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Genes
RPA3
Gene - RPA3
full name
replication protein A3
synonyms
REPA3, RPA3, ENSG00000106399
HGNC
HGNC:10291
Entrez Gene
Gene:6119
ENSEMBL
ENSG00000106399
location
chr: 7
start: 7676347
stop: 7758238
strand: -
transcripts
NM_002947.3
pathways
Activation of ATR in response to replication stress
[NCBI:1269757]
[REACTOME:R-HSA-176187]
[PUBMED:12791985]
Activation of the pre-replicative complex
[NCBI:1269773]
[REACTOME:R-HSA-68962]
[PUBMED:10402192]
[PUBMED:11779870]
[PUBMED:10801458]
[PUBMED:12169736]
[PUBMED:11323433]
[PUBMED:9038340]
[PUBMED:9765232]
[PUBMED:9829972]
[PUBMED:10970868]
[PUBMED:9353276]
[PUBMED:7502077]
[PUBMED:11459976]
[PUBMED:11395502]
Base Excision Repair
[NCBI:1270351]
[REACTOME:R-HSA-73884]
[PUBMED:11937636]
[PUBMED:10583946]
Cell Cycle
[NCBI:1269741]
[REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints
[NCBI:1269742]
[REACTOME:R-HSA-69620]
Cell Cycle, Mitotic
[NCBI:1269763]
[REACTOME:R-HSA-69278]
Cellular response to heat stress
[NCBI:1270421]
[REACTOME:R-HSA-3371556]
[PUBMED:8455624]
[PUBMED:8441385]
Cellular responses to stress
[NCBI:1270414]
[REACTOME:R-HSA-2262752]
[PUBMED:15709958]
Chromosome Maintenance
[NCBI:1269853]
[REACTOME:R-HSA-73886]
DNA Damage Bypass
[NCBI:1270367]
[REACTOME:R-HSA-73893]
[PUBMED:21605556]
[PUBMED:10925197]
[PUBMED:11595180]
[PUBMED:12800216]
[PUBMED:19225445]
[PUBMED:25038291]
DNA Double-Strand Break Repair
[NCBI:1309095]
[REACTOME:R-HSA-5693532]
[PUBMED:12897142]
[PUBMED:20965415]
DNA Repair
[NCBI:1270350]
[REACTOME:R-HSA-73894]
[PUBMED:10583946]
[PUBMED:23175119]
DNA Replication
[NCBI:1269875]
[REACTOME:R-HSA-69306]
[PUBMED:11257218]
[PUBMED:12045100]
[PUBMED:1536007]
[PUBMED:10966477]
[PUBMED:1579437]
[PUBMED:8223461]
DNA Replication Pre-Initiation
[NCBI:1269832]
[REACTOME:R-HSA-69002]
DNA replication
[NCBI:83039]
[KEGG:hsa03030]
[PUBMED:9759502]
[PUBMED:8087839]
DNA strand elongation
[NCBI:1269784]
[REACTOME:R-HSA-69190]
[PUBMED:9081985]
[PUBMED:1976634]
[PUBMED:7623835]
[PUBMED:1536007]
[PUBMED:8594377]
Dual Incision in GG-NER
[NCBI:1309115]
[REACTOME:R-HSA-5696400]
[PUBMED:19279666]
Dual incision in TC-NER
[NCBI:1309119]
[REACTOME:R-HSA-6782135]
[PUBMED:19279666]
[PUBMED:23906714]
[PUBMED:8078911]
[PUBMED:16246722]
[PUBMED:19023283]
[PUBMED:11904382]
[PUBMED:24402227]
Extension of Telomeres
[NCBI:1269857]
[REACTOME:R-HSA-180786]
[PUBMED:15189140]
Fanconi Anemia Pathway
[NCBI:1309121]
[REACTOME:R-HSA-6783310]
[PUBMED:23325218]
[PUBMED:21734703]
[PUBMED:18082604]
[PUBMED:25099582]
[PUBMED:18995829]
[PUBMED:17768402]
[PUBMED:26048987]
[PUBMED:21701511]
Fanconi anemia pathway
[NCBI:377262]
[KEGG:hsa03460]
[PUBMED:19805513]
[PUBMED:18518821]
[PUBMED:18047734]
[PUBMED:20039786]
