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Genes
VAV3
Gene - VAV3
full name
vav guanine nucleotide exchange factor 3
synonyms
VAV3, ENSG00000134215
HGNC
HGNC:12659
Entrez Gene
Gene:10451
ENSEMBL
ENSG00000134215
location
chr: 1
start: 108113782
stop: 108507545
strand: -
transcripts
NM_006113.4
NM_001079874.1
pathways
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
B cell receptor signaling pathway
[NCBI:83081]
[KEGG:hsa04662]
[PUBMED:15626471]
[PUBMED:12119152]
[PUBMED:15886119]
[PUBMED:12461567]
[PUBMED:9697839]
[PUBMED:15752555]
[PUBMED:11163197]
[PUBMED:18086859]
[PUBMED:15364057]
[PUBMED:15457440]
[PUBMED:15322145]
[PUBMED:15771577]
[PUBMED:12033741]
[PUBMED:15886112]
[PUBMED:10358768]
Cell death signalling via NRAGE, NRIF and NADE
[NCBI:1269447]
[REACTOME:R-HSA-204998]
[PUBMED:12787561]
Chemokine signaling pathway
[NCBI:99051]
[KEGG:hsa04062]
[PUBMED:17371236]
[PUBMED:19159344]
[PUBMED:17169327]
[PUBMED:10852130]
[PUBMED:9765254]
[PUBMED:15771581]
[PUBMED:14607270]
[PUBMED:18662984]
[PUBMED:12495636]
[PUBMED:15803148]
[PUBMED:15046611]
[PUBMED:12069927]
[PUBMED:18711432]
[PUBMED:17675482]
[PUBMED:16144840]
[PUBMED:17496928]
[PUBMED:17537990]
[PUBMED:11872087]
[PUBMED:12051620]
[PUBMED:14625285]
[PUBMED:8576262]
[PUBMED:11244042]
Coregulation of Androgen receptor activity
[NCBI:138085]
[Pathway Interaction Database:ar_pathway]
[PUBMED:16724108]
[PUBMED:16027218]
[PUBMED:11818503]
[PUBMED:17277772]
[PUBMED:11719514]
[PUBMED:15833840]
[PUBMED:16384856]
[PUBMED:14645241]
[PUBMED:12218053]
[PUBMED:11016951]
[PUBMED:12621049]
[PUBMED:15784617]
[PUBMED:16446156]
[PUBMED:17110431]
[PUBMED:16254014]
[PUBMED:17698582]
[PUBMED:15131260]
[PUBMED:16705743]
[PUBMED:11682623]
[PUBMED:17192406]
[PUBMED:15882980]
[PUBMED:10934038]
[PUBMED:12165860]
[PUBMED:11856738]
[PUBMED:16720717]
[PUBMED:9710597]
[PUBMED:14609956]
[PUBMED:17170703]
[PUBMED:10383460]
[PUBMED:14576337]
[PUBMED:12941811]
[PUBMED:14612401]
[PUBMED:17975004]
[PUBMED:12799378]
[PUBMED:15790678]
[PUBMED:8643607]
[PUBMED:11792840]
[PUBMED:16603237]
[PUBMED:16079795]
[PUBMED:16951154]
[PUBMED:15166229]
[PUBMED:17142810]
[PUBMED:12361945]
[PUBMED:11439351]
[PUBMED:15640154]
[PUBMED:17909037]
[PUBMED:15539430]
[PUBMED:11792709]
[PUBMED:11931767]
[PUBMED:10344732]
[PUBMED:10428808]
DAP12 interactions
[NCBI:1269283]
[REACTOME:R-HSA-2172127]
[PUBMED:19120482]
[PUBMED:17220916]
[PUBMED:9490415]
[PUBMED:18192027]
[PUBMED:15884055]
DAP12 signaling
[NCBI:1269284]
[REACTOME:R-HSA-2424491]
[PUBMED:15884055]
[PUBMED:17110943]
[PUBMED:17220916]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
EPH-Ephrin signaling
[NCBI:1270330]
[REACTOME:R-HSA-2682334]
