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Genes
NCF1
Gene - NCF1
full name
neutrophil cytosolic factor 1
synonyms
NCF1A, NOXO2, p47phox, SH3PXD1A, NCF1, ENSG00000158517
HGNC
HGNC:7660
Entrez Gene
Gene:653361
ENSEMBL
ENSG00000158517
ENSG00000261919
location
chr: 7
start: 74188309
stop: 74203720
strand: +
OMIM
OMIM:608512
: NCF1
(Autosomal recessive inheritance)
OMIM:233700
: Chronic granulomatous disease due to deficiency of NCF-1
transcripts
ENST00000289473.4
pathways
Adaptive Immune System
[NCBI:1269171]
[REACTOME:R-HSA-1280218]
[PUBMED:16551257]
[PUBMED:21682741]
[PUBMED:11861602]
Antigen processing-Cross presentation
[NCBI:1269195]
[REACTOME:R-HSA-1236975]
[PUBMED:17157489]
[PUBMED:20171863]
[PUBMED:16181333]
[PUBMED:15761154]
[PUBMED:16181335]
[PUBMED:19218463]
Cellular responses to stress
[NCBI:1270414]
[REACTOME:R-HSA-2262752]
[PUBMED:15709958]
Chemokine signaling pathway
[NCBI:99051]
[KEGG:hsa04062]
[PUBMED:17371236]
[PUBMED:19159344]
[PUBMED:17169327]
[PUBMED:10852130]
[PUBMED:9765254]
[PUBMED:15771581]
[PUBMED:14607270]
[PUBMED:18662984]
[PUBMED:12495636]
[PUBMED:15803148]
[PUBMED:15046611]
[PUBMED:12069927]
[PUBMED:18711432]
[PUBMED:17675482]
[PUBMED:16144840]
[PUBMED:17496928]
[PUBMED:17537990]
[PUBMED:11872087]
[PUBMED:12051620]
[PUBMED:14625285]
[PUBMED:8576262]
[PUBMED:11244042]
Class I MHC mediated antigen processing & presentation
[NCBI:1269192]
[REACTOME:R-HSA-983169]
[PUBMED:8717519]
[PUBMED:17145306]
[PUBMED:18926908]
[PUBMED:17055423]
[PUBMED:12495737]
[PUBMED:18641646]
[PUBMED:18243674]
Cross-presentation of particulate exogenous antigens (phagosomes)
[NCBI:1269196]
[REACTOME:R-HSA-1236973]
Detoxification of Reactive Oxygen Species
[NCBI:1270420]
[REACTOME:R-HSA-3299685]
[PUBMED:23469953]
[PUBMED:23268465]
[PUBMED:20064600]
[PUBMED:22286106]
[PUBMED:21473702]
[PUBMED:22196163]
[PUBMED:21375475]
[PUBMED:19061483]
[PUBMED:21453242]
Fc gamma R-mediated phagocytosis
[NCBI:114228]
[KEGG:hsa04666]
[PUBMED:11304556]
[PUBMED:11244038]
[PUBMED:10755615]
[PUBMED:17308335]
[PUBMED:12821647]
[PUBMED:15466916]
[PUBMED:17050193]
[PUBMED:11228151]
[PUBMED:12488490]
[PUBMED:10224668]
[PUBMED:11708889]
[PUBMED:9581795]
[PUBMED:10586078]
[PUBMED:9417101]
[PUBMED:15485887]
[PUBMED:18322649]
[PUBMED:10577498]
[PUBMED:10376013]
[PUBMED:10601359]
[PUBMED:9545263]
Fluid shear stress and atherosclerosis
[NCBI:1474302]
[KEGG:hsa05418]
[PUBMED:23429585]
[PUBMED:21050140]
[PUBMED:17599600]
[PUBMED:24190880]
