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Genes
JAK1
Gene - JAK1
full name
Janus kinase 1
synonyms
JAK1A, JAK1B, JTK3, JAK1, ENSG00000162434
HGNC
HGNC:6190
Entrez Gene
Gene:3716
ENSEMBL
ENSG00000162434
location
chr: 1
start: 65298906
stop: 65432593
strand: -
transcripts
NM_002227.2
pathways
ARMS-mediated activation
[NCBI:1269471]
[REACTOME:R-HSA-170984]
[PUBMED:9069267]
Antiviral mechanism by IFN-stimulated genes
[NCBI:1269316]
[REACTOME:R-HSA-1169410]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
DAP12 interactions
[NCBI:1269283]
[REACTOME:R-HSA-2172127]
[PUBMED:19120482]
[PUBMED:17220916]
[PUBMED:9490415]
[PUBMED:18192027]
[PUBMED:15884055]
DAP12 signaling
[NCBI:1269284]
[REACTOME:R-HSA-2424491]
[PUBMED:15884055]
[PUBMED:17110943]
[PUBMED:17220916]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
Downstream signal transduction
[NCBI:1269479]
[REACTOME:R-HSA-186763]
[PUBMED:10508235]
[PUBMED:9739761]
EGFR tyrosine kinase inhibitor resistance
[NCBI:1404798]
[KEGG:hsa01521]
[PUBMED:16843264]
[PUBMED:23401451]
[PUBMED:20966921]
[PUBMED:24307395]
[PUBMED:22956644]
[PUBMED:25232485]
[PUBMED:24493829]
[PUBMED:23071030]
[PUBMED:18483355]
[PUBMED:24202392]
[PUBMED:19632948]
[PUBMED:23361103]
[PUBMED:26579470]
[PUBMED:22970367]
[PUBMED:23358468]
[PUBMED:17554333]
[PUBMED:25337673]
[PUBMED:22474259]
[PUBMED:20551942]
Epstein-Barr virus infection
[NCBI:585562]
[KEGG:hsa05169]
[PUBMED:1658397]
[PUBMED:10683340]
[PUBMED:19375142]
[PUBMED:12438576]
[PUBMED:12910248]
[PUBMED:10400785]
[PUBMED:16007144]
[PUBMED:14576817]
[PUBMED:18559925]
[PUBMED:16352731]
[PUBMED:7895172]
[PUBMED:15510157]
[PUBMED:21518914]
[PUBMED:10891508]
[PUBMED:14673102]
[PUBMED:17159145]
[PUBMED:15542638]
[PUBMED:18786993]
[PUBMED:16603506]
[PUBMED:10644367]
[PUBMED:15021898]
[PUBMED:10666279]
[PUBMED:9565632]
FCERI mediated MAPK activation
[NCBI:1269299]
[REACTOME:R-HSA-2871796]
[PUBMED:19290926]
[PUBMED:19909365]
[PUBMED:17122878]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
Frs2-mediated activation
[NCBI:1269470]
[REACTOME:R-HSA-170968]
[PUBMED:9069267]
G beta:gamma signalling through PI3Kgamma
[NCBI:1269581]
[REACTOME:R-HSA-392451]
[PUBMED:17916723]
[PUBMED:17041586]
G-protein beta:gamma signalling
[NCBI:1269580]
[REACTOME:R-HSA-397795]
[PUBMED:18834311]
GPCR downstream signaling
[NCBI:1269574]
[REACTOME:R-HSA-388396]
[PUBMED:12040175]
GPVI-mediated activation cascade
[NCBI:1269357]
[REACTOME:R-HSA-114604]
[PUBMED:16102042]
[PUBMED:11943772]
GRB2 events in EGFR signaling
[NCBI:1269382]
[REACTOME:R-HSA-179812]
[PUBMED:11706405]
[PUBMED:11498013]
Gastrin-CREB signalling pathway via PKC and MAPK
[NCBI:1269592]
[REACTOME:R-HSA-881907]
[PUBMED:10413847]
[PUBMED:7491953]
[PUBMED:17698287]
HTLV-I infection
[NCBI:373901]
[KEGG:hsa05166]
[PUBMED:17446673]
[PUBMED:16436385]
[PUBMED:14686485]
[PUBMED:19861996]
[PUBMED:19092975]
[PUBMED:11325603]
[PUBMED:16155602]
[PUBMED:12910251]
[PUBMED:16155605]
[PUBMED:16036567]
