Logo
full name
vav guanine nucleotide exchange factor 3

synonyms
VAV3, ENSG00000134215

HGNC
HGNC:12659

Entrez Gene
Gene:10451

ENSEMBL
ENSG00000134215

location
chr: 1
start: 108113782
stop: 108507545
strand: -

transcripts
NM_006113.4
NM_001079874.1

pathways
Axon guidance [NCBI:83065] [KEGG:hsa04360] [NCBI:1270303] [REACTOME:R-HSA-422475] [PUBMED:14682358] [PUBMED:15084255] [PUBMED:11687826] [PUBMED:15818466] [PUBMED:15363605] [PUBMED:12471249] [PUBMED:15630019] [PUBMED:11891122] [PUBMED:15960985] [PUBMED:12677003]
B cell receptor signaling pathway [NCBI:83081] [KEGG:hsa04662] [PUBMED:15626471] [PUBMED:12119152] [PUBMED:15886119] [PUBMED:12461567] [PUBMED:9697839] [PUBMED:15752555] [PUBMED:11163197] [PUBMED:18086859] [PUBMED:15364057] [PUBMED:15457440] [PUBMED:15322145] [PUBMED:15771577] [PUBMED:12033741] [PUBMED:15886112] [PUBMED:10358768]
Cell death signalling via NRAGE, NRIF and NADE [NCBI:1269447] [REACTOME:R-HSA-204998] [PUBMED:12787561]
Chemokine signaling pathway [NCBI:99051] [KEGG:hsa04062] [PUBMED:17371236] [PUBMED:19159344] [PUBMED:17169327] [PUBMED:10852130] [PUBMED:9765254] [PUBMED:15771581] [PUBMED:14607270] [PUBMED:18662984] [PUBMED:12495636] [PUBMED:15803148] [PUBMED:15046611] [PUBMED:12069927] [PUBMED:18711432] [PUBMED:17675482] [PUBMED:16144840] [PUBMED:17496928] [PUBMED:17537990] [PUBMED:11872087] [PUBMED:12051620] [PUBMED:14625285] [PUBMED:8576262] [PUBMED:11244042]
Coregulation of Androgen receptor activity [NCBI:138085] [Pathway Interaction Database:ar_pathway] [PUBMED:16724108] [PUBMED:16027218] [PUBMED:11818503] [PUBMED:17277772] [PUBMED:11719514] [PUBMED:15833840] [PUBMED:16384856] [PUBMED:14645241] [PUBMED:12218053] [PUBMED:11016951] [PUBMED:12621049] [PUBMED:15784617] [PUBMED:16446156] [PUBMED:17110431] [PUBMED:16254014] [PUBMED:17698582] [PUBMED:15131260] [PUBMED:16705743] [PUBMED:11682623] [PUBMED:17192406] [PUBMED:15882980] [PUBMED:10934038] [PUBMED:12165860] [PUBMED:11856738] [PUBMED:16720717] [PUBMED:9710597] [PUBMED:14609956] [PUBMED:17170703] [PUBMED:10383460] [PUBMED:14576337] [PUBMED:12941811] [PUBMED:14612401] [PUBMED:17975004] [PUBMED:12799378] [PUBMED:15790678] [PUBMED:8643607] [PUBMED:11792840] [PUBMED:16603237] [PUBMED:16079795] [PUBMED:16951154] [PUBMED:15166229] [PUBMED:17142810] [PUBMED:12361945] [PUBMED:11439351] [PUBMED:15640154] [PUBMED:17909037] [PUBMED:15539430] [PUBMED:11792709] [PUBMED:11931767] [PUBMED:10344732] [PUBMED:10428808]
DAP12 interactions [NCBI:1269283] [REACTOME:R-HSA-2172127] [PUBMED:19120482] [PUBMED:17220916] [PUBMED:9490415] [PUBMED:18192027] [PUBMED:15884055]
DAP12 signaling [NCBI:1269284] [REACTOME:R-HSA-2424491] [PUBMED:15884055] [PUBMED:17110943] [PUBMED:17220916]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
