full name
histone cluster 1 H2A family member e

synonyms
H2A.1, H2A.2, H2A%2Fa, H2AFA, HIST1H2AE, ENSG00000277075

HGNC
HGNC:4724

Entrez Gene
Gene:3012

ENSEMBL
ENSG00000277075
ENSG00000168274

location
chr: 6
start: 26217148
stop: 26217711
strand: +

transcripts
NM_021052.2

pathways
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 [NCBI:1269513] [REACTOME:R-HSA-5625886] [PUBMED:18066052] [PUBMED:16079795] [PUBMED:12514133]
Activation of HOX genes during differentiation [NCBI:1339139] [REACTOME:R-HSA-5619507] [PUBMED:19923920] [PUBMED:25804734] [PUBMED:23973942] [PUBMED:23650639] [PUBMED:20435029] [PUBMED:24529385]
Activation of anterior HOX genes in hindbrain development during early embryogenesis [NCBI:1339140] [REACTOME:R-HSA-5617472] [PUBMED:19575673] [PUBMED:23973942] [PUBMED:18394579] [PUBMED:24529385] [PUBMED:24115586] [PUBMED:18412118] [PUBMED:19651303] [PUBMED:25804734] [PUBMED:22770981] [PUBMED:19923920] [PUBMED:16155570] [PUBMED:18816852] [PUBMED:25560970] [PUBMED:10068641] [PUBMED:10662633] [PUBMED:20435029] [PUBMED:17368312] [PUBMED:21497760] [PUBMED:10668974]
Alcoholism [NCBI:585563] [KEGG:hsa05034] [PUBMED:16764827] [PUBMED:18616668] [PUBMED:19077056] [PUBMED:18991950] [PUBMED:19756388] [PUBMED:12068305] [PUBMED:16102840] [PUBMED:20947635] [PUBMED:20729980] [PUBMED:16278489] [PUBMED:17270154] [PUBMED:20626732] [PUBMED:18310464] [PUBMED:10774721] [PUBMED:19342616] [PUBMED:12605085] [PUBMED:15500908] [PUBMED:14729391] [PUBMED:12085089] [PUBMED:16776597]
Amyloid fiber formation [NCBI:1269169] [REACTOME:R-HSA-977225] [PUBMED:16302959]
B-WICH complex positively regulates rRNA expression [NCBI:1339126] [REACTOME:R-HSA-5250924] [PUBMED:23555303] [PUBMED:21559432] [PUBMED:16514417] [PUBMED:23667505] [PUBMED:16603771] [PUBMED:16574391]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Cellular Senescence [NCBI:1270426] [REACTOME:R-HSA-2559583] [PUBMED:21078816] [PUBMED:18711403] [PUBMED:22048312] [PUBMED:19818705] [PUBMED:17662938] [PUBMED:23746838] [PUBMED:9282108] [PUBMED:17667954] [PUBMED:13905658]
Cellular responses to stress [NCBI:1270414] [REACTOME:R-HSA-2262752] [PUBMED:15709958]
Chromatin modifying enzymes [NCBI:1270434] [REACTOME:R-HSA-3247509]
Chromatin organization [NCBI:1270433] [REACTOME:R-HSA-4839726] [PUBMED:21342762] [PUBMED:15598472]
Chromosome Maintenance [NCBI:1269853] [REACTOME:R-HSA-73886]
Condensation of Prophase Chromosomes [NCBI:1269813] [REACTOME:R-HSA-2299718] [PUBMED:18367646] [PUBMED:12208845] [PUBMED:21498573] [PUBMED:20966048] [PUBMED:12086618] [PUBMED:20622854]
DNA Damage/Telomere Stress Induced Senescence [NCBI:1270429] [REACTOME:R-HSA-2559586] [PUBMED:15790808] [PUBMED:15574587] [PUBMED:10669743] [PUBMED:9733515] [PUBMED:9357549] [PUBMED:8242751] [PUBMED:17694070] [PUBMED:2342578] [PUBMED:9733514] [PUBMED:10037601] [PUBMED:2392154] [PUBMED:9843217] [PUBMED:19528227] [PUBMED:16166375] [PUBMED:8242752]
