Logo
full name
replication factor C subunit 2

synonyms
RFC40, RFC2, ENSG00000049541

HGNC
HGNC:9970

Entrez Gene
Gene:5982

ENSEMBL
ENSG00000049541
ENSG00000261911

location
chr: 7
start: 73645832
stop: 73668788
strand: -

transcripts
NM_001278792.1
NM_002914.4
NM_181471.2
NM_001278793.1
NM_001278791.1

pathways
Activation of ATR in response to replication stress [NCBI:1269757] [REACTOME:R-HSA-176187] [PUBMED:12791985]
Base Excision Repair [NCBI:1270351] [REACTOME:R-HSA-73884] [PUBMED:11937636] [PUBMED:10583946]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints [NCBI:1269742] [REACTOME:R-HSA-69620]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Chromosome Maintenance [NCBI:1269853] [REACTOME:R-HSA-73886]
DNA Damage Bypass [NCBI:1270367] [REACTOME:R-HSA-73893] [PUBMED:21605556] [PUBMED:10925197] [PUBMED:11595180] [PUBMED:12800216] [PUBMED:19225445] [PUBMED:25038291]
DNA Double-Strand Break Repair [NCBI:1309095] [REACTOME:R-HSA-5693532] [PUBMED:12897142] [PUBMED:20965415]
DNA Repair [NCBI:1270350] [REACTOME:R-HSA-73894] [PUBMED:10583946] [PUBMED:23175119]
DNA Replication [NCBI:1269875] [REACTOME:R-HSA-69306] [PUBMED:11257218] [PUBMED:12045100] [PUBMED:1536007] [PUBMED:10966477] [PUBMED:1579437] [PUBMED:8223461]
DNA replication [NCBI:83039] [KEGG:hsa03030] [PUBMED:9759502] [PUBMED:8087839]
DNA strand elongation [NCBI:1269784] [REACTOME:R-HSA-69190] [PUBMED:9081985] [PUBMED:1976634] [PUBMED:7623835] [PUBMED:1536007] [PUBMED:8594377]
Dual Incision in GG-NER [NCBI:1309115] [REACTOME:R-HSA-5696400] [PUBMED:19279666]
Dual incision in TC-NER [NCBI:1309119] [REACTOME:R-HSA-6782135] [PUBMED:19279666] [PUBMED:23906714] [PUBMED:8078911] [PUBMED:16246722] [PUBMED:19023283] [PUBMED:11904382] [PUBMED:24402227]
Extension of Telomeres [NCBI:1269857] [REACTOME:R-HSA-180786] [PUBMED:15189140]
G2/M Checkpoints [NCBI:1269753] [REACTOME:R-HSA-69481]
G2/M DNA damage checkpoint [NCBI:1269754] [REACTOME:R-HSA-69473]
Gap-filling DNA repair synthesis and ligation in GG-NER [NCBI:1309116] [REACTOME:R-HSA-5696397] [PUBMED:17643379] [PUBMED:19279666] [PUBMED:20227374]
Gap-filling DNA repair synthesis and ligation in TC-NER [NCBI:1309120] [REACTOME:R-HSA-6782210] [PUBMED:20227374] [PUBMED:19279666] [PUBMED:17643379]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
Global Genome Nucleotide Excision Repair (GG-NER) [NCBI:1309112] [REACTOME:R-HSA-5696399] [PUBMED:24954209]
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) [NCBI:1309100] [REACTOME:R-HSA-5693567] [PUBMED:20965415]
HDR through Homologous Recombination (HRR) [NCBI:1309102] [REACTOME:R-HSA-5685942] [PUBMED:20965415]
