Logo
full name
Janus kinase 1

synonyms
JAK1A, JAK1B, JTK3, JAK1, ENSG00000162434

HGNC
HGNC:6190

Entrez Gene
Gene:3716

ENSEMBL
ENSG00000162434

location
chr: 1
start: 65298906
stop: 65432593
strand: -

transcripts
NM_002227.2

pathways
ARMS-mediated activation [NCBI:1269471] [REACTOME:R-HSA-170984] [PUBMED:9069267]
Antiviral mechanism by IFN-stimulated genes [NCBI:1269316] [REACTOME:R-HSA-1169410]
Axon guidance [NCBI:83065] [KEGG:hsa04360] [NCBI:1270303] [REACTOME:R-HSA-422475] [PUBMED:14682358] [PUBMED:15084255] [PUBMED:11687826] [PUBMED:15818466] [PUBMED:15363605] [PUBMED:12471249] [PUBMED:15630019] [PUBMED:11891122] [PUBMED:15960985] [PUBMED:12677003]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
DAP12 interactions [NCBI:1269283] [REACTOME:R-HSA-2172127] [PUBMED:19120482] [PUBMED:17220916] [PUBMED:9490415] [PUBMED:18192027] [PUBMED:15884055]
DAP12 signaling [NCBI:1269284] [REACTOME:R-HSA-2424491] [PUBMED:15884055] [PUBMED:17110943] [PUBMED:17220916]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Downstream signal transduction [NCBI:1269479] [REACTOME:R-HSA-186763] [PUBMED:10508235] [PUBMED:9739761]
EGFR tyrosine kinase inhibitor resistance [NCBI:1404798] [KEGG:hsa01521] [PUBMED:16843264] [PUBMED:23401451] [PUBMED:20966921] [PUBMED:24307395] [PUBMED:22956644] [PUBMED:25232485] [PUBMED:24493829] [PUBMED:23071030] [PUBMED:18483355] [PUBMED:24202392] [PUBMED:19632948] [PUBMED:23361103] [PUBMED:26579470] [PUBMED:22970367] [PUBMED:23358468] [PUBMED:17554333] [PUBMED:25337673] [PUBMED:22474259] [PUBMED:20551942]
Epstein-Barr virus infection [NCBI:585562] [KEGG:hsa05169] [PUBMED:1658397] [PUBMED:10683340] [PUBMED:19375142] [PUBMED:12438576] [PUBMED:12910248] [PUBMED:10400785] [PUBMED:16007144] [PUBMED:14576817] [PUBMED:18559925] [PUBMED:16352731] [PUBMED:7895172] [PUBMED:15510157] [PUBMED:21518914] [PUBMED:10891508] [PUBMED:14673102] [PUBMED:17159145] [PUBMED:15542638] [PUBMED:18786993] [PUBMED:16603506] [PUBMED:10644367] [PUBMED:15021898] [PUBMED:10666279] [PUBMED:9565632]
FCERI mediated MAPK activation [NCBI:1269299] [REACTOME:R-HSA-2871796] [PUBMED:19290926] [PUBMED:19909365] [PUBMED:17122878]
Fc epsilon receptor (FCERI) signaling [NCBI:1269298] [REACTOME:R-HSA-2454202] [PUBMED:15099567] [PUBMED:21799019]
Frs2-mediated activation [NCBI:1269470] [REACTOME:R-HSA-170968] [PUBMED:9069267]
G beta:gamma signalling through PI3Kgamma [NCBI:1269581] [REACTOME:R-HSA-392451] [PUBMED:17916723] [PUBMED:17041586]
G-protein beta:gamma signalling [NCBI:1269580] [REACTOME:R-HSA-397795] [PUBMED:18834311]
GPCR downstream signaling [NCBI:1269574] [REACTOME:R-HSA-388396] [PUBMED:12040175]
GPVI-mediated activation cascade [NCBI:1269357] [REACTOME:R-HSA-114604] [PUBMED:16102042] [PUBMED:11943772]
GRB2 events in EGFR signaling [NCBI:1269382] [REACTOME:R-HSA-179812] [PUBMED:11706405] [PUBMED:11498013]
Gastrin-CREB signalling pathway via PKC and MAPK [NCBI:1269592] [REACTOME:R-HSA-881907] [PUBMED:10413847] [PUBMED:7491953] [PUBMED:17698287]
HTLV-I infection [NCBI:373901] [KEGG:hsa05166] [PUBMED:17446673] [PUBMED:16436385] [PUBMED:14686485] [PUBMED:19861996] [PUBMED:19092975] [PUBMED:11325603] [PUBMED:16155602] [PUBMED:12910251] [PUBMED:16155605] [PUBMED:16036567] [PUBMED:11244044] [PUBMED:18702816] [PUBMED:15569630] [PUBMED:21114861] [PUBMED:16155611] [PUBMED:17384582] [PUBMED:16155608] [PUBMED:10602469] [PUBMED:19014483] [PUBMED:9325311]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Hepatitis B [NCBI:694606] [KEGG:hsa05161] [PUBMED:19854353] [PUBMED:11604508] [PUBMED:11325602] [PUBMED:18931690] [PUBMED:16891440] [PUBMED:17158882] [PUBMED:11099494] [PUBMED:9325306] [PUBMED:18024894] [PUBMED:11483993] [PUBMED:15107488] [PUBMED:11278872] [PUBMED:21647825] [PUBMED:11287574] [PUBMED:18481805] [PUBMED:17188775] [PUBMED:19784739] [PUBMED:19263472] [PUBMED:16203685] [PUBMED:18605975] [PUBMED:10454581] [PUBMED:22504921] [PUBMED:21334391] [PUBMED:20657822] [PUBMED:18046710] [PUBMED:9843511] [PUBMED:15542625] [PUBMED:21618535] [PUBMED:15132991] [PUBMED:15173177] [PUBMED:12771941] [PUBMED:21994545] [PUBMED:8764004] [PUBMED:16459163] [PUBMED:9738022] [PUBMED:11821950] [PUBMED:12839924]
Hepatitis C [NCBI:173973] [KEGG:hsa05160] [PUBMED:19708811] [PUBMED:16314558] [PUBMED:17467654] [PUBMED:19515018] [PUBMED:18514579] [PUBMED:16107833] [PUBMED:19074178] [PUBMED:12691459] [PUBMED:15302943] [PUBMED:20537953] [PUBMED:11991644] [PUBMED:19148799] [PUBMED:19187070] [PUBMED:12655344]
Herpes simplex infection [NCBI:377873] [KEGG:hsa05168] [PUBMED:12224518] [PUBMED:17913820] [PUBMED:12844494] [PUBMED:10998601] [PUBMED:15163721] [PUBMED:19694546] [PUBMED:16297150] [PUBMED:14747533] [PUBMED:12826401] [PUBMED:14963113] [PUBMED:15056211] [PUBMED:12797447] [PUBMED:21107701] [PUBMED:10918307] [PUBMED:10696424] [PUBMED:16076403] [PUBMED:10364308] [PUBMED:17222692] [PUBMED:9621021] [PUBMED:12224508] [PUBMED:19879619] [PUBMED:11070032] [PUBMED:9499021] [PUBMED:18596690] [PUBMED:12525427] [PUBMED:12224517] [PUBMED:10196275] [PUBMED:15047834] [PUBMED:18508584] [PUBMED:20036979]
IFN-gamma pathway [NCBI:138040] [Pathway Interaction Database:ifngpathway] [PUBMED:9724754] [PUBMED:10657627] [PUBMED:10067896] [PUBMED:9271410] [PUBMED:8608598] [PUBMED:15878863] [PUBMED:11971965] [PUBMED:11438544] [PUBMED:15051500] [PUBMED:17032168] [PUBMED:11909529] [PUBMED:11171987] [PUBMED:7514165] [PUBMED:12817007] [PUBMED:8232552] [PUBMED:10485906] [PUBMED:8755534] [PUBMED:10490100] [PUBMED:8156998] [PUBMED:11972023] [PUBMED:8986769] [PUBMED:12438563] [PUBMED:10022928] [PUBMED:12270932] [PUBMED:7510216] [PUBMED:15311277] [PUBMED:14670297] [PUBMED:12048245] [PUBMED:10777554] [PUBMED:12138178] [PUBMED:9336467] [PUBMED:7690989] [PUBMED:1281555] [PUBMED:17606919] [PUBMED:10805787] [PUBMED:12050152] [PUBMED:8608597] [PUBMED:15879117] [PUBMED:12855578] [PUBMED:10995751] [PUBMED:10490099] [PUBMED:7777519]
IGF1R signaling cascade [NCBI:1269618] [REACTOME:R-HSA-2428924] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959]
IL-6-type cytokine receptor ligand interactions [NCBI:1339143] [REACTOME:R-HSA-6788467] [PUBMED:9716487] [PUBMED:12773095]
IL2 signaling events mediated by PI3K [NCBI:137938] [Pathway Interaction Database:il2_pi3kpathway] [PUBMED:15271800] [PUBMED:8617294] [PUBMED:7543780] [PUBMED:9092570] [PUBMED:9162082] [PUBMED:7737351] [PUBMED:9108028] [PUBMED:11486019] [PUBMED:1614535] [PUBMED:15843522] [PUBMED:7760801] [PUBMED:9029085] [PUBMED:1652056] [PUBMED:11994454] [PUBMED:12393431] [PUBMED:9771966] [PUBMED:10373522] [PUBMED:12525482] [PUBMED:3523754] [PUBMED:7736574] [PUBMED:10982827] [PUBMED:7589144] [PUBMED:7528328]
IL2 signaling events mediated by STAT5 [NCBI:137988] [Pathway Interaction Database:il2_stat5pathway] [PUBMED:11160217] [PUBMED:16645171] [PUBMED:9121484] [PUBMED:17182565] [PUBMED:14607901] [PUBMED:9104808] [PUBMED:11485747] [PUBMED:14614860] [PUBMED:10679091] [PUBMED:12196288] [PUBMED:10072077] [PUBMED:10544201] [PUBMED:15004274] [PUBMED:9390691] [PUBMED:9395528] [PUBMED:10514006] [PUBMED:14500638] [PUBMED:16757175] [PUBMED:9541574] [PUBMED:8617294]