DNA methylation [NCBI:1269740] [REACTOME:R-HSA-5334118] [PUBMED:24560929] [PUBMED:21243710] [PUBMED:23587238] [PUBMED:23938249] [PUBMED:22781841] [PUBMED:24214338] [PUBMED:16403636] [PUBMED:24589714] [PUBMED:23687512] [PUBMED:23166392] [PUBMED:19657014] [PUBMED:7079182] [PUBMED:24059801]
Deposition of new CENPA-containing nucleosomes at the centromere [NCBI:1269855] [REACTOME:R-HSA-606279] [PUBMED:20080577] [PUBMED:19410545] [PUBMED:19629040] [PUBMED:19410544] [PUBMED:19660450] [PUBMED:19590885] [PUBMED:19410539] [PUBMED:17339380]
Deubiquitination [NCBI:1427860] [REACTOME:R-HSA-5688426] [PUBMED:19243136] [PUBMED:20074029] [PUBMED:15571815] [PUBMED:20418328] [PUBMED:16325574] [PUBMED:12944365] [PUBMED:23845989] [PUBMED:22201797]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression [NCBI:1383084] [REACTOME:R-HSA-427389] [PUBMED:20026667] [PUBMED:23063748] [PUBMED:17707230] [PUBMED:18948749] [PUBMED:23153826] [PUBMED:23150253] [PUBMED:18631128]
Epigenetic regulation of gene expression [NCBI:1269734] [REACTOME:R-HSA-212165] [PUBMED:12610534]
Formation of the beta-catenin:TCF transactivating complex [NCBI:1269602] [REACTOME:R-HSA-201722] [PUBMED:19305417] [PUBMED:11713476] [PUBMED:18334222] [PUBMED:11934263] [PUBMED:16751178] [PUBMED:22617422] [PUBMED:20951344] [PUBMED:11136974] [PUBMED:19619488] [PUBMED:10831834] [PUBMED:21285352]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Gene Silencing by RNA [NCBI:1269719] [REACTOME:R-HSA-211000] [PUBMED:15741316] [PUBMED:25565029] [PUBMED:19165215] [PUBMED:21755468] [PUBMED:16510870] [PUBMED:19412884] [PUBMED:17560368] [PUBMED:19239886]
HATs acetylate histones [NCBI:1270435] [REACTOME:R-HSA-3214847] [PUBMED:18722564]
HDACs deacetylate histones [NCBI:1270436] [REACTOME:R-HSA-3214815] [PUBMED:21872466] [PUBMED:12429021]
M Phase [NCBI:1269810] [REACTOME:R-HSA-68886]
Meiosis [NCBI:1269865] [REACTOME:R-HSA-1500620] [PUBMED:20051984] [PUBMED:20364103] [PUBMED:16543383] [PUBMED:18948708]
Meiotic recombination [NCBI:1269866] [REACTOME:R-HSA-912446] [PUBMED:16543383] [PUBMED:20364103] [PUBMED:20051984]
Meiotic synapsis [NCBI:1269867] [REACTOME:R-HSA-1221632] [PUBMED:20364103] [PUBMED:18948708]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Metalloprotease DUBs [NCBI:1427865] [REACTOME:R-HSA-5689901] [PUBMED:14737182]
Mitotic Prophase [NCBI:1269811] [REACTOME:R-HSA-68875]
Negative epigenetic regulation of rRNA expression [NCBI:1269737] [REACTOME:R-HSA-5250941] [PUBMED:23063748] [PUBMED:23150253] [PUBMED:18616426]
NoRC negatively regulates rRNA expression [NCBI:1269739] [REACTOME:R-HSA-427413] [PUBMED:17439825] [PUBMED:17613545] [PUBMED:23063748] [PUBMED:11583633] [PUBMED:18631128] [PUBMED:18616426]
