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Genes
RFC2
Gene - RFC2
full name
replication factor C subunit 2
synonyms
RFC40, RFC2, ENSG00000049541
HGNC
HGNC:9970
Entrez Gene
Gene:5982
ENSEMBL
ENSG00000049541
ENSG00000261911
location
chr: 7
start: 73645832
stop: 73668788
strand: -
transcripts
NM_001278792.1
NM_002914.4
NM_181471.2
NM_001278793.1
NM_001278791.1
pathways
Activation of ATR in response to replication stress
[NCBI:1269757]
[REACTOME:R-HSA-176187]
[PUBMED:12791985]
Base Excision Repair
[NCBI:1270351]
[REACTOME:R-HSA-73884]
[PUBMED:11937636]
[PUBMED:10583946]
Cell Cycle
[NCBI:1269741]
[REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints
[NCBI:1269742]
[REACTOME:R-HSA-69620]
Cell Cycle, Mitotic
[NCBI:1269763]
[REACTOME:R-HSA-69278]
Chromosome Maintenance
[NCBI:1269853]
[REACTOME:R-HSA-73886]
DNA Damage Bypass
[NCBI:1270367]
[REACTOME:R-HSA-73893]
[PUBMED:21605556]
[PUBMED:10925197]
[PUBMED:11595180]
[PUBMED:12800216]
[PUBMED:19225445]
[PUBMED:25038291]
DNA Double-Strand Break Repair
[NCBI:1309095]
[REACTOME:R-HSA-5693532]
[PUBMED:12897142]
[PUBMED:20965415]
DNA Repair
[NCBI:1270350]
[REACTOME:R-HSA-73894]
[PUBMED:10583946]
[PUBMED:23175119]
DNA Replication
[NCBI:1269875]
[REACTOME:R-HSA-69306]
[PUBMED:11257218]
[PUBMED:12045100]
[PUBMED:1536007]
[PUBMED:10966477]
[PUBMED:1579437]
[PUBMED:8223461]
DNA replication
[NCBI:83039]
[KEGG:hsa03030]
[PUBMED:9759502]
[PUBMED:8087839]
DNA strand elongation
[NCBI:1269784]
[REACTOME:R-HSA-69190]
[PUBMED:9081985]
[PUBMED:1976634]
[PUBMED:7623835]
[PUBMED:1536007]
[PUBMED:8594377]
Dual Incision in GG-NER
[NCBI:1309115]
[REACTOME:R-HSA-5696400]
[PUBMED:19279666]
Dual incision in TC-NER
[NCBI:1309119]
[REACTOME:R-HSA-6782135]
[PUBMED:19279666]
[PUBMED:23906714]
[PUBMED:8078911]
[PUBMED:16246722]
[PUBMED:19023283]
[PUBMED:11904382]
[PUBMED:24402227]
Extension of Telomeres
[NCBI:1269857]
[REACTOME:R-HSA-180786]
[PUBMED:15189140]
G2/M Checkpoints
[NCBI:1269753]
[REACTOME:R-HSA-69481]
G2/M DNA damage checkpoint
[NCBI:1269754]
[REACTOME:R-HSA-69473]
Gap-filling DNA repair synthesis and ligation in GG-NER
[NCBI:1309116]
[REACTOME:R-HSA-5696397]
[PUBMED:17643379]
[PUBMED:19279666]
[PUBMED:20227374]
Gap-filling DNA repair synthesis and ligation in TC-NER
[NCBI:1309120]
[REACTOME:R-HSA-6782210]
[PUBMED:20227374]
[PUBMED:19279666]
[PUBMED:17643379]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
Global Genome Nucleotide Excision Repair (GG-NER)
[NCBI:1309112]
[REACTOME:R-HSA-5696399]
[PUBMED:24954209]
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
[NCBI:1309100]
[REACTOME:R-HSA-5693567]
[PUBMED:20965415]
HDR through Homologous Recombination (HRR)
[NCBI:1309102]
[REACTOME:R-HSA-5685942]
[PUBMED:20965415]
HDR through Single Strand Annealing (SSA)
[NCBI:1309108]
[REACTOME:R-HSA-5685938]
[PUBMED:12791985]
[PUBMED:17962301]
