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Genes
HLA-A
Gene - HLA-A
full name
major histocompatibility complex, class I, A
synonyms
HLAA, HLA-A, ENSG00000206503
HGNC
HGNC:4931
Entrez Gene
Gene:3105
ENSEMBL
ENSG00000206503
ENSG00000206505
ENSG00000229215
ENSG00000235657
ENSG00000231834
ENSG00000223980
ENSG00000227715
ENSG00000224320
location
chr: 6
start: 29910247
stop: 29913661
strand: +
OMIM
OMIM:142800
: HLA-A
OMIM:608579
: {Hypersensitivity syndrome, carbamazepine-induced, susceptibility to}
transcripts
ENST00000376809.5
NM_002116.7
pathways
Adaptive Immune System
[NCBI:1269171]
[REACTOME:R-HSA-1280218]
[PUBMED:16551257]
[PUBMED:21682741]
[PUBMED:11861602]
Allograft rejection
[NCBI:83123]
[KEGG:hsa05330]
[PUBMED:8835634]
[PUBMED:12023610]
[PUBMED:12563298]
[PUBMED:17445565]
[PUBMED:12216939]
[PUBMED:14710779]
[PUBMED:10746853]
[PUBMED:10571983]
[PUBMED:10331992]
[PUBMED:10667806]
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
[NCBI:1269194]
[REACTOME:R-HSA-983170]
[PUBMED:19178136]
[PUBMED:18926908]
[PUBMED:12495737]
[PUBMED:15224092]
[PUBMED:18641646]
Antigen processing and presentation
[NCBI:83074]
[KEGG:hsa04612]
[PUBMED:12776207]
[PUBMED:15653315]
[PUBMED:15814328]
[PUBMED:20010787]
[PUBMED:15224094]
[PUBMED:15745856]
[PUBMED:11244040]
[PUBMED:15304636]
[PUBMED:11905820]
[PUBMED:16181333]
[PUBMED:16200082]
[PUBMED:15653312]
[PUBMED:15224093]
[PUBMED:15771591]
[PUBMED:12974477]
Antigen processing-Cross presentation
[NCBI:1269195]
[REACTOME:R-HSA-1236975]
[PUBMED:17157489]
[PUBMED:20171863]
[PUBMED:16181333]
[PUBMED:15761154]
[PUBMED:16181335]
[PUBMED:19218463]
Autoimmune thyroid disease
[NCBI:83121]
[KEGG:hsa05320]
[PUBMED:15132715]
[PUBMED:12192541]
[PUBMED:17192582]
[PUBMED:9534029]
[PUBMED:11396701]
[PUBMED:11913070]
[PUBMED:15049952]
[PUBMED:11577986]
[PUBMED:15762980]
Cell adhesion molecules (CAMs)
[NCBI:83069]
[KEGG:hsa04514]
[PUBMED:15923648]
[PUBMED:12500939]
[PUBMED:15056568]
[PUBMED:14519386]
[PUBMED:12234363]
[PUBMED:10964748]
[PUBMED:15071551]
[PUBMED:15551862]
[PUBMED:14690046]
[PUBMED:9150551]
[PUBMED:14519398]
[PUBMED:14556710]
[PUBMED:11860281]
[PUBMED:10664064]
[PUBMED:9597126]
[PUBMED:11050419]
[PUBMED:12367625]
[PUBMED:10798271]
[PUBMED:16034094]
[PUBMED:15115723]
[PUBMED:15728677]
[PUBMED:11910893]
[PUBMED:15561584]
[PUBMED:15882774]
[PUBMED:12810109]
Class I MHC mediated antigen processing & presentation
[NCBI:1269192]
[REACTOME:R-HSA-983169]
[PUBMED:8717519]
[PUBMED:17145306]
[PUBMED:18926908]
