full name
neuregulin 1
synonyms
ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, NDF, SMDF, NRG1, ENSG00000157168
HGNC
HGNC:7997
Entrez Gene
Gene:3084
ENSEMBL
ENSG00000157168
location
chr: 8
start: 31496820
stop: 32622558
strand: +
OMIM
OMIM:142445:
NRG1
OMIM:603013:
{?Schizophrenia, susceptibility to}
transcripts
NM_001159999.1
NM_001159995.1
NM_001160001.1
NM_013962.2
NM_013960.3
NM_013964.3
NM_013956.3
NM_001160004.1
NM_013957.3
NM_001160008.1
NM_013958.3
NM_001160005.1
NM_004495.3
NM_001160002.1
NM_001160007.1
NM_013959.3
NM_001159996.1
pathways
ARMS-mediated activation
[NCBI:1269471]
[REACTOME:R-HSA-170984]
[PUBMED:9069267]
Adaptive Immune System
[NCBI:1269171]
[REACTOME:R-HSA-1280218]
[PUBMED:16551257]
[PUBMED:21682741]
[PUBMED:11861602]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
Constitutive Signaling by Aberrant PI3K in Cancer
[NCBI:1268880]
[REACTOME:R-HSA-2219530]
[PUBMED:18317450]
[PUBMED:19962665]
[PUBMED:20009532]
[PUBMED:20713702]
[PUBMED:21478295]
[PUBMED:16339315]
[PUBMED:18079394]
[PUBMED:17626883]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
DAP12 interactions
[NCBI:1269283]
[REACTOME:R-HSA-2172127]
[PUBMED:19120482]
[PUBMED:17220916]
[PUBMED:9490415]
[PUBMED:18192027]
[PUBMED:15884055]
DAP12 signaling
[NCBI:1269284]
[REACTOME:R-HSA-2424491]
[PUBMED:15884055]
[PUBMED:17110943]
[PUBMED:17220916]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
Disease
[NCBI:1268854]
[REACTOME:R-HSA-1643685]
Diseases of signal transduction
[NCBI:1268855]
[REACTOME:R-HSA-5663202]
[PUBMED:12509752]
Downregulation of ERBB2 signaling
[NCBI:1457793]
[REACTOME:R-HSA-8863795]
[PUBMED:19933325]
[PUBMED:21376233]
[PUBMED:17210635]
[PUBMED:12239347]
[PUBMED:25081058]
Downregulation of ERBB2:ERBB3 signaling
[NCBI:1269495]
[REACTOME:R-HSA-1358803]
Downstream signal transduction
[NCBI:1269479]
[REACTOME:R-HSA-186763]
[PUBMED:10508235]
[PUBMED:9739761]
Downstream signaling events of B Cell Receptor (BCR)
[NCBI:1269185]
[REACTOME:R-HSA-1168372]
[PUBMED:17052215]
[PUBMED:19909372]
EGFR tyrosine kinase inhibitor resistance
[NCBI:1404798]
[KEGG:hsa01521]
[PUBMED:16843264]
[PUBMED:23401451]
[PUBMED:20966921]
[PUBMED:24307395]
[PUBMED:22956644]
[PUBMED:25232485]
[PUBMED:24493829]
[PUBMED:23071030]
[PUBMED:18483355]
[PUBMED:24202392]
[PUBMED:19632948]
[PUBMED:23361103]
[PUBMED:26579470]
[PUBMED:22970367]
[PUBMED:23358468]
[PUBMED:17554333]
[PUBMED:25337673]
[PUBMED:22474259]
[PUBMED:20551942]
ERBB2 Activates PTK6 Signaling
[NCBI:1383024]
[REACTOME:R-HSA-8847993]
[PUBMED:20687930]
[PUBMED:1349015]
[PUBMED:26247733]
[PUBMED:18719096]
[PUBMED:8940083]
[PUBMED:21847121]
ERBB2 Regulates Cell Motility
[NCBI:1383023]
[REACTOME:R-HSA-6785631]
[PUBMED:15156151]
[PUBMED:18955552]
[PUBMED:20937854]
[PUBMED:18045866]
ErbB signaling pathway
[NCBI:83049]
[KEGG:hsa04012]
[PUBMED:16377102]
[PUBMED:14967450]
[PUBMED:9642287]
[PUBMED:9872057]
[PUBMED:10880430]
