full name
casein kinase 1 alpha 1

synonyms
CK1, CK1a, CKIa, HLCDGP1, PRO2975, CSNK1A1, ENSG00000113712

HGNC
HGNC:2451

Entrez Gene
Gene:1452

ENSEMBL
ENSG00000113712

location
chr: 5
start: 148873896
stop: 148931115
strand: -

transcripts
NM_001271741.1
NM_001892.5
NM_001025105.2
NM_001271742.1

pathways
AMER1 mutants destabilize the destruction complex [NCBI:1268913] [REACTOME:R-HSA-4839748] [PUBMED:17510365] [PUBMED:21248786] [PUBMED:23256519]
APC truncation mutants have impaired AXIN binding [NCBI:1268909] [REACTOME:R-HSA-5467337] [PUBMED:10921899] [PUBMED:1338904] [PUBMED:11057903] [PUBMED:10213492] [PUBMED:8111410]
AXIN missense mutants destabilize the destruction complex [NCBI:1268912] [REACTOME:R-HSA-5467340] [PUBMED:12101426] [PUBMED:10862053] [PUBMED:11746989] [PUBMED:10700176]
AXIN mutants destabilize the destruction complex, activating WNT signaling [NCBI:1268910] [REACTOME:R-HSA-4839735] [PUBMED:15735151] [PUBMED:23256519] [PUBMED:12101426] [PUBMED:11746989] [PUBMED:10700176] [PUBMED:11585731]
Activation of SMO [NCBI:1269642] [REACTOME:R-HSA-5635838] [PUBMED:16339192] [PUBMED:21356043] [PUBMED:20395968] [PUBMED:23719536] [PUBMED:24582806] [PUBMED:14636583] [PUBMED:19081070] [PUBMED:17641202] [PUBMED:17762891] [PUBMED:10966113] [PUBMED:17960137] [PUBMED:22981989] [PUBMED:20412775] [PUBMED:24845016] [PUBMED:23079593] [PUBMED:21801010] [PUBMED:21695114] [PUBMED:15691767] [PUBMED:22986504] [PUBMED:16459297] [PUBMED:14614827] [PUBMED:19906846] [PUBMED:12192414] [PUBMED:20844016]
Beta-catenin phosphorylation cascade [NCBI:1269597] [REACTOME:R-HSA-196299] [PUBMED:11955436] [PUBMED:12000790]
Breast cancer [NCBI:1435207] [KEGG:hsa05224] [PUBMED:24649067] [PUBMED:26040571] [PUBMED:11879567] [PUBMED:22722193] [PUBMED:26028978] [PUBMED:25013431] [PUBMED:11737884] [PUBMED:23702927] [PUBMED:21076461] [PUBMED:21898546] [PUBMED:27390604] [PUBMED:24291072] [PUBMED:26968398] [PUBMED:20087430] [PUBMED:23000897] [PUBMED:25544707] [PUBMED:24596345] [PUBMED:23988612] [PUBMED:24111892] [PUBMED:25907219] [PUBMED:15343273] [PUBMED:21965336] [PUBMED:23881035] [PUBMED:23196196] [PUBMED:22178455] [PUBMED:20436504] [PUBMED:19088017] [PUBMED:16113099] [PUBMED:20971825]
Canonical Wnt signaling pathway [NCBI:138032] [Pathway Interaction Database:wnt_canonical_pathway] [PUBMED:16849322] [PUBMED:10228155] [PUBMED:11007767] [PUBMED:10023673] [PUBMED:19061640] [PUBMED:10074433] [PUBMED:9554852] [PUBMED:10196136] [PUBMED:18772438] [PUBMED:19309792] [PUBMED:16263762] [PUBMED:16890161] [PUBMED:16341017] [PUBMED:17569865] [PUBMED:16314428] [PUBMED:17529994] [PUBMED:10421629] [PUBMED:11751573] [PUBMED:20177058] [PUBMED:15024404] [PUBMED:12000790] [PUBMED:19107203] [PUBMED:10684251] [PUBMED:9482734] [PUBMED:16547521] [PUBMED:10092233] [PUBMED:18077588] [PUBMED:16303557] [PUBMED:19556239] [PUBMED:19561074] [PUBMED:11274398] [PUBMED:14966280] [PUBMED:9566905] [PUBMED:11834740] [PUBMED:19801552] [PUBMED:12554650] [PUBMED:16341016] [PUBMED:17510365] [PUBMED:15459103] [PUBMED:18929646] [PUBMED:15327768] [PUBMED:9312064]