[PUBMED:22003002]
[PUBMED:24876354]
[PUBMED:24947523]
[PUBMED:23899566]
[PUBMED:26597822]
[PUBMED:20353494]
[PUBMED:22076424]
[PUBMED:20538799]
[PUBMED:25165867]
[PUBMED:20032497]
[PUBMED:23084990]
[PUBMED:26822720]
[PUBMED:24573382]
[PUBMED:23555159]
[PUBMED:26212910]
[PUBMED:21457103]
[PUBMED:19151844]
[PUBMED:15388638]
[PUBMED:16765337]
[PUBMED:27027326]
[PUBMED:25638487]
[PUBMED:21733876]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Leishmaniasis
[NCBI:144181]
[KEGG:hsa05140]
[PUBMED:11890722]
[PUBMED:7916951]
[PUBMED:10417174]
[PUBMED:11298294]
[PUBMED:10586030]
[PUBMED:15322192]
[PUBMED:15831826]
[PUBMED:11728310]
[PUBMED:15039466]
[PUBMED:10462516]
[PUBMED:10608501]
[PUBMED:15721837]
[PUBMED:15639739]
[PUBMED:14762510]
[PUBMED:18793215]
[PUBMED:7591091]
[PUBMED:12438359]
[PUBMED:18070909]
[PUBMED:17543969]
[PUBMED:15983048]
[PUBMED:16848789]
[PUBMED:10770277]
[PUBMED:9504340]
Leukocyte transendothelial migration
[NCBI:83083]
[KEGG:hsa04670]
[PUBMED:15629883]
[PUBMED:10975856]
[PUBMED:14976004]
[PUBMED:15265790]
[PUBMED:15173832]
[PUBMED:12540948]
[PUBMED:15771581]
[PUBMED:15604886]
[PUBMED:14977592]
Osteoclast differentiation
[NCBI:193147]
[KEGG:hsa04380]
[PUBMED:17633024]
[PUBMED:18382763]
[PUBMED:18329366]
[PUBMED:17869613]
[PUBMED:18722561]
[PUBMED:15122243]
[PUBMED:20703218]
[PUBMED:12748652]
[PUBMED:12110142]
[PUBMED:19585227]
[PUBMED:15546140]
[PUBMED:16184196]
[PUBMED:15817678]
[PUBMED:20392226]
[PUBMED:16313349]
[PUBMED:16313342]
[PUBMED:17380158]
[PUBMED:18451259]
Phagosome
[NCBI:153910]
[KEGG:hsa04145]
[PUBMED:17637737]
[PUBMED:18513324]
[PUBMED:15894272]
[PUBMED:10684585]
[PUBMED:18492791]
[PUBMED:15036145]
[PUBMED:17245426]
RAC1 signaling pathway
[NCBI:169355]
[Pathway Interaction Database:rac1_pathway]
[PUBMED:19158278]
[PUBMED:16702231]
[PUBMED:16440308]
[PUBMED:14765121]
[PUBMED:12453877]
[PUBMED:12657629]
[PUBMED:9799233]
[PUBMED:9694656]
[PUBMED:9317150]
[PUBMED:14970210]
[PUBMED:8305740]
[PUBMED:8805275]
[PUBMED:17178910]
[PUBMED:11060298]
[PUBMED:11304531]
[PUBMED:11804587]
[PUBMED:11470914]
[PUBMED:11309380]
[PUBMED:17244649]
[PUBMED:11021801]
[PUBMED:7592586]
[PUBMED:15681696]
[PUBMED:7744004]
[PUBMED:15225553]
[PUBMED:10559936]
[PUBMED:19917258]
[PUBMED:7600581]
[PUBMED:19363480]
[PUBMED:18423204]
[PUBMED:20097736]
[PUBMED:19852956]
[PUBMED:12181570]
[PUBMED:19822663]
[PUBMED:7652575]
[PUBMED:7629060]
[PUBMED:8107774]
[PUBMED:16636067]
[PUBMED:9042860]
[PUBMED:12213441]