[PUBMED:12851486]
[PUBMED:16729045]
[PUBMED:15863494]
[PUBMED:15864276]
[PUBMED:17000658]
[PUBMED:16729043]
[PUBMED:10490623]
[PUBMED:11252954]
[PUBMED:14744244]
[PUBMED:16829981]
FCERI mediated MAPK activation
[NCBI:1269299]
[REACTOME:R-HSA-2871796]
[PUBMED:19290926]
[PUBMED:19909365]
[PUBMED:17122878]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
Frs2-mediated activation
[NCBI:1269470]
[REACTOME:R-HSA-170968]
[PUBMED:9069267]
GAB1 signalosome
[NCBI:1269384]
[REACTOME:R-HSA-180292]
[PUBMED:15550174]
GRB2 events in EGFR signaling
[NCBI:1269382]
[REACTOME:R-HSA-179812]
[PUBMED:11706405]
[PUBMED:11498013]
GRB2 events in ERBB2 signaling
[NCBI:1269491]
[REACTOME:R-HSA-1963640]
GRB7 events in ERBB2 signaling
[NCBI:1269494]
[REACTOME:R-HSA-1306955]
Gastrin-CREB signalling pathway via PKC and MAPK
[NCBI:1269592]
[REACTOME:R-HSA-881907]
[PUBMED:10413847]
[PUBMED:7491953]
[PUBMED:17698287]
Glypican 1 network
[NCBI:138010]
[Pathway Interaction Database:glypican_1pathway]
[PUBMED:15063764]
[PUBMED:18717736]
[PUBMED:9949192]
[PUBMED:10514475]
[PUBMED:16723715]
[PUBMED:12972423]
[PUBMED:12914968]
[PUBMED:15249209]
[PUBMED:12649175]
[PUBMED:15084524]
[PUBMED:16123806]
[PUBMED:1400362]
[PUBMED:17516498]
[PUBMED:10196157]
[PUBMED:11375980]
[PUBMED:16923158]
IGF1R signaling cascade
[NCBI:1269618]
[REACTOME:R-HSA-2428924]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
IRS-mediated signalling
[NCBI:1269431]
[REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R
[NCBI:1269620]
[REACTOME:R-HSA-2428928]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:18927274]
[PUBMED:21042815]
[PUBMED:20098959]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Insulin receptor signalling cascade
[NCBI:1269429]
[REACTOME:R-HSA-74751]
[PUBMED:9677303]
[PUBMED:11282018]
Interleukin receptor SHC signaling
[NCBI:1269322]
[REACTOME:R-HSA-912526]
[PUBMED:8294403]
Interleukin-2 signaling
[NCBI:1269321]
[REACTOME:R-HSA-451927]
[PUBMED:17936914]
[PUBMED:18817510]
[PUBMED:19543225]
[PUBMED:18062768]
Interleukin-3, 5 and GM-CSF signaling
[NCBI:1269323]
[REACTOME:R-HSA-512988]
[PUBMED:10450743]
[PUBMED:9766809]
MAPK family signaling cascades
[NCBI:1269501]
[REACTOME:R-HSA-5683057]
[PUBMED:21167873]
[PUBMED:17161475]
[PUBMED:22535895]
[PUBMED:21372320]
MAPK1/MAPK3 signaling
[NCBI:1269502]
[REACTOME:R-HSA-5684996]
[PUBMED:25378393]
[PUBMED:18199641]
[PUBMED:17496909]
[PUBMED:21779496]
[PUBMED:15520807]
[PUBMED:16393692]
[PUBMED:19520853]
[PUBMED:17496910]
[PUBMED:22569528]
NCAM signaling for neurite out-growth
[NCBI:1270312]
[REACTOME:R-HSA-375165]
[PUBMED:18760361]
[PUBMED:12587671]
[PUBMED:15662836]
[PUBMED:17975827]
[PUBMED:15153429]
[PUBMED:12700044]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
Negative regulation of the PI3K/AKT network
[NCBI:1269191]
[REACTOME:R-HSA-199418]
Nuclear signaling by ERBB4
[NCBI:1269499]
[REACTOME:R-HSA-1251985]
PI3K events in ERBB2 signaling
