full name
nitric oxide synthase 3

synonyms
ECNOS, eNOS, NOS3, ENSG00000164867

HGNC
HGNC:7876

Entrez Gene
Gene:4846

ENSEMBL
ENSG00000164867

location
chr: 7
start: 150688144
stop: 150711687
strand: +

OMIM
OMIM:163729: NOS3
OMIM:104300: {Alzheimer disease, late-onset, susceptibility to}
OMIM:189800: {Hypertension, pregnancy-induced}
OMIM:145500: {Hypertension, susceptibility to}
OMIM:601367: {Ischemic stroke, susceptibility to}

transcripts
NM_000603.4
NM_001160111.1
NM_001160110.1
NM_001160109.1

pathways
AGE-RAGE signaling pathway in diabetic complications [NCBI:1319988] [KEGG:hsa04933] [PUBMED:23776698] [PUBMED:15569303] [PUBMED:16894049] [PUBMED:18323529] [PUBMED:11375353] [PUBMED:21111800] [PUBMED:19404313] [PUBMED:20470857] [PUBMED:17005604] [PUBMED:23961320] [PUBMED:21261520] [PUBMED:11180401] [PUBMED:18922799] [PUBMED:21680901] [PUBMED:11684565] [PUBMED:21590515] [PUBMED:12709399] [PUBMED:20300563] [PUBMED:21440603] [PUBMED:22558488]
Angiopoietin receptor Tie2-mediated signaling [NCBI:137917] [Pathway Interaction Database:angiopoietinreceptor_pathway] [PUBMED:9204896] [PUBMED:12609966] [PUBMED:14726409] [PUBMED:11157678] [PUBMED:10347092] [PUBMED:11967990] [PUBMED:15162796] [PUBMED:11289054] [PUBMED:12759249] [PUBMED:10051567] [PUBMED:12824293] [PUBMED:16895971] [PUBMED:10807867] [PUBMED:12933576] [PUBMED:11513602] [PUBMED:12074640] [PUBMED:8980223] [PUBMED:14665640] [PUBMED:15132996] [PUBMED:10944458] [PUBMED:11230987] [PUBMED:15242771] [PUBMED:10585289] [PUBMED:16061664] [PUBMED:10376602] [PUBMED:15350545] [PUBMED:9632797] [PUBMED:10625301] [PUBMED:9926914] [PUBMED:17189382] [PUBMED:11139469] [PUBMED:11689432] [PUBMED:11416142] [PUBMED:11166279] [PUBMED:15284220] [PUBMED:15985432] [PUBMED:16049136] [PUBMED:16157706] [PUBMED:10521483] [PUBMED:12816861] [PUBMED:9478921] [PUBMED:10376603] [PUBMED:15769741] [PUBMED:12890486] [PUBMED:14749497] [PUBMED:7561682] [PUBMED:11801735] [PUBMED:12665569] [PUBMED:12117724] [PUBMED:9764820]
Apelin signaling pathway [NCBI:1492886] [KEGG:hsa04371] [PUBMED:23973488] [PUBMED:16182514] [PUBMED:21725702] [PUBMED:22842084] [PUBMED:27825851] [PUBMED:27650065] [PUBMED:22140623] [PUBMED:23943882] [PUBMED:26944568] [PUBMED:24055369] [PUBMED:26385179] [PUBMED:26143239] [PUBMED:22028387] [PUBMED:26254105] [PUBMED:26756969] [PUBMED:22995518] [PUBMED:27979574] [PUBMED:23924696] [PUBMED:21464822] [PUBMED:25914650] [PUBMED:24990699] [PUBMED:26607438] [PUBMED:25164121] [PUBMED:25275559] [PUBMED:25139773] [PUBMED:25931124] [PUBMED:19093215] [PUBMED:20539939] [PUBMED:25652330] [PUBMED:18272138] [PUBMED:23603510]
Arginine and proline metabolism [NCBI:82957] [KEGG:hsa00330] [PUBMED:15590624] [PUBMED:5288244] [PUBMED:16499623]