Degradation of GLI2 by the proteasome [NCBI:1269638] [REACTOME:R-HSA-5610783] [PUBMED:19056373] [PUBMED:17283082] [PUBMED:23719536] [PUBMED:16611981]
Degradation of beta-catenin by the destruction complex [NCBI:1269596] [REACTOME:R-HSA-195253] [PUBMED:17143292]
Disassembly of the destruction complex and recruitment of AXIN to the membrane [NCBI:1269601] [REACTOME:R-HSA-4641262] [PUBMED:10647780] [PUBMED:10581160] [PUBMED:14551908] [PUBMED:15084453] [PUBMED:19619488] [PUBMED:19759537] [PUBMED:14731402] [PUBMED:18234723] [PUBMED:15459103] [PUBMED:22363759] [PUBMED:17318175] [PUBMED:11336703] [PUBMED:16341017] [PUBMED:10421629] [PUBMED:17569865]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases of signal transduction [NCBI:1268855] [REACTOME:R-HSA-5663202] [PUBMED:12509752]
FoxO family signaling [NCBI:138036] [Pathway Interaction Database:foxopathway] [PUBMED:17038621] [PUBMED:15788402] [PUBMED:14976264] [PUBMED:11864996] [PUBMED:12517744] [PUBMED:11050388] [PUBMED:10960473] [PUBMED:10783894] [PUBMED:11154281] [PUBMED:11313479] [PUBMED:11777915] [PUBMED:11980723] [PUBMED:10102273] [PUBMED:15509806] [PUBMED:11237865] [PUBMED:16751106] [PUBMED:12857750] [PUBMED:15538382] [PUBMED:12239572] [PUBMED:12048180] [PUBMED:11884717] [PUBMED:11884591] [PUBMED:15084260] [PUBMED:11964479] [PUBMED:10217147] [PUBMED:15109499] [PUBMED:16964248] [PUBMED:15905404] [PUBMED:11607034] [PUBMED:15668399] [PUBMED:15220471] [PUBMED:10358075] [PUBMED:16424905]
GLI3 is processed to GLI3R by the proteasome [NCBI:1269637] [REACTOME:R-HSA-5610785] [PUBMED:21921029] [PUBMED:20154143] [PUBMED:16371461] [PUBMED:10693759] [PUBMED:16705181] [PUBMED:17283082]
Hedgehog 'off' state [NCBI:1269636] [REACTOME:R-HSA-5610787] [PUBMED:21801010] [PUBMED:20395968] [PUBMED:23719536] [PUBMED:21502959]
Hedgehog 'on' state [NCBI:1269640] [REACTOME:R-HSA-5632684] [PUBMED:23719536] [PUBMED:21502959] [PUBMED:21801010] [PUBMED:20395968]
Hedgehog signaling events mediated by Gli proteins [NCBI:137912] [Pathway Interaction Database:hedgehog_glipathway] [PUBMED:14611647] [PUBMED:16908539] [PUBMED:16885213] [PUBMED:16459297] [PUBMED:15087129] [PUBMED:10075717] [PUBMED:10725236] [PUBMED:10564661] [PUBMED:15215207] [PUBMED:16611981] [PUBMED:16364285] [PUBMED:11748151] [PUBMED:16537363] [PUBMED:10531011] [PUBMED:11449277] [PUBMED:12812795] [PUBMED:16424016] [PUBMED:14723851] [PUBMED:10693759] [PUBMED:15545630] [PUBMED:16254602] [PUBMED:14603322] [PUBMED:16061793] [PUBMED:10559945] [PUBMED:16740475] [PUBMED:16705181] [PUBMED:9636069] [PUBMED:10806483] [PUBMED:11960000] [PUBMED:15930098]
Hedgehog signaling pathway [NCBI:83063] [KEGG:hsa04340] [PUBMED:22534646] [PUBMED:26077918] [PUBMED:24925320] [PUBMED:23719536] [PUBMED:26064136] [PUBMED:26366162] [PUBMED:20708941] [PUBMED:22056910] [PUBMED:18583599] [PUBMED:23799571] [PUBMED:26875496]