[PUBMED:11244044]
[PUBMED:18702816]
[PUBMED:15569630]
[PUBMED:21114861]
[PUBMED:16155611]
[PUBMED:17384582]
[PUBMED:16155608]
[PUBMED:10602469]
[PUBMED:19014483]
[PUBMED:9325311]
Hemostasis
[NCBI:1269340]
[REACTOME:R-HSA-109582]
Hepatitis B
[NCBI:694606]
[KEGG:hsa05161]
[PUBMED:19854353]
[PUBMED:11604508]
[PUBMED:11325602]
[PUBMED:18931690]
[PUBMED:16891440]
[PUBMED:17158882]
[PUBMED:11099494]
[PUBMED:9325306]
[PUBMED:18024894]
[PUBMED:11483993]
[PUBMED:15107488]
[PUBMED:11278872]
[PUBMED:21647825]
[PUBMED:11287574]
[PUBMED:18481805]
[PUBMED:17188775]
[PUBMED:19784739]
[PUBMED:19263472]
[PUBMED:16203685]
[PUBMED:18605975]
[PUBMED:10454581]
[PUBMED:22504921]
[PUBMED:21334391]
[PUBMED:20657822]
[PUBMED:18046710]
[PUBMED:9843511]
[PUBMED:15542625]
[PUBMED:21618535]
[PUBMED:15132991]
[PUBMED:15173177]
[PUBMED:12771941]
[PUBMED:21994545]
[PUBMED:8764004]
[PUBMED:16459163]
[PUBMED:9738022]
[PUBMED:11821950]
[PUBMED:12839924]
Hepatitis C
[NCBI:173973]
[KEGG:hsa05160]
[PUBMED:19708811]
[PUBMED:16314558]
[PUBMED:17467654]
[PUBMED:19515018]
[PUBMED:18514579]
[PUBMED:16107833]
[PUBMED:19074178]
[PUBMED:12691459]
[PUBMED:15302943]
[PUBMED:20537953]
[PUBMED:11991644]
[PUBMED:19148799]
[PUBMED:19187070]
[PUBMED:12655344]
Herpes simplex infection
[NCBI:377873]
[KEGG:hsa05168]
[PUBMED:12224518]
[PUBMED:17913820]
[PUBMED:12844494]
[PUBMED:10998601]
[PUBMED:15163721]
[PUBMED:19694546]
[PUBMED:16297150]
[PUBMED:14747533]
[PUBMED:12826401]
[PUBMED:14963113]
[PUBMED:15056211]
[PUBMED:12797447]
[PUBMED:21107701]
[PUBMED:10918307]
[PUBMED:10696424]
[PUBMED:16076403]
[PUBMED:10364308]
[PUBMED:17222692]
[PUBMED:9621021]
[PUBMED:12224508]
[PUBMED:19879619]
[PUBMED:11070032]
[PUBMED:9499021]
[PUBMED:18596690]
[PUBMED:12525427]
[PUBMED:12224517]
[PUBMED:10196275]
[PUBMED:15047834]
[PUBMED:18508584]
[PUBMED:20036979]
IFN-gamma pathway
[NCBI:138040]
[Pathway Interaction Database:ifngpathway]
[PUBMED:9724754]
[PUBMED:10657627]
[PUBMED:10067896]
[PUBMED:9271410]
[PUBMED:8608598]
[PUBMED:15878863]
[PUBMED:11971965]
[PUBMED:11438544]
[PUBMED:15051500]
[PUBMED:17032168]
[PUBMED:11909529]
[PUBMED:11171987]
[PUBMED:7514165]
[PUBMED:12817007]
[PUBMED:8232552]
[PUBMED:10485906]
[PUBMED:8755534]
[PUBMED:10490100]
[PUBMED:8156998]
[PUBMED:11972023]
[PUBMED:8986769]
[PUBMED:12438563]
[PUBMED:10022928]
[PUBMED:12270932]
[PUBMED:7510216]
[PUBMED:15311277]
[PUBMED:14670297]
[PUBMED:12048245]
[PUBMED:10777554]
[PUBMED:12138178]
[PUBMED:9336467]
[PUBMED:7690989]
[PUBMED:1281555]
[PUBMED:17606919]
[PUBMED:10805787]
[PUBMED:12050152]
[PUBMED:8608597]
[PUBMED:15879117]
[PUBMED:12855578]
[PUBMED:10995751]
[PUBMED:10490099]
[PUBMED:7777519]
IGF1R signaling cascade
[NCBI:1269618]
[REACTOME:R-HSA-2428924]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
IL-6-type cytokine receptor ligand interactions
[NCBI:1339143]
[REACTOME:R-HSA-6788467]
[PUBMED:9716487]
[PUBMED:12773095]
IL2 signaling events mediated by PI3K
[NCBI:137938]
[Pathway Interaction Database:il2_pi3kpathway]