Arginine biosynthesis [NCBI:82943] [KEGG:hsa00220]
Calcium signaling pathway [NCBI:83050] [KEGG:hsa04020] [PUBMED:11080247] [PUBMED:14572802] [PUBMED:11413485] [PUBMED:22129055] [PUBMED:10508738] [PUBMED:15000521] [PUBMED:9235901] [PUBMED:7861177] [PUBMED:9149541] [PUBMED:14517314] [PUBMED:15111104] [PUBMED:11698232] [PUBMED:10331643] [PUBMED:12838335] [PUBMED:8125957] [PUBMED:19172794] [PUBMED:10997573] [PUBMED:21338471] [PUBMED:11299192] [PUBMED:22002090] [PUBMED:12972622]
Estrogen signaling pathway [NCBI:799177] [KEGG:hsa04915] [PUBMED:15695368] [PUBMED:16112267] [PUBMED:9278514] [PUBMED:19187465] [PUBMED:12421825] [PUBMED:12650715] [PUBMED:18253054] [PUBMED:16516516] [PUBMED:14573532] [PUBMED:18755790] [PUBMED:18538919] [PUBMED:19767412] [PUBMED:14993035] [PUBMED:19549587] [PUBMED:15862823] [PUBMED:20694192] [PUBMED:19464786] [PUBMED:21779010] [PUBMED:16270355] [PUBMED:21742056] [PUBMED:19700741] [PUBMED:21844907]
Fluid shear stress and atherosclerosis [NCBI:1474302] [KEGG:hsa05418] [PUBMED:23429585] [PUBMED:21050140] [PUBMED:17599600] [PUBMED:24190880] [PUBMED:22003002] [PUBMED:24876354] [PUBMED:24947523] [PUBMED:23899566] [PUBMED:26597822] [PUBMED:20353494] [PUBMED:22076424] [PUBMED:20538799] [PUBMED:25165867] [PUBMED:20032497] [PUBMED:23084990] [PUBMED:26822720] [PUBMED:24573382] [PUBMED:23555159] [PUBMED:26212910] [PUBMED:21457103] [PUBMED:19151844] [PUBMED:15388638] [PUBMED:16765337] [PUBMED:27027326] [PUBMED:25638487] [PUBMED:21733876]
HIF-1 signaling pathway [NCBI:695200] [KEGG:hsa04066] [PUBMED:11902584] [PUBMED:20965423] [PUBMED:20679415] [PUBMED:15031665] [PUBMED:18259201] [PUBMED:22205687] [PUBMED:19364912] [PUBMED:19147540] [PUBMED:15448722] [PUBMED:16234508] [PUBMED:18505681] [PUBMED:20836033] [PUBMED:19861159] [PUBMED:17955264] [PUBMED:22562152]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Insulin resistance [NCBI:1272486] [KEGG:hsa04931] [PUBMED:17130651] [PUBMED:20466550] [PUBMED:16364488] [PUBMED:12765939] [PUBMED:15166380] [PUBMED:7666792] [PUBMED:16756496] [PUBMED:23647930] [PUBMED:10923637] [PUBMED:17141630] [PUBMED:9886945] [PUBMED:8048519] [PUBMED:18309108] [PUBMED:15107844] [PUBMED:20526383] [PUBMED:22360800] [PUBMED:16186396] [PUBMED:22675355] [PUBMED:22677645]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of nitric oxide [NCBI:1270115] [REACTOME:R-HSA-202131] [PUBMED:17237348]
NOSIP mediated eNOS trafficking [NCBI:1270118] [REACTOME:R-HSA-203754] [PUBMED:16722822] [PUBMED:16234328] [PUBMED:12842859]
NOSTRIN mediated eNOS trafficking [NCBI:1270119] [REACTOME:R-HSA-203641] [PUBMED:12842859] [PUBMED:16722822] [PUBMED:12446846] [PUBMED:16234328]
