full name
estrogen receptor 1

synonyms
ER, Era, ESR, ESRA, NR3A1, ESR1, ENSG00000091831

HGNC
HGNC:3467

Entrez Gene
Gene:2099

ENSEMBL
ENSG00000091831

location
chr: 6
start: 152011631
stop: 152424409
strand: +

OMIM
OMIM:133430: ESR1
OMIM:114480: Breast cancer, somatic
OMIM:615363: Estrogen resistance
OMIM:157300: {Migraine, susceptibility to}
OMIM:608446: {Myocardial infarction, susceptibility to}

transcripts
ENST00000440973.1
ENST00000338799.5
ENST00000443427.1
ENST00000206249.3

pathways
Breast cancer [NCBI:1435207] [KEGG:hsa05224] [PUBMED:24649067] [PUBMED:26040571] [PUBMED:11879567] [PUBMED:22722193] [PUBMED:26028978] [PUBMED:25013431] [PUBMED:11737884] [PUBMED:23702927] [PUBMED:21076461] [PUBMED:21898546] [PUBMED:27390604] [PUBMED:24291072] [PUBMED:26968398] [PUBMED:20087430] [PUBMED:23000897] [PUBMED:25544707] [PUBMED:24596345] [PUBMED:23988612] [PUBMED:24111892] [PUBMED:25907219] [PUBMED:15343273] [PUBMED:21965336] [PUBMED:23881035] [PUBMED:23196196] [PUBMED:22178455] [PUBMED:20436504] [PUBMED:19088017] [PUBMED:16113099] [PUBMED:20971825]
Deubiquitination [NCBI:1427860] [REACTOME:R-HSA-5688426] [PUBMED:19243136] [PUBMED:20074029] [PUBMED:15571815] [PUBMED:20418328] [PUBMED:16325574] [PUBMED:12944365] [PUBMED:23845989] [PUBMED:22201797]
Endocrine and other factor-regulated calcium reabsorption [NCBI:213307] [KEGG:hsa04961] [PUBMED:15747113] [PUBMED:20969972] [PUBMED:15618484] [PUBMED:18989697] [PUBMED:19423690] [PUBMED:18293139] [PUBMED:18596722] [PUBMED:16518325] [PUBMED:17006539] [PUBMED:12684797] [PUBMED:17233615] [PUBMED:16044309]
Endocrine resistance [NCBI:1404799] [KEGG:hsa01522] [PUBMED:24415977] [PUBMED:23625614] [PUBMED:24841429] [PUBMED:15613444] [PUBMED:23714450] [PUBMED:20960099] [PUBMED:22771991] [PUBMED:19701242] [PUBMED:24289103] [PUBMED:24130921] [PUBMED:23344024] [PUBMED:22015292] [PUBMED:26122181] [PUBMED:26473850] [PUBMED:18804516] [PUBMED:24565562] [PUBMED:26849149] [PUBMED:25907219] [PUBMED:20887199]
Estrogen signaling pathway [NCBI:799177] [KEGG:hsa04915] [PUBMED:15695368] [PUBMED:16112267] [PUBMED:9278514] [PUBMED:19187465] [PUBMED:12421825] [PUBMED:12650715] [PUBMED:18253054] [PUBMED:16516516] [PUBMED:14573532] [PUBMED:18755790] [PUBMED:18538919] [PUBMED:19767412] [PUBMED:14993035] [PUBMED:19549587] [PUBMED:15862823] [PUBMED:20694192] [PUBMED:19464786] [PUBMED:21779010] [PUBMED:16270355] [PUBMED:21742056] [PUBMED:19700741] [PUBMED:21844907]
FOXA1 transcription factor network [NCBI:137979] [Pathway Interaction Database:hnf3apathway] [PUBMED:9427758] [PUBMED:16087863] [PUBMED:12750453] [PUBMED:12441652] [PUBMED:11763995] [PUBMED:8441395] [PUBMED:8164696] [PUBMED:2786140] [PUBMED:8071346] [PUBMED:8598458] [PUBMED:16331276] [PUBMED:16214823] [PUBMED:10049364] [PUBMED:15987773] [PUBMED:10073575] [PUBMED:8058060] [PUBMED:16980581] [PUBMED:9685261] [PUBMED:16009131]