[PUBMED:18281458]
[PUBMED:22120527]
EPH-ephrin mediated repulsion of cells
[NCBI:1270334]
[REACTOME:R-HSA-3928665]
[PUBMED:10958785]
[PUBMED:16239146]
[PUBMED:12973357]
[PUBMED:18713744]
[PUBMED:17420126]
EPHA forward signaling
[NCBI:138041]
[Pathway Interaction Database:epha_fwdpathway]
[PUBMED:16491080]
[PUBMED:15848800]
[PUBMED:12356866]
[PUBMED:14660665]
[PUBMED:11416136]
[PUBMED:11870224]
[PUBMED:12496371]
[PUBMED:12775584]
[PUBMED:14664814]
[PUBMED:12681484]
[PUBMED:15848799]
[PUBMED:12794130]
[PUBMED:15254079]
[PUBMED:9886291]
[PUBMED:8755474]
[PUBMED:10769020]
[PUBMED:17494698]
[PUBMED:11336673]
EPHA2 forward signaling
[NCBI:137961]
[Pathway Interaction Database:epha2_fwdpathway]
[PUBMED:12496371]
[PUBMED:18387945]
[PUBMED:18198190]
[PUBMED:12134157]
[PUBMED:15054110]
[PUBMED:7982920]
[PUBMED:17135240]
[PUBMED:10655584]
[PUBMED:16782872]
[PUBMED:12400011]
[PUBMED:8755474]
[PUBMED:12615978]
[PUBMED:14988728]
FCERI mediated Ca+2 mobilization
[NCBI:1269300]
[REACTOME:R-HSA-2871809]
[PUBMED:17336609]
[PUBMED:10807788]
[PUBMED:1309940]
FCERI mediated MAPK activation
[NCBI:1269299]
[REACTOME:R-HSA-2871796]
[PUBMED:19290926]
[PUBMED:19909365]
[PUBMED:17122878]
Fc epsilon RI signaling pathway
[NCBI:83082]
[KEGG:hsa04664]
[PUBMED:16470226]
[PUBMED:12145654]
[PUBMED:11079101]
[PUBMED:10586892]
[PUBMED:14630197]
[PUBMED:12360215]
[PUBMED:11449275]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
Fc gamma R-mediated phagocytosis
[NCBI:114228]
[KEGG:hsa04666]
[PUBMED:11304556]
[PUBMED:11244038]
[PUBMED:10755615]
[PUBMED:17308335]
[PUBMED:12821647]
[PUBMED:15466916]
[PUBMED:17050193]
[PUBMED:11228151]
[PUBMED:12488490]
[PUBMED:10224668]
[PUBMED:11708889]
[PUBMED:9581795]
[PUBMED:10586078]
[PUBMED:9417101]
[PUBMED:15485887]
[PUBMED:18322649]
[PUBMED:10577498]
[PUBMED:10376013]
[PUBMED:10601359]
[PUBMED:9545263]
Fcgamma receptor (FCGR) dependent phagocytosis
[NCBI:1269279]
[REACTOME:R-HSA-2029480]
[PUBMED:8541526]
[PUBMED:12488490]
[PUBMED:16413920]
[PUBMED:17050193]
Focal adhesion
[NCBI:83067]
[KEGG:hsa04510]
[PUBMED:10698680]
[PUBMED:15459662]
[PUBMED:14756624]
[PUBMED:11573199]
[PUBMED:12640026]
[PUBMED:15179030]
[PUBMED:15108811]
[PUBMED:15053919]
[PUBMED:11082269]
[PUBMED:15034601]
[PUBMED:12235283]
[PUBMED:14519391]
[PUBMED:11146675]
[PUBMED:11229600]
[PUBMED:15688067]
[PUBMED:14744429]
[PUBMED:11882383]
G alpha (12/13) signalling events
[NCBI:1269579]
[REACTOME:R-HSA-416482]
[PUBMED:18814923]
[PUBMED:19212140]
GPCR downstream signaling
[NCBI:1269574]
[REACTOME:R-HSA-388396]
[PUBMED:12040175]
GPVI-mediated activation cascade
[NCBI:1269357]
[REACTOME:R-HSA-114604]
[PUBMED:16102042]
