Logo
full name
serum/glucocorticoid regulated kinase 1

synonyms
SGK, SGK1, ENSG00000118515

HGNC
HGNC:10810

Entrez Gene
Gene:6446

ENSEMBL
ENSG00000118515

location
chr: 6
start: 134490384
stop: 134639196
strand: -

transcripts
NM_001143676.1
NM_001143677.1
NM_001143678.1
NM_005627.3

pathways
Aldosterone-regulated sodium reabsorption [NCBI:130626] [KEGG:hsa04960] [PUBMED:17332888] [PUBMED:12943727] [PUBMED:11208606] [PUBMED:18197893] [PUBMED:19549592] [PUBMED:12649599] [PUBMED:16286565] [PUBMED:15590995] [PUBMED:11850323] [PUBMED:17309947] [PUBMED:18174920] [PUBMED:16002531]
Class I PI3K signaling events [NCBI:138022] [Pathway Interaction Database:pi3kcipathway] [PUBMED:9072969] [PUBMED:15296756] [PUBMED:12780340] [PUBMED:11154281] [PUBMED:9326591] [PUBMED:10357815] [PUBMED:10586033] [PUBMED:9824312] [PUBMED:11001876] [PUBMED:9593664] [PUBMED:10770799] [PUBMED:9442017] [PUBMED:8643691] [PUBMED:7627555] [PUBMED:11102801] [PUBMED:9307042] [PUBMED:10506192] [PUBMED:11804589] [PUBMED:15879121] [PUBMED:11226282] [PUBMED:18024423] [PUBMED:8629002] [PUBMED:9550703] [PUBMED:14688341] [PUBMED:16418224] [PUBMED:8945478] [PUBMED:10333475] [PUBMED:10764758] [PUBMED:9417041] [PUBMED:8052307]
FoxO family signaling [NCBI:138036] [Pathway Interaction Database:foxopathway] [PUBMED:17038621] [PUBMED:15788402] [PUBMED:14976264] [PUBMED:11864996] [PUBMED:12517744] [PUBMED:11050388] [PUBMED:10960473] [PUBMED:10783894] [PUBMED:11154281] [PUBMED:11313479] [PUBMED:11777915] [PUBMED:11980723] [PUBMED:10102273] [PUBMED:15509806] [PUBMED:11237865] [PUBMED:16751106] [PUBMED:12857750] [PUBMED:15538382] [PUBMED:12239572] [PUBMED:12048180] [PUBMED:11884717] [PUBMED:11884591] [PUBMED:15084260] [PUBMED:11964479] [PUBMED:10217147] [PUBMED:15109499] [PUBMED:16964248] [PUBMED:15905404] [PUBMED:11607034] [PUBMED:15668399] [PUBMED:15220471] [PUBMED:10358075] [PUBMED:16424905]
FoxO signaling pathway [NCBI:921162] [KEGG:hsa04068] [PUBMED:23325358] [PUBMED:15005655] [PUBMED:18951090] [PUBMED:22761423] [PUBMED:22902436] [PUBMED:16288288] [PUBMED:19701188] [PUBMED:16964248] [PUBMED:18045156] [PUBMED:18403263] [PUBMED:21613825] [PUBMED:21440011] [PUBMED:17470511] [PUBMED:21238503] [PUBMED:17522590] [PUBMED:15084259] [PUBMED:23801966] [PUBMED:17569704] [PUBMED:15516968]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
Glucocorticoid receptor regulatory network [NCBI:138014] [Pathway Interaction