Misspliced GSK3beta mutants stabilize beta-catenin [NCBI:1268921] [REACTOME:R-HSA-5339716] [PUBMED:15306667] [PUBMED:19237556]
Noncanonical Wnt signaling pathway [NCBI:169354] [Pathway Interaction Database:wnt_noncanonical_pathway] [PUBMED:11408485] [PUBMED:20457807] [PUBMED:17646398] [PUBMED:15509575] [PUBMED:10391247] [PUBMED:12482967] [PUBMED:10777564] [PUBMED:19720827] [PUBMED:18667433] [PUBMED:18162551] [PUBMED:18215320] [PUBMED:17101698] [PUBMED:12839624] [PUBMED:19910923] [PUBMED:10395542] [PUBMED:15121866] [PUBMED:11779461] [PUBMED:16880514] [PUBMED:18606138] [PUBMED:12771126] [PUBMED:18615587] [PUBMED:17952062]
Presenilin action in Notch and Wnt signaling [NCBI:137914] [Pathway Interaction Database:ps1pathway] [PUBMED:10391247] [PUBMED:11921277] [PUBMED:11357136] [PUBMED:15620650] [PUBMED:11739397] [PUBMED:15747065] [PUBMED:10359821] [PUBMED:15327768] [PUBMED:12554650] [PUBMED:15292388] [PUBMED:11266469] [PUBMED:12794186] [PUBMED:10882062] [PUBMED:8923452] [PUBMED:12050670] [PUBMED:10201374] [PUBMED:12857724] [PUBMED:9171444]
Role of Calcineurin-dependent NFAT signaling in lymphocytes [NCBI:137953] [Pathway Interaction Database:nfat_3pathway] [PUBMED:15743762] [PUBMED:9109491] [PUBMED:1715244] [PUBMED:15121840] [PUBMED:10195903] [PUBMED:10788511] [PUBMED:9630228] [PUBMED:9834092] [PUBMED:9655484] [PUBMED:10933397] [PUBMED:11030334] [PUBMED:8684469] [PUBMED:10861295] [PUBMED:15117942] [PUBMED:12351631] [PUBMED:15902271] [PUBMED:16406492] [PUBMED:10944115] [PUBMED:10611249] [PUBMED:15733859] [PUBMED:15757646] [PUBMED:9768749] [PUBMED:9072970] [PUBMED:12510191] [PUBMED:9585406] [PUBMED:293720] [PUBMED:12925851] [PUBMED:16943420] [PUBMED:11823475] [PUBMED:16141075] [PUBMED:9374467] [PUBMED:9660798] [PUBMED:7528941] [PUBMED:11356833] [PUBMED:10593895] [PUBMED:10866678] [PUBMED:9171236] [PUBMED:12809556] [PUBMED:10652349] [PUBMED:12021260] [PUBMED:16455648]
S33 mutants of beta-catenin aren't phosphorylated [NCBI:1268920] [REACTOME:R-HSA-5358747] [PUBMED:10487827] [PUBMED:12067995] [PUBMED:10921899] [PUBMED:18757411]
S37 mutants of beta-catenin aren't phosphorylated [NCBI:1268919] [REACTOME:R-HSA-5358749] [PUBMED:10487827] [PUBMED:12067995] [PUBMED:10921899]
S45 mutants of beta-catenin aren't phosphorylated [NCBI:1268917] [REACTOME:R-HSA-5358751] [PUBMED:9065402] [PUBMED:12000790] [PUBMED:10921899]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Hedgehog [NCBI:1269633] [REACTOME:R-HSA-5358351] [PUBMED:19081070] [PUBMED:21801010] [PUBMED:15549094] [PUBMED:23719536]
Signaling by WNT in cancer [NCBI:1268906] [REACTOME:R-HSA-4791275] [PUBMED:7749328] [PUBMED:6318122] [PUBMED:22438566] [PUBMED:17510365] [PUBMED:10700176] [PUBMED:10733430] [PUBMED:17143297] [PUBMED:18311776] [PUBMED:11375957]