[PUBMED:15271800]
[PUBMED:8617294]
[PUBMED:7543780]
[PUBMED:9092570]
[PUBMED:9162082]
[PUBMED:7737351]
[PUBMED:9108028]
[PUBMED:11486019]
[PUBMED:1614535]
[PUBMED:15843522]
[PUBMED:7760801]
[PUBMED:9029085]
[PUBMED:1652056]
[PUBMED:11994454]
[PUBMED:12393431]
[PUBMED:9771966]
[PUBMED:10373522]
[PUBMED:12525482]
[PUBMED:3523754]
[PUBMED:7736574]
[PUBMED:10982827]
[PUBMED:7589144]
[PUBMED:7528328]
IL2 signaling events mediated by STAT5
[NCBI:137988]
[Pathway Interaction Database:il2_stat5pathway]
[PUBMED:11160217]
[PUBMED:16645171]
[PUBMED:9121484]
[PUBMED:17182565]
[PUBMED:14607901]
[PUBMED:9104808]
[PUBMED:11485747]
[PUBMED:14614860]
[PUBMED:10679091]
[PUBMED:12196288]
[PUBMED:10072077]
[PUBMED:10544201]
[PUBMED:15004274]
[PUBMED:9390691]
[PUBMED:9395528]
[PUBMED:10514006]
[PUBMED:14500638]
[PUBMED:16757175]
[PUBMED:9541574]
[PUBMED:8617294]
IL2-mediated signaling events
[NCBI:137976]
[Pathway Interaction Database:il2_1pathway]
[PUBMED:7568005]
[PUBMED:10962026]
[PUBMED:1545122]
[PUBMED:10602027]
[PUBMED:15170389]
[PUBMED:9092570]
[PUBMED:7509794]
[PUBMED:15356145]
[PUBMED:9973481]
[PUBMED:10899310]
[PUBMED:9195132]
[PUBMED:7544001]
[PUBMED:7777534]
[PUBMED:12681450]
[PUBMED:7665592]
[PUBMED:8702919]
[PUBMED:1708096]
[PUBMED:8643566]
[PUBMED:7988557]
[PUBMED:7737351]
[PUBMED:1532814]
[PUBMED:8262551]
[PUBMED:8025955]
[PUBMED:10993906]
[PUBMED:3095922]
[PUBMED:8805624]
[PUBMED:9391116]
[PUBMED:7973658]
[PUBMED:11331873]
[PUBMED:10421845]
[PUBMED:8119884]
[PUBMED:7781605]
[PUBMED:12543077]
[PUBMED:9133424]
[PUBMED:1618313]
[PUBMED:1940342]
[PUBMED:9382798]
[PUBMED:10514520]
[PUBMED:7973659]
[PUBMED:1639773]
[PUBMED:9029085]
[PUBMED:7760801]
[PUBMED:1460037]
[PUBMED:9202126]
[PUBMED:1652056]
[PUBMED:12393431]
[PUBMED:8397196]
[PUBMED:2047859]
[PUBMED:7688728]
[PUBMED:8700888]
[PUBMED:7528668]
[PUBMED:9305919]
[PUBMED:2303462]
[PUBMED:7568001]
[PUBMED:9822600]
[PUBMED:7543676]
[PUBMED:7499365]
[PUBMED:10843677]
[PUBMED:7600304]
[PUBMED:7719937]
[PUBMED:9590209]
[PUBMED:9794391]
[PUBMED:10849428]
[PUBMED:8294403]
[PUBMED:10373548]
[PUBMED:2590941]
[PUBMED:9512511]
[PUBMED:6434688]
[PUBMED:9697832]
[PUBMED:10982827]
[PUBMED:10214954]
[PUBMED:10825200]
[PUBMED:1535827]
[PUBMED:10369681]
[PUBMED:7719938]
[PUBMED:1655887]
[PUBMED:8376945]
[PUBMED:1996324]
[PUBMED:7479881]
[PUBMED:10962581]
[PUBMED:7973657]
[PUBMED:1631559]
[PUBMED:10066828]
[PUBMED:9169478]
[PUBMED:8552611]
[PUBMED:8483935]
[PUBMED:2106566]
[PUBMED:16199887]
IL27-mediated signaling events
[NCBI:137929]
[Pathway Interaction Database:il27pathway]
[PUBMED:11672539]
[PUBMED:16365415]
[PUBMED:16906167]
[PUBMED:15356135]
[PUBMED:14657353]
[PUBMED:15944269]
[PUBMED:14764690]
[PUBMED:14614852]
[PUBMED:15308705]
[PUBMED:15004160]
[PUBMED:12734330]
[PUBMED:11057672]
[PUBMED:15494513]
[PUBMED:14614853]
[PUBMED:12121660]
[PUBMED:16906166]
[PUBMED:15749890]
IL4-mediated signaling events
[NCBI:137933]
[Pathway Interaction Database:il4_2pathway]