[PUBMED:11943772]
Hemostasis
[NCBI:1269340]
[REACTOME:R-HSA-109582]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Integrins in angiogenesis
[NCBI:137999]
[Pathway Interaction Database:avb3_integrin_pathway]
[PUBMED:10837460]
[PUBMED:9182576]
[PUBMED:12642872]
[PUBMED:15711558]
[PUBMED:10037797]
[PUBMED:10196194]
[PUBMED:11877390]
[PUBMED:16418218]
[PUBMED:16600665]
[PUBMED:16982628]
[PUBMED:15479743]
[PUBMED:16720645]
[PUBMED:11684710]
[PUBMED:10821695]
[PUBMED:12237112]
[PUBMED:12750158]
[PUBMED:11551924]
[PUBMED:8794870]
[PUBMED:10022831]
[PUBMED:15187087]
[PUBMED:16195423]
[PUBMED:16760434]
[PUBMED:12682293]
[PUBMED:9420328]
[PUBMED:15247219]
[PUBMED:9490736]
[PUBMED:11313365]
Leukocyte transendothelial migration
[NCBI:83083]
[KEGG:hsa04670]
[PUBMED:15629883]
[PUBMED:10975856]
[PUBMED:14976004]
[PUBMED:15265790]
[PUBMED:15173832]
[PUBMED:12540948]
[PUBMED:15771581]
[PUBMED:15604886]
[PUBMED:14977592]
NRAGE signals death through JNK
[NCBI:1269448]
[REACTOME:R-HSA-193648]
[PUBMED:12376548]
Natural killer cell mediated cytotoxicity
[NCBI:83079]
[KEGG:hsa04650]
[PUBMED:12530970]
[PUBMED:15567854]
[PUBMED:8942070]
[PUBMED:11905813]
[PUBMED:9143705]
[PUBMED:9862693]
[PUBMED:11895890]
[PUBMED:12205470]
[PUBMED:11836514]
[PUBMED:15607806]
[PUBMED:16002670]
[PUBMED:15618404]
[PUBMED:11390470]
[PUBMED:11062493]
[PUBMED:14710949]
[PUBMED:12752668]
[PUBMED:15607802]
[PUBMED:16109839]
[PUBMED:12766758]
[PUBMED:16177799]
Osteopontin-mediated events
[NCBI:137960]
[Pathway Interaction Database:avb3_opn_pathway]
[PUBMED:9727056]
[PUBMED:9585425]
[PUBMED:16888388]
[PUBMED:16474180]
[PUBMED:15757900]
[PUBMED:9682033]
[PUBMED:12529435]
[PUBMED:15142256]
[PUBMED:14624447]
[PUBMED:15711558]
[PUBMED:9988732]
[PUBMED:12730217]
[PUBMED:11600576]
[PUBMED:8744948]
[PUBMED:16691505]
[PUBMED:11940607]
[PUBMED:16006560]
[PUBMED:10766830]
[PUBMED:10559185]
Platelet activation, signaling and aggregation
[NCBI:1269350]
[REACTOME:R-HSA-76002]
[PUBMED:16543958]
[PUBMED:8704248]
[PUBMED:2018971]
[PUBMED:1672265]
[PUBMED:17059469]
[PUBMED:12681240]
[PUBMED:12411949]
[PUBMED:11511514]
Regulation of CDC42 activity
[NCBI:137990]
[Pathway Interaction Database:cdc42_reg_pathway]
[PUBMED:19581296]
[PUBMED:17297291]
[PUBMED:14506234]
[PUBMED:17145773]
[PUBMED:8798610]
[PUBMED:17015620]
[PUBMED:9535855]
[PUBMED:15710388]
[PUBMED:12547822]
[PUBMED:15728722]
[PUBMED:11285260]
[PUBMED:11748279]
[PUBMED:8969170]
[PUBMED:17538024]
[PUBMED:11336673]
[PUBMED:12172552]
[PUBMED:15850391]
[PUBMED:18208356]
[PUBMED:10523665]
[PUBMED:1429634]
[PUBMED:19156867]
[PUBMED:19356586]
[PUBMED:16616186]
[PUBMED:15247287]
[PUBMED:9497316]
[PUBMED:10559246]