[PUBMED:17055423]
[PUBMED:12495737]
[PUBMED:18641646]
[PUBMED:18243674]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
Disease
[NCBI:1268854]
[REACTOME:R-HSA-1643685]
Downstream signaling in naive CD8+ T cells
[NCBI:138018]
[Pathway Interaction Database:cd8tcrdownstreampathway]
[PUBMED:293720]
[PUBMED:7935374]
[PUBMED:12065418]
[PUBMED:8566027]
[PUBMED:12917261]
[PUBMED:8394352]
[PUBMED:8441422]
[PUBMED:1386920]
[PUBMED:8617294]
[PUBMED:12732656]
[PUBMED:7889942]
[PUBMED:1737937]
[PUBMED:1381507]
[PUBMED:16210616]
[PUBMED:11927626]
[PUBMED:10477579]
[PUBMED:10206983]
[PUBMED:8376940]
[PUBMED:9395475]
[PUBMED:12972619]
[PUBMED:8394845]
[PUBMED:11485747]
[PUBMED:15814665]
[PUBMED:14645153]
[PUBMED:2119889]
[PUBMED:8208531]
[PUBMED:10970869]
[PUBMED:8612134]
[PUBMED:8623163]
[PUBMED:16237086]
[PUBMED:16585578]
[PUBMED:10544201]
[PUBMED:8397339]
[PUBMED:14605368]
[PUBMED:12560487]
[PUBMED:7982959]
ER-Phagosome pathway
[NCBI:1269197]
[REACTOME:R-HSA-1236974]
[PUBMED:16213220]
[PUBMED:20171863]
[PUBMED:14508490]
[PUBMED:17027300]
[PUBMED:14561893]
[PUBMED:15845646]
[PUBMED:22915823]
[PUBMED:18006660]
[PUBMED:14508489]
[PUBMED:12151002]
[PUBMED:15728715]
Endocytosis
[NCBI:102279]
[KEGG:hsa04144]
[PUBMED:19696797]
[PUBMED:19007773]
[PUBMED:16203612]
[PUBMED:15687999]
[PUBMED:19924646]
[PUBMED:15261671]
[PUBMED:18647649]
[PUBMED:19325624]
[PUBMED:20110990]
[PUBMED:22193161]
Endosomal/Vacuolar pathway
[NCBI:1269198]
[REACTOME:R-HSA-1236977]
[PUBMED:18376401]
Epstein-Barr virus infection
[NCBI:585562]
[KEGG:hsa05169]
[PUBMED:1658397]
[PUBMED:10683340]
[PUBMED:19375142]
[PUBMED:12438576]
[PUBMED:12910248]
[PUBMED:10400785]
[PUBMED:16007144]
[PUBMED:14576817]
[PUBMED:18559925]
[PUBMED:16352731]
[PUBMED:7895172]
[PUBMED:15510157]
[PUBMED:21518914]
[PUBMED:10891508]
[PUBMED:14673102]
[PUBMED:17159145]
[PUBMED:15542638]
[PUBMED:18786993]
[PUBMED:16603506]
[PUBMED:10644367]
[PUBMED:15021898]
[PUBMED:10666279]
[PUBMED:9565632]
Graft-versus-host disease
[NCBI:83124]
[KEGG:hsa05332]
[PUBMED:14556773]
[PUBMED:17784964]
[PUBMED:14735553]
[PUBMED:16412784]
[PUBMED:17900507]
[PUBMED:15372473]
[PUBMED:16147539]
[PUBMED:12359826]
[PUBMED:15882431]
HIV Infection
[NCBI:1269057]
[REACTOME:R-HSA-162906]
[PUBMED:16354571]
[PUBMED:9759480]
HTLV-I infection
[NCBI:373901]
[KEGG:hsa05166]
[PUBMED:17446673]
[PUBMED:16436385]
[PUBMED:14686485]
[PUBMED:19861996]
[PUBMED:19092975]
[PUBMED:11325603]
[PUBMED:16155602]
[PUBMED:12910251]
[PUBMED:16155605]
[PUBMED:16036567]
[PUBMED:11244044]
