Logo
full name
eukaryotic translation initiation factor 4E binding protein 1

synonyms
4E-BP1, 4EBP1, BP-1, PHAS-I, EIF4EBP1, ENSG00000187840

HGNC
HGNC:3288

Entrez Gene
Gene:1978

ENSEMBL
ENSG00000187840

location
chr: 8
start: 37888020
stop: 37917883
strand: +

transcripts
NM_004095.3

pathways
AMPK signaling pathway [NCBI:989139] [KEGG:hsa04152] [PUBMED:22885100] [PUBMED:18725075] [PUBMED:22700795] [PUBMED:19724019] [PUBMED:19584320] [PUBMED:16644802] [PUBMED:20010958] [PUBMED:16479585] [PUBMED:19197243] [PUBMED:23565491] [PUBMED:20357764] [PUBMED:16723978] [PUBMED:16054041] [PUBMED:19393004] [PUBMED:23899560] [PUBMED:17307971] [PUBMED:15509864] [PUBMED:23024365] [PUBMED:23747347] [PUBMED:19629071]
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S [NCBI:1268683] [REACTOME:R-HSA-72662] [PUBMED:9732867] [PUBMED:592399] [PUBMED:641056] [PUBMED:6853548]
Acute myeloid leukemia [NCBI:83117] [KEGG:hsa05221] [PUBMED:12951584] [PUBMED:12563308] [PUBMED:16352814] [PUBMED:16236521] [PUBMED:16146838] [PUBMED:16642045] [PUBMED:15625120] [PUBMED:11721960] [PUBMED:17554387] [PUBMED:12468433]
Cap-dependent Translation Initiation [NCBI:1268680] [REACTOME:R-HSA-72737]
Choline metabolism in cancer [NCBI:1059539] [KEGG:hsa05231] [PUBMED:23076158] [PUBMED:19264150] [PUBMED:16230400] [PUBMED:23350810] [PUBMED:22429397] [PUBMED:16432178] [PUBMED:19136975] [PUBMED:22089420] [PUBMED:14517341] [PUBMED:22921309] [PUBMED:19855431] [PUBMED:20528734] [PUBMED:19935796] [PUBMED:14523987] [PUBMED:21793073]
EGFR tyrosine kinase inhibitor resistance [NCBI:1404798] [KEGG:hsa01521] [PUBMED:16843264] [PUBMED:23401451] [PUBMED:20966921] [PUBMED:24307395] [PUBMED:22956644] [PUBMED:25232485] [PUBMED:24493829] [PUBMED:23071030] [PUBMED:18483355] [PUBMED:24202392] [PUBMED:19632948] [PUBMED:23361103] [PUBMED:26579470] [PUBMED:22970367] [PUBMED:23358468] [PUBMED:17554333] [PUBMED:25337673] [PUBMED:22474259] [PUBMED:20551942]
ErbB signaling pathway [NCBI:83049] [KEGG:hsa04012] [PUBMED:16377102] [PUBMED:14967450] [PUBMED:9642287] [PUBMED:9872057] [PUBMED:10880430] [PUBMED:12851486] [PUBMED:16729045] [PUBMED:15863494] [PUBMED:15864276] [PUBMED:17000658] [PUBMED:16729043] [PUBMED:10490623] [PUBMED:11252954] [PUBMED:14744244] [PUBMED:16829981]
Eukaryotic Translation Initiation [NCBI:1268679] [REACTOME:R-HSA-72613] [PUBMED:20444697]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
HIF-1 signaling pathway [NCBI:695200] [KEGG:hsa04066] [PUBMED:11902584] [PUBMED:20965423] [PUBMED:20679415] [PUBMED:15031665] [PUBMED:18259201] [PUBMED:22205687] [PUBMED:19364912] [PUBMED:19147540] [PUBMED:15448722] [PUBMED:16234508] [PUBMED:18505681] [PUBMED:20836033] [PUBMED:19861159] [PUBMED:17955264] [PUBMED:22562152]