FOXM1 transcription factor network [NCBI:137935] [Pathway Interaction Database:foxm1pathway] [PUBMED:17141659] [PUBMED:12482952] [PUBMED:16913845] [PUBMED:16809346] [PUBMED:15671063] [PUBMED:16504183] [PUBMED:15082532] [PUBMED:15531365] [PUBMED:17366632] [PUBMED:16314512] [PUBMED:17173139] [PUBMED:16618419] [PUBMED:15024056] [PUBMED:11682060] [PUBMED:15654331] [PUBMED:15817462] [PUBMED:17404569] [PUBMED:16875671] [PUBMED:16965535] [PUBMED:17101782]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
LKB1 signaling events [NCBI:137957] [Pathway Interaction Database:lkb1_pathway] [PUBMED:12429843] [PUBMED:18339622] [PUBMED:16912160] [PUBMED:15454081] [PUBMED:19513107] [PUBMED:16959574] [PUBMED:11741830] [PUBMED:7706316] [PUBMED:18063805] [PUBMED:14614828] [PUBMED:16306228] [PUBMED:12489981] [PUBMED:19386264] [PUBMED:18439900] [PUBMED:12805220] [PUBMED:17959818] [PUBMED:16396636] [PUBMED:10542369] [PUBMED:16308421] [PUBMED:15016379] [PUBMED:19622832] [PUBMED:14511394] [PUBMED:14676191] [PUBMED:17482548] [PUBMED:17991864] [PUBMED:11445556] [PUBMED:14651849] [PUBMED:14517248] [PUBMED:14985505] [PUBMED:15261145] [PUBMED:16817901] [PUBMED:9108484] [PUBMED:17573348] [PUBMED:12973359] [PUBMED:19369417] [PUBMED:15705853] [PUBMED:10642527] [PUBMED:16627617] [PUBMED:17482549] [PUBMED:8631898] [PUBMED:14976552]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Nuclear Receptor transcription pathway [NCBI:1269652] [REACTOME:R-HSA-383280]
Nuclear signaling by ERBB4 [NCBI:1269499] [REACTOME:R-HSA-1251985]
Ovarian tumor domain proteases [NCBI:1427863] [REACTOME:R-HSA-5689896] [PUBMED:23827681]
Plasma membrane estrogen receptor signaling [NCBI:138009] [Pathway Interaction Database:er_nongenomic_pathway] [PUBMED:12421825] [PUBMED:12431978] [PUBMED:10376603] [PUBMED:14764897] [PUBMED:15764600] [PUBMED:11044445] [PUBMED:15020686] [PUBMED:16601072] [PUBMED:11369763] [PUBMED:11773443] [PUBMED:14963108] [PUBMED:11029403] [PUBMED:17405905] [PUBMED:12415108] [PUBMED:11090554] [PUBMED:15231873] [PUBMED:18261753] [PUBMED:15569929] [PUBMED:11029009] [PUBMED:11981029] [PUBMED:17194752] [PUBMED:9115251] [PUBMED:9973260] [PUBMED:10749889] [PUBMED:17535799]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Prolactin signaling pathway [NCBI:814182] [KEGG:hsa04917] [PUBMED:17519353] [PUBMED:17535875] [PUBMED:20149678] [PUBMED:12670737] [PUBMED:17307904] [PUBMED:18601698] [PUBMED:17975019] [PUBMED:16231422] [PUBMED:18219564] [PUBMED:9475379] [PUBMED:16677418] [PUBMED:9626554] [PUBMED:21664429] [PUBMED:11606470]