[PUBMED:21701511]
[PUBMED:20064461]
Formation of Incision Complex in GG-NER
[NCBI:1309114]
[REACTOME:R-HSA-5696395]
[PUBMED:17948053]
[PUBMED:17466626]
[PUBMED:11511374]
[PUBMED:9716411]
[PUBMED:17000769]
[PUBMED:15590680]
[PUBMED:19940136]
[PUBMED:14517266]
[PUBMED:16491090]
[PUBMED:23038248]
G1/S Transition
[NCBI:1269768]
[REACTOME:R-HSA-69206]
G2/M Checkpoints
[NCBI:1269753]
[REACTOME:R-HSA-69481]
G2/M DNA damage checkpoint
[NCBI:1269754]
[REACTOME:R-HSA-69473]
Gap-filling DNA repair synthesis and ligation in GG-NER
[NCBI:1309116]
[REACTOME:R-HSA-5696397]
[PUBMED:17643379]
[PUBMED:19279666]
[PUBMED:20227374]
Gap-filling DNA repair synthesis and ligation in TC-NER
[NCBI:1309120]
[REACTOME:R-HSA-6782210]
[PUBMED:20227374]
[PUBMED:19279666]
[PUBMED:17643379]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
Global Genome Nucleotide Excision Repair (GG-NER)
[NCBI:1309112]
[REACTOME:R-HSA-5696399]
[PUBMED:24954209]
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
[NCBI:1309100]
[REACTOME:R-HSA-5693567]
[PUBMED:20965415]
HDR through Homologous Recombination (HRR)
[NCBI:1309102]
[REACTOME:R-HSA-5685942]
[PUBMED:20965415]
HDR through Single Strand Annealing (SSA)
[NCBI:1309108]
[REACTOME:R-HSA-5685938]
[PUBMED:12791985]
[PUBMED:17962301]
[PUBMED:25122754]
[PUBMED:21804533]
[PUBMED:12139939]
[PUBMED:10212258]
[PUBMED:10921897]
[PUBMED:19357644]
[PUBMED:21240188]
[PUBMED:21325134]
[PUBMED:9837724]
[PUBMED:15485900]
[PUBMED:17928296]
[PUBMED:18539610]
[PUBMED:12370410]
[PUBMED:17965729]
[PUBMED:22977173]
[PUBMED:14734547]
[PUBMED:21052091]
HSF1 activation
[NCBI:1270422]
[REACTOME:R-HSA-3371511]
[PUBMED:7623826]
[PUBMED:8631933]
Homologous DNA Pairing and Strand Exchange
[NCBI:1309103]
[REACTOME:R-HSA-5693579]
[PUBMED:9880493]
[PUBMED:17996710]
[PUBMED:12912992]
[PUBMED:19369211]
[PUBMED:19268590]
[PUBMED:17996711]
[PUBMED:24141787]
[PUBMED:20871615]
[PUBMED:20965415]
[PUBMED:20871616]
[PUBMED:23149936]
Homologous recombination
[NCBI:83046]
[KEGG:hsa03440]
[PUBMED:12589470]
[PUBMED:15902993]
[PUBMED:16935872]
[PUBMED:17395553]
[PUBMED:18086882]
[PUBMED:17571595]
[PUBMED:18430459]
Homology Directed Repair
[NCBI:1309099]
[REACTOME:R-HSA-5693538]
[PUBMED:11242102]
[PUBMED:20965415]
[PUBMED:11376695]
[PUBMED:12427531]
Lagging Strand Synthesis
[NCBI:1269788]
[REACTOME:R-HSA-69186]
[PUBMED:9081985]
M/G1 Transition
[NCBI:1269831]
[REACTOME:R-HSA-68874]
Meiosis
[NCBI:1269865]
[REACTOME:R-HSA-1500620]
[PUBMED:20051984]
[PUBMED:20364103]
[PUBMED:16543383]
[PUBMED:18948708]
Meiotic recombination
[NCBI:1269866]
[REACTOME:R-HSA-912446]
[PUBMED:16543383]
[PUBMED:20364103]
[PUBMED:20051984]
Mismatch Repair
[NCBI:1270411]
[REACTOME:R-HSA-5358508]
[PUBMED:19138690]
[PUBMED:23545421]
[PUBMED:16464007]
[PUBMED:20725617]