[PUBMED:18702816]
[PUBMED:15569630]
[PUBMED:21114861]
[PUBMED:16155611]
[PUBMED:17384582]
[PUBMED:16155608]
[PUBMED:10602469]
[PUBMED:19014483]
[PUBMED:9325311]
Herpes simplex infection
[NCBI:377873]
[KEGG:hsa05168]
[PUBMED:12224518]
[PUBMED:17913820]
[PUBMED:12844494]
[PUBMED:10998601]
[PUBMED:15163721]
[PUBMED:19694546]
[PUBMED:16297150]
[PUBMED:14747533]
[PUBMED:12826401]
[PUBMED:14963113]
[PUBMED:15056211]
[PUBMED:12797447]
[PUBMED:21107701]
[PUBMED:10918307]
[PUBMED:10696424]
[PUBMED:16076403]
[PUBMED:10364308]
[PUBMED:17222692]
[PUBMED:9621021]
[PUBMED:12224508]
[PUBMED:19879619]
[PUBMED:11070032]
[PUBMED:9499021]
[PUBMED:18596690]
[PUBMED:12525427]
[PUBMED:12224517]
[PUBMED:10196275]
[PUBMED:15047834]
[PUBMED:18508584]
[PUBMED:20036979]
Host Interactions of HIV factors
[NCBI:1269091]
[REACTOME:R-HSA-162909]
IL12-mediated signaling events
[NCBI:137922]
[Pathway Interaction Database:il12_2pathway]
[PUBMED:12874225]
[PUBMED:12221108]
[PUBMED:16380506]
[PUBMED:9768751]
[PUBMED:17114419]
[PUBMED:10358173]
[PUBMED:9890938]
[PUBMED:12213961]
[PUBMED:11120802]
[PUBMED:9202126]
[PUBMED:16641133]
[PUBMED:10198225]
[PUBMED:16763563]
[PUBMED:15728489]
[PUBMED:8103068]
[PUBMED:10903740]
[PUBMED:10201984]
[PUBMED:7638186]
[PUBMED:11894097]
[PUBMED:16220539]
[PUBMED:10961885]
[PUBMED:7594594]
[PUBMED:17110450]
[PUBMED:9582275]
[PUBMED:10320373]
[PUBMED:7528775]
[PUBMED:11207258]
[PUBMED:9038232]
[PUBMED:15522880]
[PUBMED:11175814]
[PUBMED:9531298]
[PUBMED:7722452]
[PUBMED:8943050]
[PUBMED:7553885]
[PUBMED:9454765]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
[NCBI:1269201]
[REACTOME:R-HSA-198933]
[PUBMED:17218381]
[PUBMED:16603343]
[PUBMED:16616474]
[PUBMED:11244041]
[PUBMED:16132082]
[PUBMED:18425107]
Infectious disease
[NCBI:1269056]
[REACTOME:R-HSA-5663205]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Interferon Signaling
[NCBI:1269311]
[REACTOME:R-HSA-913531]
[PUBMED:18929502]
[PUBMED:15607020]
[PUBMED:15864272]
[PUBMED:14525967]
[PUBMED:19059436]
Interferon alpha/beta signaling
[NCBI:1269312]
[REACTOME:R-HSA-909733]
[PUBMED:8621447]
[PUBMED:8605876]
[PUBMED:8702790]
[PUBMED:17969444]
Interferon gamma signaling
[NCBI:1269314]
[REACTOME:R-HSA-877300]
[PUBMED:9462485]
[PUBMED:18929502]
[PUBMED:9143700]
[PUBMED:14525967]
Natural killer cell mediated cytotoxicity
[NCBI:83079]
[KEGG:hsa04650]
[PUBMED:12530970]
[PUBMED:15567854]
[PUBMED:8942070]
[PUBMED:11905813]
[PUBMED:9143705]
[PUBMED:9862693]
[PUBMED:11895890]
[PUBMED:12205470]
