME:R-HSA-2894858] [PUBMED:15472075]
Signaling by NOTCH1 PEST Domain Mutants in Cancer [NCBI:1268888] [REACTOME:R-HSA-2644602] [PUBMED:17646408] [PUBMED:15472075] [PUBMED:17646409]
Signaling by NOTCH1 in Cancer [NCBI:1268883] [REACTOME:R-HSA-2644603] [PUBMED:17646409] [PUBMED:10367900] [PUBMED:16738328] [PUBMED:15951812] [PUBMED:22399357] [PUBMED:15546612] [PUBMED:11461910] [PUBMED:9118226] [PUBMED:15951813] [PUBMED:17646408] [PUBMED:15472075] [PUBMED:11585921] [PUBMED:17909001] [PUBMED:16612405] [PUBMED:1831692] [PUBMED:15187027]
Signaling events mediated by HDAC Class I [NCBI:137997] [Pathway Interaction Database:hdac_classi_pathway] [PUBMED:9885572] [PUBMED:14701748] [PUBMED:10888618] [PUBMED:12393750] [PUBMED:9804427] [PUBMED:9139820] [PUBMED:12408818] [PUBMED:16809764] [PUBMED:12788099] [PUBMED:11533489] [PUBMED:15831498] [PUBMED:15701600] [PUBMED:11532945] [PUBMED:12183469] [PUBMED:16428440] [PUBMED:9150134] [PUBMED:12972430] [PUBMED:11486036] [PUBMED:15920470] [PUBMED:9150135] [PUBMED:9651585] [PUBMED:11960997] [PUBMED:9326634] [PUBMED:11278251] [PUBMED:14521922] [PUBMED:9197243] [PUBMED:9346952] [PUBMED:16371367] [PUBMED:10444591] [PUBMED:15653507] [PUBMED:15920471] [PUBMED:11919195]
Signaling events mediated by HDAC Class II [NCBI:138062] [Pathway Interaction Database:hdac_classii_pathway] [PUBMED:15916966] [PUBMED:10869435] [PUBMED:10898795] [PUBMED:16051668] [PUBMED:12032081] [PUBMED:12606581] [PUBMED:11804585] [PUBMED:11466315] [PUBMED:11567998] [PUBMED:16767219] [PUBMED:12024216] [PUBMED:16166628] [PUBMED:16221676] [PUBMED:11948178] [PUBMED:10220385] [PUBMED:12663674] [PUBMED:14668799] [PUBMED:16236793]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Thyroid hormone signaling pathway [NCBI:946598] [KEGG:hsa04919] [PUBMED:20005976] [PUBMED:17983645] [PUBMED:15345678] [PUBMED:16951130] [PUBMED:16214361] [PUBMED:18329679] [PUBMED:20051527] [PUBMED:17574003] [PUBMED:19716314] [PUBMED:19755667] [PUBMED:20868274] [PUBMED:21835053] [PUBMED:16051672] [PUBMED:19295177] [PUBMED:23021374] [PUBMED:22484490]
Transcriptional activation of mitochondrial biogenesis [NCBI:1268841] [REACTOME:R-HSA-2151201] [PUBMED:22265687] [PUBMED:20933024] [PUBMED:19575678] [PUBMED:22817841] [PUBMED:19682549]
Transcriptional regulation of white adipocyte differentiation [NCBI:1270345] [REACTOME:R-HSA-381340] [PUBMED:21082419] [PUBMED:17956727] [PUBMED:17475546] [PUBMED:1840554] [PUBMED:17139329] [PUBMED:15860371] [PUBMED:18518822] [PUBMED:10603305] [PUBMED:7531665] [PUBMED:20054179] [PUBMED:7838715] [PUBMED:16054042] [PUBMED:17060461] [PUBMED:17011499] [PUBMED:16380219] [PUBMED:8970730]