[PUBMED:25122754]
[PUBMED:21804533]
[PUBMED:12139939]
[PUBMED:10212258]
[PUBMED:10921897]
[PUBMED:19357644]
[PUBMED:21240188]
[PUBMED:21325134]
[PUBMED:9837724]
[PUBMED:15485900]
[PUBMED:17928296]
[PUBMED:18539610]
[PUBMED:12370410]
[PUBMED:17965729]
[PUBMED:22977173]
[PUBMED:14734547]
[PUBMED:21052091]
Homologous DNA Pairing and Strand Exchange
[NCBI:1309103]
[REACTOME:R-HSA-5693579]
[PUBMED:9880493]
[PUBMED:17996710]
[PUBMED:12912992]
[PUBMED:19369211]
[PUBMED:19268590]
[PUBMED:17996711]
[PUBMED:24141787]
[PUBMED:20871615]
[PUBMED:20965415]
[PUBMED:20871616]
[PUBMED:23149936]
Homology Directed Repair
[NCBI:1309099]
[REACTOME:R-HSA-5693538]
[PUBMED:11242102]
[PUBMED:20965415]
[PUBMED:11376695]
[PUBMED:12427531]
Lagging Strand Synthesis
[NCBI:1269788]
[REACTOME:R-HSA-69186]
[PUBMED:9081985]
Leading Strand Synthesis
[NCBI:1269786]
[REACTOME:R-HSA-69109]
[PUBMED:2175912]
[PUBMED:7378348]
[PUBMED:9191022]
Mismatch repair
[NCBI:83045]
[KEGG:hsa03430]
[PUBMED:11436301]
[PUBMED:18157157]
[PUBMED:16612326]
[PUBMED:11920679]
Nucleotide Excision Repair
[NCBI:1309111]
[REACTOME:R-HSA-5696398]
[PUBMED:11900249]
[PUBMED:23906714]
[PUBMED:14599765]
[PUBMED:10583946]
[PUBMED:24954209]
[PUBMED:19023283]
Nucleotide excision repair
[NCBI:83044]
[KEGG:hsa03420]
[PUBMED:11436323]
[PUBMED:18018633]
[PUBMED:11436316]
[PUBMED:17884153]
[PUBMED:11436314]
[PUBMED:17276014]
[PUBMED:16922398]
PCNA-Dependent Long Patch Base Excision Repair
[NCBI:1270366]
[REACTOME:R-HSA-5651801]
[PUBMED:9780000]
[PUBMED:11601988]
[PUBMED:9214649]
[PUBMED:12200445]
[PUBMED:10460157]
[PUBMED:10559261]
[PUBMED:11250913]
Polymerase switching
[NCBI:1269787]
[REACTOME:R-HSA-69091]
[PUBMED:1967833]
[PUBMED:1671046]
[PUBMED:1670772]
Polymerase switching on the C-strand of the telomere
[NCBI:1269861]
[REACTOME:R-HSA-174411]
[PUBMED:1967833]
[PUBMED:1671046]
[PUBMED:1670772]
Presynaptic phase of homologous DNA pairing and strand exchange
[NCBI:1309104]
[REACTOME:R-HSA-5693616]
[PUBMED:20729858]
[PUBMED:15665856]
[PUBMED:20729832]
[PUBMED:23149936]
[PUBMED:23810717]
[PUBMED:15703751]
[PUBMED:18317453]
[PUBMED:20729859]
[PUBMED:11751635]
Processing of DNA double-strand break ends
[NCBI:1309101]
[REACTOME:R-HSA-5693607]
[PUBMED:25122754]
[PUBMED:18171670]
[PUBMED:20965415]
[PUBMED:22231403]
[PUBMED:25558984]
[PUBMED:19357644]
[PUBMED:21325134]
[PUBMED:21240188]
[PUBMED:21659603]
[PUBMED:23468639]
[PUBMED:25659039]
Recognition of DNA damage by PCNA-containing replication complex
[NCBI:1270368]
[REACTOME:R-HSA-110314]
[PUBMED:15916957]
[PUBMED:12226657]
Regulation of TP53 Activity
[NCBI:1383076]
[REACTOME:R-HSA-5633007]
[PUBMED:19450511]
[PUBMED:20457558]
[PUBMED:23825024]
[PUBMED:25641576]
Regulation of TP53 Activity through Phosphorylation
[NCBI:1383080]
[REACTOME:R-HSA-6804756]
[PUBMED:11780126]
[PUBMED:21317932]
[PUBMED:15866171]