[PUBMED:14506284]
[PUBMED:16892055]
[PUBMED:19525225]
[PUBMED:11741931]
[PUBMED:17562871]
[PUBMED:18470881]
[PUBMED:1439791]
[PUBMED:10744696]
[PUBMED:7673236]
[PUBMED:12432077]
[PUBMED:17196961]
[PUBMED:10982832]
[PUBMED:16968698]
[PUBMED:11431473]
[PUBMED:10676816]
[PUBMED:15277544]
[PUBMED:18728402]
[PUBMED:15793564]
[PUBMED:18056264]
[PUBMED:9268338]
[PUBMED:12517963]
[PUBMED:1956381]
[PUBMED:15504743]
[PUBMED:17599059]
[PUBMED:15649357]
[PUBMED:10652228]
[PUBMED:15306850]
[PUBMED:19745154]
Regulation of RAC1 activity
[NCBI:169346]
[Pathway Interaction Database:rac1_reg_pathway]
[PUBMED:8297393]
[PUBMED:12134164]
[PUBMED:15485841]
[PUBMED:11707441]
[PUBMED:17320046]
[PUBMED:9857026]
[PUBMED:9497316]
[PUBMED:17254573]
[PUBMED:15850775]
[PUBMED:8352776]
[PUBMED:15128856]
[PUBMED:17403664]
[PUBMED:8491184]
[PUBMED:7753201]
[PUBMED:9707409]
[PUBMED:12432077]
[PUBMED:8226937]
[PUBMED:19934221]
[PUBMED:17196961]
[PUBMED:17640372]
[PUBMED:11287617]
[PUBMED:12515821]
[PUBMED:16943182]
[PUBMED:19861492]
[PUBMED:10220378]
[PUBMED:11431473]
[PUBMED:10982832]
[PUBMED:7673236]
[PUBMED:10744696]
[PUBMED:17599059]
[PUBMED:17116687]
[PUBMED:12923183]
[PUBMED:10364228]
[PUBMED:16628218]
[PUBMED:8288572]
[PUBMED:15306850]
[PUBMED:11396949]
[PUBMED:8496137]
[PUBMED:11912491]
[PUBMED:15649357]
[PUBMED:7980444]
[PUBMED:18325335]
[PUBMED:15242348]
[PUBMED:11955434]
[PUBMED:15039778]
[PUBMED:11685227]
[PUBMED:15897194]
[PUBMED:11130063]
[PUBMED:10559863]
[PUBMED:17052214]
[PUBMED:11099046]
[PUBMED:15728722]
[PUBMED:16520382]
[PUBMED:16492808]
[PUBMED:12547822]
[PUBMED:12446789]
[PUBMED:11274357]
[PUBMED:8419353]
[PUBMED:16481401]
[PUBMED:8276860]
[PUBMED:15005707]
[PUBMED:10499589]
[PUBMED:11336673]
[PUBMED:1903516]
[PUBMED:12829596]
[PUBMED:17332503]
[PUBMED:11146652]
[PUBMED:12134158]
[PUBMED:8643598]
[PUBMED:18212043]
Regulation of RhoA activity
[NCBI:138070]
[Pathway Interaction Database:rhoa_reg_pathway]
[PUBMED:10579713]
[PUBMED:15039571]
[PUBMED:19605563]
[PUBMED:19755152]
[PUBMED:16954208]
[PUBMED:10744696]
[PUBMED:17702745]
[PUBMED:10837491]
[PUBMED:12454018]
[PUBMED:15023524]
[PUBMED:11396949]
[PUBMED:10523675]
[PUBMED:10026210]
[PUBMED:18948007]
[PUBMED:16112081]
[PUBMED:19713215]
[PUBMED:9425278]
[PUBMED:11085924]
[PUBMED:9582072]
[PUBMED:12071859]
[PUBMED:19066281]
[PUBMED:14512443]
[PUBMED:18851832]
[PUBMED:12775584]
[PUBMED:15632174]
[PUBMED:8356058]
[PUBMED:1907371]
[PUBMED:11058585]
[PUBMED:9032261]
[PUBMED:18211802]
[PUBMED:12414125]
[PUBMED:17971419]
[PUBMED:19625450]
[PUBMED:15069594]
[PUBMED:12221096]
[PUBMED:17804252]
[PUBMED:8276860]
[PUBMED:19635168]
[PUBMED:8910315]
[PUBMED:18096806]