[PUBMED:10072354]
[PUBMED:18157157]
[PUBMED:23572416]
Mismatch repair
[NCBI:83045]
[KEGG:hsa03430]
[PUBMED:11436301]
[PUBMED:18157157]
[PUBMED:16612326]
[PUBMED:11920679]
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
[NCBI:1270413]
[REACTOME:R-HSA-5358606]
[PUBMED:9677427]
[PUBMED:11920679]
[PUBMED:9294177]
[PUBMED:9671718]
[PUBMED:8805365]
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
[NCBI:1270412]
[REACTOME:R-HSA-5358565]
[PUBMED:9294177]
[PUBMED:23391514]
[PUBMED:9671718]
Mitotic G1-G1/S phases
[NCBI:1269764]
[REACTOME:R-HSA-453279]
Nucleotide Excision Repair
[NCBI:1309111]
[REACTOME:R-HSA-5696398]
[PUBMED:11900249]
[PUBMED:23906714]
[PUBMED:14599765]
[PUBMED:10583946]
[PUBMED:24954209]
[PUBMED:19023283]
Nucleotide excision repair
[NCBI:83044]
[KEGG:hsa03420]
[PUBMED:11436323]
[PUBMED:18018633]
[PUBMED:11436316]
[PUBMED:17884153]
[PUBMED:11436314]
[PUBMED:17276014]
[PUBMED:16922398]
PCNA-Dependent Long Patch Base Excision Repair
[NCBI:1270366]
[REACTOME:R-HSA-5651801]
[PUBMED:9780000]
[PUBMED:11601988]
[PUBMED:9214649]
[PUBMED:12200445]
[PUBMED:10460157]
[PUBMED:10559261]
[PUBMED:11250913]
Presynaptic phase of homologous DNA pairing and strand exchange
[NCBI:1309104]
[REACTOME:R-HSA-5693616]
[PUBMED:20729858]
[PUBMED:15665856]
[PUBMED:20729832]
[PUBMED:23149936]
[PUBMED:23810717]
[PUBMED:15703751]
[PUBMED:18317453]
[PUBMED:20729859]
[PUBMED:11751635]
Processing of DNA double-strand break ends
[NCBI:1309101]
[REACTOME:R-HSA-5693607]
[PUBMED:25122754]
[PUBMED:18171670]
[PUBMED:20965415]
[PUBMED:22231403]
[PUBMED:25558984]
[PUBMED:19357644]
[PUBMED:21325134]
[PUBMED:21240188]
[PUBMED:21659603]
[PUBMED:23468639]
[PUBMED:25659039]
Processive synthesis on the C-strand of the telomere
[NCBI:1269862]
[REACTOME:R-HSA-174414]
[PUBMED:1671046]
Processive synthesis on the lagging strand
[NCBI:1269789]
[REACTOME:R-HSA-69183]
[PUBMED:1671046]
Recognition of DNA damage by PCNA-containing replication complex
[NCBI:1270368]
[REACTOME:R-HSA-110314]
[PUBMED:15916957]
[PUBMED:12226657]
Regulation of HSF1-mediated heat shock response
[NCBI:1270425]
[REACTOME:R-HSA-3371453]
[PUBMED:7623826]
Regulation of TP53 Activity
[NCBI:1383076]
[REACTOME:R-HSA-5633007]
[PUBMED:19450511]
[PUBMED:20457558]
[PUBMED:23825024]
[PUBMED:25641576]
Regulation of TP53 Activity through Phosphorylation
[NCBI:1383080]
[REACTOME:R-HSA-6804756]
[PUBMED:11780126]
[PUBMED:21317932]
[PUBMED:15866171]
[PUBMED:12393879]
[PUBMED:11740489]
[PUBMED:11447225]
[PUBMED:9733515]
[PUBMED:12851404]
[PUBMED:10884347]
[PUBMED:10710310]
[PUBMED:11239457]
[PUBMED:9925639]
[PUBMED:11546806]
[PUBMED:11551930]
[PUBMED:10570149]
[PUBMED:18490454]
[PUBMED:17591690]
[PUBMED:19965871]
[PUBMED:12064478]
[PUBMED:10673501]
[PUBMED:22611192]