[NCBI:1269492]
[REACTOME:R-HSA-1963642]
PI3K events in ERBB4 signaling
[NCBI:1269498]
[REACTOME:R-HSA-1250342]
PI3K/AKT Signaling in Cancer
[NCBI:1268879]
[REACTOME:R-HSA-2219528]
[PUBMED:20713702]
[PUBMED:10555148]
[PUBMED:19644473]
[PUBMED:17611497]
[PUBMED:21478295]
[PUBMED:17626883]
[PUBMED:16339315]
[PUBMED:18317450]
[PUBMED:18079394]
[PUBMED:9467011]
[PUBMED:17604717]
[PUBMED:9326929]
[PUBMED:18954143]
[PUBMED:20009532]
[PUBMED:19962665]
[PUBMED:21430697]
[PUBMED:19487573]
[PUBMED:10866302]
PI3K/AKT activation
[NCBI:1269473]
[REACTOME:R-HSA-198203]
[PUBMED:10579926]
[PUBMED:12123609]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
[NCBI:1383020]
[REACTOME:R-HSA-6811558]
[PUBMED:12422219]
[PUBMED:16979564]
[PUBMED:19805105]
[PUBMED:17200115]
[PUBMED:21827948]
[PUBMED:19576174]
[PUBMED:18753295]
[PUBMED:19896968]
[PUBMED:16456541]
[PUBMED:25495341]
[PUBMED:15464023]
[PUBMED:23758345]
[PUBMED:9367159]
[PUBMED:9211928]
[PUBMED:17245604]
PIP3 activates AKT signaling
[NCBI:1269188]
[REACTOME:R-HSA-1257604]
Prolonged ERK activation events
[NCBI:1269469]
[REACTOME:R-HSA-169893]
[PUBMED:12765839]
[PUBMED:9069267]
RAF/MAP kinase cascade
[NCBI:1269285]
[REACTOME:R-HSA-5673001]
[PUBMED:21167873]
[PUBMED:24937142]
[PUBMED:20674547]
[PUBMED:17496910]
[PUBMED:22177953]
[PUBMED:17496919]
[PUBMED:22569528]
[PUBMED:22535895]
[PUBMED:12068308]
[PUBMED:17496923]
[PUBMED:19091303]
[PUBMED:21372320]
[PUBMED:21388974]
[PUBMED:15520807]
RET signaling
[NCBI:1427866]
[REACTOME:R-HSA-8853659]
[PUBMED:15013219]
[PUBMED:17036197]
Role of LAT2/NTAL/LAB on calcium mobilization
[NCBI:1269302]
[REACTOME:R-HSA-2730905]
[PUBMED:17993265]
[PUBMED:20643813]
[PUBMED:17420272]
SHC1 events in EGFR signaling
[NCBI:1269383]
[REACTOME:R-HSA-180336]
[PUBMED:11498013]
[PUBMED:8755247]
SHC1 events in ERBB2 signaling
[NCBI:1269490]
[REACTOME:R-HSA-1250196]
SHC1 events in ERBB4 signaling
[NCBI:1269497]
[REACTOME:R-HSA-1250347]
SOS-mediated signalling
[NCBI:1269440]
[REACTOME:R-HSA-112412]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by EGFR
[NCBI:1269380]
[REACTOME:R-HSA-177929]
[PUBMED:10459005]
[PUBMED:10404636]
[PUBMED:12297041]
[PUBMED:15142631]
Signaling by ERBB2
[NCBI:1269489]
[REACTOME:R-HSA-1227986]
Signaling by ERBB4
[NCBI:1269496]
[REACTOME:R-HSA-1236394]
[PUBMED:9275162]
[PUBMED:9168115]
[PUBMED:17545517]
[PUBMED:19193720]
[PUBMED:16914727]
[PUBMED:7929212]
[PUBMED:16912174]
[PUBMED:9135143]
[PUBMED:10867024]
[PUBMED:16778220]
[PUBMED:17018285]
[PUBMED:15534001]
[PUBMED:8665853]
[PUBMED:1706616]
[PUBMED:10744726]
[PUBMED:18653779]
[PUBMED:11679632]
[PUBMED:8617750]
[PUBMED:7565730]
[PUBMED:15023535]
[PUBMED:16061658]
[PUBMED:18721752]
[PUBMED:16978839]
[PUBMED:17463226]
[PUBMED:10722704]
[PUBMED:12869563]
[PUBMED:19047365]
[PUBMED:12807903]
[PUBMED:9556621]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signaling by Insulin receptor
[NCBI:1269428]
[REACTOME:R-HSA-74752]