Nucleosome assembly [NCBI:1269854] [REACTOME:R-HSA-774815]
Oxidative Stress Induced Senescence [NCBI:1270428] [REACTOME:R-HSA-2559580] [PUBMED:17344414] [PUBMED:17332741] [PUBMED:8622688] [PUBMED:7588633] [PUBMED:15563468] [PUBMED:15287722] [PUBMED:11062067] [PUBMED:16337592] [PUBMED:14532106] [PUBMED:17254968] [PUBMED:15866172] [PUBMED:9628874] [PUBMED:12171911] [PUBMED:7816143] [PUBMED:22020331] [PUBMED:11564866] [PUBMED:9162092] [PUBMED:8974401] [PUBMED:19451217] [PUBMED:12808055] [PUBMED:17210787] [PUBMED:8846784] [PUBMED:19462008] [PUBMED:12134156] [PUBMED:8626550] [PUBMED:8774846] [PUBMED:12189133] [PUBMED:9195981] [PUBMED:8622669] [PUBMED:8259215] [PUBMED:19528227] [PUBMED:9564042] [PUBMED:9529249] [PUBMED:16436515] [PUBMED:19451218] [PUBMED:17395714] [PUBMED:9030721] [PUBMED:12435631] [PUBMED:22325352]
PRC2 methylates histones and DNA [NCBI:1269735] [REACTOME:R-HSA-212300] [PUBMED:23473600] [PUBMED:18974828] [PUBMED:24096405] [PUBMED:21248841] [PUBMED:19738629] [PUBMED:21941108]
Packaging Of Telomere Ends [NCBI:1269864] [REACTOME:R-HSA-171306] [PUBMED:10338214]
Positive epigenetic regulation of rRNA expression [NCBI:1339125] [REACTOME:R-HSA-5250913] [PUBMED:23153826] [PUBMED:16574391] [PUBMED:23063748] [PUBMED:23150253] [PUBMED:18616426]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
RHO GTPase Effectors [NCBI:1269509] [REACTOME:R-HSA-195258] [PUBMED:9694656] [PUBMED:18066052] [PUBMED:11018042] [PUBMED:10470034] [PUBMED:8702756] [PUBMED:21730051] [PUBMED:8571126] [PUBMED:19513348] [PUBMED:17244649] [PUBMED:11145705] [PUBMED:24128008] [PUBMED:23716662] [PUBMED:8617235] [PUBMED:8543060] [PUBMED:11804587] [PUBMED:24969695] [PUBMED:12635176] [PUBMED:12778124] [PUBMED:18006505] [PUBMED:1660188] [PUBMED:21351730] [PUBMED:16507994] [PUBMED:14595335] [PUBMED:10072071] [PUBMED:10591629] [PUBMED:10753910] [PUBMED:23875749] [PUBMED:17151359] [PUBMED:10652353] [PUBMED:12221077] [PUBMED:10559936] [PUBMED:12783890] [PUBMED:11948177] [PUBMED:18237546] [PUBMED:16079795] [PUBMED:10924361] [PUBMED:14514689] [PUBMED:8107774] [PUBMED:8756646] [PUBMED:16979770] [PUBMED:16636067] [PUBMED:9751706] [PUBMED:10619026] [PUBMED:23444367] [PUBMED:15546864] [PUBMED:12473120] [PUBMED:8816443] [PUBMED:9199170] [PUBMED:12514133] [PUBMED:16762923] [PUBMED:12110184] [PUBMED:16431929] [PUBMED:10975528] [PUBMED:10940294] [PUBMED:9535855] [PUBMED:7559638] [PUBMED:11162552] [PUBMED:19737400] [PUBMED:9988689] [PUBMED:12732141] [PUBMED:8798539] [PUBMED:24914801] [PUBMED:11689693] [PUBMED:8769096] [PUBMED:9368021]
RHO GTPases activate PKNs [NCBI:1269512] [REACTOME:R-HSA-5625740] [PUBMED:21351730] [PUBMED:21749319] [PUBMED:10753910] [PUBMED:18429822] [PUBMED:9175763] [PUBMED:12783890] [PUBMED:14514689] [PUBMED:10924361] [PUBMED:7673228] [PUBMED:10619026] [PUBMED:10467162] [PUBMED:11134534] [PUBMED:9030526] [PUBMED:9988689] [PUBMED:19723632] [PUBMED:24128008] [PUBMED:18006505]