[PUBMED:8602263]
[PUBMED:15199062]
[PUBMED:7705411]
[PUBMED:11160325]
[PUBMED:8557643]
[PUBMED:8134361]
[PUBMED:1948049]
[PUBMED:10843732]
[PUBMED:11034397]
[PUBMED:8624802]
[PUBMED:14557412]
[PUBMED:1997653]
[PUBMED:10586089]
[PUBMED:14634100]
[PUBMED:17541284]
[PUBMED:8124718]
[PUBMED:16210622]
[PUBMED:7822337]
[PUBMED:11572871]
[PUBMED:2147202]
[PUBMED:10228008]
[PUBMED:7675087]
[PUBMED:12574343]
[PUBMED:14603527]
[PUBMED:15659391]
[PUBMED:11160269]
[PUBMED:7760829]
[PUBMED:7973658]
[PUBMED:10072514]
[PUBMED:9013879]
[PUBMED:8624803]
[PUBMED:10490661]
[PUBMED:14978013]
[PUBMED:10364072]
[PUBMED:12459556]
[PUBMED:11714803]
[PUBMED:8602264]
[PUBMED:9811885]
[PUBMED:12776189]
[PUBMED:15728454]
[PUBMED:10601358]
[PUBMED:11739727]
[PUBMED:11160275]
[PUBMED:9852037]
[PUBMED:9670964]
[PUBMED:15004182]
[PUBMED:8266078]
[PUBMED:3144043]
[PUBMED:8992992]
[PUBMED:8089482]
[PUBMED:9651359]
[PUBMED:16810739]
[PUBMED:7499365]
[PUBMED:7721786]
[PUBMED:9065461]
[PUBMED:11241672]
[PUBMED:10950967]
[PUBMED:8810328]
[PUBMED:8624821]
[PUBMED:9110977]
[PUBMED:8609418]
[PUBMED:15187136]
[PUBMED:9414268]
[PUBMED:8916957]
[PUBMED:10201892]
[PUBMED:17200144]
[PUBMED:8458387]
[PUBMED:11544308]
[PUBMED:10657944]
[PUBMED:15153491]
[PUBMED:7544011]
[PUBMED:8266076]
[PUBMED:11801631]
[PUBMED:12044779]
[PUBMED:8621475]
[PUBMED:9697832]
[PUBMED:12242343]
[PUBMED:7694370]
[PUBMED:9380721]
[PUBMED:9541585]
[PUBMED:7807002]
[PUBMED:16537510]
[PUBMED:8258319]
[PUBMED:9799097]
[PUBMED:12023955]
[PUBMED:8085155]
IL6-mediated signaling events
[NCBI:137932]
[Pathway Interaction Database:il6_7pathway]
[PUBMED:8559663]
[PUBMED:8662591]
[PUBMED:11689697]
[PUBMED:11727828]
[PUBMED:10383440]
[PUBMED:10777583]
[PUBMED:16774741]
[PUBMED:12754507]
[PUBMED:9295319]
[PUBMED:15722452]
[PUBMED:10859312]
[PUBMED:9590172]
[PUBMED:9880505]
[PUBMED:12445202]
[PUBMED:8134389]
[PUBMED:10409724]
[PUBMED:8164674]
[PUBMED:8272872]
[PUBMED:9794795]
[PUBMED:7678052]
[PUBMED:8511589]
[PUBMED:8668165]
[PUBMED:9724754]
[PUBMED:8083235]
[PUBMED:12754505]
[PUBMED:8621622]
[PUBMED:16254248]
[PUBMED:12361954]
[PUBMED:10605021]
[PUBMED:9388184]
[PUBMED:15935617]
[PUBMED:11120832]
[PUBMED:7875298]
[PUBMED:9973404]
[PUBMED:11335711]
[PUBMED:9632795]
[PUBMED:11468294]
[PUBMED:7898939]
[PUBMED:8626374]
[PUBMED:8670868]
[PUBMED:7537214]
[PUBMED:15677447]
[PUBMED:2261637]
[PUBMED:9874564]
[PUBMED:12829785]
[PUBMED:8537375]
[PUBMED:8272873]
[PUBMED:7523403]
[PUBMED:11251120]
[PUBMED:9163525]
[PUBMED:3136546]
[PUBMED:10727406]
[PUBMED:10023775]
[PUBMED:12754506]
[PUBMED:12456685]
[PUBMED:2788034]
[PUBMED:10446219]
[PUBMED:15572665]
[PUBMED:1662392]
[PUBMED:15010462]
[PUBMED:8140422]
[PUBMED:8467812]
IRS-mediated signalling
[NCBI:1269431]
[REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R
[NCBI:1269620]
[REACTOME:R-HSA-2428928]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:18927274]
[PUBMED:21042815]
[PUBMED:20098959]
ISG15 antiviral mechanism
[NCBI:1269317]
