full name
TATA-box binding protein

synonyms
GTF2D, GTF2D1, HDL4, SCA17, TFIID, TBP, ENSG00000112592

HGNC
HGNC:11588

Entrez Gene
Gene:6908

ENSEMBL
ENSG00000112592

location
chr: 6
start: 170863384
stop: 170881958
strand: +

OMIM
OMIM:600075: TBP (Autosomal dominant inheritance)
OMIM:607136: Spinocerebellar ataxia 17
OMIM:168600: {Parkinson disease, susceptibility to}

transcripts
NM_003194.4
NM_001172085.1

pathways
B-WICH complex positively regulates rRNA expression [NCBI:1339126] [REACTOME:R-HSA-5250924] [PUBMED:23555303] [PUBMED:21559432] [PUBMED:16514417] [PUBMED:23667505] [PUBMED:16603771] [PUBMED:16574391]
Basal transcription factors [NCBI:83038] [KEGG:hsa03022] [PUBMED:12516863] [PUBMED:10838567] [PUBMED:16858867] [PUBMED:19308322]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Epigenetic regulation of gene expression [NCBI:1269734] [REACTOME:R-HSA-212165] [PUBMED:12610534]
Epstein-Barr virus infection [NCBI:585562] [KEGG:hsa05169] [PUBMED:1658397] [PUBMED:10683340] [PUBMED:19375142] [PUBMED:12438576] [PUBMED:12910248] [PUBMED:10400785] [PUBMED:16007144] [PUBMED:14576817] [PUBMED:18559925] [PUBMED:16352731] [PUBMED:7895172] [PUBMED:15510157] [PUBMED:21518914] [PUBMED:10891508] [PUBMED:14673102] [PUBMED:17159145] [PUBMED:15542638] [PUBMED:18786993] [PUBMED:16603506] [PUBMED:10644367] [PUBMED:15021898] [PUBMED:10666279] [PUBMED:9565632]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
Glucocorticoid receptor regulatory network [NCBI:138014] [Pathway Interaction Database:reg_gr_pathway] [PUBMED:8943293] [PUBMED:1708774] [PUBMED:15826950] [PUBMED:11027313] [PUBMED:12118039] [PUBMED:9388207] [PUBMED:11751894] [PUBMED:12151000] [PUBMED:9765258] [PUBMED:9407028] [PUBMED:19074285] [PUBMED:2838908] [PUBMED:15817653] [PUBMED:9722596] [PUBMED:12917342] [PUBMED:1387550] [PUBMED:10974006] [PUBMED:15790729] [PUBMED:10825196] [PUBMED:10623828] [PUBMED:2169352] [PUBMED:9315653] [PUBMED:7759501] [PUBMED:8290595] [PUBMED:2905764] [PUBMED:12351702] [PUBMED:11080152] [PUBMED:8428574] [PUBMED:9215863] [PUBMED:15459252] [PUBMED:10400612] [PUBMED:9426156] [PUBMED:17440046] [PUBMED:18838540] [PUBMED:2169353] [PUBMED:10820245] [PUBMED:12511605] [PUBMED:2586521] [PUBMED:1740658] [PUBMED:11555652] [PUBMED:11562347] [PUBMED:9482836] [PUBMED:18337589] [PUBMED:10958685] [PUBMED:9388192] [PUBMED:15834420] [PUBMED:15657031] [PUBMED:8878484] [PUBMED:10760263] [PUBMED:12730237] [PUBMED:8702844] [PUBMED:2169351] [PUBMED:17215482] [PUBMED:8898375]
HIV Infection [NCBI:1269057] [REACTOME:R-HSA-162906] [PUBMED:16354571] [PUBMED:9759480]
HIV Life Cycle [NCBI:1269058] [REACTOME:R-HSA-162587] [PUBMED:9188609] [PUBMED:9759480]
HIV Transcription Initiation [NCBI:1269071] [REACTOME:R-HSA-167161]
HTLV-I infection [NCBI:373901] [KEGG:hsa05166] [PUBMED:17446673] [PUBMED:16436385] [PUBMED:14686485] [PUBMED:19861996] [PUBMED:19092975] [PUBMED:11325603] [PUBMED:16155602] [PUBMED:12910251] [PUBMED:16155605] [PUBMED:16036567] [PUBMED:11244044] [PUBMED:18702816] [PUBMED:15569630] [PUBMED:21114861] [PUBMED:16155611] [PUBMED:17384582] [PUBMED:16155608] [PUBMED:10602469] [PUBMED:19014483] [PUBMED:9325311]
