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Genes
EIF4EBP1
Gene - EIF4EBP1
full name
eukaryotic translation initiation factor 4E binding protein 1
synonyms
4E-BP1, 4EBP1, BP-1, PHAS-I, EIF4EBP1, ENSG00000187840
HGNC
HGNC:3288
Entrez Gene
Gene:1978
ENSEMBL
ENSG00000187840
location
chr: 8
start: 37888020
stop: 37917883
strand: +
transcripts
NM_004095.3
pathways
AMPK signaling pathway
[NCBI:989139]
[KEGG:hsa04152]
[PUBMED:22885100]
[PUBMED:18725075]
[PUBMED:22700795]
[PUBMED:19724019]
[PUBMED:19584320]
[PUBMED:16644802]
[PUBMED:20010958]
[PUBMED:16479585]
[PUBMED:19197243]
[PUBMED:23565491]
[PUBMED:20357764]
[PUBMED:16723978]
[PUBMED:16054041]
[PUBMED:19393004]
[PUBMED:23899560]
[PUBMED:17307971]
[PUBMED:15509864]
[PUBMED:23024365]
[PUBMED:23747347]
[PUBMED:19629071]
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
[NCBI:1268683]
[REACTOME:R-HSA-72662]
[PUBMED:9732867]
[PUBMED:592399]
[PUBMED:641056]
[PUBMED:6853548]
Acute myeloid leukemia
[NCBI:83117]
[KEGG:hsa05221]
[PUBMED:12951584]
[PUBMED:12563308]
[PUBMED:16352814]
[PUBMED:16236521]
[PUBMED:16146838]
[PUBMED:16642045]
[PUBMED:15625120]
[PUBMED:11721960]
[PUBMED:17554387]
[PUBMED:12468433]
Cap-dependent Translation Initiation
[NCBI:1268680]
[REACTOME:R-HSA-72737]
Choline metabolism in cancer
[NCBI:1059539]
[KEGG:hsa05231]
[PUBMED:23076158]
[PUBMED:19264150]
[PUBMED:16230400]
[PUBMED:23350810]
[PUBMED:22429397]
[PUBMED:16432178]
[PUBMED:19136975]
[PUBMED:22089420]
[PUBMED:14517341]
[PUBMED:22921309]
[PUBMED:19855431]
[PUBMED:20528734]
[PUBMED:19935796]
[PUBMED:14523987]
[PUBMED:21793073]
EGFR tyrosine kinase inhibitor resistance
[NCBI:1404798]
[KEGG:hsa01521]
[PUBMED:16843264]
[PUBMED:23401451]
[PUBMED:20966921]
[PUBMED:24307395]
[PUBMED:22956644]
[PUBMED:25232485]
[PUBMED:24493829]
[PUBMED:23071030]
[PUBMED:18483355]
[PUBMED:24202392]
[PUBMED:19632948]
[PUBMED:23361103]
[PUBMED:26579470]
[PUBMED:22970367]
[PUBMED:23358468]
[PUBMED:17554333]
[PUBMED:25337673]
[PUBMED:22474259]
[PUBMED:20551942]
ErbB signaling pathway
[NCBI:83049]
[KEGG:hsa04012]
[PUBMED:16377102]
[PUBMED:14967450]
[PUBMED:9642287]
[PUBMED:9872057]
[PUBMED:10880430]
[PUBMED:12851486]
[PUBMED:16729045]
[PUBMED:15863494]
[PUBMED:15864276]
[PUBMED:17000658]
[PUBMED:16729043]
[PUBMED:10490623]
[PUBMED:11252954]
[PUBMED:14744244]
[PUBMED:16829981]
Eukaryotic Translation Initiation
[NCBI:1268679]
[REACTOME:R-HSA-72613]
[PUBMED:20444697]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
HIF-1 signaling pathway
[NCBI:695200]
[KEGG:hsa04066]
[PUBMED:11902584]
[PUBMED:20965423]
[PUBMED:20679415]
[PUBMED:15031665]
[PUBMED:18259201]
[PUBMED:22205687]
[PUBMED:19364912]
[PUBMED:19147540]
[PUBMED:15448722]
[PUBMED:16234508]
[PUBMED:18505681]