RMTs methylate histone arginines [NCBI:1270439] [REACTOME:R-HSA-3214858] [PUBMED:19150423] [PUBMED:23235912]
RNA Polymerase I Chain Elongation [NCBI:1269662] [REACTOME:R-HSA-73777]
RNA Polymerase I Promoter Clearance [NCBI:1269658] [REACTOME:R-HSA-73854]
RNA Polymerase I Promoter Opening [NCBI:1269659] [REACTOME:R-HSA-73728]
RNA Polymerase I Transcription [NCBI:1269657] [REACTOME:R-HSA-73864]
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription [NCBI:1269656] [REACTOME:R-HSA-504046]
SIRT1 negatively regulates rRNA Expression [NCBI:1269738] [REACTOME:R-HSA-427359] [PUBMED:19010308] [PUBMED:18485871] [PUBMED:20023389]
Senescence-Associated Secretory Phenotype (SASP) [NCBI:1270431] [REACTOME:R-HSA-2559582] [PUBMED:18411265] [PUBMED:21979375] [PUBMED:18267069] [PUBMED:19597488] [PUBMED:19218920] [PUBMED:20818427] [PUBMED:11114305] [PUBMED:8617720] [PUBMED:22178396] [PUBMED:19805069] [PUBMED:23770676] [PUBMED:8384717] [PUBMED:18555777] [PUBMED:21686281] [PUBMED:20351173] [PUBMED:8688489] [PUBMED:19053174] [PUBMED:8234276] [PUBMED:18555778]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Rho GTPases [NCBI:1269507] [REACTOME:R-HSA-194315] [PUBMED:16212495] [PUBMED:15630019]
Signaling by Wnt [NCBI:1269594] [REACTOME:R-HSA-195721] [PUBMED:19530173] [PUBMED:23256519] [PUBMED:22952392] [PUBMED:19204114] [PUBMED:19365405] [PUBMED:19619488] [PUBMED:17143292] [PUBMED:17230199] [PUBMED:18710302] [PUBMED:16099039] [PUBMED:20576942] [PUBMED:10858654] [PUBMED:12967557]
Systemic lupus erythematosus [NCBI:83122] [KEGG:hsa05322] [PUBMED:12835292] [PUBMED:12965173] [PUBMED:16932712] [PUBMED:10025913] [PUBMED:15972354] [PUBMED:17943287] [PUBMED:10430616] [PUBMED:18305268] [PUBMED:15380523] [PUBMED:8048228] [PUBMED:15459673]
TCF dependent signaling in response to WNT [NCBI:1269599] [REACTOME:R-HSA-201681] [PUBMED:19619488] [PUBMED:23256519] [PUBMED:23343194]
Telomere Maintenance [NCBI:1269856] [REACTOME:R-HSA-157579] [PUBMED:16166375] [PUBMED:4507727] [PUBMED:14685173] [PUBMED:642006] [PUBMED:15189140] [PUBMED:3907856] [PUBMED:2463488] [PUBMED:4754905]
Transcriptional regulation by small RNAs [NCBI:1269723] [REACTOME:R-HSA-5578749] [PUBMED:19771207] [PUBMED:18852463] [PUBMED:25131816] [PUBMED:22283730] [PUBMED:22445173] [PUBMED:24388755] [PUBMED:15963934] [PUBMED:24468964] [PUBMED:22961379] [PUBMED:22722852] [PUBMED:21948593] [PUBMED:22053081] [PUBMED:15643423] [PUBMED:16373483] [PUBMED:24384674] [PUBMED:23150874] [PUBMED:20373265] [PUBMED:22336708] [PUBMED:16936726] [PUBMED:24680896] [PUBMED:23882114]
UCH proteinases [NCBI:1427861] [REACTOME:R-HSA-5689603] [PUBMED:16325574] [PUBMED:19243136]
Ub-specific processing proteases [NCBI:1427862] [REACTOME:R-HSA-5689880] [PUBMED:16325574]