IL2-mediated signaling events [NCBI:137976] [Pathway Interaction Database:il2_1pathway] [PUBMED:7568005] [PUBMED:10962026] [PUBMED:1545122] [PUBMED:10602027] [PUBMED:15170389] [PUBMED:9092570] [PUBMED:7509794] [PUBMED:15356145] [PUBMED:9973481] [PUBMED:10899310] [PUBMED:9195132] [PUBMED:7544001] [PUBMED:7777534] [PUBMED:12681450] [PUBMED:7665592] [PUBMED:8702919] [PUBMED:1708096] [PUBMED:8643566] [PUBMED:7988557] [PUBMED:7737351] [PUBMED:1532814] [PUBMED:8262551] [PUBMED:8025955] [PUBMED:10993906] [PUBMED:3095922] [PUBMED:8805624] [PUBMED:9391116] [PUBMED:7973658] [PUBMED:11331873] [PUBMED:10421845] [PUBMED:8119884] [PUBMED:7781605] [PUBMED:12543077] [PUBMED:9133424] [PUBMED:1618313] [PUBMED:1940342] [PUBMED:9382798] [PUBMED:10514520] [PUBMED:7973659] [PUBMED:1639773] [PUBMED:9029085] [PUBMED:7760801] [PUBMED:1460037] [PUBMED:9202126] [PUBMED:1652056] [PUBMED:12393431] [PUBMED:8397196] [PUBMED:2047859] [PUBMED:7688728] [PUBMED:8700888] [PUBMED:7528668] [PUBMED:9305919] [PUBMED:2303462] [PUBMED:7568001] [PUBMED:9822600] [PUBMED:7543676] [PUBMED:7499365] [PUBMED:10843677] [PUBMED:7600304] [PUBMED:7719937] [PUBMED:9590209] [PUBMED:9794391] [PUBMED:10849428] [PUBMED:8294403] [PUBMED:10373548] [PUBMED:2590941] [PUBMED:9512511] [PUBMED:6434688] [PUBMED:9697832] [PUBMED:10982827] [PUBMED:10214954] [PUBMED:10825200] [PUBMED:1535827] [PUBMED:10369681] [PUBMED:7719938] [PUBMED:1655887] [PUBMED:8376945] [PUBMED:1996324] [PUBMED:7479881] [PUBMED:10962581] [PUBMED:7973657] [PUBMED:1631559] [PUBMED:10066828] [PUBMED:9169478] [PUBMED:8552611] [PUBMED:8483935] [PUBMED:2106566] [PUBMED:16199887]
IL27-mediated signaling events [NCBI:137929] [Pathway Interaction Database:il27pathway] [PUBMED:11672539] [PUBMED:16365415] [PUBMED:16906167] [PUBMED:15356135] [PUBMED:14657353] [PUBMED:15944269] [PUBMED:14764690] [PUBMED:14614852] [PUBMED:15308705] [PUBMED:15004160] [PUBMED:12734330] [PUBMED:11057672] [PUBMED:15494513] [PUBMED:14614853] [PUBMED:12121660] [PUBMED:16906166] [PUBMED:15749890]
IL4-mediated signaling events [NCBI:137933] [Pathway Interaction Database:il4_2pathway] [PUBMED:8602263] [PUBMED:15199062] [PUBMED:7705411] [PUBMED:11160325] [PUBMED:8557643] [PUBMED:8134361] [PUBMED:1948049] [PUBMED:10843732] [PUBMED:11034397] [PUBMED:8624802] [PUBMED:14557412] [PUBMED:1997653] [PUBMED:10586089] [PUBMED:14634100] [PUBMED:17541284] [PUBMED:8124718] [PUBMED:16210622] [PUBMED:7822337] [PUBMED:11572871] [PUBMED:2147202] [PUBMED:10228008] [PUBMED:7675087] [PUBMED:12574343] [PUBMED:14603527] [PUBMED:15659391] [PUBMED:11160269] [PUBMED:7760829] [PUBMED:7973658] [PUBMED:10072514] [PUBMED:9013879] [PUBMED:8624803] [PUBMED:10490661] [PUBMED:14978013] [PUBMED:10364072] [PUBMED:12459556] [PUBMED:11714803] [PUBMED:8602264] [PUBMED:9811885] [PUBMED:12776189] [PUBMED:15728454] [PUBMED:10601358] [PUBMED:11739727] [PUBMED:11160275] [PUBMED:9852037] [PUBMED:9670964] [PUBMED:15004182] [PUBMED:8266078] [PUBMED:3144043] [PUBMED:8992992] [PUBMED:8089482] [PUBMED:9651359] [PUBMED:16810739] [PUBMED:7499365] [PUBMED:7721786] [PUBMED:9065461] [PUBMED:11241672] [PUBMED:10950967] [PUBMED:8810328] [PUBMED:8624821] [PUBMED:9110977] [PUBMED:8609418] [PUBMED:15187136] [PUBMED:9414268] [PUBMED:8916957] [PUBMED:10201892] [PUBMED:17200144] [PUBMED:8458387] [PUBMED:11544308] [PUBMED:10657944] [PUBMED:15153491] [PUBMED:7544011] [PUBMED:8266076] [PUBMED:11801631] [PUBMED:12044779] [PUBMED:8621475] [PUBMED:9697832] [PUBMED:12242343] [PUBMED:7694370] [PUBMED:9380721] [PUBMED:9541585] [PUBMED:7807002] [PUBMED:16537510] [PUBMED:8258319] [PUBMED:9799097] [PUBMED:12023955] [PUBMED:8085155]