[REACTOME:R-HSA-1169408]
[PUBMED:20153823]
[PUBMED:12582176]
[PUBMED:16009940]
[PUBMED:20946978]
[PUBMED:15970528]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Influenza A
[NCBI:217173]
[KEGG:hsa05164]
[PUBMED:17267598]
[PUBMED:18049471]
[PUBMED:16882036]
[PUBMED:11907320]
[PUBMED:17944269]
[PUBMED:20629046]
[PUBMED:17072332]
[PUBMED:18588994]
[PUBMED:19864182]
[PUBMED:19290913]
[PUBMED:19420020]
[PUBMED:17213831]
[PUBMED:9060654]
[PUBMED:19481124]
[PUBMED:16494716]
[PUBMED:21147034]
[PUBMED:18980544]
[PUBMED:20020828]
[PUBMED:15502848]
[PUBMED:19782761]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Insulin receptor signalling cascade
[NCBI:1269429]
[REACTOME:R-HSA-74751]
[PUBMED:9677303]
[PUBMED:11282018]
Interferon Signaling
[NCBI:1269311]
[REACTOME:R-HSA-913531]
[PUBMED:18929502]
[PUBMED:15607020]
[PUBMED:15864272]
[PUBMED:14525967]
[PUBMED:19059436]
Interferon alpha/beta signaling
[NCBI:1269312]
[REACTOME:R-HSA-909733]
[PUBMED:8621447]
[PUBMED:8605876]
[PUBMED:8702790]
[PUBMED:17969444]
Interferon gamma signaling
[NCBI:1269314]
[REACTOME:R-HSA-877300]
[PUBMED:9462485]
[PUBMED:18929502]
[PUBMED:9143700]
[PUBMED:14525967]
Interleukin receptor SHC signaling
[NCBI:1269322]
[REACTOME:R-HSA-912526]
[PUBMED:8294403]
Interleukin-10 signaling
[NCBI:1470924]
[REACTOME:R-HSA-6783783]
[PUBMED:11244051]
Interleukin-2 signaling
[NCBI:1269321]
[REACTOME:R-HSA-451927]
[PUBMED:17936914]
[PUBMED:18817510]
[PUBMED:19543225]
[PUBMED:18062768]
Interleukin-3, 5 and GM-CSF signaling
[NCBI:1269323]
[REACTOME:R-HSA-512988]
[PUBMED:10450743]
[PUBMED:9766809]
Interleukin-4 and 13 signaling
[NCBI:1470923]
[REACTOME:R-HSA-6785807]
[PUBMED:12704343]
[PUBMED:10358772]
Interleukin-6 family signaling
[NCBI:1339142]
[REACTOME:R-HSA-6783589]
[PUBMED:9685167]
[PUBMED:8666978]
[PUBMED:12773095]
[PUBMED:9143707]
[PUBMED:9716487]
[PUBMED:7632928]
Interleukin-6 signaling
[NCBI:1269325]
[REACTOME:R-HSA-1059683]
[PUBMED:20410258]
Interleukin-7 signaling
[NCBI:1269326]
[REACTOME:R-HSA-1266695]
Jak-STAT signaling pathway
[NCBI:83077]
[KEGG:hsa04630]
[PUBMED:21034406]
[PUBMED:22339650]
[PUBMED:16204702]
[PUBMED:25587654]
[PUBMED:24069565]
[PUBMED:22383755]
[PUBMED:24606160]
[PUBMED:10851053]
[PUBMED:23735217]
[PUBMED:25217450]
[PUBMED:21372217]
Leishmaniasis
[NCBI:144181]
[KEGG:hsa05140]
[PUBMED:11890722]
[PUBMED:7916951]
[PUBMED:10417174]
[PUBMED:11298294]
[PUBMED:10586030]
[PUBMED:15322192]
[PUBMED:15831826]
[PUBMED:11728310]
[PUBMED:15039466]
[PUBMED:10462516]
[PUBMED:10608501]
[PUBMED:15721837]
[PUBMED:15639739]
[PUBMED:14762510]
[PUBMED:18793215]
[PUBMED:7591091]
[PUBMED:12438359]
[PUBMED:18070909]
[PUBMED:17543969]
[PUBMED:15983048]
[PUBMED:16848789]
[PUBMED:10770277]
[PUBMED:9504340]
MAPK family signaling cascades
[NCBI:1269501]
[REACTOME:R-HSA-5683057]
[PUBMED:21167873]
[PUBMED:17161475]
[PUBMED:22535895]
[PUBMED:21372320]
MAPK1 (ERK2) activation
[NCBI:1269505]
[REACTOME:R-HSA-112411]
[PUBMED:22177953]
[PUBMED:8131746]