[PUBMED:11836514]
[PUBMED:15607806]
[PUBMED:16002670]
[PUBMED:15618404]
[PUBMED:11390470]
[PUBMED:11062493]
[PUBMED:14710949]
[PUBMED:12752668]
[PUBMED:15607802]
[PUBMED:16109839]
[PUBMED:12766758]
[PUBMED:16177799]
Nef mediated downregulation of MHC class I complex cell surface expression
[NCBI:1269104]
[REACTOME:R-HSA-164940]
[PUBMED:8612235]
[PUBMED:12414957]
[PUBMED:12526811]
[PUBMED:9586638]
[PUBMED:11593029]
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
[NCBI:1269102]
[REACTOME:R-HSA-164938]
[PUBMED:9811606]
[PUBMED:11208076]
[PUBMED:9564030]
[PUBMED:9586638]
[PUBMED:12486136]
[PUBMED:9811611]
[PUBMED:9384576]
[PUBMED:9736718]
Neutrophil degranulation
[NCBI:1457780]
[REACTOME:R-HSA-6798695]
[PUBMED:20338884]
[PUBMED:1378856]
[PUBMED:17627888]
[PUBMED:23650620]
[PUBMED:8692836]
Phagosome
[NCBI:153910]
[KEGG:hsa04145]
[PUBMED:17637737]
[PUBMED:18513324]
[PUBMED:15894272]
[PUBMED:10684585]
[PUBMED:18492791]
[PUBMED:15036145]
[PUBMED:17245426]
TCR signaling in naive CD8+ T cells
[NCBI:138055]
[Pathway Interaction Database:cd8tcrpathway]
[PUBMED:9094314]
[PUBMED:15125833]
[PUBMED:11994416]
[PUBMED:7509360]
[PUBMED:12755691]
[PUBMED:8642247]
[PUBMED:12361955]
[PUBMED:11956228]
[PUBMED:10072079]
[PUBMED:8977171]
[PUBMED:2141684]
[PUBMED:8700169]
[PUBMED:8164687]
[PUBMED:9489702]
[PUBMED:8702662]
[PUBMED:2548204]
[PUBMED:11175263]
[PUBMED:8114715]
[PUBMED:10209031]
[PUBMED:15536066]
[PUBMED:7678351]
[PUBMED:8673703]
[PUBMED:7830771]
[PUBMED:7509083]
[PUBMED:16733527]
[PUBMED:9438848]
[PUBMED:8790380]
[PUBMED:1639064]
[PUBMED:15980863]
[PUBMED:8084588]
[PUBMED:14702343]
[PUBMED:10790433]
[PUBMED:10807788]
[PUBMED:16169499]
[PUBMED:15802604]
[PUBMED:8892604]
[PUBMED:2114552]
[PUBMED:12421919]
[PUBMED:12917261]
[PUBMED:8146197]
[PUBMED:1335364]
[PUBMED:10021361]
[PUBMED:8183372]
[PUBMED:8627172]
[PUBMED:8898939]
[PUBMED:2190221]
[PUBMED:9710204]
[PUBMED:11287959]
[PUBMED:14764585]
[PUBMED:12954628]
[PUBMED:10209041]
[PUBMED:1464315]
[PUBMED:12507424]
[PUBMED:12732656]
[PUBMED:8195151]
[PUBMED:12138205]
[PUBMED:16005298]
[PUBMED:9312149]
[PUBMED:7544353]
[PUBMED:16906149]
[PUBMED:9637919]
[PUBMED:12845325]
[PUBMED:2470098]
[PUBMED:10918068]
[PUBMED:16116204]
[PUBMED:16921383]
[PUBMED:10562325]
[PUBMED:9819387]
[PUBMED:16582901]
[PUBMED:8034711]
[PUBMED:8479536]
[PUBMED:10640739]
[PUBMED:3919143]
[PUBMED:10224278]
[PUBMED:10811865]
The role of Nef in HIV-1 replication and disease pathogenesis
[NCBI:1269100]
[REACTOME:R-HSA-164952]
