full name
glucokinase

synonyms
FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2, GCK, ENSG00000106633

HGNC
HGNC:4195

Entrez Gene
Gene:2645

ENSEMBL
ENSG00000106633

location
chr: 7
start: 44183870
stop: 44229022
strand: -

OMIM
OMIM:138079: GCK (Autosomal dominant inheritance)
OMIM:125853: Diabetes mellitus, noninsulin-dependent, late onset
OMIM:606176: Diabetes mellitus, permanent neonatal
OMIM:602485: Hyperinsulinemic hypoglycemia, familial, 3
OMIM:125851: MODY, type II

transcripts
NM_000162.3
NM_033507.1
NM_033508.1

pathways
Amino sugar and nucleotide sugar metabolism [NCBI:82979] [KEGG:hsa00520] [PUBMED:16995900] [PUBMED:15134748] [PUBMED:11479276] [PUBMED:10984043] [PUBMED:16237198] [PUBMED:18199744] [PUBMED:15809294] [PUBMED:8071227] [PUBMED:14450717] [PUBMED:2793832] [PUBMED:16277754] [PUBMED:10931327] [PUBMED:17827295] [PUBMED:15695810] [PUBMED:18304669] [PUBMED:9811644] [PUBMED:11447132] [PUBMED:8444803] [PUBMED:12562791] [PUBMED:17190829] [PUBMED:17085508] [PUBMED:15489439] [PUBMED:16452451]
Carbon metabolism [NCBI:814926] [KEGG:hsa01200]
Central carbon metabolism in cancer [NCBI:1059538] [KEGG:hsa05230] [PUBMED:16982728] [PUBMED:21127244] [PUBMED:22349059] [PUBMED:19270154] [PUBMED:24113830] [PUBMED:22156302] [PUBMED:21801601] [PUBMED:15916903] [PUBMED:18177721] [PUBMED:22237205] [PUBMED:20520704] [PUBMED:23018234] [PUBMED:23897900] [PUBMED:24398961] [PUBMED:24079832] [PUBMED:18538731] [PUBMED:19460998] [PUBMED:22307140] [PUBMED:18766298] [PUBMED:22101401] [PUBMED:23071355] [PUBMED:21508971] [PUBMED:24738035] [PUBMED:22750268] [PUBMED:21258394] [PUBMED:23279446] [PUBMED:21340684]
Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC) [NCBI:1309193] [REACTOME:R-HSA-5619107] [PUBMED:20001717] [PUBMED:20628519]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Disorders of transmembrane transporters [NCBI:1268932] [REACTOME:R-HSA-5619115] [PUBMED:16399363]
FOXA2 and FOXA3 transcription factor networks [NCBI:137911] [Pathway Interaction Database:hnf3bpathway] [PUBMED:14500912] [PUBMED:9632808] [PUBMED:8668179] [PUBMED:2786140] [PUBMED:10748140] [PUBMED:8662915] [PUBMED:12865419] [PUBMED:12145169] [PUBMED:15314688] [PUBMED:12911579] [PUBMED:15123725] [PUBMED:16098831] [PUBMED:10455192] [PUBMED:15616563] [PUBMED:7524494] [PUBMED:7565696] [PUBMED:15959514] [PUBMED:11278466] [PUBMED:9369482] [PUBMED:8813720]
Galactose metabolism [NCBI:82931] [KEGG:hsa00052]
Glucagon signaling pathway [NCBI:1144996] [KEGG:hsa04922] [PUBMED:20735177] [PUBMED:19912989] [PUBMED:21941300] [PUBMED:22249520] [PUBMED:12626323] [PUBMED:16601267] [PUBMED:18669612] [PUBMED:24393785] [PUBMED:21346730] [PUBMED:22550228] [PUBMED:16479585] [PUBMED:24692138] [PUBMED:22495310] [PUBMED:22796337] [PUBMED:22004992] [PUBMED:24238363] [PUBMED:22503562]
Glucose metabolism [NCBI:1269959] [REACTOME:R-HSA-70326]
Glucose transport [NCBI:1269921] [REACTOME:R-HSA-70153] [PUBMED:11780753]
Glycolysis [NCBI:1269960] [REACTOME:R-HSA-70171] [PUBMED:16051738]
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [NCBI:413340] [KEGG:hsa_M00001]
Glycolysis / Gluconeogenesis [NCBI:82926] [KEGG:hsa00010]
HIF-1-alpha transcription factor network [NCBI:138045] [Pathway Interaction Database:hif1_tfpathway] [PUBMED:11707426] [PUBMED:9242677] [PUBMED:9038135] [PUBMED:15310764] [PUBMED:11278891] [PUBMED:8816435] [PUBMED:8663540] [PUBMED:15235127] [PUBMED:12042299] [PUBMED:15312748] [PUBMED:14612449] [PUBMED:11342587] [PUBMED:12615703] [PUBMED:9632793] [PUBMED:12228247] [PUBMED:15044468] [PUBMED:8408001] [PUBMED:9822602] [PUBMED:15252039] [PUBMED:13679920] [PUBMED:11877282] [PUBMED:15235597] [PUBMED:15199161] [PUBMED:15104534] [PUBMED:10594042] [PUBMED:12354771] [PUBMED:10446188] [PUBMED:9436976] [PUBMED:11823643] [PUBMED:12370277] [PUBMED:8955077] [PUBMED:12879018] [PUBMED:14645546] [PUBMED:9486205] [PUBMED:9887100] [PUBMED:8089148] [PUBMED:15466858] [PUBMED:11708773] [PUBMED:15611046] [PUBMED:14742449] [PUBMED:15280364] [PUBMED:12215445] [PUBMED:15611089] [PUBMED:10777486] [PUBMED:9707622] [PUBMED:8917528] [PUBMED:15563275] [PUBMED:12067980] [PUBMED:10353251]