Database:reg_gr_pathway] [PUBMED:8943293] [PUBMED:1708774] [PUBMED:15826950] [PUBMED:11027313] [PUBMED:12118039] [PUBMED:9388207] [PUBMED:11751894] [PUBMED:12151000] [PUBMED:9765258] [PUBMED:9407028] [PUBMED:19074285] [PUBMED:2838908] [PUBMED:15817653] [PUBMED:9722596] [PUBMED:12917342] [PUBMED:1387550] [PUBMED:10974006] [PUBMED:15790729] [PUBMED:10825196] [PUBMED:10623828] [PUBMED:2169352] [PUBMED:9315653] [PUBMED:7759501] [PUBMED:8290595] [PUBMED:2905764] [PUBMED:12351702] [PUBMED:11080152] [PUBMED:8428574] [PUBMED:9215863] [PUBMED:15459252] [PUBMED:10400612] [PUBMED:9426156] [PUBMED:17440046] [PUBMED:18838540] [PUBMED:2169353] [PUBMED:10820245] [PUBMED:12511605] [PUBMED:2586521] [PUBMED:1740658] [PUBMED:11555652] [PUBMED:11562347] [PUBMED:9482836] [PUBMED:18337589] [PUBMED:10958685] [PUBMED:9388192] [PUBMED:15834420] [PUBMED:15657031] [PUBMED:8878484] [PUBMED:10760263] [PUBMED:12730237] [PUBMED:8702844] [PUBMED:2169351] [PUBMED:17215482] [PUBMED:8898375]
Insulin Pathway [NCBI:138026] [Pathway Interaction Database:insulin_pathway] [PUBMED:8491186] [PUBMED:9111325] [PUBMED:7629070] [PUBMED:10499514] [PUBMED:11121405] [PUBMED:10660596] [PUBMED:8196603] [PUBMED:11096081] [PUBMED:8524328] [PUBMED:9891043] [PUBMED:12242347] [PUBMED:2123524] [PUBMED:9369444] [PUBMED:1375946] [PUBMED:9348199] [PUBMED:8826975] [PUBMED:8316835] [PUBMED:8999839] [PUBMED:8449939] [PUBMED:10807907] [PUBMED:1599438] [PUBMED:8265614] [PUBMED:11171109] [PUBMED:11821390] [PUBMED:12687004] [PUBMED:7806540] [PUBMED:11154281] [PUBMED:8244979] [PUBMED:8798417] [PUBMED:1381348] [PUBMED:7581368] [PUBMED:15787604] [PUBMED:8385105] [PUBMED:11551902] [PUBMED:8114695] [PUBMED:11997497] [PUBMED:11001060] [PUBMED:11309621] [PUBMED:9109420] [PUBMED:8383963] [PUBMED:12147684] [PUBMED:8144662] [PUBMED:12036959] [PUBMED:14734537] [PUBMED:7983051] [PUBMED:9083103] [PUBMED:15210700] [PUBMED:9065430] [PUBMED:11297536] [PUBMED:10544179] [PUBMED:1321126] [PUBMED:11502760] [PUBMED:8978681] [PUBMED:8999972] [PUBMED:14690593] [PUBMED:11832334] [PUBMED:9447983] [PUBMED:15192089] [PUBMED:8524413] [PUBMED:7685165] [PUBMED:10329736] [PUBMED:11287630] [PUBMED:15486046] [PUBMED:10330191] [PUBMED:8626723]
Ion channel transport [NCBI:1269950] [REACTOME:R-HSA-983712] [PUBMED:15071553]
PI3K-Akt signaling pathway [NCBI:692234] [KEGG:hsa04151] [PUBMED:12048182] [PUBMED:11357143] [PUBMED:21440011] [PUBMED:15209374] [PUBMED:12669022] [PUBMED:18842113] [PUBMED:16847462] [PUBMED:12660731] [PUBMED:17360849] [PUBMED:9838078] [PUBMED:15505410] [PUBMED:16248975] [PUBMED:12531180] [PUBMED:21779440] [PUBMED:16187290] [PUBMED:15784165] [PUBMED:21620960]
Regulation of TP53 Activity [NCBI:1383076] [REACTOME:R-HSA-5633007] [PUBMED:19450511] [PUBMED:20457558] [PUBMED:23825024] [PUBMED:25641576]
Regulation of TP53 Degradation [NCBI:1383079] [REACTOME:R-HSA-6804757] [PUBMED:21730132] [PUBMED:10570149] [PUBMED:15563468] [PUBMED:16845383] [PUBMED:11923872] [PUBMED:11883935] [PUBMED:17290220] [PUBMED:17121812] [PUBMED:10673500] [PUBMED:9843217] [PUBMED:9529249] [PUBMED:21730163] [PUBMED:11715018] [PUBMED:9733514] [PUBMED:19838211] [PUBMED:10608892] [PUBMED:16474402] [PUBMED:19450511] [PUBMED:16163388] [PUBMED:10722742] [PUBMED:21986495] [PUBMED:15788536] [PUBMED:19816404] [PUBMED:11359766] [PUBMED:11504915] [PUBMED:9733515] [PUBMED:19756449] [PUBMED:11983168] [PUBMED:8319905] [PUBMED:20438709]