[PUBMED:16354571]
Type I diabetes mellitus
[NCBI:83095]
[KEGG:hsa04940]
[PUBMED:11507694]
[PUBMED:8072542]
[PUBMED:15889095]
[PUBMED:15889096]
[PUBMED:12796471]
[PUBMED:14617043]
[PUBMED:8786033]
[PUBMED:9719467]
[PUBMED:12752668]
Viral carcinogenesis
[NCBI:658418]
[KEGG:hsa05203]
[PUBMED:9990017]
[PUBMED:15173177]
[PUBMED:16036567]
[PUBMED:16581947]
[PUBMED:9060639]
[PUBMED:17457345]
[PUBMED:15956361]
[PUBMED:21421561]
[PUBMED:18391203]
[PUBMED:21040832]
[PUBMED:9837909]
[PUBMED:17645777]
[PUBMED:15967719]
[PUBMED:12686421]
[PUBMED:17049016]
[PUBMED:21152115]
[PUBMED:11160754]
[PUBMED:21966251]
[PUBMED:17979705]
[PUBMED:8617242]
[PUBMED:12925958]
[PUBMED:10873631]
[PUBMED:21250384]
[PUBMED:15614436]
[PUBMED:10354594]
[PUBMED:20494113]
[PUBMED:18702816]
[PUBMED:9651361]
[PUBMED:16459163]
[PUBMED:11278402]
[PUBMED:15510157]
[PUBMED:19956178]
[PUBMED:18251977]
[PUBMED:11766888]
[PUBMED:10824878]
[PUBMED:21372216]
[PUBMED:11244044]
[PUBMED:17894800]
[PUBMED:11905817]
[PUBMED:21347341]
[PUBMED:12186904]
[PUBMED:9374493]
[PUBMED:16352731]
[PUBMED:12770701]
[PUBMED:17384582]
[PUBMED:14506283]
[PUBMED:11091847]
[PUBMED:17267064]
[PUBMED:11886269]
[PUBMED:21177815]
[PUBMED:10400746]
[PUBMED:19156753]
[PUBMED:9882379]
[PUBMED:14559998]
[PUBMED:15767449]
[PUBMED:22110506]
[PUBMED:20534855]
[PUBMED:15542638]
[PUBMED:9343405]
[PUBMED:10405893]
[PUBMED:19400863]
[PUBMED:9349482]
[PUBMED:14747563]
[PUBMED:21647825]
[PUBMED:12970441]
[PUBMED:11669605]
[PUBMED:15795286]
[PUBMED:21994562]
[PUBMED:14530271]
[PUBMED:9594662]
[PUBMED:22566809]
[PUBMED:19651473]
[PUBMED:8756622]
[PUBMED:15105524]
[PUBMED:15452270]
[PUBMED:18948197]
[PUBMED:16760382]
[PUBMED:10793105]
[PUBMED:21084867]
[PUBMED:16308315]
[PUBMED:16155604]
[PUBMED:16381817]
[PUBMED:16828973]
[PUBMED:15342967]
[PUBMED:15692053]
[PUBMED:10855768]
[PUBMED:19078975]
[PUBMED:12379483]
[PUBMED:15310405]
[PUBMED:8223437]
[PUBMED:16939421]
[PUBMED:12910250]
[PUBMED:16039586]
[PUBMED:18201576]
[PUBMED:21102637]
[PUBMED:21743832]
[PUBMED:20592731]
[PUBMED:10644344]
[PUBMED:10074132]
[PUBMED:19715458]
[PUBMED:16155601]
[PUBMED:11604508]
[PUBMED:15919895]
[PUBMED:11099494]
[PUBMED:18385245]
[PUBMED:19854353]
[PUBMED:12101418]
Viral myocarditis
[NCBI:125138]
[KEGG:hsa05416]
[PUBMED:19357408]
[PUBMED:18545064]
[PUBMED:18357777]
[PUBMED:11524405]
[PUBMED:12920582]
[PUBMED:14522402]
[PUBMED:17200452]
[PUBMED:18039131]
[PUBMED:16413486]
[PUBMED:12439638]
[PUBMED:16817756]
[PUBMED:16845885]
[PUBMED:10051305]
[PUBMED:10904843]