IL6-mediated signaling events [NCBI:137932] [Pathway Interaction Database:il6_7pathway] [PUBMED:8559663] [PUBMED:8662591] [PUBMED:11689697] [PUBMED:11727828] [PUBMED:10383440] [PUBMED:10777583] [PUBMED:16774741] [PUBMED:12754507] [PUBMED:9295319] [PUBMED:15722452] [PUBMED:10859312] [PUBMED:9590172] [PUBMED:9880505] [PUBMED:12445202] [PUBMED:8134389] [PUBMED:10409724] [PUBMED:8164674] [PUBMED:8272872] [PUBMED:9794795] [PUBMED:7678052] [PUBMED:8511589] [PUBMED:8668165] [PUBMED:9724754] [PUBMED:8083235] [PUBMED:12754505] [PUBMED:8621622] [PUBMED:16254248] [PUBMED:12361954] [PUBMED:10605021] [PUBMED:9388184] [PUBMED:15935617] [PUBMED:11120832] [PUBMED:7875298] [PUBMED:9973404] [PUBMED:11335711] [PUBMED:9632795] [PUBMED:11468294] [PUBMED:7898939] [PUBMED:8626374] [PUBMED:8670868] [PUBMED:7537214] [PUBMED:15677447] [PUBMED:2261637] [PUBMED:9874564] [PUBMED:12829785] [PUBMED:8537375] [PUBMED:8272873] [PUBMED:7523403] [PUBMED:11251120] [PUBMED:9163525] [PUBMED:3136546] [PUBMED:10727406] [PUBMED:10023775] [PUBMED:12754506] [PUBMED:12456685] [PUBMED:2788034] [PUBMED:10446219] [PUBMED:15572665] [PUBMED:1662392] [PUBMED:15010462] [PUBMED:8140422] [PUBMED:8467812]
IRS-mediated signalling [NCBI:1269431] [REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R [NCBI:1269620] [REACTOME:R-HSA-2428928] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:18927274] [PUBMED:21042815] [PUBMED:20098959]
ISG15 antiviral mechanism [NCBI:1269317] [REACTOME:R-HSA-1169408] [PUBMED:20153823] [PUBMED:12582176] [PUBMED:16009940] [PUBMED:20946978] [PUBMED:15970528]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Influenza A [NCBI:217173] [KEGG:hsa05164] [PUBMED:17267598] [PUBMED:18049471] [PUBMED:16882036] [PUBMED:11907320] [PUBMED:17944269] [PUBMED:20629046] [PUBMED:17072332] [PUBMED:18588994] [PUBMED:19864182] [PUBMED:19290913] [PUBMED:19420020] [PUBMED:17213831] [PUBMED:9060654] [PUBMED:19481124] [PUBMED:16494716] [PUBMED:21147034] [PUBMED:18980544] [PUBMED:20020828] [PUBMED:15502848] [PUBMED:19782761]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Insulin receptor signalling cascade [NCBI:1269429] [REACTOME:R-HSA-74751] [PUBMED:9677303] [PUBMED:11282018]
Interferon Signaling [NCBI:1269311] [REACTOME:R-HSA-913531] [PUBMED:18929502] [PUBMED:15607020] [PUBMED:15864272] [PUBMED:14525967] [PUBMED:19059436]
Interferon alpha/beta signaling [NCBI:1269312] [REACTOME:R-HSA-909733] [PUBMED:8621447] [PUBMED:8605876] [PUBMED:8702790] [PUBMED:17969444]
Interferon gamma signaling [NCBI:1269314] [REACTOME:R-HSA-877300] [PUBMED:9462485] [PUBMED:18929502] [PUBMED:9143700] [PUBMED:14525967]
Interleukin receptor SHC signaling [NCBI:1269322] [REACTOME:R-HSA-912526] [PUBMED:8294403]
Interleukin-10 signaling [NCBI:1470924] [REACTOME:R-HSA-6783783] [PUBMED:11244051]
Interleukin-2 signaling [NCBI:1269321] [REACTOME:R-HSA-451927] [PUBMED:17936914] [PUBMED:18817510] [PUBMED:19543225] [PUBMED:18062768]
Interleukin-3, 5 and GM-CSF signaling [NCBI:1269323] [REACTOME:R-HSA-512988] [PUBMED:10450743] [PUBMED:9766809]
Interleukin-4 and 13 signaling [NCBI:1470923] [REACTOME:R-HSA-6785807] [PUBMED:12704343] [PUBMED:10358772]
Interleukin-6 family signaling [NCBI:1339142] [REACTOME:R-HSA-6783589] [PUBMED:9685167] [PUBMED:8666978] [PUBMED:12773095] [PUBMED:9143707] [PUBMED:9716487] [PUBMED:7632928]
Interleukin-6 signaling [NCBI:1269325] [REACTOME:R-HSA-1059683] [PUBMED:20410258]
Interleukin-7 signaling [NCBI:1269326] [REACTOME:R-HSA-1266695]
Jak-STAT signaling pathway [NCBI:83077] [KEGG:hsa04630] [PUBMED:21034406] [PUBMED:22339650] [PUBMED:16204702] [PUBMED:25587654] [PUBMED:24069565] [PUBMED:22383755] [PUBMED:24606160] [PUBMED:10851053] [PUBMED:23735217] [PUBMED:25217450] [PUBMED:21372217]