[PUBMED:8276779]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signaling by Leptin
[NCBI:1269632]
[REACTOME:R-HSA-2586552]
[PUBMED:22211890]
[PUBMED:23562747]
[PUBMED:20600241]
[PUBMED:21622208]
[PUBMED:23579596]
[PUBMED:22458591]
[PUBMED:21489811]
[PUBMED:19724019]
[PUBMED:21331644]
[PUBMED:22448029]
[PUBMED:21147620]
[PUBMED:20198122]
[PUBMED:21677426]
[PUBMED:20029269]
[PUBMED:22249808]
[PUBMED:22991412]
[PUBMED:21527729]
[PUBMED:17937601]
[PUBMED:20553370]
[PUBMED:21713385]
[PUBMED:23565489]
[PUBMED:22289780]
Signaling by PDGF
[NCBI:1269478]
[REACTOME:R-HSA-186797]
[PUBMED:15207811]
[PUBMED:10508235]
[PUBMED:9739761]
Signaling by PTK6
[NCBI:1383025]
[REACTOME:R-HSA-8848021]
[PUBMED:15539407]
[PUBMED:15572663]
[PUBMED:25999240]
[PUBMED:20929863]
[PUBMED:23352614]
[PUBMED:20554524]
[PUBMED:23814047]
[PUBMED:21205088]
[PUBMED:18172307]
[PUBMED:25897081]
[PUBMED:18829532]
[PUBMED:24788754]
[PUBMED:25019382]
[PUBMED:8940083]
[PUBMED:19393627]
[PUBMED:18719096]
[PUBMED:22547065]
[PUBMED:21847121]
[PUBMED:19439179]
[PUBMED:22231447]
[PUBMED:25733683]
[PUBMED:20606012]
[PUBMED:18077133]
[PUBMED:15471878]
[PUBMED:20687930]
[PUBMED:23928995]
[PUBMED:16179349]
[PUBMED:26247733]
[PUBMED:11114724]
[PUBMED:17483331]
[PUBMED:22084245]
[PUBMED:10913193]
Signaling by SCF-KIT
[NCBI:1269487]
[REACTOME:R-HSA-1433557]
[PUBMED:17350321]
[PUBMED:16483568]
[PUBMED:7688988]
[PUBMED:19540337]
[PUBMED:16475976]
[PUBMED:15526160]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
[NCBI:1269617]
[REACTOME:R-HSA-2404192]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22044904]
[PUBMED:22649417]
Signaling by VEGF
[NCBI:1269480]
[REACTOME:R-HSA-194138]
[PUBMED:15585754]
[PUBMED:13678960]
[PUBMED:16336962]
[PUBMED:16835467]
Signaling by the B Cell Receptor (BCR)
[NCBI:1269183]
[REACTOME:R-HSA-983705]
[PUBMED:1702903]
[PUBMED:2011584]
[PUBMED:1081164]
[PUBMED:19065780]
[PUBMED:16849466]
[PUBMED:1375264]
[PUBMED:7538118]
[PUBMED:11901194]
[PUBMED:8580068]
[PUBMED:19249086]
[PUBMED:18596693]
[PUBMED:10648173]
[PUBMED:4589993]
[PUBMED:8163536]
[PUBMED:1376928]
[PUBMED:7688784]
[PUBMED:6335036]
[PUBMED:17052215]
[PUBMED:18818202]
[PUBMED:20206686]
[PUBMED:7592958]
[PUBMED:7524079]
[PUBMED:15489917]
[PUBMED:15509800]
[PUBMED:18187424]
[PUBMED:7927516]
[PUBMED:803528]
[PUBMED:19909372]
[PUBMED:20192804]
[PUBMED:8306975]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Signalling to ERKs
[NCBI:1269464]
[REACTOME:R-HSA-187687]
[PUBMED:10508738]
Signalling to RAS
[NCBI:1269465]
[REACTOME:R-HSA-167044]
[PUBMED:11520933]
Signalling to p38 via RIT and RIN
[NCBI:1269468]
[REACTOME:R-HSA-187706]
[PUBMED:10712923]
VEGFA-VEGFR2 Pathway
[NCBI:1269483]
[REACTOME:R-HSA-4420097]
[PUBMED:17344076]
[PUBMED:16633338]
[PUBMED:19230644]
[PUBMED:13678960]
VEGFR2 mediated cell proliferation
[NCBI:1269485]
[REACTOME:R-HSA-5218921]
[PUBMED:22866201]
[PUBMED:22180219]
[PUBMED:22762016]
