full name
dihydropyrimidine dehydrogenase

synonyms
DHP, DHPDHASE, DPD, DPYD, ENSG00000188641

HGNC
HGNC:3012

Entrez Gene
Gene:1806

ENSEMBL
ENSG00000188641

location
chr: 1
start: 97543299
stop: 98386615
strand: -

OMIM
OMIM:612779: DPYD (Autosomal recessive inheritance)
OMIM:274270: 5-fluorouracil toxicity
OMIM:274270: Dihydropyrimidine dehydrogenase deficiency

transcripts
ENST00000370192.3
ENST00000306031.5

pathways
Drug metabolism - other enzymes [NCBI:83033] [KEGG:hsa00983] [PUBMED:15514566] [PUBMED:15173095] [PUBMED:15788214] [PUBMED:11379777] [PUBMED:10976516] [PUBMED:11489791] [PUBMED:16048561] [PUBMED:16880012]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of nucleotides [NCBI:1270133] [REACTOME:R-HSA-15869] [PUBMED:17266529] [PUBMED:8283301] [PUBMED:20494131]
Pantothenate and CoA biosynthesis [NCBI:83015] [KEGG:hsa00770]
Pyrimidine catabolism [NCBI:1270141] [REACTOME:R-HSA-73621] [PUBMED:3090932] [PUBMED:10989446]
Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate [NCBI:605866] [KEGG:hsa_M00046]
Pyrimidine metabolism [NCBI:82946] [KEGG:hsa00240] [NCBI:1270138] [REACTOME:R-HSA-73848] [PUBMED:16098809]
beta-Alanine metabolism [NCBI:82966] [KEGG:hsa00410]
pyrimidine ribonucleosides degradation [NCBI:142431] [BIOCYC:HUMAN_PWY0-1295] [NCBI:782398] [BIOCYC:HUMAN_PWY-7209] [PUBMED:10354618] [PUBMED:13428755] [PUBMED:35970] [PUBMED:6323418] [PUBMED:10656811] [PUBMED:7877593] [PUBMED:3108250] [PUBMED:11782482] [PUBMED:16655478] [PUBMED:16769123] [PUBMED:8650301] [PUBMED:14705962] [PUBMED:8155674] [PUBMED:3966913] [PUBMED:7546322] [PUBMED:16098809] [PUBMED:6277907] [PUBMED:13535735] [PUBMED:13416173] [PUBMED:6117607] [PUBMED:16656066]
thymine degradation [NCBI:545364] [BIOCYC:HUMAN_PWY-6430] [PUBMED:11508704] [PUBMED:4841987] [PUBMED:9718352] [PUBMED:6945923] [PUBMED:12981074] [PUBMED:14705962] [PUBMED:13428755]
uracil degradation [NCBI:545270] [BIOCYC:HUMAN_PWY-3982] [PUBMED:13428755] [PUBMED:9718352] [PUBMED:6117607] [PUBMED:993199] [PUBMED:11508704] [PUBMED:12981074] [PUBMED:14705962] [PUBMED:3108250]