Herpes simplex infection [NCBI:377873] [KEGG:hsa05168] [PUBMED:12224518] [PUBMED:17913820] [PUBMED:12844494] [PUBMED:10998601] [PUBMED:15163721] [PUBMED:19694546] [PUBMED:16297150] [PUBMED:14747533] [PUBMED:12826401] [PUBMED:14963113] [PUBMED:15056211] [PUBMED:12797447] [PUBMED:21107701] [PUBMED:10918307] [PUBMED:10696424] [PUBMED:16076403] [PUBMED:10364308] [PUBMED:17222692] [PUBMED:9621021] [PUBMED:12224508] [PUBMED:19879619] [PUBMED:11070032] [PUBMED:9499021] [PUBMED:18596690] [PUBMED:12525427] [PUBMED:12224517] [PUBMED:10196275] [PUBMED:15047834] [PUBMED:18508584] [PUBMED:20036979]
Huntington's disease [NCBI:83100] [KEGG:hsa05016] [PUBMED:15336977] [PUBMED:11738471] [PUBMED:11807533] [PUBMED:15996546] [PUBMED:14526190] [PUBMED:15242639] [PUBMED:17041811] [PUBMED:15996541] [PUBMED:18951640] [PUBMED:15459747] [PUBMED:16288298] [PUBMED:17081970] [PUBMED:15695335] [PUBMED:12372277] [PUBMED:11839795]
Infectious disease [NCBI:1269056] [REACTOME:R-HSA-5663205]
Late Phase of HIV Life Cycle [NCBI:1269069] [REACTOME:R-HSA-162599] [PUBMED:2825027] [PUBMED:10550206] [PUBMED:10562489] [PUBMED:15719065] [PUBMED:15183343] [PUBMED:3031512] [PUBMED:9891806] [PUBMED:2784194]
Negative epigenetic regulation of rRNA expression [NCBI:1269737] [REACTOME:R-HSA-5250941] [PUBMED:23063748] [PUBMED:23150253] [PUBMED:18616426]
NoRC negatively regulates rRNA expression [NCBI:1269739] [REACTOME:R-HSA-427413] [PUBMED:17439825] [PUBMED:17613545] [PUBMED:23063748] [PUBMED:11583633] [PUBMED:18631128] [PUBMED:18616426]
Positive epigenetic regulation of rRNA expression [NCBI:1339125] [REACTOME:R-HSA-5250913] [PUBMED:23153826] [PUBMED:16574391] [PUBMED:23063748] [PUBMED:23150253] [PUBMED:18616426]
RNA Polymerase I Chain Elongation [NCBI:1269662] [REACTOME:R-HSA-73777]
RNA Polymerase I Promoter Clearance [NCBI:1269658] [REACTOME:R-HSA-73854]
RNA Polymerase I Promoter Escape [NCBI:1269661] [REACTOME:R-HSA-73772]
RNA Polymerase I Transcription [NCBI:1269657] [REACTOME:R-HSA-73864]
RNA Polymerase I Transcription Initiation [NCBI:1269660] [REACTOME:R-HSA-73762]
RNA Polymerase I Transcription Termination [NCBI:1269663] [REACTOME:R-HSA-73863]
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription [NCBI:1269656] [REACTOME:R-HSA-504046]
RNA Polymerase II HIV Promoter Escape [NCBI:1269072] [REACTOME:R-HSA-167162]
RNA Polymerase II Pre-transcription Events [NCBI:1269676] [REACTOME:R-HSA-674695]
RNA Polymerase II Promoter Escape [NCBI:1269680] [REACTOME:R-HSA-73776] [PUBMED:9405375]
RNA Polymerase II Transcription [NCBI:1269675] [REACTOME:R-HSA-73857]
RNA Polymerase II Transcription Initiation [NCBI:1269679] [REACTOME:R-HSA-75953] [PUBMED:7601352] [PUBMED:8612591] [PUBMED:11784853] [PUBMED:3667620] [PUBMED:9405375]
RNA Polymerase II Transcription Initiation And Promoter Clearance [NCBI:1269678] [REACTOME:R-HSA-76042]
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening [NCBI:1269677] [REACTOME:R-HSA-73779] [PUBMED:8946909]
RNA Polymerase III Abortive And Retractive Initiation [NCBI:1269665] [REACTOME:R-HSA-749476]