Leishmaniasis [NCBI:144181] [KEGG:hsa05140] [PUBMED:11890722] [PUBMED:7916951] [PUBMED:10417174] [PUBMED:11298294] [PUBMED:10586030] [PUBMED:15322192] [PUBMED:15831826] [PUBMED:11728310] [PUBMED:15039466] [PUBMED:10462516] [PUBMED:10608501] [PUBMED:15721837] [PUBMED:15639739] [PUBMED:14762510] [PUBMED:18793215] [PUBMED:7591091] [PUBMED:12438359] [PUBMED:18070909] [PUBMED:17543969] [PUBMED:15983048] [PUBMED:16848789] [PUBMED:10770277] [PUBMED:9504340]
MAPK family signaling cascades [NCBI:1269501] [REACTOME:R-HSA-5683057] [PUBMED:21167873] [PUBMED:17161475] [PUBMED:22535895] [PUBMED:21372320]
MAPK1 (ERK2) activation [NCBI:1269505] [REACTOME:R-HSA-112411] [PUBMED:22177953] [PUBMED:8131746]
MAPK1/MAPK3 signaling [NCBI:1269502] [REACTOME:R-HSA-5684996] [PUBMED:25378393] [PUBMED:18199641] [PUBMED:17496909] [PUBMED:21779496] [PUBMED:15520807] [PUBMED:16393692] [PUBMED:19520853] [PUBMED:17496910] [PUBMED:22569528]
MAPK3 (ERK1) activation [NCBI:1269504] [REACTOME:R-HSA-110056]
Measles [NCBI:213306] [KEGG:hsa05162] [PUBMED:16237742] [PUBMED:12804771] [PUBMED:19198562] [PUBMED:20376484] [PUBMED:11385511] [PUBMED:16963735] [PUBMED:19198566] [PUBMED:18922877] [PUBMED:19203114] [PUBMED:12620806] [PUBMED:16690907] [PUBMED:17720800] [PUBMED:20636817] [PUBMED:12410527] [PUBMED:11582511] [PUBMED:19203109] [PUBMED:19203113] [PUBMED:14585342] [PUBMED:12805463]
NCAM signaling for neurite out-growth [NCBI:1270312] [REACTOME:R-HSA-375165] [PUBMED:18760361] [PUBMED:12587671] [PUBMED:15662836] [PUBMED:17975827] [PUBMED:15153429] [PUBMED:12700044]
NGF signalling via TRKA from the plasma membrane [NCBI:1269460] [REACTOME:R-HSA-187037] [PUBMED:11520933] [PUBMED:12676795] [PUBMED:10851172] [PUBMED:10579918]
NOD-like receptor signaling pathway [NCBI:122191] [KEGG:hsa04621] [PUBMED:25330206] [PUBMED:21575908] [PUBMED:23846113] [PUBMED:26549800] [PUBMED:16493424] [PUBMED:23124073] [PUBMED:24840700] [PUBMED:27291964] [PUBMED:27012466] [PUBMED:24707857] [PUBMED:19767725] [PUBMED:25879280] [PUBMED:23215645] [PUBMED:22819539] [PUBMED:23702978] [PUBMED:20643110] [PUBMED:25879288] [PUBMED:26655628] [PUBMED:25145756] [PUBMED:24718315] [PUBMED:26482951] [PUBMED:25526305] [PUBMED:26121197] [PUBMED:22430786]
Osteoclast differentiation [NCBI:193147] [KEGG:hsa04380] [PUBMED:17633024] [PUBMED:18382763] [PUBMED:18329366] [PUBMED:17869613] [PUBMED:18722561] [PUBMED:15122243] [PUBMED:20703218] [PUBMED:12748652] [PUBMED:12110142] [PUBMED:19585227] [PUBMED:15546140] [PUBMED:16184196] [PUBMED:15817678] [PUBMED:20392226] [PUBMED:16313349] [PUBMED:16313342] [PUBMED:17380158] [PUBMED:18451259]
PDGFR-alpha signaling pathway [NCBI:138049] [Pathway Interaction Database:pdgfrapathway] [PUBMED:15871904] [PUBMED:10497192] [PUBMED:10733900] [PUBMED:11095946] [PUBMED:9788278] [PUBMED:10837138] [PUBMED:11297552] [PUBMED:9546424] [PUBMED:9737716] [PUBMED:10066366] [PUBMED:7535778] [PUBMED:11953315] [PUBMED:2544881]
PI3K-Akt signaling pathway [NCBI:692234] [KEGG:hsa04151] [PUBMED:12048182] [PUBMED:11357143] [PUBMED:21440011] [PUBMED:15209374] [PUBMED:12669022] [PUBMED:18842113] [PUBMED:16847462] [PUBMED:12660731] [PUBMED:17360849] [PUBMED:9838078] [PUBMED:15505410] [PUBMED:16248975] [PUBMED:12531180] [PUBMED:21779440] [PUBMED:16187290] [PUBMED:15784165] [PUBMED:21620960]
Pancreatic cancer [NCBI:83108] [KEGG:hsa05212] [PUBMED:12079267] [PUBMED:14967450] [PUBMED:15774796] [PUBMED:10740269] [PUBMED:12946833] [PUBMED:16702400] [PUBMED:14586404] [PUBMED:15823750] [PUBMED:12648469] [PUBMED:11407945] [PUBMED:12459728] [PUBMED:14580692] [PUBMED:11707511] [PUBMED:12545153]
