full name
leptin

synonyms
LEPD, OB, OBS, LEP, ENSG00000174697

HGNC
HGNC:6553

Entrez Gene
Gene:3952

ENSEMBL
ENSG00000174697

location
chr: 7
start: 127881241
stop: 127897682
strand: +

OMIM
OMIM:164160: LEP
OMIM:614962: Obesity, morbid, due to leptin deficiency

transcripts
NM_000230.2

pathways
AMPK signaling pathway [NCBI:989139] [KEGG:hsa04152] [PUBMED:22885100] [PUBMED:18725075] [PUBMED:22700795] [PUBMED:19724019] [PUBMED:19584320] [PUBMED:16644802] [PUBMED:20010958] [PUBMED:16479585] [PUBMED:19197243] [PUBMED:23565491] [PUBMED:20357764] [PUBMED:16723978] [PUBMED:16054041] [PUBMED:19393004] [PUBMED:23899560] [PUBMED:17307971] [PUBMED:15509864] [PUBMED:23024365] [PUBMED:23747347] [PUBMED:19629071]
Adipocytokine signaling pathway [NCBI:83093] [KEGG:hsa04920] [PUBMED:12829246] [PUBMED:10905472] [PUBMED:15980064] [PUBMED:12754525] [PUBMED:12368907] [PUBMED:11557972] [PUBMED:15856064] [PUBMED:9671776] [PUBMED:10766253] [PUBMED:15733744] [PUBMED:15058305] [PUBMED:14716305] [PUBMED:11479627] [PUBMED:14679176]
Cytokine-cytokine receptor interaction [NCBI:83051] [KEGG:hsa04060] [PUBMED:11071910] [PUBMED:12072446] [PUBMED:7791754] [PUBMED:15032600] [PUBMED:12651226] [PUBMED:11252892] [PUBMED:11796220] [PUBMED:11312110] [PUBMED:9862719] [PUBMED:12421671] [PUBMED:12039028] [PUBMED:9759503] [PUBMED:9395284] [PUBMED:11166270] [PUBMED:10714678] [PUBMED:12651221]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
HIF-1-alpha transcription factor network [NCBI:138045] [Pathway Interaction Database:hif1_tfpathway] [PUBMED:11707426] [PUBMED:9242677] [PUBMED:9038135] [PUBMED:15310764] [PUBMED:11278891] [PUBMED:8816435] [PUBMED:8663540] [PUBMED:15235127] [PUBMED:12042299] [PUBMED:15312748] [PUBMED:14612449] [PUBMED:11342587] [PUBMED:12615703] [PUBMED:9632793] [PUBMED:12228247] [PUBMED:15044468] [PUBMED:8408001] [PUBMED:9822602] [PUBMED:15252039] [PUBMED:13679920] [PUBMED:11877282] [PUBMED:15235597] [PUBMED:15199161] [PUBMED:15104534] [PUBMED:10594042] [PUBMED:12354771] [PUBMED:10446188] [PUBMED:9436976] [PUBMED:11823643] [PUBMED:12370277] [PUBMED:8955077] [PUBMED:12879018] [PUBMED:14645546] [PUBMED:9486205] [PUBMED:9887100] [PUBMED:8089148] [PUBMED:15466858] [PUBMED:11708773] [PUBMED:15611046] [PUBMED:14742449] [PUBMED:15280364] [PUBMED:12215445] [PUBMED:15611089] [PUBMED:10777486] [PUBMED:9707622] [PUBMED:8917528] [PUBMED:15563275] [PUBMED:12067980] [PUBMED:10353251]
Incretin synthesis, secretion, and inactivation [NCBI:1268750] [REACTOME:R-HSA-400508] [PUBMED:19074620] [PUBMED:17498508] [PUBMED:17263764]
Jak-STAT signaling pathway [NCBI:83077] [KEGG:hsa04630] [PUBMED:21034406] [PUBMED:22339650] [PUBMED:16204702] [PUBMED:25587654] [PUBMED:24069565] [PUBMED:22383755] [PUBMED:24606160] [PUBMED:10851053] [PUBMED:23735217] [PUBMED:25217450] [PUBMED:21372217]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Neuroactive ligand-receptor interaction [NCBI:83053] [KEGG:hsa04080]