Nitric oxide stimulates guanylate cyclase [NCBI:1269343] [REACTOME:R-HSA-392154] [PUBMED:12881475]
Oxytocin signaling pathway [NCBI:952859] [KEGG:hsa04921] [PUBMED:23356278] [PUBMED:9219843] [PUBMED:20626426] [PUBMED:18555543] [PUBMED:22190926] [PUBMED:21981277] [PUBMED:9575824] [PUBMED:22227279] [PUBMED:19840865] [PUBMED:11861513] [PUBMED:9326674] [PUBMED:12433531] [PUBMED:18655881] [PUBMED:23335873] [PUBMED:22902539] [PUBMED:16156781] [PUBMED:20141572] [PUBMED:14715914] [PUBMED:12009385] [PUBMED:16787565] [PUBMED:16966388]
PI3K-Akt signaling pathway [NCBI:692234] [KEGG:hsa04151] [PUBMED:12048182] [PUBMED:11357143] [PUBMED:21440011] [PUBMED:15209374] [PUBMED:12669022] [PUBMED:18842113] [PUBMED:16847462] [PUBMED:12660731] [PUBMED:17360849] [PUBMED:9838078] [PUBMED:15505410] [PUBMED:16248975] [PUBMED:12531180] [PUBMED:21779440] [PUBMED:16187290] [PUBMED:15784165] [PUBMED:21620960]
Plasma membrane estrogen receptor signaling [NCBI:138009] [Pathway Interaction Database:er_nongenomic_pathway] [PUBMED:12421825] [PUBMED:12431978] [PUBMED:10376603] [PUBMED:14764897] [PUBMED:15764600] [PUBMED:11044445] [PUBMED:15020686] [PUBMED:16601072] [PUBMED:11369763] [PUBMED:11773443] [PUBMED:14963108] [PUBMED:11029403] [PUBMED:17405905] [PUBMED:12415108] [PUBMED:11090554] [PUBMED:15231873] [PUBMED:18261753] [PUBMED:15569929] [PUBMED:11029009] [PUBMED:11981029] [PUBMED:17194752] [PUBMED:9115251] [PUBMED:9973260] [PUBMED:10749889] [PUBMED:17535799]
Platelet activation [NCBI:952858] [KEGG:hsa04611] [PUBMED:20002545] [PUBMED:18363565] [PUBMED:18544684] [PUBMED:18174460] [PUBMED:23106920] [PUBMED:18550847] [PUBMED:22119499] [PUBMED:19630797] [PUBMED:19286885] [PUBMED:17158345] [PUBMED:20089227] [PUBMED:22701130] [PUBMED:21071698] [PUBMED:23805129] [PUBMED:16149014] [PUBMED:18641368]
Platelet homeostasis [NCBI:1269341] [REACTOME:R-HSA-418346] [PUBMED:10798271]
ROS, RNS production in phagocytes [NCBI:1269138] [REACTOME:R-HSA-1222556] [PUBMED:23617726] [PUBMED:19369951]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by VEGF [NCBI:1269480] [REACTOME:R-HSA-194138] [PUBMED:15585754] [PUBMED:13678960] [PUBMED:16336962] [PUBMED:16835467]
Signaling events mediated by VEGFR1 and VEGFR2 [NCBI:137940] [Pathway Interaction