Validated targets of C-MYC transcriptional repression [NCBI:169353] [Pathway Interaction Database:myc_represspathway] [PUBMED:17082179] [PUBMED:11282029] [PUBMED:9869632] [PUBMED:15021909] [PUBMED:16167342] [PUBMED:18056446] [PUBMED:18045875] [PUBMED:1670896] [PUBMED:18393360] [PUBMED:7556187] [PUBMED:11313917] [PUBMED:17471507] [PUBMED:12418961] [PUBMED:9927431] [PUBMED:9924025] [PUBMED:18483244] [PUBMED:14716294] [PUBMED:15506972] [PUBMED:15616584] [PUBMED:12729735] [PUBMED:19219026] [PUBMED:12747840] [PUBMED:2182320] [PUBMED:12545156] [PUBMED:15367674] [PUBMED:11283613] [PUBMED:12384701] [PUBMED:18066065] [PUBMED:18455888] [PUBMED:10920185] [PUBMED:17881732] [PUBMED:20190815] [PUBMED:16352593] [PUBMED:17050536] [PUBMED:11283614] [PUBMED:16391002] [PUBMED:11804592] [PUBMED:7870572] [PUBMED:16940161] [PUBMED:12695333] [PUBMED:17159920] [PUBMED:8972190] [PUBMED:9312026] [PUBMED:17485441] [PUBMED:16288014]
Viral carcinogenesis [NCBI:658418] [KEGG:hsa05203] [PUBMED:9990017] [PUBMED:15173177] [PUBMED:16036567] [PUBMED:16581947] [PUBMED:9060639] [PUBMED:17457345] [PUBMED:15956361] [PUBMED:21421561] [PUBMED:18391203] [PUBMED:21040832] [PUBMED:9837909] [PUBMED:17645777] [PUBMED:15967719] [PUBMED:12686421] [PUBMED:17049016] [PUBMED:21152115] [PUBMED:11160754] [PUBMED:21966251] [PUBMED:17979705] [PUBMED:8617242] [PUBMED:12925958] [PUBMED:10873631] [PUBMED:21250384] [PUBMED:15614436] [PUBMED:10354594] [PUBMED:20494113] [PUBMED:18702816] [PUBMED:9651361] [PUBMED:16459163] [PUBMED:11278402] [PUBMED:15510157] [PUBMED:19956178] [PUBMED:18251977] [PUBMED:11766888] [PUBMED:10824878] [PUBMED:21372216] [PUBMED:11244044] [PUBMED:17894800] [PUBMED:11905817] [PUBMED:21347341] [PUBMED:12186904] [PUBMED:9374493] [PUBMED:16352731] [PUBMED:12770701] [PUBMED:17384582] [PUBMED:14506283] [PUBMED:11091847] [PUBMED:17267064] [PUBMED:11886269] [PUBMED:21177815] [PUBMED:10400746] [PUBMED:19156753] [PUBMED:9882379] [PUBMED:14559998] [PUBMED:15767449] [PUBMED:22110506] [PUBMED:20534855] [PUBMED:15542638] [PUBMED:9343405] [PUBMED:10405893] [PUBMED:19400863] [PUBMED:9349482] [PUBMED:14747563] [PUBMED:21647825] [PUBMED:12970441] [PUBMED:11669605] [PUBMED:15795286] [PUBMED:21994562] [PUBMED:14530271] [PUBMED:9594662] [PUBMED:22566809] [PUBMED:19651473] [PUBMED:8756622] [PUBMED:15105524] [PUBMED:15452270] [PUBMED:18948197] [PUBMED:16760382] [PUBMED:10793105] [PUBMED:21084867] [PUBMED:16308315] [PUBMED:16155604] [PUBMED:16381817] [PUBMED:16828973] [PUBMED:15342967] [PUBMED:15692053] [PUBMED:10855768] [PUBMED:19078975] [PUBMED:12379483] [PUBMED:15310405] [PUBMED:8223437] [PUBMED:16939421] [PUBMED:12910250] [PUBMED:16039586] [PUBMED:18201576] [PUBMED:21102637] [PUBMED:21743832] [PUBMED:20592731] [PUBMED:10644344] [PUBMED:10074132] [PUBMED:19715458] [PUBMED:16155601] [PUBMED:11604508] [PUBMED:15919895] [PUBMED:11099494] [PUBMED:18385245] [PUBMED:19854353] [PUBMED:12101418]
p75 NTR receptor-mediated signalling [NCBI:1269445] [REACTOME:R-HSA-193704] [PUBMED:16699811] [PUBMED:16939974] [PUBMED:12671646]
p75NTR negatively regulates cell cycle via SC1 [NCBI:1269451] [REACTOME:R-HSA-193670] [PUBMED:12371150]