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Genes
SMO
Gene - SMO
full name
smoothened, frizzled class receptor
synonyms
FZD11, Gx, SMOH, SMO, ENSG00000128602
HGNC
HGNC:11119
Entrez Gene
Gene:6608
ENSEMBL
ENSG00000128602
location
chr: 7
start: 128828713
stop: 128853386
strand: +
OMIM
OMIM:601500
: SMO
OMIM:605462
: Basal cell carcinoma, somatic
OMIM:601707
: Curry-Jones syndrome, somatic mosaic
transcripts
NM_005631.4
pathways
Activation of SMO
[NCBI:1269642]
[REACTOME:R-HSA-5635838]
[PUBMED:16339192]
[PUBMED:21356043]
[PUBMED:20395968]
[PUBMED:23719536]
[PUBMED:24582806]
[PUBMED:14636583]
[PUBMED:19081070]
[PUBMED:17641202]
[PUBMED:17762891]
[PUBMED:10966113]
[PUBMED:17960137]
[PUBMED:22981989]
[PUBMED:20412775]
[PUBMED:24845016]
[PUBMED:23079593]
[PUBMED:21801010]
[PUBMED:21695114]
[PUBMED:15691767]
[PUBMED:22986504]
[PUBMED:16459297]
[PUBMED:14614827]
[PUBMED:19906846]
[PUBMED:12192414]
[PUBMED:20844016]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
BBSome-mediated cargo-targeting to cilium
[NCBI:1268850]
[REACTOME:R-HSA-5620922]
[PUBMED:22072986]
[PUBMED:19081074]
[PUBMED:17574030]
[PUBMED:15231740]
[PUBMED:19575670]
[PUBMED:20603001]
[PUBMED:22139371]
[PUBMED:24296415]
Basal cell carcinoma
[NCBI:83113]
[KEGG:hsa05217]
[PUBMED:15948971]
[PUBMED:15978322]
[PUBMED:15468170]
[PUBMED:11276000]
[PUBMED:11130178]
[PUBMED:14737121]
[PUBMED:15270885]
[PUBMED:16306523]
[PUBMED:14556242]
[PUBMED:15656799]
[PUBMED:16054233]
[PUBMED:12588368]
[PUBMED:16881963]
[PUBMED:11736900]
Cargo trafficking to the periciliary membrane
[NCBI:1268848]
[REACTOME:R-HSA-5620920]
[PUBMED:20530210]
[PUBMED:23150559]
[PUBMED:23567335]
[PUBMED:17574030]
[PUBMED:19081074]
[PUBMED:15314642]
[PUBMED:22085962]
[PUBMED:11384985]
[PUBMED:20038682]
[PUBMED:11684707]
[PUBMED:20399632]
[PUBMED:22389062]
[PUBMED:9362062]
[PUBMED:20603001]
[PUBMED:22139371]
[PUBMED:22326026]
[PUBMED:15998802]
[PUBMED:20145001]
[PUBMED:12169685]
Cilium Assembly
[NCBI:1268846]
[REACTOME:R-HSA-5617833]
[PUBMED:21427764]
[PUBMED:23351793]
[PUBMED:25040720]
[PUBMED:17955020]
[PUBMED:22118932]
[PUBMED:22653444]
[PUBMED:22389062]
[PUBMED:20399632]
[PUBMED:25047619]
[PUBMED:20395968]
[PUBMED:23945166]
[PUBMED:19575670]
[PUBMED:24296415]
[PUBMED:20145001]
[PUBMED:19602418]
Class B/2 (Secretin family receptors)
[NCBI:1269570]
[REACTOME:R-HSA-373080]
[PUBMED:11790261]
GPCR ligand binding
[NCBI:1269544]
[REACTOME:R-HSA-500792]
[PUBMED:15251227]
Hedgehog 'off' state
[NCBI:1269636]
[REACTOME:R-HSA-5610787]
[PUBMED:21801010]
[PUBMED:20395968]
[PUBMED:23719536]
[PUBMED:21502959]
Hedgehog 'on' state
[NCBI:1269640]
[REACTOME:R-HSA-5632684]