Non-alcoholic fatty liver disease (NAFLD) [NCBI:862188] [KEGG:hsa04932] [PUBMED:21038418] [PUBMED:17498512] [PUBMED:19352614] [PUBMED:23299992] [PUBMED:22570745] [PUBMED:9285483] [PUBMED:12891546] [PUBMED:18061659] [PUBMED:22705006] [PUBMED:16364488] [PUBMED:18242193] [PUBMED:16374858] [PUBMED:22940046] [PUBMED:20619513] [PUBMED:20303879] [PUBMED:14685853] [PUBMED:16406828] [PUBMED:23545492] [PUBMED:21145844]
Peptide hormone metabolism [NCBI:1268746] [REACTOME:R-HSA-2980736] [PUBMED:2663045] [PUBMED:21805235]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Leptin [NCBI:1269632] [REACTOME:R-HSA-2586552] [PUBMED:22211890] [PUBMED:23562747] [PUBMED:20600241] [PUBMED:21622208] [PUBMED:23579596] [PUBMED:22458591] [PUBMED:21489811] [PUBMED:19724019] [PUBMED:21331644] [PUBMED:22448029] [PUBMED:21147620] [PUBMED:20198122] [PUBMED:21677426] [PUBMED:20029269] [PUBMED:22249808] [PUBMED:22991412] [PUBMED:21527729] [PUBMED:17937601] [PUBMED:20553370] [PUBMED:21713385] [PUBMED:23565489] [PUBMED:22289780]
Signaling events mediated by PTP1B [NCBI:138017] [Pathway Interaction Database:ptp1bpathway] [PUBMED:12414790] [PUBMED:8223493] [PUBMED:12857726] [PUBMED:8999839] [PUBMED:14766979] [PUBMED:9355745] [PUBMED:11579209] [PUBMED:8940134] [PUBMED:12802338] [PUBMED:10807907] [PUBMED:15866871] [PUBMED:10751417] [PUBMED:11346638] [PUBMED:11970899] [PUBMED:9083103] [PUBMED:7693694] [PUBMED:11900546] [PUBMED:7983051] [PUBMED:11694501] [PUBMED:10514492] [PUBMED:12176037] [PUBMED:16644720] [PUBMED:16388599] [PUBMED:9624118] [PUBMED:9786960] [PUBMED:14966267] [PUBMED:15894168] [PUBMED:11773439] [PUBMED:11864611] [PUBMED:8548812] [PUBMED:16477024] [PUBMED:9418872] [PUBMED:9050838] [PUBMED:12424235] [PUBMED:12748279] [PUBMED:1383688] [PUBMED:8782827] [PUBMED:8626723] [PUBMED:11007774] [PUBMED:10993888] [PUBMED:15226396] [PUBMED:10066179] [PUBMED:10660596] [PUBMED:12554649] [PUBMED:11970898] [PUBMED:9566916]
Synthesis, secretion, and deacylation of Ghrelin [NCBI:1268748] [REACTOME:R-HSA-422085] [PUBMED:19280057] [PUBMED:18396350]
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) [NCBI:1268751] [REACTOME:R-HSA-381771] [PUBMED:11564718] [PUBMED:17928588] [PUBMED:1499644] [PUBMED:17263764] [PUBMED:19074620] [PUBMED:17498508]
Transcriptional regulation of white adipocyte differentiation [NCBI:1270345] [REACTOME:R-HSA-381340] [PUBMED:21082419] [PUBMED:17956727] [PUBMED:17475546] [PUBMED:1840554] [PUBMED:17139329] [PUBMED:15860371] [PUBMED:18518822] [PUBMED:10603305] [PUBMED:7531665] [PUBMED:20054179] [PUBMED:7838715] [PUBMED:16054042] [PUBMED:17060461] [PUBMED:17011499] [PUBMED:16380219] [PUBMED:8970730]