Database:vegfr1_2_pathway] [PUBMED:9398617] [PUBMED:9405464] [PUBMED:11494124] [PUBMED:12963813] [PUBMED:11756651] [PUBMED:10744763] [PUBMED:15060076] [PUBMED:9600074] [PUBMED:10376603] [PUBMED:11425855] [PUBMED:16337972] [PUBMED:12154000] [PUBMED:11978735] [PUBMED:10692392] [PUBMED:16763158] [PUBMED:10361126] [PUBMED:10748121] [PUBMED:12598525] [PUBMED:15026417] [PUBMED:11948691] [PUBMED:16966330] [PUBMED:16835467] [PUBMED:10409677] [PUBMED:10908731] [PUBMED:8903320] [PUBMED:15962004] [PUBMED:16633338] [PUBMED:11387210] [PUBMED:16839566] [PUBMED:11312102] [PUBMED:10207622] [PUBMED:16787925] [PUBMED:12171920] [PUBMED:12509223] [PUBMED:16760434] [PUBMED:14724572] [PUBMED:11704645] [PUBMED:12821150] [PUBMED:12881528] [PUBMED:9790910] [PUBMED:10376602] [PUBMED:15247219] [PUBMED:11333271] [PUBMED:12214271] [PUBMED:9804796] [PUBMED:11986311] [PUBMED:9182576] [PUBMED:15217908] [PUBMED:10749680] [PUBMED:16763549]
Sphingolipid signaling pathway [NCBI:1144995] [KEGG:hsa04071] [PUBMED:23919551] [PUBMED:21705677] [PUBMED:18675379] [PUBMED:20534702] [PUBMED:15999095] [PUBMED:16470226] [PUBMED:11001563] [PUBMED:17913601] [PUBMED:17161984] [PUBMED:22654878] [PUBMED:17438574] [PUBMED:18216770] [PUBMED:11418646] [PUBMED:10880336] [PUBMED:15451787] [PUBMED:25309325] [PUBMED:18403224]
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation [NCBI:1270120] [REACTOME:R-HSA-1474151] [PUBMED:17555404] [PUBMED:21550412] [PUBMED:10727395] [PUBMED:18321209]
Thromboxane A2 receptor signaling [NCBI:138060] [Pathway Interaction Database:txa2pathway] [PUBMED:15100160] [PUBMED:11160627] [PUBMED:16859489] [PUBMED:7476920] [PUBMED:12193606] [PUBMED:8474027] [PUBMED:16595906] [PUBMED:11748077] [PUBMED:8948507] [PUBMED:11055976] [PUBMED:15884057] [PUBMED:1825698] [PUBMED:9054415] [PUBMED:1851174] [PUBMED:9862451] [PUBMED:11901221] [PUBMED:14976202] [PUBMED:9915793] [PUBMED:12796499] [PUBMED:16212421] [PUBMED:16956790] [PUBMED:8034687] [PUBMED:17466390] [PUBMED:12183468] [PUBMED:10085139] [PUBMED:9649216] [PUBMED:11873244] [PUBMED:12038794] [PUBMED:10771086] [PUBMED:11015313] [PUBMED:9417126] [PUBMED:12626493] [PUBMED:10827090] [PUBMED:7969066] [PUBMED:8119906] [PUBMED:11389977] [PUBMED:16876780] [PUBMED:16126723] [PUBMED:8636072] [PUBMED:8894620] [PUBMED:11526402] [PUBMED:17229546] [PUBMED:10037795] [PUBMED:15845539] [PUBMED:10670835] [PUBMED:14530262] [PUBMED:8290554] [PUBMED:11443056] [PUBMED:10800962] [PUBMED:9560198] [PUBMED:11389883] [PUBMED:7961988] [PUBMED:10212262] [PUBMED:8245033] [PUBMED:8613548] [PUBMED:7591017] [PUBMED:12187125] [PUBMED:11516166] [PUBMED:10318854]
VEGF signaling pathway [NCBI:83066] [KEGG:hsa04370] [PUBMED:11741095] [PUBMED:16104843] [PUBMED:14641020] [PUBMED:15338053] [PUBMED:14724572] [PUBMED:12391145] [PUBMED:13678960] [PUBMED:15602010]
VEGFA-VEGFR2 Pathway [NCBI:1269483] [REACTOME:R-HSA-4420097] [PUBMED:17344076] [PUBMED:16633338] [PUBMED:19230644] [PUBMED:13678960]