EPH-Ephrin signaling [NCBI:1270330] [REACTOME:R-HSA-2682334] [PUBMED:18281458] [PUBMED:22120527]
EPH-ephrin mediated repulsion of cells [NCBI:1270334] [REACTOME:R-HSA-3928665] [PUBMED:10958785] [PUBMED:16239146] [PUBMED:12973357] [PUBMED:18713744] [PUBMED:17420126]
EPHA forward signaling [NCBI:138041] [Pathway Interaction Database:epha_fwdpathway] [PUBMED:16491080] [PUBMED:15848800] [PUBMED:12356866] [PUBMED:14660665] [PUBMED:11416136] [PUBMED:11870224] [PUBMED:12496371] [PUBMED:12775584] [PUBMED:14664814] [PUBMED:12681484] [PUBMED:15848799] [PUBMED:12794130] [PUBMED:15254079] [PUBMED:9886291] [PUBMED:8755474] [PUBMED:10769020] [PUBMED:17494698] [PUBMED:11336673]
EPHA2 forward signaling [NCBI:137961] [Pathway Interaction Database:epha2_fwdpathway] [PUBMED:12496371] [PUBMED:18387945] [PUBMED:18198190] [PUBMED:12134157] [PUBMED:15054110] [PUBMED:7982920] [PUBMED:17135240] [PUBMED:10655584] [PUBMED:16782872] [PUBMED:12400011] [PUBMED:8755474] [PUBMED:12615978] [PUBMED:14988728]
FCERI mediated Ca+2 mobilization [NCBI:1269300] [REACTOME:R-HSA-2871809] [PUBMED:17336609] [PUBMED:10807788] [PUBMED:1309940]
FCERI mediated MAPK activation [NCBI:1269299] [REACTOME:R-HSA-2871796] [PUBMED:19290926] [PUBMED:19909365] [PUBMED:17122878]
Fc epsilon RI signaling pathway [NCBI:83082] [KEGG:hsa04664] [PUBMED:16470226] [PUBMED:12145654] [PUBMED:11079101] [PUBMED:10586892] [PUBMED:14630197] [PUBMED:12360215] [PUBMED:11449275]
Fc epsilon receptor (FCERI) signaling [NCBI:1269298] [REACTOME:R-HSA-2454202] [PUBMED:15099567] [PUBMED:21799019]
Fc gamma R-mediated phagocytosis [NCBI:114228] [KEGG:hsa04666] [PUBMED:11304556] [PUBMED:11244038] [PUBMED:10755615] [PUBMED:17308335] [PUBMED:12821647] [PUBMED:15466916] [PUBMED:17050193] [PUBMED:11228151] [PUBMED:12488490] [PUBMED:10224668] [PUBMED:11708889] [PUBMED:9581795] [PUBMED:10586078] [PUBMED:9417101] [PUBMED:15485887] [PUBMED:18322649] [PUBMED:10577498] [PUBMED:10376013] [PUBMED:10601359] [PUBMED:9545263]
Fcgamma receptor (FCGR) dependent phagocytosis [NCBI:1269279] [REACTOME:R-HSA-2029480] [PUBMED:8541526] [PUBMED:12488490] [PUBMED:16413920] [PUBMED:17050193]
Focal adhesion [NCBI:83067] [KEGG:hsa04510] [PUBMED:10698680] [PUBMED:15459662] [PUBMED:14756624] [PUBMED:11573199] [PUBMED:12640026] [PUBMED:15179030] [PUBMED:15108811] [PUBMED:15053919] [PUBMED:11082269] [PUBMED:15034601] [PUBMED:12235283] [PUBMED:14519391] [PUBMED:11146675] [PUBMED:11229600] [PUBMED:15688067] [PUBMED:14744429] [PUBMED:11882383]
G alpha (12/13) signalling events [NCBI:1269579] [REACTOME:R-HSA-416482] [PUBMED:18814923] [PUBMED:19212140]
