full name
pleckstrin homology and RhoGEF domain containing G5

synonyms
DSMA4, GEF720, Syx, Tech, PLEKHG5, ENSG00000171680

HGNC
HGNC:29105

Entrez Gene
Gene:57449

ENSEMBL
ENSG00000171680

location
chr: 1
start: 6526152
stop: 6580121
strand: -

OMIM
OMIM:611101: PLEKHG5 (Autosomal recessive inheritance)
OMIM:615376: Charcot-Marie-Tooth disease, recessive intermediate C
OMIM:611067: Spinal muscular atrophy, distal, autosomal recessive, 4

transcripts
NM_198681.3
NM_001042663.1
NM_001265592.1
NM_020631.4
NM_001265594.1
NM_001042664.1
NM_001042665.1
NM_001265593.1

pathways
Cell death signalling via NRAGE, NRIF and NADE [NCBI:1269447] [REACTOME:R-HSA-204998] [PUBMED:12787561]
G alpha (12/13) signalling events [NCBI:1269579] [REACTOME:R-HSA-416482] [PUBMED:18814923] [PUBMED:19212140]
GPCR downstream signaling [NCBI:1269574] [REACTOME:R-HSA-388396] [PUBMED:12040175]
NRAGE signals death through JNK [NCBI:1269448] [REACTOME:R-HSA-193648] [PUBMED:12376548]
Pathways in cancer [NCBI:83105] [KEGG:hsa05200] [PUBMED:12244301] [PUBMED:16001072] [PUBMED:16699851] [PUBMED:11902573] [PUBMED:16555243] [PUBMED:15156182] [PUBMED:15310786] [PUBMED:21193867] [PUBMED:11707511] [PUBMED:11253051] [PUBMED:12951584] [PUBMED:11071626] [PUBMED:9834202] [PUBMED:15721476] [PUBMED:11895903] [PUBMED:17251915] [PUBMED:11736900] [PUBMED:11477132] [PUBMED:15724144] [PUBMED:10647931] [PUBMED:16700615] [PUBMED:11527574] [PUBMED:16339096] [PUBMED:12545153] [PUBMED:15942304] [PUBMED:16352814] [PUBMED:15656799] [PUBMED:10740269] [PUBMED:16881963] [PUBMED:15978322] [PUBMED:15774796] [PUBMED:17287871] [PUBMED:15557758] [PUBMED:10944551] [PUBMED:11170304] [PUBMED:12154354] [PUBMED:15639402] [PUBMED:16326109] [PUBMED:11276000] [PUBMED:15573119] [PUBMED:15625120] [PUBMED:15109562] [PUBMED:11160144] [PUBMED:15611513] [PUBMED:15349822] [PUBMED:16236521] [PUBMED:14967450] [PUBMED:16551846] [PUBMED:9196022] [PUBMED:12079267] [PUBMED:11130178] [PUBMED:14580692] [PUBMED:14634372] [PUBMED:12407699] [PUBMED:12588368] [PUBMED:15009714] [PUBMED:16001050] [PUBMED:16112428] [PUBMED:9643506] [PUBMED:15468170] [PUBMED:16248975] [PUBMED:12946833] [PUBMED:11057895] [PUBMED:11559746] [PUBMED:16306523] [PUBMED:16064138] [PUBMED:15479695] [PUBMED:11900250] [PUBMED:9422516] [PUBMED:15551095] [PUBMED:17062879] [PUBMED:12894244] [PUBMED:11103787] [PUBMED:12878745] [PUBMED:16702400] [PUBMED:14685170] [PUBMED:16189154] [PUBMED:11720739] [PUBMED:15122209] [PUBMED:11078609] [PUBMED:12243753] [PUBMED:14982876] [PUBMED:16642045] [PUBMED:12563308] [PUBMED:11407945] [PUBMED:14586404] [PUBMED:15270885] [PUBMED:16095998] [PUBMED:15948971] [PUBMED:16484590] [PUBMED:24508914] [PUBMED:12084351] [PUBMED:11459867] [PUBMED:10505543] [PUBMED:15746962] [PUBMED:16146838] [PUBMED:15947972] [PUBMED:15711891] [PUBMED:12094241] [PUBMED:15841168] [PUBMED:11463388] [PUBMED:16474624] [PUBMED:15719031] [PUBMED:10843728] [PUBMED:14556242] [PUBMED:10453277] [PUBMED:11721960] [PUBMED:11905738] [PUBMED:10403855] [PUBMED:12741677] [PUBMED:12616528] [PUBMED:15823750] [PUBMED:12737309] [PUBMED:14695152] [PUBMED:16750612] [PUBMED:11807782] [PUBMED:12351585] [PUBMED:14737121] [PUBMED:12801837] [PUBMED:11431710] [PUBMED:11165748] [PUBMED:11750244] [PUBMED:11224709] [PUBMED:16110317] [PUBMED:16508724] [PUBMED:15948711] [PUBMED:16870043] [PUBMED:7585656] [PUBMED:12379883] [PUBMED:12850530] [PUBMED:10835690] [PUBMED:16551847] [PUBMED:12459728] [PUBMED:14747944] [PUBMED:15000146] [PUBMED:17149381] [PUBMED:17158541] [PUBMED:12468433] [PUBMED:16042571] [PUBMED:16557281] [PUBMED:16899407] [PUBMED:12621137] [PUBMED:16189702] [PUBMED:8069858] [PUBMED:12951588] [PUBMED:16242838] [PUBMED:15082523] [PUBMED:17211469] [PUBMED:12711111] [PUBMED:15284264] [PUBMED:11223406] [PUBMED:12648469] [PUBMED:12867060] [PUBMED:16946003] [PUBMED:12762887] [PUBMED:16054233] [PUBMED:16822996] [PUBMED:17554387] [PUBMED:17028294]
Rho GTPase cycle [NCBI:1269508] [REACTOME:R-HSA-194840] [PUBMED:17222083] [PUBMED:9308960]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:19648010] [PUBMED:17604717] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:15863030] [PUBMED:21252999] [PUBMED:19379690] [PUBMED:19536106] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:15450248] [PUBMED:15520807] [PUBMED:16939974] [PUBMED:18483217] [PUBMED:18043707] [PUBMED:19762341] [PUBMED:21781017] [PUBMED:17084981] [PUBMED:19619488] [PUBMED:17496910]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Signaling by Rho GTPases [NCBI:1269507] [REACTOME:R-HSA-194315] [PUBMED:16212495] [PUBMED:15630019]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
p75 NTR receptor-mediated signalling [NCBI:1269445] [REACTOME:R-HSA-193704] [PUBMED:16699811] [PUBMED:16939974] [PUBMED:12671646]