full name
cathepsin B

synonyms
APPS, CPSB, CTSB, ENSG00000164733

HGNC
HGNC:2527

Entrez Gene
Gene:1508

ENSEMBL
ENSG00000164733

location
chr: 8
start: 11700033
stop: 11725646
strand: -

OMIM
OMIM:116810: CTSB
OMIM:148370: Keratolytic winter erythema

transcripts
NM_001908.3
NM_147783.2
NM_147781.2
NM_147782.2
NM_147780.2

pathways
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Antigen processing and presentation [NCBI:83074] [KEGG:hsa04612] [PUBMED:12776207] [PUBMED:15653315] [PUBMED:15814328] [PUBMED:20010787] [PUBMED:15224094] [PUBMED:15745856] [PUBMED:11244040] [PUBMED:15304636] [PUBMED:11905820] [PUBMED:16181333] [PUBMED:16200082] [PUBMED:15653312] [PUBMED:15224093] [PUBMED:15771591] [PUBMED:12974477]
Apoptosis [NCBI:83060] [KEGG:hsa04210] [NCBI:1270262] [REACTOME:R-HSA-109581] [PUBMED:12189384] [PUBMED:20533903] [PUBMED:18208375] [PUBMED:22429822] [PUBMED:15218528] [PUBMED:24769728] [PUBMED:18023214] [PUBMED:25526085] [PUBMED:23070002] [PUBMED:15654015] [PUBMED:15601572] [PUBMED:14561771] [PUBMED:24278747] [PUBMED:21914490] [PUBMED:22465226] [PUBMED:21145844] [PUBMED:12838338] [PUBMED:18238895] [PUBMED:12949498] [PUBMED:18304445] [PUBMED:14737178] [PUBMED:26231733] [PUBMED:9916983] [PUBMED:14634621] [PUBMED:19770840] [PUBMED:22075987] [PUBMED:4561027] [PUBMED:20075940] [PUBMED:9894605] [PUBMED:26615431] [PUBMED:12505355] [PUBMED:11520933] [PUBMED:19148180] [PUBMED:16397578] [PUBMED:15719025] [PUBMED:15322527] [PUBMED:15725726] [PUBMED:12209154] [PUBMED:23803157]
Assembly of collagen fibrils and other multimeric structures [NCBI:1270247] [REACTOME:R-HSA-2022090] [PUBMED:8645190] [PUBMED:21182410]
Autophagy - animal [NCBI:83058] [KEGG:hsa04140] [PUBMED:16200202] [PUBMED:15325588] [PUBMED:24343578] [PUBMED:15978794] [PUBMED:19802558] [PUBMED:16099218] [PUBMED:11099404] [PUBMED:19653858] [PUBMED:15325584] [PUBMED:20034776] [PUBMED:15928708] [PUBMED:21801009] [PUBMED:25948417] [PUBMED:16125113] [PUBMED:21187343]
Collagen degradation [NCBI:1270259] [REACTOME:R-HSA-1442490] [PUBMED:11076937] [PUBMED:21087458] [PUBMED:9818170]
Collagen formation [NCBI:1270245] [REACTOME:R-HSA-1474290] [PUBMED:7574488] [PUBMED:19693541]
Degradation of the extracellular matrix [NCBI:1270257] [REACTOME:R-HSA-1474228] [PUBMED:21917992]
Extracellular matrix organization [NCBI:1270244] [REACTOME:R-HSA-1474244] [PUBMED:21123617] [PUBMED:21917992] [PUBMED:12845610]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Lysosome [NCBI:99052] [KEGG:hsa04142] [PUBMED:2943218] [PUBMED:12628346] [PUBMED:1883197] [PUBMED:18635948] [PUBMED:15987739]
MHC class II antigen presentation [NCBI:1269200] [REACTOME:R-HSA-2132295] [PUBMED:19703008] [PUBMED:9316394] [PUBMED:11684289] [PUBMED:19217269] [PUBMED:8689559]
NOD-like receptor signaling pathway [NCBI:122191] [KEGG:hsa04621] [PUBMED:25330206] [PUBMED:21575908] [PUBMED:23846113] [PUBMED:26549800] [PUBMED:16493424] [PUBMED:23124073] [PUBMED:24840700] [PUBMED:27291964] [PUBMED:27012466] [PUBMED:24707857] [PUBMED:19767725] [PUBMED:25879280] [PUBMED:23215645] [PUBMED:22819539] [PUBMED:23702978] [PUBMED:20643110] [PUBMED:25879288] [PUBMED:26655628] [PUBMED:25145756] [PUBMED:24718315] [PUBMED:26482951] [PUBMED:25526305] [PUBMED:26121197] [PUBMED:22430786]
Neutrophil degranulation [NCBI:1457780] [REACTOME:R-HSA-6798695] [PUBMED:20338884] [PUBMED:1378856] [PUBMED:17627888] [PUBMED:23650620] [PUBMED:8692836]
Renin secretion [NCBI:1222951] [KEGG:hsa04924] [PUBMED:24944035] [PUBMED:22733355] [PUBMED:20936939] [PUBMED:12949225] [PUBMED:17360952] [PUBMED:17928544] [PUBMED:19948673] [PUBMED:12388321] [PUBMED:15283749] [PUBMED:22237158] [PUBMED:22258323] [PUBMED:9882634] [PUBMED:20393195] [PUBMED:22124804]
Toll-Like Receptors Cascades [NCBI:1269204] [REACTOME:R-HSA-168898] [PUBMED:15950447] [PUBMED:12893815] [PUBMED:15976490] [PUBMED:15585605] [PUBMED:14751757]
Trafficking and processing of endosomal TLR [NCBI:1269205] [REACTOME:R-HSA-1679131] [PUBMED:16144834] [PUBMED:18776324] [PUBMED:16857668] [PUBMED:18820679] [PUBMED:19521997] [PUBMED:18420935] [PUBMED:16341217] [PUBMED:9799232] [PUBMED:15226270] [PUBMED:21402738]