[PUBMED:20836033]
[PUBMED:19861159]
[PUBMED:17955264]
[PUBMED:22562152]
IGF1R signaling cascade
[NCBI:1269618]
[REACTOME:R-HSA-2428924]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
IRS-mediated signalling
[NCBI:1269431]
[REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R
[NCBI:1269620]
[REACTOME:R-HSA-2428928]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:18927274]
[PUBMED:21042815]
[PUBMED:20098959]
Insulin Pathway
[NCBI:138026]
[Pathway Interaction Database:insulin_pathway]
[PUBMED:8491186]
[PUBMED:9111325]
[PUBMED:7629070]
[PUBMED:10499514]
[PUBMED:11121405]
[PUBMED:10660596]
[PUBMED:8196603]
[PUBMED:11096081]
[PUBMED:8524328]
[PUBMED:9891043]
[PUBMED:12242347]
[PUBMED:2123524]
[PUBMED:9369444]
[PUBMED:1375946]
[PUBMED:9348199]
[PUBMED:8826975]
[PUBMED:8316835]
[PUBMED:8999839]
[PUBMED:8449939]
[PUBMED:10807907]
[PUBMED:1599438]
[PUBMED:8265614]
[PUBMED:11171109]
[PUBMED:11821390]
[PUBMED:12687004]
[PUBMED:7806540]
[PUBMED:11154281]
[PUBMED:8244979]
[PUBMED:8798417]
[PUBMED:1381348]
[PUBMED:7581368]
[PUBMED:15787604]
[PUBMED:8385105]
[PUBMED:11551902]
[PUBMED:8114695]
[PUBMED:11997497]
[PUBMED:11001060]
[PUBMED:11309621]
[PUBMED:9109420]
[PUBMED:8383963]
[PUBMED:12147684]
[PUBMED:8144662]
[PUBMED:12036959]
[PUBMED:14734537]
[PUBMED:7983051]
[PUBMED:9083103]
[PUBMED:15210700]
[PUBMED:9065430]
[PUBMED:11297536]
[PUBMED:10544179]
[PUBMED:1321126]
[PUBMED:11502760]
[PUBMED:8978681]
[PUBMED:8999972]
[PUBMED:14690593]
[PUBMED:11832334]
[PUBMED:9447983]
[PUBMED:15192089]
[PUBMED:8524413]
[PUBMED:7685165]
[PUBMED:10329736]
[PUBMED:11287630]
[PUBMED:15486046]
[PUBMED:10330191]
[PUBMED:8626723]
Insulin receptor signalling cascade
[NCBI:1269429]
[REACTOME:R-HSA-74751]
[PUBMED:9677303]
[PUBMED:11282018]
Insulin signaling pathway
[NCBI:83090]
[KEGG:hsa04910]
[PUBMED:11742412]
[PUBMED:11343120]
[PUBMED:15733744]
[PUBMED:11282018]
[PUBMED:10196204]
[PUBMED:18291668]
[PUBMED:9609110]
[PUBMED:10567225]
[PUBMED:12791379]
[PUBMED:9748166]
[PUBMED:15624019]
[PUBMED:9445476]
[PUBMED:9346240]
[PUBMED:14635525]
[PUBMED:16288289]
[PUBMED:12867054]
[PUBMED:15229476]
[PUBMED:17344645]
[PUBMED:9609111]
Longevity regulating pathway
[NCBI:1319989]
[KEGG:hsa04211]
[PUBMED:21779512]
[PUBMED:23594965]
[PUBMED:25654554]
[PUBMED:25832544]
[PUBMED:24997879]
[PUBMED:22618766]
[PUBMED:20336132]
[PUBMED:24905167]
[PUBMED:25601466]
[PUBMED:20103737]
[PUBMED:18692468]
[PUBMED:20395504]
[PUBMED:25824609]
[PUBMED:17701476]
[PUBMED:23939249]
[PUBMED:20848587]
[PUBMED:22983298]
[PUBMED:19262508]
[PUBMED:20357764]
[PUBMED:18946478]
[PUBMED:23061800]
Metabolism of proteins
[NCBI:1268677]
[REACTOME:R-HSA-392499]
PI3K Cascade
[NCBI:1269432]
[REACTOME:R-HSA-109704]
PI3K-Akt signaling pathway
[NCBI:692234]