Pathways in cancer [NCBI:83105] [KEGG:hsa05200] [PUBMED:12244301] [PUBMED:15156182] [PUBMED:16899407] [PUBMED:12621137] [PUBMED:21193867] [PUBMED:16001072] [PUBMED:11707511] [PUBMED:11253051] [PUBMED:11071626] [PUBMED:17251915] [PUBMED:11736900] [PUBMED:16557281] [PUBMED:16699851] [PUBMED:16189702] [PUBMED:11902573] [PUBMED:16555243] [PUBMED:8069858] [PUBMED:15310786] [PUBMED:9834202] [PUBMED:16700615] [PUBMED:12545153] [PUBMED:15656799] [PUBMED:12154354] [PUBMED:11895903] [PUBMED:11527574] [PUBMED:16326109] [PUBMED:16339096] [PUBMED:11160144] [PUBMED:15724144] [PUBMED:12951584] [PUBMED:10647931] [PUBMED:16881963] [PUBMED:15557758] [PUBMED:11477132] [PUBMED:15721476] [PUBMED:15625120] [PUBMED:16236521] [PUBMED:14967450] [PUBMED:15942304] [PUBMED:17287871] [PUBMED:14634372] [PUBMED:15573119] [PUBMED:15009714] [PUBMED:16112428] [PUBMED:15611513] [PUBMED:16001050] [PUBMED:15349822] [PUBMED:16551846] [PUBMED:15978322] [PUBMED:15774796] [PUBMED:16352814] [PUBMED:12951588] [PUBMED:10944551] [PUBMED:10740269] [PUBMED:15639402] [PUBMED:12407699] [PUBMED:11130178] [PUBMED:15109562] [PUBMED:11170304] [PUBMED:11276000] [PUBMED:9643506] [PUBMED:16248975] [PUBMED:16242838] [PUBMED:12946833] [PUBMED:11559746] [PUBMED:9196022] [PUBMED:12079267] [PUBMED:15468170] [PUBMED:16064138] [PUBMED:14580692] [PUBMED:15082523] [PUBMED:15551095] [PUBMED:17062879] [PUBMED:17211469] [PUBMED:11720739] [PUBMED:12588368] [PUBMED:11057895] [PUBMED:9422516] [PUBMED:12894244] [PUBMED:15479695] [PUBMED:16189154] [PUBMED:12878745] [PUBMED:11900250] [PUBMED:11103787] [PUBMED:15122209] [PUBMED:12711111] [PUBMED:12243753] [PUBMED:16306523] [PUBMED:16702400] [PUBMED:15270885] [PUBMED:14685170] [PUBMED:14586404] [PUBMED:11078609] [PUBMED:15284264] [PUBMED:10505543] [PUBMED:11223406] [PUBMED:14982876] [PUBMED:12648469] [PUBMED:12867060] [PUBMED:15711891] [PUBMED:12094241] [PUBMED:16642045] [PUBMED:11463388] [PUBMED:12762887] [PUBMED:15746962] [PUBMED:15823750] [PUBMED:16750612] [PUBMED:16484590] [PUBMED:11459867] [PUBMED:16146838] [PUBMED:14556242] [PUBMED:15947972] [PUBMED:12563308] [PUBMED:16946003] [PUBMED:15948971] [PUBMED:11407945] [PUBMED:12737309] [PUBMED:16095998] [PUBMED:12351585] [PUBMED:24508914] [PUBMED:12084351] [PUBMED:11807782] [PUBMED:14695152] [PUBMED:10453277] [PUBMED:17554387] [PUBMED:15841168] [PUBMED:12616528] [PUBMED:10403855] [PUBMED:16054233] [PUBMED:16474624] [PUBMED:16822996] [PUBMED:17028294] [PUBMED:11224709] [PUBMED:11750244] [PUBMED:11905738] [PUBMED:15719031] [PUBMED:10843728] [PUBMED:16110317] [PUBMED:11721960] [PUBMED:12741677] [PUBMED:7585656] [PUBMED:12801837] [PUBMED:16551847] [PUBMED:12459728] [PUBMED:11431710] [PUBMED:12468433] [PUBMED:11165748] [PUBMED:16042571] [PUBMED:16508724] [PUBMED:15000146] [PUBMED:17149381] [PUBMED:15948711] [PUBMED:14747944] [PUBMED:14737121] [PUBMED:12379883] [PUBMED:17158541] [PUBMED:12850530] [PUBMED:10835690] [PUBMED:16870043]
Platelet activation, signaling and aggregation [NCBI:1269350] [REACTOME:R-HSA-76002] [PUBMED:16543958] [PUBMED:8704248] [PUBMED:2018971] [PUBMED:1672265] [PUBMED:17059469] [PUBMED:12681240] [PUBMED:12411949] [PUBMED:11511514]
Prolonged ERK activation events [NCBI:1269469] [REACTOME:R-HSA-169893] [PUBMED:12765839] [PUBMED:9069267]
RAF-independent MAPK1/3 activation [NCBI:1269503] [REACTOME:R-HSA-112409] [PUBMED:21135874] [PUBMED:22569528] [PUBMED:23954936]
RAF/MAP kinase cascade [NCBI:1269285] [REACTOME:R-HSA-5673001] [PUBMED:21167873] [PUBMED:24937142] [PUBMED:20674547] [PUBMED:17496910] [PUBMED:22177953] [PUBMED:17496919] [PUBMED:22569528] [PUBMED:22535895] [PUBMED:12068308] [PUBMED:17496923] [PUBMED:19091303] [PUBMED:21372320] [PUBMED:21388974] [PUBMED:15520807]