IGF1R signaling cascade [NCBI:1269618] [REACTOME:R-HSA-2428924] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959]
IRS-mediated signalling [NCBI:1269431] [REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R [NCBI:1269620] [REACTOME:R-HSA-2428928] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:18927274] [PUBMED:21042815] [PUBMED:20098959]
Insulin Pathway [NCBI:138026] [Pathway Interaction Database:insulin_pathway] [PUBMED:8491186] [PUBMED:9111325] [PUBMED:7629070] [PUBMED:10499514] [PUBMED:11121405] [PUBMED:10660596] [PUBMED:8196603] [PUBMED:11096081] [PUBMED:8524328] [PUBMED:9891043] [PUBMED:12242347] [PUBMED:2123524] [PUBMED:9369444] [PUBMED:1375946] [PUBMED:9348199] [PUBMED:8826975] [PUBMED:8316835] [PUBMED:8999839] [PUBMED:8449939] [PUBMED:10807907] [PUBMED:1599438] [PUBMED:8265614] [PUBMED:11171109] [PUBMED:11821390] [PUBMED:12687004] [PUBMED:7806540] [PUBMED:11154281] [PUBMED:8244979] [PUBMED:8798417] [PUBMED:1381348] [PUBMED:7581368] [PUBMED:15787604] [PUBMED:8385105] [PUBMED:11551902] [PUBMED:8114695] [PUBMED:11997497] [PUBMED:11001060] [PUBMED:11309621] [PUBMED:9109420] [PUBMED:8383963] [PUBMED:12147684] [PUBMED:8144662] [PUBMED:12036959] [PUBMED:14734537] [PUBMED:7983051] [PUBMED:9083103] [PUBMED:15210700] [PUBMED:9065430] [PUBMED:11297536] [PUBMED:10544179] [PUBMED:1321126] [PUBMED:11502760] [PUBMED:8978681] [PUBMED:8999972] [PUBMED:14690593] [PUBMED:11832334] [PUBMED:9447983] [PUBMED:15192089] [PUBMED:8524413] [PUBMED:7685165] [PUBMED:10329736] [PUBMED:11287630] [PUBMED:15486046] [PUBMED:10330191] [PUBMED:8626723]
Insulin receptor signalling cascade [NCBI:1269429] [REACTOME:R-HSA-74751] [PUBMED:9677303] [PUBMED:11282018]
Insulin signaling pathway [NCBI:83090] [KEGG:hsa04910] [PUBMED:11742412] [PUBMED:11343120] [PUBMED:15733744] [PUBMED:11282018] [PUBMED:10196204] [PUBMED:18291668] [PUBMED:9609110] [PUBMED:10567225] [PUBMED:12791379] [PUBMED:9748166] [PUBMED:15624019] [PUBMED:9445476] [PUBMED:9346240] [PUBMED:14635525] [PUBMED:16288289] [PUBMED:12867054] [PUBMED:15229476] [PUBMED:17344645] [PUBMED:9609111]
Longevity regulating pathway [NCBI:1319989] [KEGG:hsa04211] [PUBMED:21779512] [PUBMED:23594965] [PUBMED:25654554] [PUBMED:25832544] [PUBMED:24997879] [PUBMED:22618766] [PUBMED:20336132] [PUBMED:24905167] [PUBMED:25601466] [PUBMED:20103737] [PUBMED:18692468] [PUBMED:20395504] [PUBMED:25824609] [PUBMED:17701476] [PUBMED:23939249] [PUBMED:20848587] [PUBMED:22983298] [PUBMED:19262508] [PUBMED:20357764] [PUBMED:18946478] [PUBMED:23061800]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
PI3K Cascade [NCBI:1269432] [REACTOME:R-HSA-109704]