[KEGG:hsa04151]
[PUBMED:12048182]
[PUBMED:11357143]
[PUBMED:21440011]
[PUBMED:15209374]
[PUBMED:12669022]
[PUBMED:18842113]
[PUBMED:16847462]
[PUBMED:12660731]
[PUBMED:17360849]
[PUBMED:9838078]
[PUBMED:15505410]
[PUBMED:16248975]
[PUBMED:12531180]
[PUBMED:21779440]
[PUBMED:16187290]
[PUBMED:15784165]
[PUBMED:21620960]
PKB-mediated events
[NCBI:1269434]
[REACTOME:R-HSA-109703]
RNA transport
[NCBI:177876]
[KEGG:hsa03013]
[PUBMED:10872469]
[PUBMED:17401408]
[PUBMED:20733056]
[PUBMED:11018020]
[PUBMED:15519698]
[PUBMED:16314458]
[PUBMED:15901496]
[PUBMED:9548260]
[PUBMED:18313922]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by Insulin receptor
[NCBI:1269428]
[REACTOME:R-HSA-74752]
[PUBMED:8276779]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
[NCBI:1269617]
[REACTOME:R-HSA-2404192]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22044904]
[PUBMED:22649417]
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
[NCBI:137930]
[Pathway Interaction Database:met_pathway]
[PUBMED:10793146]
[PUBMED:8906793]
[PUBMED:11929826]
[PUBMED:10022866]
[PUBMED:11532961]
[PUBMED:12475979]
[PUBMED:1718989]
[PUBMED:1846706]
[PUBMED:10970810]
[PUBMED:10516287]
[PUBMED:12138161]
[PUBMED:11046147]
[PUBMED:18073207]
[PUBMED:12951049]
[PUBMED:15494312]
[PUBMED:9001234]
[PUBMED:11352916]
[PUBMED:11896055]
[PUBMED:9440692]
[PUBMED:8607979]
[PUBMED:12244132]
[PUBMED:11162460]
[PUBMED:11809798]
[PUBMED:9693375]
[PUBMED:14636584]
[PUBMED:17297451]
[PUBMED:17682062]
[PUBMED:19628037]
[PUBMED:11069926]
[PUBMED:18819921]
[PUBMED:16423831]
[PUBMED:10558875]
[PUBMED:16858414]
[PUBMED:10995442]
[PUBMED:20332103]
[PUBMED:11146548]
[PUBMED:18346875]
[PUBMED:17894413]
[PUBMED:9252406]
[PUBMED:17635922]
[PUBMED:11134526]
[PUBMED:2005882]
[PUBMED:19609305]
[PUBMED:8380735]
[PUBMED:16537482]
[PUBMED:10618718]
[PUBMED:9591773]
[PUBMED:12894582]
[PUBMED:9748249]
[PUBMED:11741535]
[PUBMED:17881575]
[PUBMED:10713050]
[PUBMED:1655790]
[PUBMED:11784715]
[PUBMED:10753869]
[PUBMED:10713700]
[PUBMED:11118451]
[PUBMED:16952352]
[PUBMED:15314156]
[PUBMED:19272169]
[PUBMED:12802068]
[PUBMED:17363898]
[PUBMED:7513258]
[PUBMED:1827664]
[PUBMED:2541345]
[PUBMED:8387483]
[PUBMED:16620780]
[PUBMED:11445578]
[PUBMED:10734310]
[PUBMED:16227611]
[PUBMED:12941962]
[PUBMED:15735664]
[PUBMED:19071214]
[PUBMED:7731718]
[PUBMED:19289496]
[PUBMED:11438654]
[PUBMED:11896612]
[PUBMED:11894096]
[PUBMED:11896575]
[PUBMED:7499247]
[PUBMED:12147692]
[PUBMED:11948414]
[PUBMED:19881549]
[PUBMED:19525225]
[PUBMED:14684163]
[PUBMED:17055484]
[PUBMED:9668053]
[PUBMED:10531383]
[PUBMED:9681449]
[PUBMED:1655405]
[PUBMED:12686592]
[PUBMED:19109251]
[PUBMED:10679787]
[PUBMED:9487126]
[PUBMED:9886295]
[PUBMED:12058075]
[PUBMED:15452053]