MAPK1/MAPK3 signaling
[NCBI:1269502]
[REACTOME:R-HSA-5684996]
[PUBMED:25378393]
[PUBMED:18199641]
[PUBMED:17496909]
[PUBMED:21779496]
[PUBMED:15520807]
[PUBMED:16393692]
[PUBMED:19520853]
[PUBMED:17496910]
[PUBMED:22569528]
MAPK3 (ERK1) activation
[NCBI:1269504]
[REACTOME:R-HSA-110056]
Measles
[NCBI:213306]
[KEGG:hsa05162]
[PUBMED:16237742]
[PUBMED:12804771]
[PUBMED:19198562]
[PUBMED:20376484]
[PUBMED:11385511]
[PUBMED:16963735]
[PUBMED:19198566]
[PUBMED:18922877]
[PUBMED:19203114]
[PUBMED:12620806]
[PUBMED:16690907]
[PUBMED:17720800]
[PUBMED:20636817]
[PUBMED:12410527]
[PUBMED:11582511]
[PUBMED:19203109]
[PUBMED:19203113]
[PUBMED:14585342]
[PUBMED:12805463]
NCAM signaling for neurite out-growth
[NCBI:1270312]
[REACTOME:R-HSA-375165]
[PUBMED:18760361]
[PUBMED:12587671]
[PUBMED:15662836]
[PUBMED:17975827]
[PUBMED:15153429]
[PUBMED:12700044]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
NOD-like receptor signaling pathway
[NCBI:122191]
[KEGG:hsa04621]
[PUBMED:25330206]
[PUBMED:21575908]
[PUBMED:23846113]
[PUBMED:26549800]
[PUBMED:16493424]
[PUBMED:23124073]
[PUBMED:24840700]
[PUBMED:27291964]
[PUBMED:27012466]
[PUBMED:24707857]
[PUBMED:19767725]
[PUBMED:25879280]
[PUBMED:23215645]
[PUBMED:22819539]
[PUBMED:23702978]
[PUBMED:20643110]
[PUBMED:25879288]
[PUBMED:26655628]
[PUBMED:25145756]
[PUBMED:24718315]
[PUBMED:26482951]
[PUBMED:25526305]
[PUBMED:26121197]
[PUBMED:22430786]
Osteoclast differentiation
[NCBI:193147]
[KEGG:hsa04380]
[PUBMED:17633024]
[PUBMED:18382763]
[PUBMED:18329366]
[PUBMED:17869613]
[PUBMED:18722561]
[PUBMED:15122243]
[PUBMED:20703218]
[PUBMED:12748652]
[PUBMED:12110142]
[PUBMED:19585227]
[PUBMED:15546140]
[PUBMED:16184196]
[PUBMED:15817678]
[PUBMED:20392226]
[PUBMED:16313349]
[PUBMED:16313342]
[PUBMED:17380158]
[PUBMED:18451259]
PDGFR-alpha signaling pathway
[NCBI:138049]
[Pathway Interaction Database:pdgfrapathway]
[PUBMED:15871904]
[PUBMED:10497192]
[PUBMED:10733900]
[PUBMED:11095946]
[PUBMED:9788278]
[PUBMED:10837138]
[PUBMED:11297552]
[PUBMED:9546424]
[PUBMED:9737716]
[PUBMED:10066366]
[PUBMED:7535778]
[PUBMED:11953315]
[PUBMED:2544881]
PI3K-Akt signaling pathway
[NCBI:692234]
[KEGG:hsa04151]
[PUBMED:12048182]
[PUBMED:11357143]
[PUBMED:21440011]
[PUBMED:15209374]
[PUBMED:12669022]
[PUBMED:18842113]
[PUBMED:16847462]
[PUBMED:12660731]
[PUBMED:17360849]
[PUBMED:9838078]
[PUBMED:15505410]
[PUBMED:16248975]
[PUBMED:12531180]
[PUBMED:21779440]
[PUBMED:16187290]
[PUBMED:15784165]
[PUBMED:21620960]
Pancreatic cancer
[NCBI:83108]
[KEGG:hsa05212]
[PUBMED:12079267]
[PUBMED:14967450]
[PUBMED:15774796]
[PUBMED:10740269]
[PUBMED:12946833]
[PUBMED:16702400]
[PUBMED:14586404]
[PUBMED:15823750]
[PUBMED:12648469]
[PUBMED:11407945]
[PUBMED:12459728]
[PUBMED:14580692]
[PUBMED:11707511]
[PUBMED:12545153]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Platelet activation, signaling and aggregation
[NCBI:1269350]
[REACTOME:R-HSA-76002]
[PUBMED:16543958]
[PUBMED:8704248]
[PUBMED:2018971]