PI3K-Akt signaling pathway [NCBI:692234] [KEGG:hsa04151] [PUBMED:12048182] [PUBMED:11357143] [PUBMED:21440011] [PUBMED:15209374] [PUBMED:12669022] [PUBMED:18842113] [PUBMED:16847462] [PUBMED:12660731] [PUBMED:17360849] [PUBMED:9838078] [PUBMED:15505410] [PUBMED:16248975] [PUBMED:12531180] [PUBMED:21779440] [PUBMED:16187290] [PUBMED:15784165] [PUBMED:21620960]
PKB-mediated events [NCBI:1269434] [REACTOME:R-HSA-109703]
RNA transport [NCBI:177876] [KEGG:hsa03013] [PUBMED:10872469] [PUBMED:17401408] [PUBMED:20733056] [PUBMED:11018020] [PUBMED:15519698] [PUBMED:16314458] [PUBMED:15901496] [PUBMED:9548260] [PUBMED:18313922]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Insulin receptor [NCBI:1269428] [REACTOME:R-HSA-74752] [PUBMED:8276779]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) [NCBI:1269617] [REACTOME:R-HSA-2404192] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22044904] [PUBMED:22649417]
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) [NCBI:137930] [Pathway Interaction Database:met_pathway] [PUBMED:10793146] [PUBMED:8906793] [PUBMED:11929826] [PUBMED:10022866] [PUBMED:11532961] [PUBMED:12475979] [PUBMED:1718989] [PUBMED:1846706] [PUBMED:10970810] [PUBMED:10516287] [PUBMED:12138161] [PUBMED:11046147] [PUBMED:18073207] [PUBMED:12951049] [PUBMED:15494312] [PUBMED:9001234] [PUBMED:11352916] [PUBMED:11896055] [PUBMED:9440692] [PUBMED:8607979] [PUBMED:12244132] [PUBMED:11162460] [PUBMED:11809798] [PUBMED:9693375] [PUBMED:14636584] [PUBMED:17297451] [PUBMED:17682062] [PUBMED:19628037] [PUBMED:11069926] [PUBMED:18819921] [PUBMED:16423831] [PUBMED:10558875] [PUBMED:16858414] [PUBMED:10995442] [PUBMED:20332103] [PUBMED:11146548] [PUBMED:18346875] [PUBMED:17894413] [PUBMED:9252406] [PUBMED:17635922] [PUBMED:11134526] [PUBMED:2005882] [PUBMED:19609305] [PUBMED:8380735] [PUBMED:16537482] [PUBMED:10618718] [PUBMED:9591773] [PUBMED:12894582] [PUBMED:9748249] [PUBMED:11741535] [PUBMED:17881575] [PUBMED:10713050] [PUBMED:1655790] [PUBMED:11784715] [PUBMED:10753869] [PUBMED:10713700] [PUBMED:11118451] [PUBMED:16952352] [PUBMED:15314156] [PUBMED:19272169] [PUBMED:12802068] [PUBMED:17363898] [PUBMED:7513258] [PUBMED:1827664] [PUBMED:2541345] [PUBMED:8387483] [PUBMED:16620780] [PUBMED:11445578] [PUBMED:10734310] [PUBMED:16227611] [PUBMED:12941962] [PUBMED:15735664] [PUBMED:19071214] [PUBMED:7731718] [PUBMED:19289496] [PUBMED:11438654] [PUBMED:11896612] [PUBMED:11894096] [PUBMED:11896575] [PUBMED:7499247] [PUBMED:12147692] [PUBMED:11948414] [PUBMED:19881549] [PUBMED:19525225] [PUBMED:14684163] [PUBMED:17055484] [PUBMED:9668053] [PUBMED:10531383] [PUBMED:9681449] [PUBMED:1655405] [PUBMED:12686592] [PUBMED:19109251] [PUBMED:10679787] [PUBMED:9487126] [PUBMED:9886295] [PUBMED:12058075] [PUBMED:15452053] [PUBMED:9184210] [PUBMED:10871282] [PUBMED:17329361] [PUBMED:2554238]