HDR through Single Strand Annealing (SSA) [NCBI:1309108] [REACTOME:R-HSA-5685938] [PUBMED:12791985] [PUBMED:17962301] [PUBMED:25122754] [PUBMED:21804533] [PUBMED:12139939] [PUBMED:10212258] [PUBMED:10921897] [PUBMED:19357644] [PUBMED:21240188] [PUBMED:21325134] [PUBMED:9837724] [PUBMED:15485900] [PUBMED:17928296] [PUBMED:18539610] [PUBMED:12370410] [PUBMED:17965729] [PUBMED:22977173] [PUBMED:14734547] [PUBMED:21052091]
Homologous DNA Pairing and Strand Exchange [NCBI:1309103] [REACTOME:R-HSA-5693579] [PUBMED:9880493] [PUBMED:17996710] [PUBMED:12912992] [PUBMED:19369211] [PUBMED:19268590] [PUBMED:17996711] [PUBMED:24141787] [PUBMED:20871615] [PUBMED:20965415] [PUBMED:20871616] [PUBMED:23149936]
Homology Directed Repair [NCBI:1309099] [REACTOME:R-HSA-5693538] [PUBMED:11242102] [PUBMED:20965415] [PUBMED:11376695] [PUBMED:12427531]
Lagging Strand Synthesis [NCBI:1269788] [REACTOME:R-HSA-69186] [PUBMED:9081985]
Leading Strand Synthesis [NCBI:1269786] [REACTOME:R-HSA-69109] [PUBMED:2175912] [PUBMED:7378348] [PUBMED:9191022]
Mismatch repair [NCBI:83045] [KEGG:hsa03430] [PUBMED:11436301] [PUBMED:18157157] [PUBMED:16612326] [PUBMED:11920679]
Nucleotide Excision Repair [NCBI:1309111] [REACTOME:R-HSA-5696398] [PUBMED:11900249] [PUBMED:23906714] [PUBMED:14599765] [PUBMED:10583946] [PUBMED:24954209] [PUBMED:19023283]
Nucleotide excision repair [NCBI:83044] [KEGG:hsa03420] [PUBMED:11436323] [PUBMED:18018633] [PUBMED:11436316] [PUBMED:17884153] [PUBMED:11436314] [PUBMED:17276014] [PUBMED:16922398]
PCNA-Dependent Long Patch Base Excision Repair [NCBI:1270366] [REACTOME:R-HSA-5651801] [PUBMED:9780000] [PUBMED:11601988] [PUBMED:9214649] [PUBMED:12200445] [PUBMED:10460157] [PUBMED:10559261] [PUBMED:11250913]
Polymerase switching [NCBI:1269787] [REACTOME:R-HSA-69091] [PUBMED:1967833] [PUBMED:1671046] [PUBMED:1670772]
Polymerase switching on the C-strand of the telomere [NCBI:1269861] [REACTOME:R-HSA-174411] [PUBMED:1967833] [PUBMED:1671046] [PUBMED:1670772]
Presynaptic phase of homologous DNA pairing and strand exchange [NCBI:1309104] [REACTOME:R-HSA-5693616] [PUBMED:20729858] [PUBMED:15665856] [PUBMED:20729832] [PUBMED:23149936] [PUBMED:23810717] [PUBMED:15703751] [PUBMED:18317453] [PUBMED:20729859] [PUBMED:11751635]
Processing of DNA double-strand break ends [NCBI:1309101] [REACTOME:R-HSA-5693607] [PUBMED:25122754] [PUBMED:18171670] [PUBMED:20965415] [PUBMED:22231403] [PUBMED:25558984] [PUBMED:19357644] [PUBMED:21325134] [PUBMED:21240188] [PUBMED:21659603] [PUBMED:23468639] [PUBMED:25659039]
Recognition of DNA damage by PCNA-containing replication complex [NCBI:1270368] [REACTOME:R-HSA-110314] [PUBMED:15916957] [PUBMED:12226657]
Regulation of TP53 Activity [NCBI:1383076] [REACTOME:R-HSA-5633007] [PUBMED:19450511] [PUBMED:20457558] [PUBMED:23825024] [PUBMED:25641576]