[PUBMED:23719536]
[PUBMED:21502959]
[PUBMED:21801010]
[PUBMED:20395968]
Hedgehog signaling events mediated by Gli proteins
[NCBI:137912]
[Pathway Interaction Database:hedgehog_glipathway]
[PUBMED:14611647]
[PUBMED:16908539]
[PUBMED:16885213]
[PUBMED:16459297]
[PUBMED:15087129]
[PUBMED:10075717]
[PUBMED:10725236]
[PUBMED:10564661]
[PUBMED:15215207]
[PUBMED:16611981]
[PUBMED:16364285]
[PUBMED:11748151]
[PUBMED:16537363]
[PUBMED:10531011]
[PUBMED:11449277]
[PUBMED:12812795]
[PUBMED:16424016]
[PUBMED:14723851]
[PUBMED:10693759]
[PUBMED:15545630]
[PUBMED:16254602]
[PUBMED:14603322]
[PUBMED:16061793]
[PUBMED:10559945]
[PUBMED:16740475]
[PUBMED:16705181]
[PUBMED:9636069]
[PUBMED:10806483]
[PUBMED:11960000]
[PUBMED:15930098]
Hedgehog signaling pathway
[NCBI:83063]
[KEGG:hsa04340]
[PUBMED:22534646]
[PUBMED:26077918]
[PUBMED:24925320]
[PUBMED:23719536]
[PUBMED:26064136]
[PUBMED:26366162]
[PUBMED:20708941]
[PUBMED:22056910]
[PUBMED:18583599]
[PUBMED:23799571]
[PUBMED:26875496]
Organelle biogenesis and maintenance
[NCBI:1268838]
[REACTOME:R-HSA-1852241]
[PUBMED:8608592]
[PUBMED:16103713]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Proteoglycans in cancer
[NCBI:782000]
[KEGG:hsa05205]
[PUBMED:19433454]
[PUBMED:20655987]
[PUBMED:18798267]
[PUBMED:10633082]
[PUBMED:10687947]
[PUBMED:22735579]
[PUBMED:24412155]
[PUBMED:9346940]
[PUBMED:22087031]
[PUBMED:22194599]
[PUBMED:14711376]
[PUBMED:19255147]
[PUBMED:15655247]
[PUBMED:11717317]
[PUBMED:17971838]
[PUBMED:18413366]
[PUBMED:20974860]
[PUBMED:11830493]
[PUBMED:23058688]
[PUBMED:18450475]
[PUBMED:12748184]
[PUBMED:19733083]
[PUBMED:18812315]
[PUBMED:12509413]
[PUBMED:21155971]
[PUBMED:11931647]
[PUBMED:18949819]
[PUBMED:12729888]
[PUBMED:15994311]
[PUBMED:23305321]
[PUBMED:18505598]
[PUBMED:22563565]
[PUBMED:22033227]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signaling by Hedgehog
[NCBI:1269633]
[REACTOME:R-HSA-5358351]
[PUBMED:19081070]
[PUBMED:21801010]
[PUBMED:15549094]
[PUBMED:23719536]
Signaling events mediated by the Hedgehog family
[NCBI:137950]
[Pathway Interaction Database:hedgehog_2pathway]
[PUBMED:8906794]
[PUBMED:16647303]
[PUBMED:12917290]
[PUBMED:12192414]
[PUBMED:12421714]
[PUBMED:7891723]
[PUBMED:16136078]
[PUBMED:10984056]
[PUBMED:16229832]
[PUBMED:15019948]
[PUBMED:11934857]
[PUBMED:11572986]
[PUBMED:16537363]
[PUBMED:16647304]
[PUBMED:9811851]
[PUBMED:11668681]
[PUBMED:9593755]
[PUBMED:15618519]
[PUBMED:16895439]
[PUBMED:12123571]
[PUBMED:10050855]
[PUBMED:11517919]
[PUBMED:12372301]
[PUBMED:16284117]
[PUBMED:10465785]
[PUBMED:11964399]
[PUBMED:11027307]
[PUBMED:8824192]
[PUBMED:11486055]