full name
sequestosome 1

synonyms
A170, OSIL, p60, p62, p62B, PDB3, ZIP3, SQSTM1, ENSG00000161011

HGNC
HGNC:11280

Entrez Gene
Gene:8878

ENSEMBL
ENSG00000161011

location
chr: 5
start: 179233388
stop: 179265078
strand: +

OMIM
OMIM:601530: SQSTM1
OMIM:616437: Frontotemporal dementia and/or amyotrophic lateral sclerosis 3
OMIM:617158: Myopathy, distal, with rimmed vacuoles
OMIM:617145: Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset
OMIM:167250: Paget disease of bone 3

transcripts
NM_001142298.1
NM_001142299.1
NM_003900.4

pathways
Cell death signalling via NRAGE, NRIF and NADE [NCBI:1269447] [REACTOME:R-HSA-204998] [PUBMED:12787561]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
Fluid shear stress and atherosclerosis [NCBI:1474302] [KEGG:hsa05418] [PUBMED:23429585] [PUBMED:21050140] [PUBMED:17599600] [PUBMED:24190880] [PUBMED:22003002] [PUBMED:24876354] [PUBMED:24947523] [PUBMED:23899566] [PUBMED:26597822] [PUBMED:20353494] [PUBMED:22076424] [PUBMED:20538799] [PUBMED:25165867] [PUBMED:20032497] [PUBMED:23084990] [PUBMED:26822720] [PUBMED:24573382] [PUBMED:23555159] [PUBMED:26212910] [PUBMED:21457103] [PUBMED:19151844] [PUBMED:15388638] [PUBMED:16765337] [PUBMED:27027326] [PUBMED:25638487] [PUBMED:21733876]
IL1-mediated signaling events [NCBI:137944] [Pathway Interaction Database:il1pathway] [PUBMED:10854325] [PUBMED:11287640] [PUBMED:10747026] [PUBMED:11960013] [PUBMED:12150927] [PUBMED:1837145] [PUBMED:17197697] [PUBMED:9374458] [PUBMED:12721283] [PUBMED:8035875] [PUBMED:9261174] [PUBMED:9734363] [PUBMED:11460167] [PUBMED:7878046] [PUBMED:10373529] [PUBMED:2530587] [PUBMED:12538665] [PUBMED:10882101] [PUBMED:9360994] [PUBMED:9062194] [PUBMED:12242293] [PUBMED:8837778] [PUBMED:9430229] [PUBMED:7775431]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Interleukin-1 signaling [NCBI:1269320] [REACTOME:R-HSA-446652] [PUBMED:19302047] [PUBMED:19022706]
Mitophagy [NCBI:1309218] [REACTOME:R-HSA-5205647] [PUBMED:21179058]
Mitophagy - animal [NCBI:1496831] [KEGG:hsa04137] [PUBMED:26611876] [PUBMED:27443527] [PUBMED:25995186] [PUBMED:25611507] [PUBMED:27021519] [PUBMED:25999423] [PUBMED:27701735] [PUBMED:26882551]
NF-kB is activated and signals survival [NCBI:1269454] [REACTOME:R-HSA-209560] [PUBMED:16187223]
NRIF signals cell death from the nucleus [NCBI:1269449] [REACTOME:R-HSA-205043] [PUBMED:15721744]
Neurotrophic factor-mediated Trk receptor signaling [NCBI:137977] [Pathway Interaction Database:trkrpathway] [PUBMED:1849459] [PUBMED:8226808] [PUBMED:11163269] [PUBMED:7510697] [PUBMED:11027277] [PUBMED:15758069] [PUBMED:11425862] [PUBMED:11238898] [PUBMED:11251075] [PUBMED:8344249] [PUBMED:9356464] [PUBMED:11150291] [PUBMED:10092678] [PUBMED:1280261] [PUBMED:11150334] [PUBMED:11244088] [PUBMED:10985348] [PUBMED:15753086] [PUBMED:1653651] [PUBMED:11466412] [PUBMED:15167895] [PUBMED:1831195] [PUBMED:10490030] [PUBMED:8384556] [PUBMED:16697063] [PUBMED:17003042] [PUBMED:15520226] [PUBMED:15632082] [PUBMED:16611639] [PUBMED:16187212] [PUBMED:9182757] [PUBMED:1604323] [PUBMED:16284401] [PUBMED:8356095] [PUBMED:10329710] [PUBMED:9927421] [PUBMED:9856458] [PUBMED:10691301] [PUBMED:1375038] [PUBMED:10679771] [PUBMED:15122257] [PUBMED:15513915] [PUBMED:16701206] [PUBMED:1710174] [PUBMED:8155326] [PUBMED:8288573] [PUBMED:7972023] [PUBMED:7512734] [PUBMED:10601297] [PUBMED:16203995] [PUBMED:12510192] [PUBMED:16481401] [PUBMED:8106527] [PUBMED:11278445] [PUBMED:9099755] [PUBMED:1850821] [PUBMED:9632781] [PUBMED:10235685] [PUBMED:15917464] [PUBMED:9285826] [PUBMED:12446789] [PUBMED:7657612] [PUBMED:1850549] [PUBMED:12879077] [PUBMED:16157584] [PUBMED:10207144] [PUBMED:12006576] [PUBMED:8052307] [PUBMED:8382740] [PUBMED:10629055]
Osteoclast differentiation [NCBI:193147] [KEGG:hsa04380] [PUBMED:17633024] [PUBMED:18382763] [PUBMED:18329366] [PUBMED:17869613] [PUBMED:18722561] [PUBMED:15122243] [PUBMED:20703218] [PUBMED:12748652] [PUBMED:12110142] [PUBMED:19585227] [PUBMED:15546140] [PUBMED:16184196] [PUBMED:15817678] [PUBMED:20392226] [PUBMED:16313349] [PUBMED:16313342] [PUBMED:17380158] [PUBMED:18451259]
Pink/Parkin Mediated Mitophagy [NCBI:1309219] [REACTOME:R-HSA-5205685] [PUBMED:21179058]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
TNF receptor signaling pathway [NCBI:138053] [Pathway Interaction Database:tnfpathway] [PUBMED:17024246] [PUBMED:7923351] [PUBMED:9774977] [PUBMED:15258597] [PUBMED:11429546] [PUBMED:10848577] [PUBMED:12917689] [PUBMED:11031259] [PUBMED:8974401] [PUBMED:7758105] [PUBMED:10510344] [PUBMED:15793306] [PUBMED:12391233] [PUBMED:18450452] [PUBMED:15218148] [PUBMED:8692885] [PUBMED:10026132] [PUBMED:9275185] [PUBMED:11684013] [PUBMED:8521496] [PUBMED:12917690] [PUBMED:10795740] [PUBMED:16603398] [PUBMED:9405407] [PUBMED:2158863] [PUBMED:16260783] [PUBMED:8808629] [PUBMED:9034190] [PUBMED:16543241] [PUBMED:12077366] [PUBMED:9384583] [PUBMED:8612133] [PUBMED:9712898] [PUBMED:1313189] [PUBMED:8069916] [PUBMED:11907583] [PUBMED:9639556] [PUBMED:12917691] [PUBMED:9115275] [PUBMED:8681376] [PUBMED:10356400] [PUBMED:10801798] [PUBMED:10097111] [PUBMED:8565075] [PUBMED:10187805] [PUBMED:15357952] [PUBMED:9915703] [PUBMED:9564042] [PUBMED:8943045]
p75 NTR receptor-mediated signalling [NCBI:1269445] [REACTOME:R-HSA-193704] [PUBMED:16699811] [PUBMED:16939974] [PUBMED:12671646]
p75(NTR)-mediated signaling [NCBI:138019] [Pathway Interaction Database:p75ntrpathway] [PUBMED:14673001] [PUBMED:14593116] [PUBMED:10545116] [PUBMED:11729324] [PUBMED:16252010] [PUBMED:11756426] [PUBMED:12414813] [PUBMED:2157470] [PUBMED:11777929] [PUBMED:1547788] [PUBMED:10764727] [PUBMED:8614802] [PUBMED:14960584] [PUBMED:12376548] [PUBMED:11756498] [PUBMED:8079174] [PUBMED:16498402] [PUBMED:15051733] [PUBMED:12682012] [PUBMED:14638693] [PUBMED:14966521] [PUBMED:9915784] [PUBMED:11487608] [PUBMED:10485890] [PUBMED:16630834] [PUBMED:11312266] [PUBMED:10985348] [PUBMED:11244088] [PUBMED:6093111] [PUBMED:10595511] [PUBMED:14985763] [PUBMED:12097334] [PUBMED:15548667] [PUBMED:15470142] [PUBMED:11279271] [PUBMED:8878481] [PUBMED:12422217] [PUBMED:15987945] [PUBMED:15668238] [PUBMED:10433815] [PUBMED:12692556] [PUBMED:2025430] [PUBMED:15930396] [PUBMED:11278287] [PUBMED:12034707]
p75NTR recruits signalling complexes [NCBI:1269453] [REACTOME:R-HSA-209543]
p75NTR signals via NF-kB [NCBI:1269452] [REACTOME:R-HSA-193639] [PUBMED:16997282]