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Genes
DPYD
Gene - DPYD
full name
dihydropyrimidine dehydrogenase
synonyms
DHP, DHPDHASE, DPD, DPYD, ENSG00000188641
HGNC
HGNC:3012
Entrez Gene
Gene:1806
ENSEMBL
ENSG00000188641
location
chr: 1
start: 97543299
stop: 98386615
strand: -
OMIM
OMIM:612779
: DPYD
(Autosomal recessive inheritance)
OMIM:274270
: 5-fluorouracil toxicity
OMIM:274270
: Dihydropyrimidine dehydrogenase deficiency
transcripts
ENST00000370192.3
ENST00000306031.5
pathways
Drug metabolism - other enzymes
[NCBI:83033]
[KEGG:hsa00983]
[PUBMED:15514566]
[PUBMED:15173095]
[PUBMED:15788214]
[PUBMED:11379777]
[PUBMED:10976516]
[PUBMED:11489791]
[PUBMED:16048561]
[PUBMED:16880012]
Metabolic pathways
[NCBI:132956]
[KEGG:hsa01100]
Metabolism
[NCBI:1269956]
[REACTOME:R-HSA-1430728]
Metabolism of nucleotides
[NCBI:1270133]
[REACTOME:R-HSA-15869]
[PUBMED:17266529]
[PUBMED:8283301]
[PUBMED:20494131]
Pantothenate and CoA biosynthesis
[NCBI:83015]
[KEGG:hsa00770]
Pyrimidine catabolism
[NCBI:1270141]
[REACTOME:R-HSA-73621]
[PUBMED:3090932]
[PUBMED:10989446]
Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
[NCBI:605866]
[KEGG:hsa_M00046]
Pyrimidine metabolism
[NCBI:82946]
[KEGG:hsa00240]
[NCBI:1270138]
[REACTOME:R-HSA-73848]
[PUBMED:16098809]
beta-Alanine metabolism
[NCBI:82966]
[KEGG:hsa00410]
pyrimidine ribonucleosides degradation
[NCBI:142431]
[BIOCYC:HUMAN_PWY0-1295]
[NCBI:782398]
[BIOCYC:HUMAN_PWY-7209]
[PUBMED:10354618]
[PUBMED:13428755]
[PUBMED:35970]
[PUBMED:6323418]
[PUBMED:10656811]
[PUBMED:7877593]
[PUBMED:3108250]
[PUBMED:11782482]
[PUBMED:16655478]
[PUBMED:16769123]
[PUBMED:8650301]
[PUBMED:14705962]
[PUBMED:8155674]
[PUBMED:3966913]
[PUBMED:7546322]
[PUBMED:16098809]
[PUBMED:6277907]
[PUBMED:13535735]
[PUBMED:13416173]
[PUBMED:6117607]
[PUBMED:16656066]
thymine degradation
[NCBI:545364]
[BIOCYC:HUMAN_PWY-6430]
[PUBMED:11508704]
[PUBMED:4841987]
[PUBMED:9718352]
[PUBMED:6945923]
[PUBMED:12981074]
[PUBMED:14705962]
[PUBMED:13428755]
uracil degradation
[NCBI:545270]
[BIOCYC:HUMAN_PWY-3982]
[PUBMED:13428755]
[PUBMED:9718352]
[PUBMED:6117607]
[PUBMED:993199]
[PUBMED:11508704]
[PUBMED:12981074]
[PUBMED:14705962]
[PUBMED:3108250]