[PUBMED:12393879]
[PUBMED:11740489]
[PUBMED:11447225]
[PUBMED:9733515]
[PUBMED:12851404]
[PUBMED:10884347]
[PUBMED:10710310]
[PUBMED:11239457]
[PUBMED:9925639]
[PUBMED:11546806]
[PUBMED:11551930]
[PUBMED:10570149]
[PUBMED:18490454]
[PUBMED:17591690]
[PUBMED:19965871]
[PUBMED:12064478]
[PUBMED:10673501]
[PUBMED:22611192]
[PUBMED:9843217]
[PUBMED:15053879]
[PUBMED:12914926]
[PUBMED:10673500]
[PUBMED:17349958]
[PUBMED:14702041]
[PUBMED:20959462]
[PUBMED:10435622]
[PUBMED:9733514]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
[NCBI:1270364]
[REACTOME:R-HSA-110373]
[PUBMED:10583946]
[PUBMED:9214649]
[PUBMED:10559261]
[PUBMED:10460157]
[PUBMED:11440997]
[PUBMED:11601988]
Resolution of Abasic Sites (AP sites)
[NCBI:1270359]
[REACTOME:R-HSA-73933]
[PUBMED:11601988]
[PUBMED:15260972]
[PUBMED:17395641]
[PUBMED:19329425]
[PUBMED:9804798]
[PUBMED:15556996]
[PUBMED:9214649]
[PUBMED:7608159]
[PUBMED:11440997]
[PUBMED:15871698]
[PUBMED:9207062]
[PUBMED:16982218]
[PUBMED:8978692]
S Phase
[NCBI:1269777]
[REACTOME:R-HSA-69242]
Synthesis of DNA
[NCBI:1269779]
[REACTOME:R-HSA-69239]
Telomere C-strand (Lagging Strand) Synthesis
[NCBI:1269859]
[REACTOME:R-HSA-174417]
[PUBMED:15189140]
Telomere Maintenance
[NCBI:1269856]
[REACTOME:R-HSA-157579]
[PUBMED:16166375]
[PUBMED:4507727]
[PUBMED:14685173]
[PUBMED:642006]
[PUBMED:15189140]
[PUBMED:3907856]
[PUBMED:2463488]
[PUBMED:4754905]
Termination of translesion DNA synthesis
[NCBI:1270374]
[REACTOME:R-HSA-5656169]
[PUBMED:24768535]
[PUBMED:23000965]
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
[NCBI:1309117]
[REACTOME:R-HSA-6781827]
[PUBMED:24954209]
[PUBMED:11823795]
[PUBMED:19023283]
[PUBMED:23906714]
[PUBMED:3466163]
Transcriptional Regulation by TP53
[NCBI:1269654]
[REACTOME:R-HSA-3700989]
[PUBMED:26122615]
[PUBMED:19410540]
Translesion Synthesis by POLH
[NCBI:1270371]
[REACTOME:R-HSA-110320]
[PUBMED:10369688]
[PUBMED:10856253]
Translesion synthesis by POLI
[NCBI:1270373]
[REACTOME:R-HSA-5656121]
[PUBMED:10984059]
[PUBMED:15254543]
[PUBMED:20159559]
[PUBMED:15657443]
[PUBMED:23143872]
[PUBMED:15189446]
[PUBMED:14657033]
[PUBMED:16357261]
[PUBMED:16819516]
[PUBMED:18242152]
Translesion synthesis by POLK
[NCBI:1270372]
[REACTOME:R-HSA-5655862]
[PUBMED:12444249]
[PUBMED:11006276]
[PUBMED:12145297]
[PUBMED:15475561]
[PUBMED:11058110]
[PUBMED:22772988]
[PUBMED:22721435]
[PUBMED:11784855]
[PUBMED:24648516]
[PUBMED:20660785]
[PUBMED:19492058]
[PUBMED:19170759]
Translesion synthesis by REV1
[NCBI:1270370]
[REACTOME:R-HSA-110312]
[PUBMED:19153606]
[PUBMED:10760286]
[PUBMED:8658138]
[PUBMED:22859296]
[PUBMED:17517887]
[PUBMED:16344468]
[PUBMED:10536157]
[PUBMED:24449906]
[PUBMED:20164194]
[PUBMED:23143872]
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
[NCBI:1270369]
[REACTOME:R-HSA-110313]
[PUBMED:10583946]
[PUBMED:10856253]
[PUBMED:24716551]