full name
transcription factor AP-2 alpha

synonyms
AP-2, AP-2alpha, AP2TF, BOFS, TFAP2, TFAP2A, ENSG00000137203

HGNC
HGNC:11742

Entrez Gene
Gene:7020

ENSEMBL
ENSG00000137203

location
chr: 6
start: 10393419
stop: 10419797
strand: -

OMIM
OMIM:107580: TFAP2A (Autosomal dominant inheritance)
OMIM:113620: Branchiooculofacial syndrome

transcripts
NM_001042425.1
NM_003220.2
NM_001032280.2

pathways
Activation of the TFAP2 (AP-2) family of transcription factors [NCBI:1427840] [REACTOME:R-HSA-8866907] [PUBMED:10497269] [PUBMED:1998122] [PUBMED:11694877] [PUBMED:12586840] [PUBMED:11744733] [PUBMED:2010091] [PUBMED:20525283] [PUBMED:16698963]
Caspase cascade in apoptosis [NCBI:137974] [Pathway Interaction Database:caspase_pathway] [PUBMED:7774019] [PUBMED:8626669] [PUBMED:9850096] [PUBMED:11803376] [PUBMED:15189451] [PUBMED:10564664] [PUBMED:9642276] [PUBMED:10567584] [PUBMED:12419244] [PUBMED:11423904] [PUBMED:9422506] [PUBMED:11438643] [PUBMED:9070648] [PUBMED:9588194] [PUBMED:11085743] [PUBMED:9298992] [PUBMED:9933635] [PUBMED:9528810] [PUBMED:9323209] [PUBMED:10809769] [PUBMED:8700869] [PUBMED:9463409] [PUBMED:10497198] [PUBMED:11953316] [PUBMED:9422513] [PUBMED:10409650] [PUBMED:11463840] [PUBMED:10611247] [PUBMED:8605870]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Negative regulation of activity of TFAP2 (AP-2) family transcription factors [NCBI:1427845] [REACTOME:R-HSA-8866904] [PUBMED:12072434] [PUBMED:19115315] [PUBMED:25114211] [PUBMED:23382213] [PUBMED:15548692] [PUBMED:21375726] [PUBMED:24835590] [PUBMED:20805990]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
SUMO E3 ligases SUMOylate target proteins [NCBI:1268743] [REACTOME:R-HSA-3108232] [PUBMED:20674646] [PUBMED:17763827] [PUBMED:19471022] [PUBMED:23746258] [PUBMED:24016193] [PUBMED:23503365] [PUBMED:21252943] [PUBMED:17000644] [PUBMED:24273646] [PUBMED:22811915] [PUBMED:21693764] [PUBMED:23277067] [PUBMED:21102611]
SUMOylation [NCBI:1268738] [REACTOME:R-HSA-2990846] [PUBMED:21102611] [PUBMED:20674646] [PUBMED:23514139] [PUBMED:19923268] [PUBMED:20462400] [PUBMED:17768054]
SUMOylation of transcription factors [NCBI:1339110] [REACTOME:R-HSA-3232118] [PUBMED:16095902] [PUBMED:21892772] [PUBMED:19107415] [PUBMED:19616654] [PUBMED:15209380] [PUBMED:18031228]
TFAP2 (AP-2) family regulates transcription of cell cycle factors [NCBI:1427843] [REACTOME:R-HSA-8866911] [PUBMED:22371483] [PUBMED:21084835] [PUBMED:19798054] [PUBMED:8988173]
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors [NCBI:1427841] [REACTOME:R-HSA-8866910] [PUBMED:14744778] [PUBMED:9162057] [PUBMED:22735262] [PUBMED:26832794] [PUBMED:10648798] [PUBMED:10497269] [PUBMED:9850080] [PUBMED:9687504] [PUBMED:7891714] [PUBMED:15870067] [PUBMED:9182571] [PUBMED:8895516]
TFAP2 (AP-2) family regulates transcription of other transcription factors [NCBI:1427842] [REACTOME:R-HSA-8866906] [PUBMED:15475956] [PUBMED:22735262]
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation [NCBI:1427844] [REACTOME:R-HSA-8869496] [PUBMED:1394192] [PUBMED:17318229] [PUBMED:9840932]
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors [NCBI:1427839] [REACTOME:R-HSA-8864260] [PUBMED:2010091] [PUBMED:11744733] [PUBMED:24469049] [PUBMED:23382213] [PUBMED:19798054] [PUBMED:9162057] [PUBMED:21084835] [PUBMED:22735262] [PUBMED:21375726] [PUBMED:14744778] [PUBMED:10648798] [PUBMED:26832794] [PUBMED:24835590] [PUBMED:9687504] [PUBMED:20805990] [PUBMED:10497269] [PUBMED:16420676] [PUBMED:12072434] [PUBMED:9850080] [PUBMED:9182571] [PUBMED:8988173] [PUBMED:1998122] [PUBMED:22371483] [PUBMED:15870067] [PUBMED:12586840] [PUBMED:8895516] [PUBMED:7891714] [PUBMED:11694877] [PUBMED:19115315] [PUBMED:15475956] [PUBMED:25114211]