RNA Polymerase III Transcription [NCBI:1269664] [REACTOME:R-HSA-74158] [PUBMED:9308965] [PUBMED:11121026] [PUBMED:11040218]
RNA Polymerase III Transcription Initiation [NCBI:1269666] [REACTOME:R-HSA-76046] [PUBMED:7357599] [PUBMED:7312050] [PUBMED:6947245] [PUBMED:7357604] [PUBMED:2308839] [PUBMED:2752422]
RNA Polymerase III Transcription Initiation From Type 1 Promoter [NCBI:1269667] [REACTOME:R-HSA-76061] [PUBMED:7226225] [PUBMED:6153931] [PUBMED:3967290] [PUBMED:3972795] [PUBMED:6356356]
RNA Polymerase III Transcription Initiation From Type 2 Promoter [NCBI:1269668] [REACTOME:R-HSA-76066]
RNA Polymerase III Transcription Initiation From Type 3 Promoter [NCBI:1269669] [REACTOME:R-HSA-76071] [PUBMED:2853685] [PUBMED:1535687] [PUBMED:8979085] [PUBMED:8339931] [PUBMED:8336708] [PUBMED:9705341] [PUBMED:9776743] [PUBMED:1868835] [PUBMED:2905684]
RNA polymerase II transcribes snRNA genes [NCBI:1383088] [REACTOME:R-HSA-6807505] [PUBMED:23932780] [PUBMED:18482001] [PUBMED:20659008] [PUBMED:3837185] [PUBMED:18442490] [PUBMED:24097444] [PUBMED:18631122] [PUBMED:18378697] [PUBMED:6201719] [PUBMED:22622228] [PUBMED:11390411] [PUBMED:25882383]
Regulation of TP53 Activity [NCBI:1383076] [REACTOME:R-HSA-5633007] [PUBMED:19450511] [PUBMED:20457558] [PUBMED:23825024] [PUBMED:25641576]
Regulation of TP53 Activity through Phosphorylation [NCBI:1383080] [REACTOME:R-HSA-6804756] [PUBMED:11780126] [PUBMED:21317932] [PUBMED:15866171] [PUBMED:12393879] [PUBMED:11740489] [PUBMED:11447225] [PUBMED:9733515] [PUBMED:12851404] [PUBMED:10884347] [PUBMED:10710310] [PUBMED:11239457] [PUBMED:9925639] [PUBMED:11546806] [PUBMED:11551930] [PUBMED:10570149] [PUBMED:18490454] [PUBMED:17591690] [PUBMED:19965871] [PUBMED:12064478] [PUBMED:10673501] [PUBMED:22611192] [PUBMED:9843217] [PUBMED:15053879] [PUBMED:12914926] [PUBMED:10673500] [PUBMED:17349958] [PUBMED:14702041] [PUBMED:20959462] [PUBMED:10435622] [PUBMED:9733514]
Regulation of retinoblastoma protein [NCBI:137916] [Pathway Interaction Database:rb_1pathway] [PUBMED:15469821] [PUBMED:11470869] [PUBMED:8493578] [PUBMED:7596417] [PUBMED:8449399] [PUBMED:9468140] [PUBMED:11596110] [PUBMED:9545246] [PUBMED:16360038] [PUBMED:14673169] [PUBMED:17991896] [PUBMED:8805225] [PUBMED:7926730] [PUBMED:10322110] [PUBMED:11533237] [PUBMED:1828393] [PUBMED:8657117] [PUBMED:9491888] [PUBMED:7877691] [PUBMED:14729964] [PUBMED:1710781] [PUBMED:10778858] [PUBMED:11566021] [PUBMED:8246996] [PUBMED:12450794] [PUBMED:16374512] [PUBMED:10783144] [PUBMED:15949438] [PUBMED:9468139] [PUBMED:8242749] [PUBMED:9464541] [PUBMED:1531329] [PUBMED:9819434] [PUBMED:12479814] [PUBMED:10888886] [PUBMED:10597288] [PUBMED:8626527] [PUBMED:7629134] [PUBMED:11545733] [PUBMED:17620057] [PUBMED:11433299] [PUBMED:9858607] [PUBMED:15716956] [PUBMED:10490602] [PUBMED:1828392] [PUBMED:15577944] [PUBMED:11484059] [PUBMED:11583618] [PUBMED:10499802]
SIRT1 negatively regulates rRNA Expression [NCBI:1269738] [REACTOME:R-HSA-427359] [PUBMED:19010308] [PUBMED:18485871] [PUBMED:20023389]
