full name
oxoglutarate dehydrogenase

synonyms
AKGDH, E1k, OGDC, OGDH, ENSG00000105953

HGNC
HGNC:8124

Entrez Gene
Gene:4967

ENSEMBL
ENSG00000105953

location
chr: 7
start: 44646104
stop: 44748669
strand: +

OMIM
OMIM:613022: OGDH (Autosomal recessive inheritance)
OMIM:203740: Alpha-ketoglutarate dehydrogenase deficiency

transcripts
NM_001165036.1
NM_002541.3
NM_001003941.2

pathways
2-oxoglutarate decarboxylation to succinyl-CoA [NCBI:142336] [BIOCYC:HUMAN_PWY-5084] [PUBMED:9655933]
Carbon metabolism [NCBI:814926] [KEGG:hsa01200]
Citrate cycle (TCA cycle) [NCBI:82927] [KEGG:hsa00020]
Citrate cycle (TCA cycle, Krebs cycle) [NCBI:855811] [KEGG:hsa_M00009]
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [NCBI:413348] [KEGG:hsa_M00011]
Citric acid cycle (TCA cycle) [NCBI:1270125] [REACTOME:R-HSA-71403] [PUBMED:16746585] [PUBMED:16747180] [PUBMED:6773467]
Glyoxylate metabolism and glycine degradation [NCBI:1270180] [REACTOME:R-HSA-389661] [PUBMED:15956068]
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism [NCBI:1309221] [REACTOME:R-HSA-6788656]
Lysine catabolism [NCBI:1270163] [REACTOME:R-HSA-71064] [PUBMED:6434529] [PUBMED:12126930]
Lysine degradation [NCBI:82956] [KEGG:hsa00310] [PUBMED:11802770] [PUBMED:1682209]
Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [NCBI:413352] [KEGG:hsa_M00032]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of amino acids and derivatives [NCBI:1270158] [REACTOME:R-HSA-71291]
Pyruvate metabolism and Citric Acid (TCA) cycle [NCBI:1270122] [REACTOME:R-HSA-71406]
TCA cycle [NCBI:782397] [BIOCYC:HUMAN_PWY66-398] [PUBMED:16746585] [PUBMED:20167786] [PUBMED:16746397] [PUBMED:15234968] [PUBMED:2198251] [PUBMED:16747930]
The citric acid (TCA) cycle and respiratory electron transport [NCBI:1270121] [REACTOME:R-HSA-1428517]
Tryptophan metabolism [NCBI:82964] [KEGG:hsa00380] [PUBMED:15749753]
superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle [NCBI:835393] [BIOCYC:HUMAN_PWY66-407]