Proteoglycans in cancer [NCBI:782000] [KEGG:hsa05205] [PUBMED:19433454] [PUBMED:20655987] [PUBMED:18798267] [PUBMED:10633082] [PUBMED:10687947] [PUBMED:22735579] [PUBMED:24412155] [PUBMED:9346940] [PUBMED:22087031] [PUBMED:22194599] [PUBMED:14711376] [PUBMED:19255147] [PUBMED:15655247] [PUBMED:11717317] [PUBMED:17971838] [PUBMED:18413366] [PUBMED:20974860] [PUBMED:11830493] [PUBMED:23058688] [PUBMED:18450475] [PUBMED:12748184] [PUBMED:19733083] [PUBMED:18812315] [PUBMED:12509413] [PUBMED:21155971] [PUBMED:11931647] [PUBMED:18949819] [PUBMED:12729888] [PUBMED:15994311] [PUBMED:23305321] [PUBMED:18505598] [PUBMED:22563565] [PUBMED:22033227]
Regulation of Telomerase [NCBI:137987] [Pathway Interaction Database:telomerasepathway] [PUBMED:12037663] [PUBMED:11191110] [PUBMED:15381700] [PUBMED:10637317] [PUBMED:15314656] [PUBMED:10601322] [PUBMED:12545159] [PUBMED:11110707] [PUBMED:15371341] [PUBMED:12681489] [PUBMED:15824061] [PUBMED:15048073] [PUBMED:10850490] [PUBMED:16730176] [PUBMED:12181313] [PUBMED:16890531] [PUBMED:9837921] [PUBMED:10224060] [PUBMED:15331176] [PUBMED:16522649] [PUBMED:9822378] [PUBMED:15316005] [PUBMED:12699629] [PUBMED:16843438] [PUBMED:12151407] [PUBMED:12135483] [PUBMED:15655249] [PUBMED:10888888] [PUBMED:16765199] [PUBMED:16869756] [PUBMED:10837221] [PUBMED:16135795] [PUBMED:11074006] [PUBMED:11191109] [PUBMED:14712220] [PUBMED:16508638] [PUBMED:10471503] [PUBMED:11854288] [PUBMED:16785237] [PUBMED:9130722] [PUBMED:12956959] [PUBMED:15710386] [PUBMED:12586360] [PUBMED:12377759] [PUBMED:11433024] [PUBMED:15843522] [PUBMED:14749375] [PUBMED:11274138] [PUBMED:12676087] [PUBMED:16166375] [PUBMED:15371412]
Regulation of nuclear SMAD2/3 signaling [NCBI:137963] [Pathway Interaction Database:smad2_3nuclearpathway] [PUBMED:15009097] [PUBMED:11790301] [PUBMED:11836524] [PUBMED:10995736] [PUBMED:11114293] [PUBMED:10973944] [PUBMED:10022869] [PUBMED:11058129] [PUBMED:9722503] [PUBMED:12904571] [PUBMED:14993291] [PUBMED:11013220] [PUBMED:15363409] [PUBMED:9702197] [PUBMED:12718878] [PUBMED:11331591] [PUBMED:12167862] [PUBMED:14729983] [PUBMED:9707553] [PUBMED:10878024] [PUBMED:9679060] [PUBMED:10887155] [PUBMED:10199400] [PUBMED:12631740] [PUBMED:11555647] [PUBMED:15688032] [PUBMED:12150994] [PUBMED:12374795] [PUBMED:9606191] [PUBMED:9702198] [PUBMED:10518526] [PUBMED:10575014] [PUBMED:10485843] [PUBMED:11283614] [PUBMED:10722728] [PUBMED:10037600] [PUBMED:15241418] [PUBMED:14691252] [PUBMED:10748032] [PUBMED:12551947] [PUBMED:14671321] [PUBMED:11427533] [PUBMED:11711431] [PUBMED:10531362] [PUBMED:11571228] [PUBMED:10085140] [PUBMED:17478422] [PUBMED:15044954] [PUBMED:10964912] [PUBMED:11707452] [PUBMED:11801598] [PUBMED:17074756] [PUBMED:12226080] [PUBMED:10557285] [PUBMED:10843994] [PUBMED:15084259] [PUBMED:10531062] [PUBMED:16959612] [PUBMED:9679056] [PUBMED:10652350] [PUBMED:9618481] [PUBMED:11927558] [PUBMED:9732876]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by ERBB4 [NCBI:1269496] [REACTOME:R-HSA-1236394] [PUBMED:9275162] [PUBMED:9168115] [PUBMED:17545517] [PUBMED:19193720] [PUBMED:16914727] [PUBMED:7929212] [PUBMED:16912174] [PUBMED:9135143] [PUBMED:10867024] [PUBMED:16778220] [PUBMED:17018285] [PUBMED:15534001] [PUBMED:8665853] [PUBMED:1706616] [PUBMED:10744726] [PUBMED:18653779] [PUBMED:11679632] [PUBMED:8617750] [PUBMED:7565730] [PUBMED:15023535] [PUBMED:16061658] [PUBMED:18721752] [PUBMED:16978839] [PUBMED:17463226] [PUBMED:10722704] [PUBMED:12869563] [PUBMED:19047365] [PUBMED:12807903] [PUBMED:9556621]