Signaling mediated by p38-alpha and p38-beta [NCBI:138012] [Pathway Interaction Database:p38alphabetadownstreampathway] [PUBMED:11909979] [PUBMED:7923353] [PUBMED:14612426] [PUBMED:12138194] [PUBMED:9069290] [PUBMED:9130707] [PUBMED:10362538] [PUBMED:9155018] [PUBMED:11239470] [PUBMED:9685422] [PUBMED:9628874] [PUBMED:9873047] [PUBMED:10978317] [PUBMED:11741533] [PUBMED:7923354] [PUBMED:9468497] [PUBMED:9647257] [PUBMED:8910365] [PUBMED:8626550] [PUBMED:9776729] [PUBMED:10581204] [PUBMED:7839144] [PUBMED:7750577] [PUBMED:11604491] [PUBMED:11792706] [PUBMED:7535770] [PUBMED:10212189] [PUBMED:10747897] [PUBMED:9687510] [PUBMED:11777913] [PUBMED:9155017] [PUBMED:7737130] [PUBMED:9792677] [PUBMED:11532965] [PUBMED:9822687] [PUBMED:8650547] [PUBMED:9582321] [PUBMED:9858528]
Translation [NCBI:1268678] [REACTOME:R-HSA-72766]
mTOR signaling pathway [NCBI:83059] [KEGG:hsa04150] [NCBI:138001] [Pathway Interaction Database:mtor_4pathway] [PUBMED:17277771] [PUBMED:15341740] [PUBMED:12172553] [PUBMED:15718470] [PUBMED:14651849] [PUBMED:15268862] [PUBMED:15306821] [PUBMED:26046644] [PUBMED:12869586] [PUBMED:24556838] [PUBMED:17928295] [PUBMED:9427642] [PUBMED:18046414] [PUBMED:12912918] [PUBMED:16286006] [PUBMED:26658722] [PUBMED:24842496] [PUBMED:23465396] [PUBMED:17709744] [PUBMED:17599906] [PUBMED:16919458] [PUBMED:10364159] [PUBMED:15342917] [PUBMED:11500364] [PUBMED:19812304] [PUBMED:12482958] [PUBMED:11729323] [PUBMED:16962653] [PUBMED:18952604] [PUBMED:9465032] [PUBMED:1496022] [PUBMED:10567431] [PUBMED:19114562] [PUBMED:17510057] [PUBMED:18604198] [PUBMED:15545625] [PUBMED:11914378] [PUBMED:17461779] [PUBMED:9445476] [PUBMED:18497260] [PUBMED:12604610] [PUBMED:15071500] [PUBMED:18925875] [PUBMED:12906785] [PUBMED:11287630] [PUBMED:15004009] [PUBMED:16756488] [PUBMED:17043309] [PUBMED:18198340] [PUBMED:12820960] [PUBMED:12747827] [PUBMED:17053147] [PUBMED:15851026] [PUBMED:15467718] [PUBMED:18762023] [PUBMED:25242279] [PUBMED:24698685] [PUBMED:11175345] [PUBMED:27304501] [PUBMED:18411301] [PUBMED:11500365] [PUBMED:17693255] [PUBMED:23694989] [PUBMED:12231510] [PUBMED:19446321] [PUBMED:11418588] [PUBMED:19258318] [PUBMED:18439900] [PUBMED:19225151] [PUBMED:26185979] [PUBMED:10357815] [PUBMED:26269525] [PUBMED:23421405] [PUBMED:9271440] [PUBMED:16915281] [PUBMED:17141160] [PUBMED:15249583] [PUBMED:12912989] [PUBMED:27027448] [PUBMED:18423201] [PUBMED:19211835] [PUBMED:9204908] [PUBMED:26700098] [PUBMED:18566587] [PUBMED:17386266]
mTOR signalling [NCBI:1269436] [REACTOME:R-HSA-165159] [PUBMED:21157483]
mTORC1-mediated signalling [NCBI:1269438] [REACTOME:R-HSA-166208] [PUBMED:23641065] [PUBMED:22500797]