full name
glycoprotein hormones, alpha polypeptide

synonyms
CG-ALPHA, FSHA, GPHa, GPHA1, HCG, LHA, TSHA, CGA, ENSG00000135346

HGNC
HGNC:1885

Entrez Gene
Gene:1081

ENSEMBL
ENSG00000135346

location
chr: 6
start: 87795216
stop: 87804865
strand: -

transcripts
NM_000735.3
NM_001252383.1

pathways
Amine-derived hormones [NCBI:1270175] [REACTOME:R-HSA-209776] [PUBMED:10691773] [PUBMED:3297964] [PUBMED:16942634]
Androgen biosynthesis [NCBI:1270050] [REACTOME:R-HSA-193048] [PUBMED:12428201]
Asparagine N-linked glycosylation [NCBI:1268714] [REACTOME:R-HSA-446203] [PUBMED:16807922] [PUBMED:19647993] [PUBMED:10580125] [PUBMED:19616933] [PUBMED:20301507] [PUBMED:20301244]
Autoimmune thyroid disease [NCBI:83121] [KEGG:hsa05320] [PUBMED:15132715] [PUBMED:12192541] [PUBMED:17192582] [PUBMED:9534029] [PUBMED:11396701] [PUBMED:11913070] [PUBMED:15049952] [PUBMED:11577986] [PUBMED:15762980]
Class A/1 (Rhodopsin-like receptors) [NCBI:1269545] [REACTOME:R-HSA-373076] [PUBMED:16902930]
G alpha (s) signalling events [NCBI:1269575] [REACTOME:R-HSA-418555] [PUBMED:12036966]
GPCR downstream signaling [NCBI:1269574] [REACTOME:R-HSA-388396] [PUBMED:12040175]
GPCR ligand binding [NCBI:1269544] [REACTOME:R-HSA-500792] [PUBMED:15251227]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
Glucocorticoid receptor regulatory network [NCBI:138014] [Pathway Interaction Database:reg_gr_pathway] [PUBMED:8943293] [PUBMED:1708774] [PUBMED:15826950] [PUBMED:11027313] [PUBMED:12118039] [PUBMED:9388207] [PUBMED:11751894] [PUBMED:12151000] [PUBMED:9765258] [PUBMED:9407028] [PUBMED:19074285] [PUBMED:2838908] [PUBMED:15817653] [PUBMED:9722596] [PUBMED:12917342] [PUBMED:1387550] [PUBMED:10974006] [PUBMED:15790729] [PUBMED:10825196] [PUBMED:10623828] [PUBMED:2169352] [PUBMED:9315653] [PUBMED:7759501] [PUBMED:8290595] [PUBMED:2905764] [PUBMED:12351702] [PUBMED:11080152] [PUBMED:8428574] [PUBMED:9215863] [PUBMED:15459252] [PUBMED:10400612] [PUBMED:9426156] [PUBMED:17440046] [PUBMED:18838540] [PUBMED:2169353] [PUBMED:10820245] [PUBMED:12511605] [PUBMED:2586521] [PUBMED:1740658] [PUBMED:11555652] [PUBMED:11562347] [PUBMED:9482836] [PUBMED:18337589] [PUBMED:10958685] [PUBMED:9388192] [PUBMED:15834420] [PUBMED:15657031] [PUBMED:8878484] [PUBMED:10760263] [PUBMED:12730237] [PUBMED:8702844] [PUBMED:2169351] [PUBMED:17215482] [PUBMED:8898375]
Glycoprotein hormones [NCBI:1268754] [REACTOME:R-HSA-209822] [PUBMED:6267989]
GnRH signaling pathway [NCBI:83091] [KEGG:hsa04912] [PUBMED:15080147] [PUBMED:15982836] [PUBMED:14596811] [PUBMED:15613448] [PUBMED:12943720] [PUBMED:10707049] [PUBMED:15350605] [PUBMED:12963732]
Hormone ligand-binding receptors [NCBI:1269559] [REACTOME:R-HSA-375281] [PUBMED:11861490] [PUBMED:11943741] [PUBMED:11750726] [PUBMED:11917095]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of amino acids and derivatives [NCBI:1270158] [REACTOME:R-HSA-71291]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Metabolism of steroid hormones [NCBI:1270046] [REACTOME:R-HSA-196071] [PUBMED:15583024]
Mineralocorticoid biosynthesis [NCBI:1270049] [REACTOME:R-HSA-193993] [PUBMED:15583024]