GPCR downstream signaling [NCBI:1269574] [REACTOME:R-HSA-388396] [PUBMED:12040175]
GPVI-mediated activation cascade [NCBI:1269357] [REACTOME:R-HSA-114604] [PUBMED:16102042] [PUBMED:11943772]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Integrins in angiogenesis [NCBI:137999] [Pathway Interaction Database:avb3_integrin_pathway] [PUBMED:10837460] [PUBMED:9182576] [PUBMED:12642872] [PUBMED:15711558] [PUBMED:10037797] [PUBMED:10196194] [PUBMED:11877390] [PUBMED:16418218] [PUBMED:16600665] [PUBMED:16982628] [PUBMED:15479743] [PUBMED:16720645] [PUBMED:11684710] [PUBMED:10821695] [PUBMED:12237112] [PUBMED:12750158] [PUBMED:11551924] [PUBMED:8794870] [PUBMED:10022831] [PUBMED:15187087] [PUBMED:16195423] [PUBMED:16760434] [PUBMED:12682293] [PUBMED:9420328] [PUBMED:15247219] [PUBMED:9490736] [PUBMED:11313365]
Leukocyte transendothelial migration [NCBI:83083] [KEGG:hsa04670] [PUBMED:15629883] [PUBMED:10975856] [PUBMED:14976004] [PUBMED:15265790] [PUBMED:15173832] [PUBMED:12540948] [PUBMED:15771581] [PUBMED:15604886] [PUBMED:14977592]
NRAGE signals death through JNK [NCBI:1269448] [REACTOME:R-HSA-193648] [PUBMED:12376548]
Natural killer cell mediated cytotoxicity [NCBI:83079] [KEGG:hsa04650] [PUBMED:12530970] [PUBMED:15567854] [PUBMED:8942070] [PUBMED:11905813] [PUBMED:9143705] [PUBMED:9862693] [PUBMED:11895890] [PUBMED:12205470] [PUBMED:11836514] [PUBMED:15607806] [PUBMED:16002670] [PUBMED:15618404] [PUBMED:11390470] [PUBMED:11062493] [PUBMED:14710949] [PUBMED:12752668] [PUBMED:15607802] [PUBMED:16109839] [PUBMED:12766758] [PUBMED:16177799]
Osteopontin-mediated events [NCBI:137960] [Pathway Interaction Database:avb3_opn_pathway] [PUBMED:9727056] [PUBMED:9585425] [PUBMED:16888388] [PUBMED:16474180] [PUBMED:15757900] [PUBMED:9682033] [PUBMED:12529435] [PUBMED:15142256] [PUBMED:14624447] [PUBMED:15711558] [PUBMED:9988732] [PUBMED:12730217] [PUBMED:11600576] [PUBMED:8744948] [PUBMED:16691505] [PUBMED:11940607] [PUBMED:16006560] [PUBMED:10766830] [PUBMED:10559185]
Platelet activation, signaling and aggregation [NCBI:1269350] [REACTOME:R-HSA-76002] [PUBMED:16543958] [PUBMED:8704248] [PUBMED:2018971] [PUBMED:1672265] [PUBMED:17059469] [PUBMED:12681240] [PUBMED:12411949] [PUBMED:11511514]
Regulation of CDC42 activity [NCBI:137990] [Pathway Interaction Database:cdc42_reg_pathway] [PUBMED:19581296] [PUBMED:17297291] [PUBMED:14506234] [PUBMED:17145773] [PUBMED:8798610] [PUBMED:17015620] [PUBMED:9535855] [PUBMED:15710388] [PUBMED:12547822] [PUBMED:15728722] [PUBMED:11285260] [PUBMED:11748279] [PUBMED:8969170] [PUBMED:17538024] [PUBMED:11336673] [PUBMED:12172552] [PUBMED:15850391] [PUBMED:18208356] [PUBMED:10523665] [PUBMED:1429634] [PUBMED:19156867] [PUBMED:19356586] [PUBMED:16616186] [PUBMED:15247287] [PUBMED:9497316] [PUBMED:10559246] [PUBMED:14506284] [PUBMED:16892055] [PUBMED:19525225] [PUBMED:11741931] [PUBMED:17562871] [PUBMED:18470881] [PUBMED:1439791] [PUBMED:10744696] [PUBMED:7673236] [PUBMED:12432077] [PUBMED:17196961] [PUBMED:10982832] [PUBMED:16968698] [PUBMED:11431473] [PUBMED:10676816] [PUBMED:15277544] [PUBMED:18728402] [PUBMED:15793564] [PUBMED:18056264] [PUBMED:9268338] [PUBMED:12517963] [PUBMED:1956381] [PUBMED:15504743] [PUBMED:17599059] [PUBMED:15649357] [PUBMED:10652228] [PUBMED:15306850] [PUBMED:19745154]
Regulation of RAC1 activity [NCBI:169346] [Pathway Interaction Database:rac1_reg_pathway] [PUBMED:8297393] [PUBMED:12134164] [PUBMED:15485841] [PUBMED:11707441] [PUBMED:17320046] [PUBMED:9857026] [PUBMED:9497316] [PUBMED:17254573] [PUBMED:15850775] [PUBMED:8352776] [PUBMED:15128856] [PUBMED:17403664] [PUBMED:8491184] [PUBMED:7753201] [PUBMED:9707409] [PUBMED:12432077] [PUBMED:8226937] [PUBMED:19934221] [PUBMED:17196961] [PUBMED:17640372] [PUBMED:11287617] [PUBMED:12515821] [PUBMED:16943182] [PUBMED:19861492] [PUBMED:10220378] [PUBMED:11431473] [PUBMED:10982832] [PUBMED:7673236] [PUBMED:10744696] [PUBMED:17599059] [PUBMED:17116687] [PUBMED:12923183] [PUBMED:10364228] [PUBMED:16628218] [PUBMED:8288572] [PUBMED:15306850] [PUBMED:11396949] [PUBMED:8496137] [PUBMED:11912491] [PUBMED:15649357] [PUBMED:7980444] [PUBMED:18325335] [PUBMED:15242348] [PUBMED:11955434] [PUBMED:15039778] [PUBMED:11685227] [PUBMED:15897194] [PUBMED:11130063] [PUBMED:10559863] [PUBMED:17052214] [PUBMED:11099046] [PUBMED:15728722] [PUBMED:16520382] [PUBMED:16492808] [PUBMED:12547822] [PUBMED:12446789] [PUBMED:11274357] [PUBMED:8419353] [PUBMED:16481401] [PUBMED:8276860] [PUBMED:15005707] [PUBMED:10499589] [PUBMED:11336673] [PUBMED:1903516] [PUBMED:12829596] [PUBMED:17332503] [PUBMED:11146652] [PUBMED:12134158] [PUBMED:8643598] [PUBMED:18212043]
Regulation of RhoA activity [NCBI:138070] [Pathway Interaction Database:rhoa_reg_pathway] [PUBMED:10579713] [PUBMED:15039571] [PUBMED:19605563] [PUBMED:19755152] [PUBMED:16954208] [PUBMED:10744696] [PUBMED:17702745] [PUBMED:10837491] [PUBMED:12454018] [PUBMED:15023524] [PUBMED:11396949] [PUBMED:10523675] [PUBMED:10026210] [PUBMED:18948007] [PUBMED:16112081] [PUBMED:19713215] [PUBMED:9425278] [PUBMED:11085924] [PUBMED:9582072] [PUBMED:12071859] [PUBMED:19066281] [PUBMED:14512443] [PUBMED:18851832] [PUBMED:12775584] [PUBMED:15632174] [PUBMED:8356058] [PUBMED:1907371] [PUBMED:11058585] [PUBMED:9032261] [PUBMED:18211802] [PUBMED:12414125] [PUBMED:17971419] [PUBMED:19625450] [PUBMED:15069594] [PUBMED:12221096] [PUBMED:17804252] [PUBMED:8276860] [PUBMED:19635168] [PUBMED:8910