Signaling by Wnt [NCBI:1269594] [REACTOME:R-HSA-195721] [PUBMED:19530173] [PUBMED:23256519] [PUBMED:22952392] [PUBMED:19204114] [PUBMED:19365405] [PUBMED:19619488] [PUBMED:17143292] [PUBMED:17230199] [PUBMED:18710302] [PUBMED:16099039] [PUBMED:20576942] [PUBMED:10858654] [PUBMED:12967557]
T41 mutants of beta-catenin aren't phosphorylated [NCBI:1268918] [REACTOME:R-HSA-5358752] [PUBMED:12101426] [PUBMED:12439748] [PUBMED:22438566] [PUBMED:10921899] [PUBMED:23256519]
TCF dependent signaling in response to WNT [NCBI:1269599] [REACTOME:R-HSA-201681] [PUBMED:19619488] [PUBMED:23256519] [PUBMED:23343194]
Truncations of AMER1 destabilize the destruction complex [NCBI:1268915] [REACTOME:R-HSA-5467348] [PUBMED:19760609] [PUBMED:18311776] [PUBMED:17510365] [PUBMED:21248786]
Wnt signaling pathway [NCBI:83061] [KEGG:hsa04310] [PUBMED:12446114] [PUBMED:14745971] [PUBMED:14530294] [PUBMED:15102436] [PUBMED:14635791] [PUBMED:19482104] [PUBMED:23256519] [PUBMED:12967557] [PUBMED:11433294] [PUBMED:18838381]
p53 pathway [NCBI:138067] [Pathway Interaction Database:p53regulationpathway] [PUBMED:9153395] [PUBMED:15448695] [PUBMED:10734067] [PUBMED:11340074] [PUBMED:15525938] [PUBMED:17189186] [PUBMED:18454141] [PUBMED:11715018] [PUBMED:9733514] [PUBMED:12963717] [PUBMED:15989956] [PUBMED:10581258] [PUBMED:18566590] [PUBMED:15029243] [PUBMED:14612427] [PUBMED:19011621] [PUBMED:12842086] [PUBMED:16377624] [PUBMED:17268548] [PUBMED:16845383] [PUBMED:17534149] [PUBMED:12397361] [PUBMED:11740489] [PUBMED:12110584] [PUBMED:11713287] [PUBMED:17646389] [PUBMED:14654783] [PUBMED:9153396] [PUBMED:18243116] [PUBMED:10673501] [PUBMED:17719542] [PUBMED:11983168] [PUBMED:12397362] [PUBMED:17189187] [PUBMED:16757976] [PUBMED:12667443] [PUBMED:9733515] [PUBMED:9878046] [PUBMED:9363941] [PUBMED:11504915] [PUBMED:11359766] [PUBMED:9529248] [PUBMED:17936559] [PUBMED:15210108] [PUBMED:17293853] [PUBMED:16107876] [PUBMED:9724636] [PUBMED:17707234] [PUBMED:10606744] [PUBMED:11780126] [PUBMED:10821866] [PUBMED:18485870] [PUBMED:17110336] [PUBMED:11046142] [PUBMED:11331603] [PUBMED:19597489] [PUBMED:16163388] [PUBMED:14671306] [PUBMED:17108971] [PUBMED:15242646] [PUBMED:15314173] [PUBMED:12654245] [PUBMED:15308643] [PUBMED:9744860] [PUBMED:17906639] [PUBMED:9891054] [PUBMED:17098746] [PUBMED:17349958] [PUBMED:11030628] [PUBMED:15103385] [PUBMED:14744935] [PUBMED:9529249] [PUBMED:11283254] [PUBMED:11606419] [PUBMED:11078726] [PUBMED:10611322] [PUBMED:9288740] [PUBMED:11127820] [PUBMED:19357310] [PUBMED:9450543]
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex [NCBI:1268916] [REACTOME:R-HSA-4839743] [PUBMED:9601641] [PUBMED:10733430] [PUBMED:9065402] [PUBMED:23256519] [PUBMED:11375957] [PUBMED:9065403]
truncated APC mutants destabilize the destruction complex [NCBI:1268907] [REACTOME:R-HSA-4839744] [PUBMED:1338904] [PUBMED:8756721] [PUBMED:9065402] [PUBMED:17143297] [PUBMED:23256519] [PUBMED:8111410] [PUBMED:23169527] [PUBMED:15327768] [PUBMED:22761442] [PUBMED:10921899] [PUBMED:9065401]