Signaling events mediated by HDAC Class II [NCBI:138062] [Pathway Interaction Database:hdac_classii_pathway] [PUBMED:15916966] [PUBMED:10869435] [PUBMED:10898795] [PUBMED:16051668] [PUBMED:12032081] [PUBMED:12606581] [PUBMED:11804585] [PUBMED:11466315] [PUBMED:11567998] [PUBMED:16767219] [PUBMED:12024216] [PUBMED:16166628] [PUBMED:16221676] [PUBMED:11948178] [PUBMED:10220385] [PUBMED:12663674] [PUBMED:14668799] [PUBMED:16236793]
Signaling mediated by p38-alpha and p38-beta [NCBI:138012] [Pathway Interaction Database:p38alphabetadownstreampathway] [PUBMED:11909979] [PUBMED:7923353] [PUBMED:14612426] [PUBMED:12138194] [PUBMED:9069290] [PUBMED:9130707] [PUBMED:10362538] [PUBMED:9155018] [PUBMED:11239470] [PUBMED:9685422] [PUBMED:9628874] [PUBMED:9873047] [PUBMED:10978317] [PUBMED:11741533] [PUBMED:7923354] [PUBMED:9468497] [PUBMED:9647257] [PUBMED:8910365] [PUBMED:8626550] [PUBMED:9776729] [PUBMED:10581204] [PUBMED:7839144] [PUBMED:7750577] [PUBMED:11604491] [PUBMED:11792706] [PUBMED:7535770] [PUBMED:10212189] [PUBMED:10747897] [PUBMED:9687510] [PUBMED:11777913] [PUBMED:9155017] [PUBMED:7737130] [PUBMED:9792677] [PUBMED:11532965] [PUBMED:9822687] [PUBMED:8650547] [PUBMED:9582321] [PUBMED:9858528]
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors [NCBI:1427841] [REACTOME:R-HSA-8866910] [PUBMED:14744778] [PUBMED:9162057] [PUBMED:22735262] [PUBMED:26832794] [PUBMED:10648798] [PUBMED:10497269] [PUBMED:9850080] [PUBMED:9687504] [PUBMED:7891714] [PUBMED:15870067] [PUBMED:9182571] [PUBMED:8895516]
Thyroid hormone signaling pathway [NCBI:946598] [KEGG:hsa04919] [PUBMED:20005976] [PUBMED:17983645] [PUBMED:15345678] [PUBMED:16951130] [PUBMED:16214361] [PUBMED:18329679] [PUBMED:20051527] [PUBMED:17574003] [PUBMED:19716314] [PUBMED:19755667] [PUBMED:20868274] [PUBMED:21835053] [PUBMED:16051672] [PUBMED:19295177] [PUBMED:23021374] [PUBMED:22484490]
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors [NCBI:1427839] [REACTOME:R-HSA-8864260] [PUBMED:2010091] [PUBMED:11744733] [PUBMED:24469049] [PUBMED:23382213] [PUBMED:19798054] [PUBMED:9162057] [PUBMED:21084835] [PUBMED:22735262] [PUBMED:21375726] [PUBMED:14744778] [PUBMED:10648798] [PUBMED:26832794] [PUBMED:24835590] [PUBMED:9687504] [PUBMED:20805990] [PUBMED:10497269] [PUBMED:16420676] [PUBMED:12072434] [PUBMED:9850080] [PUBMED:9182571] [PUBMED:8988173] [PUBMED:1998122] [PUBMED:22371483] [PUBMED:15870067] [PUBMED:12586840] [PUBMED:8895516] [PUBMED:7891714] [PUBMED:11694877] [PUBMED:19115315] [PUBMED:15475956] [PUBMED:25114211]