315] [PUBMED:18096806] [PUBMED:12183458] [PUBMED:15601624] [PUBMED:9464532] [PUBMED:11336673] [PUBMED:16721066] [PUBMED:12215546] [PUBMED:15078817] [PUBMED:12196628] [PUBMED:11553710] [PUBMED:7479768] [PUBMED:8643598] [PUBMED:10699171] [PUBMED:9490638] [PUBMED:8491184] [PUBMED:8352776] [PUBMED:20018869] [PUBMED:12944407] [PUBMED:11804590] [PUBMED:8297393] [PUBMED:11672528] [PUBMED:15296756] [PUBMED:17488622] [PUBMED:9670022] [PUBMED:8537347] [PUBMED:19261619] [PUBMED:16896804] [PUBMED:11094164] [PUBMED:15691829] [PUBMED:19103606] [PUBMED:9641916]
Regulation of actin cytoskeleton [NCBI:83089] [KEGG:hsa04810] [PUBMED:11152757] [PUBMED:11082272] [PUBMED:10574699] [PUBMED:11082269] [PUBMED:14657486] [PUBMED:14744429] [PUBMED:12700767]
Regulation of actin dynamics for phagocytic cup formation [NCBI:1269281] [REACTOME:R-HSA-2029482] [PUBMED:17477841] [PUBMED:15452139] [PUBMED:15981459]
Rho GTPase cycle [NCBI:1269508] [REACTOME:R-HSA-194840] [PUBMED:17222083] [PUBMED:9308960]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Signaling by Rho GTPases [NCBI:1269507] [REACTOME:R-HSA-194315] [PUBMED:16212495] [PUBMED:15630019]
Signaling by VEGF [NCBI:1269480] [REACTOME:R-HSA-194138] [PUBMED:15585754] [PUBMED:13678960] [PUBMED:16336962] [PUBMED:16835467]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
T cell receptor signaling pathway [NCBI:83080] [KEGG:hsa04660] [PUBMED:17395537] [PUBMED:15308211] [PUBMED:15928679] [PUBMED:14656980] [PUBMED:17187070] [PUBMED:15084594] [PUBMED:16799472] [PUBMED:12669022] [PUBMED:15286727] [PUBMED:15122199] [PUBMED:19132916] [PUBMED:15489916] [PUBMED:11905831] [PUBMED:12195013] [PUBMED:15343367] [PUBMED:12133805] [PUBMED:14647476] [PUBMED:15771581] [PUBMED:15099566] [PUBMED:14617194] [PUBMED:19290929] [PUBMED:15345216]
VEGFA-VEGFR2 Pathway [NCBI:1269483] [REACTOME:R-HSA-4420097] [PUBMED:17344076] [PUBMED:16633338] [PUBMED:19230644] [PUBMED:13678960]
VEGFR2 mediated vascular permeability [NCBI:1269484] [REACTOME:R-HSA-5218920] [PUBMED:17008595]
cAMP signaling pathway [NCBI:1017634] [KEGG:hsa04024] [PUBMED:10880354] [PUBMED:9204709] [PUBMED:21693691] [PUBMED:24062645] [PUBMED:24450633] [PUBMED:21346730] [PUBMED:24613710] [PUBMED:21744067] [PUBMED:22082266] [PUBMED:16460276] [PUBMED:18176800] [PUBMED:14715909] [PUBMED:7688165] [PUBMED:24281338] [PUBMED:11117527] [PUBMED:16765984] [PUBMED:18323530] [PUBMED:18064650] [PUBMED:21852968] [PUBMED:11493633] [PUBMED:21212391] [PUBMED:15142747] [PUBMED:17077866] [PUBMED:19460777] [PUBMED:19874988] [PUBMED:16571352] [PUBMED:22022314]
p75 NTR receptor-mediated signalling [NCBI:1269445] [REACTOME:R-HSA-193704] [PUBMED:16699811] [PUBMED:16939974] [PUBMED:12671646]