[PUBMED:9184210]
[PUBMED:10871282]
[PUBMED:17329361]
[PUBMED:2554238]
Signaling mediated by p38-alpha and p38-beta
[NCBI:138012]
[Pathway Interaction Database:p38alphabetadownstreampathway]
[PUBMED:11909979]
[PUBMED:7923353]
[PUBMED:14612426]
[PUBMED:12138194]
[PUBMED:9069290]
[PUBMED:9130707]
[PUBMED:10362538]
[PUBMED:9155018]
[PUBMED:11239470]
[PUBMED:9685422]
[PUBMED:9628874]
[PUBMED:9873047]
[PUBMED:10978317]
[PUBMED:11741533]
[PUBMED:7923354]
[PUBMED:9468497]
[PUBMED:9647257]
[PUBMED:8910365]
[PUBMED:8626550]
[PUBMED:9776729]
[PUBMED:10581204]
[PUBMED:7839144]
[PUBMED:7750577]
[PUBMED:11604491]
[PUBMED:11792706]
[PUBMED:7535770]
[PUBMED:10212189]
[PUBMED:10747897]
[PUBMED:9687510]
[PUBMED:11777913]
[PUBMED:9155017]
[PUBMED:7737130]
[PUBMED:9792677]
[PUBMED:11532965]
[PUBMED:9822687]
[PUBMED:8650547]
[PUBMED:9582321]
[PUBMED:9858528]
Translation
[NCBI:1268678]
[REACTOME:R-HSA-72766]
mTOR signaling pathway
[NCBI:83059]
[KEGG:hsa04150]
[NCBI:138001]
[Pathway Interaction Database:mtor_4pathway]
[PUBMED:17277771]
[PUBMED:15341740]
[PUBMED:12172553]
[PUBMED:15718470]
[PUBMED:14651849]
[PUBMED:15268862]
[PUBMED:15306821]
[PUBMED:26046644]
[PUBMED:12869586]
[PUBMED:24556838]
[PUBMED:17928295]
[PUBMED:9427642]
[PUBMED:18046414]
[PUBMED:12912918]
[PUBMED:16286006]
[PUBMED:26658722]
[PUBMED:24842496]
[PUBMED:23465396]
[PUBMED:17709744]
[PUBMED:17599906]
[PUBMED:16919458]
[PUBMED:10364159]
[PUBMED:15342917]
[PUBMED:11500364]
[PUBMED:19812304]
[PUBMED:12482958]
[PUBMED:11729323]
[PUBMED:16962653]
[PUBMED:18952604]
[PUBMED:9465032]
[PUBMED:1496022]
[PUBMED:10567431]
[PUBMED:19114562]
[PUBMED:17510057]
[PUBMED:18604198]
[PUBMED:15545625]
[PUBMED:11914378]
[PUBMED:17461779]
[PUBMED:9445476]
[PUBMED:18497260]
[PUBMED:12604610]
[PUBMED:15071500]
[PUBMED:18925875]
[PUBMED:12906785]
[PUBMED:11287630]
[PUBMED:15004009]
[PUBMED:16756488]
[PUBMED:17043309]
[PUBMED:18198340]
[PUBMED:12820960]
[PUBMED:12747827]
[PUBMED:17053147]
[PUBMED:15851026]
[PUBMED:15467718]
[PUBMED:18762023]
[PUBMED:25242279]
[PUBMED:24698685]
[PUBMED:11175345]
[PUBMED:27304501]
[PUBMED:18411301]
[PUBMED:11500365]
[PUBMED:17693255]
[PUBMED:23694989]
[PUBMED:12231510]
[PUBMED:19446321]
[PUBMED:11418588]
[PUBMED:19258318]
[PUBMED:18439900]
[PUBMED:19225151]
[PUBMED:26185979]
[PUBMED:10357815]
[PUBMED:26269525]
[PUBMED:23421405]
[PUBMED:9271440]
[PUBMED:16915281]
[PUBMED:17141160]
[PUBMED:15249583]
[PUBMED:12912989]
[PUBMED:27027448]
[PUBMED:18423201]
[PUBMED:19211835]
[PUBMED:9204908]
[PUBMED:26700098]
[PUBMED:18566587]
[PUBMED:17386266]
mTOR signalling
[NCBI:1269436]
[REACTOME:R-HSA-165159]
[PUBMED:21157483]
mTORC1-mediated signalling
[NCBI:1269438]
[REACTOME:R-HSA-166208]
[PUBMED:23641065]
[PUBMED:22500797]