[PUBMED:10679324]
[PUBMED:12682053]
[PUBMED:18198193]
[PUBMED:16542153]
[PUBMED:7600582]
[PUBMED:18948007]
[PUBMED:18319301]
[PUBMED:10559253]
[PUBMED:17115053]
[PUBMED:10473551]
[PUBMED:17682062]
[PUBMED:17164293]
[PUBMED:15557278]
[PUBMED:15677464]
[PUBMED:16837009]
[PUBMED:12796474]
[PUBMED:10559863]
[PUBMED:9535855]
[PUBMED:8910292]
[PUBMED:11432831]
[PUBMED:17981134]
[PUBMED:16762923]
[PUBMED:8798539]
[PUBMED:18160398]
[PUBMED:16099876]
[PUBMED:14681219]
RHO GTPase Effectors
[NCBI:1269509]
[REACTOME:R-HSA-195258]
[PUBMED:9694656]
[PUBMED:18066052]
[PUBMED:11018042]
[PUBMED:10470034]
[PUBMED:8702756]
[PUBMED:21730051]
[PUBMED:8571126]
[PUBMED:19513348]
[PUBMED:17244649]
[PUBMED:11145705]
[PUBMED:24128008]
[PUBMED:23716662]
[PUBMED:8617235]
[PUBMED:8543060]
[PUBMED:11804587]
[PUBMED:24969695]
[PUBMED:12635176]
[PUBMED:12778124]
[PUBMED:18006505]
[PUBMED:1660188]
[PUBMED:21351730]
[PUBMED:16507994]
[PUBMED:14595335]
[PUBMED:10072071]
[PUBMED:10591629]
[PUBMED:10753910]
[PUBMED:23875749]
[PUBMED:17151359]
[PUBMED:10652353]
[PUBMED:12221077]
[PUBMED:10559936]
[PUBMED:12783890]
[PUBMED:11948177]
[PUBMED:18237546]
[PUBMED:16079795]
[PUBMED:10924361]
[PUBMED:14514689]
[PUBMED:8107774]
[PUBMED:8756646]
[PUBMED:16979770]
[PUBMED:16636067]
[PUBMED:9751706]
[PUBMED:10619026]
[PUBMED:23444367]
[PUBMED:15546864]
[PUBMED:12473120]
[PUBMED:8816443]
[PUBMED:9199170]
[PUBMED:12514133]
[PUBMED:16762923]
[PUBMED:12110184]
[PUBMED:16431929]
[PUBMED:10975528]
[PUBMED:10940294]
[PUBMED:9535855]
[PUBMED:7559638]
[PUBMED:11162552]
[PUBMED:19737400]
[PUBMED:9988689]
[PUBMED:12732141]
[PUBMED:8798539]
[PUBMED:24914801]
[PUBMED:11689693]
[PUBMED:8769096]
[PUBMED:9368021]
RHO GTPases Activate NADPH Oxidases
[NCBI:1269521]
[REACTOME:R-HSA-5668599]
[PUBMED:16507994]
[PUBMED:1660188]
[PUBMED:17237347]
[PUBMED:11145705]
[PUBMED:23875749]
[PUBMED:10072071]
[PUBMED:16636067]
[PUBMED:12480817]
[PUBMED:16762923]
[PUBMED:19628035]
ROS, RNS production in phagocytes
[NCBI:1269138]
[REACTOME:R-HSA-1222556]
[PUBMED:23617726]
[PUBMED:19369951]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by Rho GTPases
[NCBI:1269507]
[REACTOME:R-HSA-194315]
[PUBMED:16212495]
[PUBMED:15630019]
Signaling by VEGF
[NCBI:1269480]
[REACTOME:R-HSA-194138]
[PUBMED:15585754]
[PUBMED:13678960]
[PUBMED:16336962]
[PUBMED:16835467]
VEGFA-VEGFR2 Pathway
[NCBI:1269483]
[REACTOME:R-HSA-4420097]
[PUBMED:17344076]
[PUBMED:16633338]
[PUBMED:19230644]
[PUBMED:13678960]