[PUBMED:1672265]
[PUBMED:17059469]
[PUBMED:12681240]
[PUBMED:12411949]
[PUBMED:11511514]
Prolonged ERK activation events
[NCBI:1269469]
[REACTOME:R-HSA-169893]
[PUBMED:12765839]
[PUBMED:9069267]
RAF-independent MAPK1/3 activation
[NCBI:1269503]
[REACTOME:R-HSA-112409]
[PUBMED:21135874]
[PUBMED:22569528]
[PUBMED:23954936]
RAF/MAP kinase cascade
[NCBI:1269285]
[REACTOME:R-HSA-5673001]
[PUBMED:21167873]
[PUBMED:24937142]
[PUBMED:20674547]
[PUBMED:17496910]
[PUBMED:22177953]
[PUBMED:17496919]
[PUBMED:22569528]
[PUBMED:22535895]
[PUBMED:12068308]
[PUBMED:17496923]
[PUBMED:19091303]
[PUBMED:21372320]
[PUBMED:21388974]
[PUBMED:15520807]
RET signaling
[NCBI:1427866]
[REACTOME:R-HSA-8853659]
[PUBMED:15013219]
[PUBMED:17036197]
Regulation of IFNA signaling
[NCBI:1269313]
[REACTOME:R-HSA-912694]
[PUBMED:16710296]
[PUBMED:16311601]
[PUBMED:10526574]
Regulation of IFNG signaling
[NCBI:1269315]
[REACTOME:R-HSA-877312]
[PUBMED:10526574]
[PUBMED:18031232]
[PUBMED:12645661]
SHC1 events in EGFR signaling
[NCBI:1269383]
[REACTOME:R-HSA-180336]
[PUBMED:11498013]
[PUBMED:8755247]
SOS-mediated signalling
[NCBI:1269440]
[REACTOME:R-HSA-112412]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by EGFR
[NCBI:1269380]
[REACTOME:R-HSA-177929]
[PUBMED:10459005]
[PUBMED:10404636]
[PUBMED:12297041]
[PUBMED:15142631]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signaling by Insulin receptor
[NCBI:1269428]
[REACTOME:R-HSA-74752]
[PUBMED:8276779]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signaling by Leptin
[NCBI:1269632]
[REACTOME:R-HSA-2586552]
[PUBMED:22211890]
[PUBMED:23562747]
[PUBMED:20600241]
[PUBMED:21622208]
[PUBMED:23579596]
[PUBMED:22458591]
[PUBMED:21489811]
[PUBMED:19724019]
[PUBMED:21331644]
[PUBMED:22448029]
[PUBMED:21147620]
[PUBMED:20198122]
[PUBMED:21677426]
[PUBMED:20029269]
[PUBMED:22249808]
[PUBMED:22991412]
[PUBMED:21527729]
[PUBMED:17937601]
[PUBMED:20553370]
[PUBMED:21713385]
[PUBMED:23565489]
[PUBMED:22289780]
Signaling by PDGF
[NCBI:1269478]
[REACTOME:R-HSA-186797]
[PUBMED:15207811]
[PUBMED:10508235]
[PUBMED:9739761]
Signaling by SCF-KIT
[NCBI:1269487]
[REACTOME:R-HSA-1433557]
[PUBMED:17350321]
[PUBMED:16483568]
[PUBMED:7688988]
[PUBMED:19540337]
[PUBMED:16475976]
[PUBMED:15526160]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
[NCBI:1269617]
[REACTOME:R-HSA-2404192]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22044904]
[PUBMED:22649417]
Signaling by VEGF
[NCBI:1269480]
[REACTOME:R-HSA-194138]
[PUBMED:15585754]
[PUBMED:13678960]
[PUBMED:16336962]
[PUBMED:16835467]
Signaling events mediated by TCPTP
[NCBI:169350]
[Pathway Interaction Database:tcptp_pathway]
[PUBMED:12612081]
[PUBMED:18716132]
[PUBMED:19171783]
[PUBMED:9488479]
[PUBMED:15592458]
[PUBMED:9261175]
[PUBMED:16431927]
[PUBMED:15632081]
[PUBMED:12359225]
[PUBMED:12138178]
[PUBMED:7593185]
[PUBMED:18840653]
[PUBMED:15696169]
[PUBMED:18691551]
[PUBMED:20484139]
[PUBMED:11773439]
[PUBMED:16595549]
[PUBMED:18948751]