[PUBMED:9843217]
[PUBMED:15053879]
[PUBMED:12914926]
[PUBMED:10673500]
[PUBMED:17349958]
[PUBMED:14702041]
[PUBMED:20959462]
[PUBMED:10435622]
[PUBMED:9733514]
Removal of the Flap Intermediate
[NCBI:1269790]
[REACTOME:R-HSA-69166]
[PUBMED:7926735]
[PUBMED:8131753]
[PUBMED:7644470]
Removal of the Flap Intermediate from the C-strand
[NCBI:1269863]
[REACTOME:R-HSA-174437]
[PUBMED:1671046]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
[NCBI:1270364]
[REACTOME:R-HSA-110373]
[PUBMED:10583946]
[PUBMED:9214649]
[PUBMED:10559261]
[PUBMED:10460157]
[PUBMED:11440997]
[PUBMED:11601988]
Resolution of Abasic Sites (AP sites)
[NCBI:1270359]
[REACTOME:R-HSA-73933]
[PUBMED:11601988]
[PUBMED:15260972]
[PUBMED:17395641]
[PUBMED:19329425]
[PUBMED:9804798]
[PUBMED:15556996]
[PUBMED:9214649]
[PUBMED:7608159]
[PUBMED:11440997]
[PUBMED:15871698]
[PUBMED:9207062]
[PUBMED:16982218]
[PUBMED:8978692]
S Phase
[NCBI:1269777]
[REACTOME:R-HSA-69242]
Synthesis of DNA
[NCBI:1269779]
[REACTOME:R-HSA-69239]
Telomere C-strand (Lagging Strand) Synthesis
[NCBI:1269859]
[REACTOME:R-HSA-174417]
[PUBMED:15189140]
Telomere Maintenance
[NCBI:1269856]
[REACTOME:R-HSA-157579]
[PUBMED:16166375]
[PUBMED:4507727]
[PUBMED:14685173]
[PUBMED:642006]
[PUBMED:15189140]
[PUBMED:3907856]
[PUBMED:2463488]
[PUBMED:4754905]
Termination of translesion DNA synthesis
[NCBI:1270374]
[REACTOME:R-HSA-5656169]
[PUBMED:24768535]
[PUBMED:23000965]
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
[NCBI:1309117]
[REACTOME:R-HSA-6781827]
[PUBMED:24954209]
[PUBMED:11823795]
[PUBMED:19023283]
[PUBMED:23906714]
[PUBMED:3466163]
Transcriptional Regulation by TP53
[NCBI:1269654]
[REACTOME:R-HSA-3700989]
[PUBMED:26122615]
[PUBMED:19410540]
Translesion Synthesis by POLH
[NCBI:1270371]
[REACTOME:R-HSA-110320]
[PUBMED:10369688]
[PUBMED:10856253]
Translesion synthesis by POLI
[NCBI:1270373]
[REACTOME:R-HSA-5656121]
[PUBMED:10984059]
[PUBMED:15254543]
[PUBMED:20159559]
[PUBMED:15657443]
[PUBMED:23143872]
[PUBMED:15189446]
[PUBMED:14657033]
[PUBMED:16357261]
[PUBMED:16819516]
[PUBMED:18242152]
Translesion synthesis by POLK
[NCBI:1270372]
[REACTOME:R-HSA-5655862]
[PUBMED:12444249]
[PUBMED:11006276]
[PUBMED:12145297]
[PUBMED:15475561]
[PUBMED:11058110]
[PUBMED:22772988]
[PUBMED:22721435]
[PUBMED:11784855]
[PUBMED:24648516]
[PUBMED:20660785]
[PUBMED:19492058]
[PUBMED:19170759]
Translesion synthesis by REV1
[NCBI:1270370]
[REACTOME:R-HSA-110312]
[PUBMED:19153606]
[PUBMED:10760286]
[PUBMED:8658138]
[PUBMED:22859296]
[PUBMED:17517887]
[PUBMED:16344468]
[PUBMED:10536157]
[PUBMED:24449906]
[PUBMED:20164194]
[PUBMED:23143872]
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
[NCBI:1270369]
[REACTOME:R-HSA-110313]
[PUBMED:10583946]
[PUBMED:10856253]
[PUBMED:24716551]