full name
dopa decarboxylase

synonyms
AADC, DDC, ENSG00000132437

HGNC
HGNC:2719

Entrez Gene
Gene:1644

ENSEMBL
ENSG00000132437

location
chr: 7
start: 50526134
stop: 50633154
strand: -

OMIM
OMIM:107930: DDC (Autosomal recessive inheritance)
OMIM:608643: Aromatic L-amino acid decarboxylase deficiency

transcripts
ENST00000444124.2
ENST00000426377.1
ENST00000431062.1
ENST00000357936.5
ENST00000380984.4

pathways
Alcoholism [NCBI:585563] [KEGG:hsa05034] [PUBMED:16764827] [PUBMED:18616668] [PUBMED:19077056] [PUBMED:18991950] [PUBMED:19756388] [PUBMED:12068305] [PUBMED:16102840] [PUBMED:20947635] [PUBMED:20729980] [PUBMED:16278489] [PUBMED:17270154] [PUBMED:20626732] [PUBMED:18310464] [PUBMED:10774721] [PUBMED:19342616] [PUBMED:12605085] [PUBMED:15500908] [PUBMED:14729391] [PUBMED:12085089] [PUBMED:16776597]
Amine-derived hormones [NCBI:1270175] [REACTOME:R-HSA-209776] [PUBMED:10691773] [PUBMED:3297964] [PUBMED:16942634]
Amphetamine addiction [NCBI:547607] [KEGG:hsa05031] [PUBMED:16776597] [PUBMED:18617632] [PUBMED:16724157] [PUBMED:19222557] [PUBMED:14746512] [PUBMED:18632938] [PUBMED:8630246] [PUBMED:14622123] [PUBMED:21338876] [PUBMED:8753884] [PUBMED:10774721] [PUBMED:14529709] [PUBMED:17728700] [PUBMED:21989194] [PUBMED:16151049] [PUBMED:18440072] [PUBMED:19199083] [PUBMED:10414964]
Catecholamine biosynthesis [NCBI:1270176] [REACTOME:R-HSA-209905] [PUBMED:1684650] [PUBMED:363400] [PUBMED:10691773]
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [NCBI:413357] [KEGG:hsa_M00042]
Cocaine addiction [NCBI:546258] [KEGG:hsa05030] [PUBMED:15091342] [PUBMED:16278489] [PUBMED:14566342] [PUBMED:12064476] [PUBMED:16251986] [PUBMED:18440072] [PUBMED:19403004] [PUBMED:11595774] [PUBMED:11268215] [PUBMED:15582154] [PUBMED:12818179] [PUBMED:14746512] [PUBMED:10234039]
Dopaminergic synapse [NCBI:469199] [KEGG:hsa04728] [PUBMED:20727368] [PUBMED:10433257] [PUBMED:17408758] [PUBMED:15292232] [PUBMED:9457173] [PUBMED:17349698] [PUBMED:15521361] [PUBMED:18353279] [PUBMED:21303898] [PUBMED:19251795] [PUBMED:15381316] [PUBMED:15590733] [PUBMED:20224735] [PUBMED:19138563] [PUBMED:12967774]
Histidine metabolism [NCBI:82958] [KEGG:hsa00340]
Melatonin biosynthesis, tryptophan => serotonin => melatonin [NCBI:413355] [KEGG:hsa_M00037]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of amino acids and derivatives [NCBI:1270158] [REACTOME:R-HSA-71291]
Phenylalanine metabolism [NCBI:82960] [KEGG:hsa00360] [PUBMED:19016485] [PUBMED:10537203] [PUBMED:20660314] [PUBMED:9098055] [PUBMED:9603882]
Serotonergic synapse [NCBI:525336] [KEGG:hsa04726] [PUBMED:9658404] [PUBMED:15034221] [PUBMED:11043573] [PUBMED:9651340] [PUBMED:9542727] [PUBMED:18676031] [PUBMED:12543273] [PUBMED:15710402] [PUBMED:16826372] [PUBMED:19545642] [PUBMED:11916537] [PUBMED:11701344] [PUBMED:12676358] [PUBMED:20561690] [PUBMED:16896947]
Serotonin and melatonin biosynthesis [NCBI:1270179] [REACTOME:R-HSA-209931] [PUBMED:18155917] [PUBMED:16942634]
Tryptophan metabolism [NCBI:82964] [KEGG:hsa00380] [PUBMED:15749753]
Tyrosine metabolism [NCBI:82959] [KEGG:hsa00350] [PUBMED:8550403] [PUBMED:1194238] [PUBMED:11171088] [PUBMED:18435614]
catecholamine biosynthesis [NCBI:142238] [BIOCYC:HUMAN_PWY66-301] [PUBMED:14216443] [PUBMED:7487868] [PUBMED:13667411] [PUBMED:14416204] [PUBMED:5836553]
serotonin and melatonin biosynthesis [NCBI:545297] [BIOCYC:HUMAN_PWY-6030] [PUBMED:12379098] [PUBMED:9238858] [PUBMED:19630576] [PUBMED:21517957] [PUBMED:16615082] [PUBMED:18516223] [PUBMED:9674691] [PUBMED:20478436] [PUBMED:1540578]
superpathway of tryptophan utilization [NCBI:835392] [BIOCYC:HUMAN_PWY66-401]
tryptophan degradation via tryptamine [NCBI:545342] [BIOCYC:HUMAN_PWY-6307] [PUBMED:9291104] [PUBMED:16942634] [PUBMED:18282734] [PUBMED:12538805] [PUBMED:3689382] [PUBMED:3373215] [PUBMED:15018833] [PUBMED:4146452] [PUBMED:8098507]