VEGFR1 specific signals [NCBI:137924] [Pathway Interaction Database:vegfr1_pathway] [PUBMED:9299537] [PUBMED:9751730] [PUBMED:9722576] [PUBMED:14633857] [PUBMED:11978735] [PUBMED:11278319] [PUBMED:12649282] [PUBMED:16839566] [PUBMED:12598525] [PUBMED:12171920] [PUBMED:12796773] [PUBMED:16633338] [PUBMED:11312102] [PUBMED:9295307] [PUBMED:10908731] [PUBMED:16787925] [PUBMED:11704645] [PUBMED:9790910] [PUBMED:10376602] [PUBMED:9804796] [PUBMED:11986311] [PUBMED:10749680] [PUBMED:12214271] [PUBMED:9398617] [PUBMED:8621427] [PUBMED:11425855] [PUBMED:15001553] [PUBMED:10376603] [PUBMED:7824266] [PUBMED:10842181] [PUBMED:9600074]
VEGFR2 mediated vascular permeability [NCBI:1269484] [REACTOME:R-HSA-5218920] [PUBMED:17008595]
Validated transcriptional targets of AP1 family members Fra1 and Fra2 [NCBI:169349] [Pathway Interaction Database:fra_pathway] [PUBMED:20386569] [PUBMED:1827665] [PUBMED:17510314] [PUBMED:17001307] [PUBMED:19419315] [PUBMED:12121977] [PUBMED:15790882] [PUBMED:18435914] [PUBMED:1406676] [PUBMED:20543861] [PUBMED:19687301] [PUBMED:9651314] [PUBMED:20392257] [PUBMED:20472895] [PUBMED:16554298] [PUBMED:17496887] [PUBMED:19995753] [PUBMED:8058317] [PUBMED:2497053] [PUBMED:8798756] [PUBMED:17347653] [PUBMED:18331200] [PUBMED:19966854] [PUBMED:17882273] [PUBMED:9858556] [PUBMED:3130660] [PUBMED:19289495] [PUBMED:11756554] [PUBMED:1945831] [PUBMED:15688012] [PUBMED:8441422] [PUBMED:17371847] [PUBMED:10421804] [PUBMED:2110368] [PUBMED:18548006] [PUBMED:20353950] [PUBMED:15229648] [PUBMED:11425864] [PUBMED:15601844] [PUBMED:10918580] [PUBMED:9858557] [PUBMED:19716794] [PUBMED:9819396] [PUBMED:17052890] [PUBMED:20398633] [PUBMED:20371606] [PUBMED:10359014] [PUBMED:15143165] [PUBMED:15618352] [PUBMED:9160889] [PUBMED:12052899] [PUBMED:9409785] [PUBMED:15291758] [PUBMED:1923525] [PUBMED:7759510] [PUBMED:15608675] [PUBMED:14519134] [PUBMED:20053986] [PUBMED:15256456] [PUBMED:19923172] [PUBMED:15558021] [PUBMED:12773579]
cGMP-PKG signaling pathway [NCBI:983748] [KEGG:hsa04022] [PUBMED:18006449] [PUBMED:9003029] [PUBMED:18040025] [PUBMED:19306895] [PUBMED:21666108] [PUBMED:12524221] [PUBMED:16460276] [PUBMED:20716671] [PUBMED:22785374] [PUBMED:11522789] [PUBMED:16439998] [PUBMED:16371594] [PUBMED:20388537] [PUBMED:18757523] [PUBMED:16815627] [PUBMED:23212367] [PUBMED:21685243] [PUBMED:20024580] [PUBMED:15894227] [PUBMED:22965426] [PUBMED:17643091] [PUBMED:19176601] [PUBMED:19961855]
citrulline-nitric oxide cycle [NCBI:703092] [BIOCYC:HUMAN_PWY-4983] [PUBMED:7511585] [PUBMED:2236071] [PUBMED:1731766]
eNOS activation [NCBI:1270117] [REACTOME:R-HSA-203615] [PUBMED:10551886] [PUBMED:12482742] [PUBMED:11208594] [PUBMED:16722822]
eNOS activation and regulation [NCBI:1270116] [REACTOME:R-HSA-203765] [PUBMED:12842859] [PUBMED:16722822]