Regulation of TP53 Expression and Degradation [NCBI:1383077] [REACTOME:R-HSA-6806003] [PUBMED:11883935] [PUBMED:11923872] [PUBMED:19293287] [PUBMED:23303139] [PUBMED:17499002] [PUBMED:15563468] [PUBMED:17121812] [PUBMED:21986495] [PUBMED:15103385] [PUBMED:9529249] [PUBMED:21814038] [PUBMED:19250907] [PUBMED:8319905] [PUBMED:7878469] [PUBMED:12654245] [PUBMED:16213212]
Stimuli-sensing channels [NCBI:1269953] [REACTOME:R-HSA-2672351] [PUBMED:15728426] [PUBMED:16460286] [PUBMED:12907679] [PUBMED:18391176] [PUBMED:19278523] [PUBMED:11904445] [PUBMED:22934072] [PUBMED:20807551] [PUBMED:19783045] [PUBMED:16219661] [PUBMED:21932071] [PUBMED:22277752]
Transcriptional Regulation by TP53 [NCBI:1269654] [REACTOME:R-HSA-3700989] [PUBMED:26122615] [PUBMED:19410540]
Transmembrane transport of small molecules [NCBI:1269903] [REACTOME:R-HSA-382551]
mTOR signaling pathway [NCBI:83059] [KEGG:hsa04150] [NCBI:138001] [Pathway Interaction Database:mtor_4pathway] [PUBMED:17277771] [PUBMED:15341740] [PUBMED:12172553] [PUBMED:15718470] [PUBMED:14651849] [PUBMED:15268862] [PUBMED:15306821] [PUBMED:26046644] [PUBMED:12869586] [PUBMED:24556838] [PUBMED:17928295] [PUBMED:9427642] [PUBMED:18046414] [PUBMED:12912918] [PUBMED:16286006] [PUBMED:26658722] [PUBMED:24842496] [PUBMED:23465396] [PUBMED:17709744] [PUBMED:17599906] [PUBMED:16919458] [PUBMED:10364159] [PUBMED:15342917] [PUBMED:11500364] [PUBMED:19812304] [PUBMED:12482958] [PUBMED:11729323] [PUBMED:16962653] [PUBMED:18952604] [PUBMED:9465032] [PUBMED:1496022] [PUBMED:10567431] [PUBMED:19114562] [PUBMED:17510057] [PUBMED:18604198] [PUBMED:15545625] [PUBMED:11914378] [PUBMED:17461779] [PUBMED:9445476] [PUBMED:18497260] [PUBMED:12604610] [PUBMED:15071500] [PUBMED:18925875] [PUBMED:12906785] [PUBMED:11287630] [PUBMED:15004009] [PUBMED:16756488] [PUBMED:17043309] [PUBMED:18198340] [PUBMED:12820960] [PUBMED:12747827] [PUBMED:17053147] [PUBMED:15851026] [PUBMED:15467718] [PUBMED:18762023] [PUBMED:25242279] [PUBMED:24698685] [PUBMED:11175345] [PUBMED:27304501] [PUBMED:18411301] [PUBMED:11500365] [PUBMED:17693255] [PUBMED:23694989] [PUBMED:12231510] [PUBMED:19446321] [PUBMED:11418588] [PUBMED:19258318] [PUBMED:18439900] [PUBMED:19225151] [PUBMED:26185979] [PUBMED:10357815] [PUBMED:26269525] [PUBMED:23421405] [PUBMED:9271440] [PUBMED:16915281] [PUBMED:17141160] [PUBMED:15249583] [PUBMED:12912989] [PUBMED:27027448] [PUBMED:18423201] [PUBMED:19211835] [PUBMED:9204908] [PUBMED:26700098] [PUBMED:18566587] [PUBMED:17386266]