[PUBMED:16971512]
[PUBMED:12171910]
[PUBMED:18819921]
[PUBMED:15192089]
[PUBMED:17210636]
[PUBMED:10488121]
[PUBMED:16705167]
[PUBMED:14966296]
[PUBMED:11909529]
[PUBMED:11479308]
Signaling pathways regulating pluripotency of stem cells
[NCBI:1026136]
[KEGG:hsa04550]
[PUBMED:20705693]
[PUBMED:23653415]
[PUBMED:16518401]
[PUBMED:17211451]
[PUBMED:22649650]
[PUBMED:24910449]
[PUBMED:19551525]
[PUBMED:22298652]
[PUBMED:23370346]
[PUBMED:24315442]
[PUBMED:18414030]
[PUBMED:17647265]
[PUBMED:18295576]
[PUBMED:24957798]
[PUBMED:24147644]
[PUBMED:16153702]
[PUBMED:19427042]
[PUBMED:18220859]
[PUBMED:19571885]
[PUBMED:23585347]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Signalling to ERKs
[NCBI:1269464]
[REACTOME:R-HSA-187687]
[PUBMED:10508738]
Signalling to RAS
[NCBI:1269465]
[REACTOME:R-HSA-167044]
[PUBMED:11520933]
Signalling to p38 via RIT and RIN
[NCBI:1269468]
[REACTOME:R-HSA-187706]
[PUBMED:10712923]
Th1 and Th2 cell differentiation
[NCBI:1458885]
[KEGG:hsa04658]
[PUBMED:15819694]
[PUBMED:12171942]
[PUBMED:19165228]
[PUBMED:23336087]
[PUBMED:26044597]
[PUBMED:19151746]
[PUBMED:19362457]
[PUBMED:22044277]
[PUBMED:11752608]
[PUBMED:23405903]
[PUBMED:19375293]
[PUBMED:24113868]
[PUBMED:19151747]
[PUBMED:23624818]
[PUBMED:22566933]
[PUBMED:11121747]
[PUBMED:20969597]
[PUBMED:20065998]
Th17 cell differentiation
[NCBI:1469482]
[KEGG:hsa04659]
[PUBMED:23325835]
[PUBMED:23036716]
[PUBMED:20488727]
[PUBMED:21151104]
[PUBMED:21084214]
[PUBMED:20054607]
[PUBMED:22754770]
[PUBMED:22640807]
[PUBMED:19379825]
[PUBMED:22133865]
[PUBMED:22324470]
[PUBMED:17768419]
[PUBMED:18408735]
[PUBMED:21776333]
[PUBMED:26253381]
[PUBMED:16200068]
[PUBMED:18362914]
[PUBMED:24325586]
[PUBMED:19381306]
[PUBMED:18166487]
Toxoplasmosis
[NCBI:169642]
[KEGG:hsa05145]
[PUBMED:18617274]
[PUBMED:19400868]
[PUBMED:17024357]
[PUBMED:19744886]
[PUBMED:19891610]
[PUBMED:17110955]
[PUBMED:12106793]
[PUBMED:12580944]
[PUBMED:12857995]
[PUBMED:10234174]
[PUBMED:18327664]
[PUBMED:10525166]
[PUBMED:18059289]
[PUBMED:18775432]
[PUBMED:14642303]
[PUBMED:15361242]
[PUBMED:16339966]
[PUBMED:14987366]
[PUBMED:15639739]
Tuberculosis
[NCBI:213780]
[KEGG:hsa05152]
[PUBMED:20199890]
[PUBMED:21274449]
[PUBMED:17359235]
[PUBMED:20415982]
[PUBMED:18541216]
[PUBMED:19369951]
[PUBMED:15083155]
[PUBMED:11378475]
[PUBMED:15228522]
[PUBMED:19634703]
[PUBMED:21274433]
[PUBMED:19563525]
[PUBMED:18407066]
[PUBMED:18288961]
[PUBMED:16200082]
[PUBMED:17785780]
[PUBMED:11932234]
VEGFA-VEGFR2 Pathway
[NCBI:1269483]
[REACTOME:R-HSA-4420097]
[PUBMED:17344076]
[PUBMED:16633338]
[PUBMED:19230644]
[PUBMED:13678960]
VEGFR2 mediated cell proliferation
[NCBI:1269485]
[REACTOME:R-HSA-5218921]
[PUBMED:22866201]
[PUBMED:22180219]
[PUBMED:22762016]
Viral carcinogenesis
[NCBI:658418]
[KEGG:hsa05203]
[PUBMED:9990017]
[PUBMED:15173177]
[PUBMED:16036567]
[PUBMED:16581947]
[PUBMED:9060639]
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[PUBMED:19854353]
[PUBMED:12101418]