Transcription of the HIV genome [NCBI:1269070] [REACTOME:R-HSA-167172] [PUBMED:10550206] [PUBMED:9791012]
Transcriptional Regulation by TP53 [NCBI:1269654] [REACTOME:R-HSA-3700989] [PUBMED:26122615] [PUBMED:19410540]
Validated targets of C-MYC transcriptional repression [NCBI:169353] [Pathway Interaction Database:myc_represspathway] [PUBMED:17082179] [PUBMED:11282029] [PUBMED:9869632] [PUBMED:15021909] [PUBMED:16167342] [PUBMED:18056446] [PUBMED:18045875] [PUBMED:1670896] [PUBMED:18393360] [PUBMED:7556187] [PUBMED:11313917] [PUBMED:17471507] [PUBMED:12418961] [PUBMED:9927431] [PUBMED:9924025] [PUBMED:18483244] [PUBMED:14716294] [PUBMED:15506972] [PUBMED:15616584] [PUBMED:12729735] [PUBMED:19219026] [PUBMED:12747840] [PUBMED:2182320] [PUBMED:12545156] [PUBMED:15367674] [PUBMED:11283613] [PUBMED:12384701] [PUBMED:18066065] [PUBMED:18455888] [PUBMED:10920185] [PUBMED:17881732] [PUBMED:20190815] [PUBMED:16352593] [PUBMED:17050536] [PUBMED:11283614] [PUBMED:16391002] [PUBMED:11804592] [PUBMED:7870572] [PUBMED:16940161] [PUBMED:12695333] [PUBMED:17159920] [PUBMED:8972190] [PUBMED:9312026] [PUBMED:17485441] [PUBMED:16288014]
Viral carcinogenesis [NCBI:658418] [KEGG:hsa05203] [PUBMED:9990017] [PUBMED:15173177] [PUBMED:16036567] [PUBMED:16581947] [PUBMED:9060639] [PUBMED:17457345] [PUBMED:15956361] [PUBMED:21421561] [PUBMED:18391203] [PUBMED:21040832] [PUBMED:9837909] [PUBMED:17645777] [PUBMED:15967719] [PUBMED:12686421] [PUBMED:17049016] [PUBMED:21152115] [PUBMED:11160754] [PUBMED:21966251] [PUBMED:17979705] [PUBMED:8617242] [PUBMED:12925958] [PUBMED:10873631] [PUBMED:21250384] [PUBMED:15614436] [PUBMED:10354594] [PUBMED:20494113] [PUBMED:18702816] [PUBMED:9651361] [PUBMED:16459163] [PUBMED:11278402] [PUBMED:15510157] [PUBMED:19956178] [PUBMED:18251977] [PUBMED:11766888] [PUBMED:10824878] [PUBMED:21372216] [PUBMED:11244044] [PUBMED:17894800] [PUBMED:11905817] [PUBMED:21347341] [PUBMED:12186904] [PUBMED:9374493] [PUBMED:16352731] [PUBMED:12770701] [PUBMED:17384582] [PUBMED:14506283] [PUBMED:11091847] [PUBMED:17267064] [PUBMED:11886269] [PUBMED:21177815] [PUBMED:10400746] [PUBMED:19156753] [PUBMED:9882379] [PUBMED:14559998] [PUBMED:15767449] [PUBMED:22110506] [PUBMED:20534855] [PUBMED:15542638] [PUBMED:9343405] [PUBMED:10405893] [PUBMED:19400863] [PUBMED:9349482] [PUBMED:14747563] [PUBMED:21647825] [PUBMED:12970441] [PUBMED:11669605] [PUBMED:15795286] [PUBMED:21994562] [PUBMED:14530271] [PUBMED:9594662] [PUBMED:22566809] [PUBMED:19651473] [PUBMED:8756622] [PUBMED:15105524] [PUBMED:15452270] [PUBMED:18948197] [PUBMED:16760382] [PUBMED:10793105] [PUBMED:21084867] [PUBMED:16308315] [PUBMED:16155604] [PUBMED:16381817] [PUBMED:16828973] [PUBMED:15342967] [PUBMED:15692053] [PUBMED:10855768] [PUBMED:19078975] [PUBMED:12379483] [PUBMED:15310405] [PUBMED:8223437] [PUBMED:16939421] [PUBMED:12910250] [PUBMED:16039586] [PUBMED:18201576] [PUBMED:21102637] [PUBMED:21743832] [PUBMED:20592731] [PUBMED:10644344] [PUBMED:10074132] [PUBMED:19715458] [PUBMED:16155601] [PUBMED:11604508] [PUBMED:15919895] [PUBMED:11099494] [PUBMED:18385245] [PUBMED:19854353] [PUBMED:12101418]