full name
parkin RBR E3 ubiquitin protein ligase

synonyms
AR-JP, LPRS2, PDJ, PRKN, PARK2, ENSG00000185345

HGNC
HGNC:8607

Entrez Gene
Gene:5071

ENSEMBL
ENSG00000185345

location
chr: 6
start: 161768590
stop: 163148834
strand: -

OMIM
OMIM:602544: PRKN (Autosomal recessive inheritance)
OMIM:211980: Adenocarcinoma of lung, somatic
OMIM:167000: Adenocarcinoma, ovarian, somatic
OMIM:600116: Parkinson disease, juvenile, type 2
OMIM:607572: {Leprosy, susceptibility to}

transcripts
NM_013988.2
NM_013987.2
NM_004562.2

pathways
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Alpha-synuclein signaling [NCBI:137913] [Pathway Interaction Database:alphasynuclein_pathway] [PUBMED:12551928] [PUBMED:15671022] [PUBMED:12887682] [PUBMED:14991825] [PUBMED:11431533] [PUBMED:11588587] [PUBMED:16030137] [PUBMED:15845543] [PUBMED:11590439] [PUBMED:12096713] [PUBMED:11687285] [PUBMED:15978696] [PUBMED:10407019] [PUBMED:11078745] [PUBMED:16403519] [PUBMED:14985429] [PUBMED:14645218] [PUBMED:12787066] [PUBMED:11292651] [PUBMED:12421356] [PUBMED:15944382] [PUBMED:10567343] [PUBMED:11744621] [PUBMED:15935068] [PUBMED:12928483] [PUBMED:11821392] [PUBMED:10852916]
Amyloid fiber formation [NCBI:1269169] [REACTOME:R-HSA-977225] [PUBMED:16302959]
Antigen processing: Ubiquitination & Proteasome degradation [NCBI:1269193] [REACTOME:R-HSA-983168] [PUBMED:12648452] [PUBMED:11917093] [PUBMED:19489725] [PUBMED:14734113] [PUBMED:20351195] [PUBMED:17145306]
Class I MHC mediated antigen processing & presentation [NCBI:1269192] [REACTOME:R-HSA-983169] [PUBMED:8717519] [PUBMED:17145306] [PUBMED:18926908] [PUBMED:17055423] [PUBMED:12495737] [PUBMED:18641646] [PUBMED:18243674]
Deubiquitination [NCBI:1427860] [REACTOME:R-HSA-5688426] [PUBMED:19243136] [PUBMED:20074029] [PUBMED:15571815] [PUBMED:20418328] [PUBMED:16325574] [PUBMED:12944365] [PUBMED:23845989] [PUBMED:22201797]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Josephin domain DUBs [NCBI:1427864] [REACTOME:R-HSA-5689877] [PUBMED:23845989]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Mitophagy [NCBI:1309218] [REACTOME:R-HSA-5205647] [PUBMED:21179058]
Mitophagy - animal [NCBI:1496831] [KEGG:hsa04137] [PUBMED:26611876] [PUBMED:27443527] [PUBMED:25995186] [PUBMED:25611507] [PUBMED:27021519] [PUBMED:25999423] [PUBMED:27701735] [PUBMED:26882551]
Parkinson's disease [NCBI:83098] [KEGG:hsa05012] [PUBMED:15767499] [PUBMED:12461550] [PUBMED:21811441] [PUBMED:17911161] [PUBMED:15525720] [PUBMED:16022590] [PUBMED:12971891] [PUBMED:15681812] [PUBMED:16495942] [PUBMED:11331916] [PUBMED:18426756] [PUBMED:16278972] [PUBMED:18680555] [PUBMED:12938733] [PUBMED:15770999] [PUBMED:12728264] [PUBMED:15054086] [PUBMED:20236221] [PUBMED:22927178]
Pink/Parkin Mediated Mitophagy [NCBI:1309219] [REACTOME:R-HSA-5205685] [PUBMED:21179058]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Protein processing in endoplasmic reticulum [NCBI:167325] [KEGG:hsa04141] [PUBMED:20347046] [PUBMED:18023214] [PUBMED:20219571] [PUBMED:19491040] [PUBMED:20112977]
Ubiquitin mediated proteolysis [NCBI:83056] [KEGG:hsa04120] [PUBMED:16405856] [PUBMED:12944364] [PUBMED:16922408] [PUBMED:17588513] [PUBMED:16922367] [PUBMED:16922370] [PUBMED:16816840]