Hexose transport [NCBI:1269920] [REACTOME:R-HSA-189200] [PUBMED:16186415] [PUBMED:15546855]
Insulin secretion [NCBI:777534] [KEGG:hsa04911] [PUBMED:9715374] [PUBMED:10605628] [PUBMED:9914469] [PUBMED:17306374] [PUBMED:20055708] [PUBMED:15655710] [PUBMED:19817784] [PUBMED:19074620] [PUBMED:14693691] [PUBMED:17084085] [PUBMED:20551594] [PUBMED:19036624] [PUBMED:22970724] [PUBMED:20225132] [PUBMED:19817800] [PUBMED:22974438] [PUBMED:21934040] [PUBMED:15271645] [PUBMED:19660440] [PUBMED:11522660]
Insulin signaling pathway [NCBI:83090] [KEGG:hsa04910] [PUBMED:11742412] [PUBMED:11343120] [PUBMED:15733744] [PUBMED:11282018] [PUBMED:10196204] [PUBMED:18291668] [PUBMED:9609110] [PUBMED:10567225] [PUBMED:12791379] [PUBMED:9748166] [PUBMED:15624019] [PUBMED:9445476] [PUBMED:9346240] [PUBMED:14635525] [PUBMED:16288289] [PUBMED:12867054] [PUBMED:15229476] [PUBMED:17344645] [PUBMED:9609111]
Maturity onset diabetes of the young [NCBI:83096] [KEGG:hsa04950] [PUBMED:14614204] [PUBMED:15604203] [PUBMED:15028942] [PUBMED:15298336]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of carbohydrates [NCBI:1269957] [REACTOME:R-HSA-71387]
Neomycin, kanamycin and gentamicin biosynthesis [NCBI:145809] [KEGG:hsa00524] [PUBMED:17462573] [PUBMED:23179168] [PUBMED:15975512] [PUBMED:17226887] [PUBMED:19644520] [PUBMED:27120352] [PUBMED:17879343] [PUBMED:16506694] [PUBMED:25600434] [PUBMED:18685777] [PUBMED:18550838] [PUBMED:23679096] [PUBMED:21983602] [PUBMED:19362652] [PUBMED:12374384] [PUBMED:18311744] [PUBMED:21689223] [PUBMED:18001019] [PUBMED:19466609] [PUBMED:26083124] [PUBMED:26455715] [PUBMED:17482823] [PUBMED:18802637] [PUBMED:18672902] [PUBMED:25641167] [PUBMED:12870817] [PUBMED:15839685] [PUBMED:24746560] [PUBMED:17119636]
Nucleotide sugar biosynthesis, glucose => UDP-glucose [NCBI:664436] [KEGG:hsa_M00549]
Prolactin signaling pathway [NCBI:814182] [KEGG:hsa04917] [PUBMED:17519353] [PUBMED:17535875] [PUBMED:20149678] [PUBMED:12670737] [PUBMED:17307904] [PUBMED:18601698] [PUBMED:17975019] [PUBMED:16231422] [PUBMED:18219564] [PUBMED:9475379] [PUBMED:16677418] [PUBMED:9626554] [PUBMED:21664429] [PUBMED:11606470]
Regulation of Glucokinase by Glucokinase Regulatory Protein [NCBI:1269922] [REACTOME:R-HSA-170822] [PUBMED:14627435] [PUBMED:10601273]
Regulation of beta-cell development [NCBI:1270337] [REACTOME:R-HSA-186712] [PUBMED:15298336] [PUBMED:18094957] [PUBMED:11575290] [PUBMED:12591178]
Regulation of gene expression in beta cells [NCBI:1270341] [REACTOME:R-HSA-210745] [PUBMED:12591178] [PUBMED:15298336]
SLC transporter disorders [NCBI:1309123] [REACTOME:R-HSA-5619102] [PUBMED:23506860]
SLC-mediated transmembrane transport [NCBI:1269907] [REACTOME:R-HSA-425407] [PUBMED:14624363] [PUBMED:19164095]
Starch and sucrose metabolism [NCBI:82974] [KEGG:hsa00500]
Transmembrane transport of small molecules [NCBI:1269903] [REACTOME:R-HSA-382551]
Type II diabetes mellitus [NCBI:83094] [KEGG:hsa04930] [PUBMED:12480546] [PUBMED:15759102] [PUBMED:9011569] [PUBMED:11078440] [PUBMED:11390407] [PUBMED:15258147] [PUBMED:15823385] [PUBMED:11272200] [PUBMED:11325516] [PUBMED:15733744] [PUBMED:9974390] [PUBMED:7491105] [PUBMED:15585596]