RET signaling [NCBI:1427866] [REACTOME:R-HSA-8853659] [PUBMED:15013219] [PUBMED:17036197]
Regulation of IFNA signaling [NCBI:1269313] [REACTOME:R-HSA-912694] [PUBMED:16710296] [PUBMED:16311601] [PUBMED:10526574]
Regulation of IFNG signaling [NCBI:1269315] [REACTOME:R-HSA-877312] [PUBMED:10526574] [PUBMED:18031232] [PUBMED:12645661]
SHC1 events in EGFR signaling [NCBI:1269383] [REACTOME:R-HSA-180336] [PUBMED:11498013] [PUBMED:8755247]
SOS-mediated signalling [NCBI:1269440] [REACTOME:R-HSA-112412]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by EGFR [NCBI:1269380] [REACTOME:R-HSA-177929] [PUBMED:10459005] [PUBMED:10404636] [PUBMED:12297041] [PUBMED:15142631]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Signaling by Insulin receptor [NCBI:1269428] [REACTOME:R-HSA-74752] [PUBMED:8276779]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
Signaling by Leptin [NCBI:1269632] [REACTOME:R-HSA-2586552] [PUBMED:22211890] [PUBMED:23562747] [PUBMED:20600241] [PUBMED:21622208] [PUBMED:23579596] [PUBMED:22458591] [PUBMED:21489811] [PUBMED:19724019] [PUBMED:21331644] [PUBMED:22448029] [PUBMED:21147620] [PUBMED:20198122] [PUBMED:21677426] [PUBMED:20029269] [PUBMED:22249808] [PUBMED:22991412] [PUBMED:21527729] [PUBMED:17937601] [PUBMED:20553370] [PUBMED:21713385] [PUBMED:23565489] [PUBMED:22289780]
Signaling by PDGF [NCBI:1269478] [REACTOME:R-HSA-186797] [PUBMED:15207811] [PUBMED:10508235] [PUBMED:9739761]
Signaling by SCF-KIT [NCBI:1269487] [REACTOME:R-HSA-1433557] [PUBMED:17350321] [PUBMED:16483568] [PUBMED:7688988] [PUBMED:19540337] [PUBMED:16475976] [PUBMED:15526160]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) [NCBI:1269617] [REACTOME:R-HSA-2404192] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22044904] [PUBMED:22649417]
Signaling by VEGF [NCBI:1269480] [REACTOME:R-HSA-194138] [PUBMED:15585754] [PUBMED:13678960] [PUBMED:16336962] [PUBMED:16835467]
Signaling events mediated by TCPTP [NCBI:169350] [Pathway Interaction Database:tcptp_pathway] [PUBMED:12612081] [PUBMED:18716132] [PUBMED:19171783] [PUBMED:9488479] [PUBMED:15592458] [PUBMED:9261175] [PUBMED:16431927] [PUBMED:15632081] [PUBMED:12359225] [PUBMED:12138178] [PUBMED:7593185] [PUBMED:18840653] [PUBMED:15696169] [PUBMED:18691551] [PUBMED:20484139] [PUBMED:11773439] [PUBMED:16595549] [PUBMED:18948751] [PUBMED:16971512] [PUBMED:12171910] [PUBMED:18819921] [PUBMED:15192089] [PUBMED:17210636] [PUBMED:10488121] [PUBMED:16705167] [PUBMED:14966296] [PUBMED:11909529] [PUBMED:11479308]
Signaling pathways regulating pluripotency of stem cells [NCBI:1026136] [KEGG:hsa04550] [PUBMED:20705693] [PUBMED:23653415] [PUBMED:16518401] [PUBMED:17211451] [PUBMED:22649650] [PUBMED:24910449] [PUBMED:19551525] [PUBMED:22298652] [PUBMED:23370346] [PUBMED:24315442] [PUBMED:18414030] [PUBMED:17647265] [PUBMED:18295576] [PUBMED:24957798] [PUBMED:24147644] [PUBMED:16153702] [PUBMED:19427042] [PUBMED:18220859] [PUBMED:19571885] [PUBMED:23585347]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Signalling to ERKs [NCBI:1269464] [REACTOME:R-HSA-187687] [PUBMED:10508738]
Signalling to RAS [NCBI:1269465] [REACTOME:R-HSA-167044] [PUBMED:11520933]
Signalling to p38 via RIT and RIN [NCBI:1269468] [REACTOME:R-HSA-187706] [PUBMED:10712923]