Regulation of TP53 Activity through Phosphorylation [NCBI:1383080] [REACTOME:R-HSA-6804756] [PUBMED:11780126] [PUBMED:21317932] [PUBMED:15866171] [PUBMED:12393879] [PUBMED:11740489] [PUBMED:11447225] [PUBMED:9733515] [PUBMED:12851404] [PUBMED:10884347] [PUBMED:10710310] [PUBMED:11239457] [PUBMED:9925639] [PUBMED:11546806] [PUBMED:11551930] [PUBMED:10570149] [PUBMED:18490454] [PUBMED:17591690] [PUBMED:19965871] [PUBMED:12064478] [PUBMED:10673501] [PUBMED:22611192] [PUBMED:9843217] [PUBMED:15053879] [PUBMED:12914926] [PUBMED:10673500] [PUBMED:17349958] [PUBMED:14702041] [PUBMED:20959462] [PUBMED:10435622] [PUBMED:9733514]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway [NCBI:1270364] [REACTOME:R-HSA-110373] [PUBMED:10583946] [PUBMED:9214649] [PUBMED:10559261] [PUBMED:10460157] [PUBMED:11440997] [PUBMED:11601988]
Resolution of Abasic Sites (AP sites) [NCBI:1270359] [REACTOME:R-HSA-73933] [PUBMED:11601988] [PUBMED:15260972] [PUBMED:17395641] [PUBMED:19329425] [PUBMED:9804798] [PUBMED:15556996] [PUBMED:9214649] [PUBMED:7608159] [PUBMED:11440997] [PUBMED:15871698] [PUBMED:9207062] [PUBMED:16982218] [PUBMED:8978692]
S Phase [NCBI:1269777] [REACTOME:R-HSA-69242]
Synthesis of DNA [NCBI:1269779] [REACTOME:R-HSA-69239]
Telomere C-strand (Lagging Strand) Synthesis [NCBI:1269859] [REACTOME:R-HSA-174417] [PUBMED:15189140]
Telomere Maintenance [NCBI:1269856] [REACTOME:R-HSA-157579] [PUBMED:16166375] [PUBMED:4507727] [PUBMED:14685173] [PUBMED:642006] [PUBMED:15189140] [PUBMED:3907856] [PUBMED:2463488] [PUBMED:4754905]
Termination of translesion DNA synthesis [NCBI:1270374] [REACTOME:R-HSA-5656169] [PUBMED:24768535] [PUBMED:23000965]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) [NCBI:1309117] [REACTOME:R-HSA-6781827] [PUBMED:24954209] [PUBMED:11823795] [PUBMED:19023283] [PUBMED:23906714] [PUBMED:3466163]
Transcriptional Regulation by TP53 [NCBI:1269654] [REACTOME:R-HSA-3700989] [PUBMED:26122615] [PUBMED:19410540]
Translesion Synthesis by POLH [NCBI:1270371] [REACTOME:R-HSA-110320] [PUBMED:10369688] [PUBMED:10856253]
Translesion synthesis by POLI [NCBI:1270373] [REACTOME:R-HSA-5656121] [PUBMED:10984059] [PUBMED:15254543] [PUBMED:20159559] [PUBMED:15657443] [PUBMED:23143872] [PUBMED:15189446] [PUBMED:14657033] [PUBMED:16357261] [PUBMED:16819516] [PUBMED:18242152]
Translesion synthesis by POLK [NCBI:1270372] [REACTOME:R-HSA-5655862] [PUBMED:12444249] [PUBMED:11006276] [PUBMED:12145297] [PUBMED:15475561] [PUBMED:11058110] [PUBMED:22772988] [PUBMED:22721435] [PUBMED:11784855] [PUBMED:24648516] [PUBMED:20660785] [PUBMED:19492058] [PUBMED:19170759]
Translesion synthesis by REV1 [NCBI:1270370] [REACTOME:R-HSA-110312] [PUBMED:19153606] [PUBMED:10760286] [PUBMED:8658138] [PUBMED:22859296] [PUBMED:17517887] [PUBMED:16344468] [PUBMED:10536157] [PUBMED:24449906] [PUBMED:20164194] [PUBMED:23143872]
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template [NCBI:1270369] [REACTOME:R-HSA-110313] [PUBMED:10583946] [PUBMED:10856253] [PUBMED:24716551]