N-glycan antennae elongation in the medial/trans-Golgi [NCBI:1268730] [REACTOME:R-HSA-975576] [PUBMED:20816477] [PUBMED:16807922] [PUBMED:11421343] [PUBMED:3896128]
Neuroactive ligand-receptor interaction [NCBI:83053] [KEGG:hsa04080]
Ovarian steroidogenesis [NCBI:790011] [KEGG:hsa04913] [PUBMED:11883103] [PUBMED:11408113] [PUBMED:16603089] [PUBMED:15831519] [PUBMED:11447221] [PUBMED:20628033] [PUBMED:10630400] [PUBMED:18440223] [PUBMED:20937107] [PUBMED:11704115] [PUBMED:17003287] [PUBMED:17008391] [PUBMED:15541573] [PUBMED:21862696] [PUBMED:16414178] [PUBMED:14769828]
Peptide hormone biosynthesis [NCBI:1268753] [REACTOME:R-HSA-209952] [PUBMED:4368999]
Peptide hormone metabolism [NCBI:1268746] [REACTOME:R-HSA-2980736] [PUBMED:2663045] [PUBMED:21805235]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Prolactin signaling pathway [NCBI:814182] [KEGG:hsa04917] [PUBMED:17519353] [PUBMED:17535875] [PUBMED:20149678] [PUBMED:12670737] [PUBMED:17307904] [PUBMED:18601698] [PUBMED:17975019] [PUBMED:16231422] [PUBMED:18219564] [PUBMED:9475379] [PUBMED:16677418] [PUBMED:9626554] [PUBMED:21664429] [PUBMED:11606470]
Reactions specific to the complex N-glycan synthesis pathway [NCBI:1268732] [REACTOME:R-HSA-975578]
Regulation of lipolysis in adipocytes [NCBI:1222950] [KEGG:hsa04923] [PUBMED:24676492] [PUBMED:21241784] [PUBMED:17313320] [PUBMED:21900692] [PUBMED:20025992] [PUBMED:19375517] [PUBMED:22298655] [PUBMED:19464318] [PUBMED:24872083] [PUBMED:19136990] [PUBMED:19796963] [PUBMED:18762440] [PUBMED:17878492] [PUBMED:24731595] [PUBMED:17218471]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors [NCBI:1427841] [REACTOME:R-HSA-8866910] [PUBMED:14744778] [PUBMED:9162057] [PUBMED:22735262] [PUBMED:26832794] [PUBMED:10648798] [PUBMED:10497269] [PUBMED:9850080] [PUBMED:9687504] [PUBMED:7891714] [PUBMED:15870067] [PUBMED:9182571] [PUBMED:8895516]
Thyroid hormone synthesis [NCBI:835410] [KEGG:hsa04918] [PUBMED:21448409] [PUBMED:9086577] [PUBMED:21986207] [PUBMED:11137035] [PUBMED:17666482] [PUBMED:20407074] [PUBMED:20093166] [PUBMED:20122987] [PUBMED:15611820] [PUBMED:20378719] [PUBMED:23438835] [PUBMED:11717564] [PUBMED:16870170] [PUBMED:19196800] [PUBMED:9538302] [PUBMED:11029276] [PUBMED:20167242] [PUBMED:10893432] [PUBMED:21683758]
Thyroxine biosynthesis [NCBI:1270177] [REACTOME:R-HSA-209968] [PUBMED:3297964]
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors [NCBI:1427839] [REACTOME:R-HSA-8864260] [PUBMED:2010091] [PUBMED:11744733] [PUBMED:24469049] [PUBMED:23382213] [PUBMED:19798054] [PUBMED:9162057] [PUBMED:21084835] [PUBMED:22735262] [PUBMED:21375726] [PUBMED:14744778] [PUBMED:10648798] [PUBMED:26832794] [PUBMED:24835590] [PUBMED:9687504] [PUBMED:20805990] [PUBMED:10497269] [PUBMED:16420676] [PUBMED:12072434] [PUBMED:9850080] [PUBMED:9182571] [PUBMED:8988173] [PUBMED:1998122] [PUBMED:22371483] [PUBMED:15870067] [PUBMED:12586840] [PUBMED:8895516] [PUBMED:7891714] [PUBMED:11694877] [PUBMED:19115315] [PUBMED:15475956] [PUBMED:25114211]
Transport to the Golgi and subsequent modification [NCBI:1268725] [REACTOME:R-HSA-948021] [PUBMED:12717434] [PUBMED:10412983] [PUBMED:3594573]