Th1 and Th2 cell differentiation [NCBI:1458885] [KEGG:hsa04658] [PUBMED:15819694] [PUBMED:12171942] [PUBMED:19165228] [PUBMED:23336087] [PUBMED:26044597] [PUBMED:19151746] [PUBMED:19362457] [PUBMED:22044277] [PUBMED:11752608] [PUBMED:23405903] [PUBMED:19375293] [PUBMED:24113868] [PUBMED:19151747] [PUBMED:23624818] [PUBMED:22566933] [PUBMED:11121747] [PUBMED:20969597] [PUBMED:20065998]
Th17 cell differentiation [NCBI:1469482] [KEGG:hsa04659] [PUBMED:23325835] [PUBMED:23036716] [PUBMED:20488727] [PUBMED:21151104] [PUBMED:21084214] [PUBMED:20054607] [PUBMED:22754770] [PUBMED:22640807] [PUBMED:19379825] [PUBMED:22133865] [PUBMED:22324470] [PUBMED:17768419] [PUBMED:18408735] [PUBMED:21776333] [PUBMED:26253381] [PUBMED:16200068] [PUBMED:18362914] [PUBMED:24325586] [PUBMED:19381306] [PUBMED:18166487]
Toxoplasmosis [NCBI:169642] [KEGG:hsa05145] [PUBMED:18617274] [PUBMED:19400868] [PUBMED:17024357] [PUBMED:19744886] [PUBMED:19891610] [PUBMED:17110955] [PUBMED:12106793] [PUBMED:12580944] [PUBMED:12857995] [PUBMED:10234174] [PUBMED:18327664] [PUBMED:10525166] [PUBMED:18059289] [PUBMED:18775432] [PUBMED:14642303] [PUBMED:15361242] [PUBMED:16339966] [PUBMED:14987366] [PUBMED:15639739]
Tuberculosis [NCBI:213780] [KEGG:hsa05152] [PUBMED:20199890] [PUBMED:21274449] [PUBMED:17359235] [PUBMED:20415982] [PUBMED:18541216] [PUBMED:19369951] [PUBMED:15083155] [PUBMED:11378475] [PUBMED:15228522] [PUBMED:19634703] [PUBMED:21274433] [PUBMED:19563525] [PUBMED:18407066] [PUBMED:18288961] [PUBMED:16200082] [PUBMED:17785780] [PUBMED:11932234]
VEGFA-VEGFR2 Pathway [NCBI:1269483] [REACTOME:R-HSA-4420097] [PUBMED:17344076] [PUBMED:16633338] [PUBMED:19230644] [PUBMED:13678960]
VEGFR2 mediated cell proliferation [NCBI:1269485] [REACTOME:R-HSA-5218921] [PUBMED:22866201] [PUBMED:22180219] [PUBMED:22762016]
Viral carcinogenesis [NCBI:658418] [KEGG:hsa05203] [PUBMED:9990017] [PUBMED:15173177] [PUBMED:16036567] [PUBMED:16581947] [PUBMED:9060639] [PUBMED:17457345] [PUBMED:15956361] [PUBMED:21421561] [PUBMED:18391203] [PUBMED:21040832] [PUBMED:9837909] [PUBMED:17645777] [PUBMED:15967719] [PUBMED:12686421] [PUBMED:17049016] [PUBMED:21152115] [PUBMED:11160754] [PUBMED:21966251] [PUBMED:17979705] [PUBMED:8617242] [PUBMED:12925958] [PUBMED:10873631] [PUBMED:21250384] [PUBMED:15614436] [PUBMED:10354594] [PUBMED:20494113] [PUBMED:18702816] [PUBMED:9651361] [PUBMED:16459163] [PUBMED:11278402] [PUBMED:15510157] [PUBMED:19956178] [PUBMED:18251977] [PUBMED:11766888] [PUBMED:10824878] [PUBMED:21372216] [PUBMED:11244044] [PUBMED:17894800] [PUBMED:11905817] [PUBMED:21347341] [PUBMED:12186904] [PUBMED:9374493] [PUBMED:16352731] [PUBMED:12770701] [PUBMED:17384582] [PUBMED:14506283] [PUBMED:11091847] [PUBMED:17267064] [PUBMED:11886269] [PUBMED:21177815] [PUBMED:10400746] [PUBMED:19156753] [PUBMED:9882379] [PUBMED:14559998] [PUBMED:15767449] [PUBMED:22110506] [PUBMED:20534855] [PUBMED:15542638] [PUBMED:9343405] [PUBMED:10405893] [PUBMED:19400863] [PUBMED:9349482] [PUBMED:14747563] [PUBMED:21647825] [PUBMED:12970441] [PUBMED:11669605] [PUBMED:15795286] [PUBMED:21994562] [PUBMED:14530271] [PUBMED:9594662] [PUBMED:22566809] [PUBMED:19651473] [PUBMED:8756622] [PUBMED:15105524] [PUBMED:15452270] [PUBMED:18948197] [PUBMED:16760382] [PUBMED:10793105] [PUBMED:21084867] [PUBMED:16308315] [PUBMED:16155604] [PUBMED:16381817] [PUBMED:16828973] [PUBMED:15342967] [PUBMED:15692053] [PUBMED:10855768] [PUBMED:19078975] [PUBMED:12379483] [PUBMED:15310405] [PUBMED:8223437] [PUBMED:16939421] [PUBMED:12910250] [PUBMED:16039586] [PUBMED:18201576] [PUBMED:21102637] [PUBMED:21743832] [PUBMED:20592731] [PUBMED:10644344] [PUBMED:10074132] [PUBMED:19715458] [PUBMED:16155601] [PUBMED:11604508] [PUBMED:15919895] [PUBMED:11099494] [PUBMED:18385245] [PUBMED:19854353] [PUBMED:12101418]