[PUBMED:12183458]
[PUBMED:15601624]
[PUBMED:9464532]
[PUBMED:11336673]
[PUBMED:16721066]
[PUBMED:12215546]
[PUBMED:15078817]
[PUBMED:12196628]
[PUBMED:11553710]
[PUBMED:7479768]
[PUBMED:8643598]
[PUBMED:10699171]
[PUBMED:9490638]
[PUBMED:8491184]
[PUBMED:8352776]
[PUBMED:20018869]
[PUBMED:12944407]
[PUBMED:11804590]
[PUBMED:8297393]
[PUBMED:11672528]
[PUBMED:15296756]
[PUBMED:17488622]
[PUBMED:9670022]
[PUBMED:8537347]
[PUBMED:19261619]
[PUBMED:16896804]
[PUBMED:11094164]
[PUBMED:15691829]
[PUBMED:19103606]
[PUBMED:9641916]
Regulation of actin cytoskeleton
[NCBI:83089]
[KEGG:hsa04810]
[PUBMED:11152757]
[PUBMED:11082272]
[PUBMED:10574699]
[PUBMED:11082269]
[PUBMED:14657486]
[PUBMED:14744429]
[PUBMED:12700767]
Regulation of actin dynamics for phagocytic cup formation
[NCBI:1269281]
[REACTOME:R-HSA-2029482]
[PUBMED:17477841]
[PUBMED:15452139]
[PUBMED:15981459]
Rho GTPase cycle
[NCBI:1269508]
[REACTOME:R-HSA-194840]
[PUBMED:17222083]
[PUBMED:9308960]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signaling by Rho GTPases
[NCBI:1269507]
[REACTOME:R-HSA-194315]
[PUBMED:16212495]
[PUBMED:15630019]
Signaling by VEGF
[NCBI:1269480]
[REACTOME:R-HSA-194138]
[PUBMED:15585754]
[PUBMED:13678960]
[PUBMED:16336962]
[PUBMED:16835467]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
T cell receptor signaling pathway
[NCBI:83080]
[KEGG:hsa04660]
[PUBMED:17395537]
[PUBMED:15308211]
[PUBMED:15928679]
[PUBMED:14656980]
[PUBMED:17187070]
[PUBMED:15084594]
[PUBMED:16799472]
[PUBMED:12669022]
[PUBMED:15286727]
[PUBMED:15122199]
[PUBMED:19132916]
[PUBMED:15489916]
[PUBMED:11905831]
[PUBMED:12195013]
[PUBMED:15343367]
[PUBMED:12133805]
[PUBMED:14647476]
[PUBMED:15771581]
[PUBMED:15099566]
[PUBMED:14617194]
[PUBMED:19290929]
[PUBMED:15345216]
VEGFA-VEGFR2 Pathway
[NCBI:1269483]
[REACTOME:R-HSA-4420097]
[PUBMED:17344076]
[PUBMED:16633338]
[PUBMED:19230644]
[PUBMED:13678960]
VEGFR2 mediated vascular permeability
[NCBI:1269484]
[REACTOME:R-HSA-5218920]
[PUBMED:17008595]
cAMP signaling pathway
[NCBI:1017634]
[KEGG:hsa04024]
[PUBMED:10880354]
[PUBMED:9204709]
[PUBMED:21693691]
[PUBMED:24062645]
[PUBMED:24450633]
[PUBMED:21346730]
[PUBMED:24613710]
[PUBMED:21744067]
[PUBMED:22082266]
[PUBMED:16460276]
[PUBMED:18176800]
[PUBMED:14715909]
[PUBMED:7688165]
[PUBMED:24281338]
[PUBMED:11117527]
[PUBMED:16765984]
[PUBMED:18323530]
[PUBMED:18064650]
[PUBMED:21852968]
[PUBMED:11493633]
[PUBMED:21212391]
[PUBMED:15142747]
[PUBMED:17077866]
[PUBMED:19460777]
[PUBMED:19874988]
[PUBMED:16571352]
[PUBMED:22022314]
p75 NTR receptor-mediated signalling
[NCBI:1269445]
[REACTOME:R-HSA-193704]
[PUBMED:16699811]
[PUBMED:16939974]
[PUBMED:12671646]