full name
minichromosome maintenance complex component 4

synonyms
CDC21, CDC54, hCdc21, NKCD, NKGCD, P1-CDC21, MCM4, ENSG00000104738

HGNC
HGNC:6947

Entrez Gene
Gene:4173

ENSEMBL
ENSG00000104738

location
chr: 8
start: 48872763
stop: 48890720
strand: +

OMIM
OMIM:602638: MCM4 (Autosomal recessive inheritance)
OMIM:609981: Immunodeficiency 54

transcripts
NM_005914.3
NM_182746.2

pathways
Activation of ATR in response to replication stress [NCBI:1269757] [REACTOME:R-HSA-176187] [PUBMED:12791985]
Activation of the pre-replicative complex [NCBI:1269773] [REACTOME:R-HSA-68962] [PUBMED:10402192] [PUBMED:11779870] [PUBMED:10801458] [PUBMED:12169736] [PUBMED:11323433] [PUBMED:9038340] [PUBMED:9765232] [PUBMED:9829972] [PUBMED:10970868] [PUBMED:9353276] [PUBMED:7502077] [PUBMED:11459976] [PUBMED:11395502]
Assembly of the pre-replicative complex [NCBI:1269833] [REACTOME:R-HSA-68867] [PUBMED:11801723] [PUBMED:9829972] [PUBMED:9288745] [PUBMED:9407030] [PUBMED:9927482] [PUBMED:9335335] [PUBMED:11046155]
C-MYB transcription factor network [NCBI:138073] [Pathway Interaction Database:cmyb_pathway] [PUBMED:17152050] [PUBMED:1944282] [PUBMED:7964503] [PUBMED:8598284] [PUBMED:15608679] [PUBMED:10619021] [PUBMED:2233716] [PUBMED:9244354] [PUBMED:8654374] [PUBMED:10590070] [PUBMED:17587615] [PUBMED:12424255] [PUBMED:1679531] [PUBMED:17077080] [PUBMED:8946914] [PUBMED:16055116] [PUBMED:11259163] [PUBMED:9659917] [PUBMED:9135152] [PUBMED:7721782] [PUBMED:11290610] [PUBMED:12244173] [PUBMED:11792321] [PUBMED:17242210] [PUBMED:10722757] [PUBMED:8264615] [PUBMED:15687240] [PUBMED:14761981] [PUBMED:10542314] [PUBMED:12673198] [PUBMED:11779867] [PUBMED:8756344] [PUBMED:11427482] [PUBMED:9809063] [PUBMED:10523863] [PUBMED:11094072] [PUBMED:15356292] [PUBMED:11781241] [PUBMED:15778089] [PUBMED:9096387] [PUBMED:17931383] [PUBMED:14576818] [PUBMED:11259170] [PUBMED:8491193] [PUBMED:11581319] [PUBMED:10644988] [PUBMED:7565722] [PUBMED:9490676] [PUBMED:9244356] [PUBMED:17641686] [PUBMED:16407849] [PUBMED:1594249] [PUBMED:17822556] [PUBMED:15867358] [PUBMED:17959653] [PUBMED:7509358] [PUBMED:11287612] [PUBMED:15082531] [PUBMED:10766162] [PUBMED:8756629] [PUBMED:11115410] [PUBMED:7684005] [PUBMED:9566892]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints [NCBI:1269742] [REACTOME:R-HSA-69620]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Cell cycle [NCBI:83054] [KEGG:hsa04110] [PUBMED:7973727] [PUBMED:17568790] [PUBMED:9832503] [PUBMED:16936746] [PUBMED:9029154] [PUBMED:12573239] [PUBMED:19020303] [PUBMED:9618481] [PUBMED:12809600] [PUBMED:8242749] [PUBMED:10385618] [PUBMED:17426725] [PUBMED:17018296] [PUBMED:16212951] [PUBMED:12925736] [PUBMED:11099028] [PUBMED:15568976] [PUBMED:15838516] [PUBMED:15838523] [PUBMED:15876871] [PUBMED:7908906] [PUBMED:9889196]
DNA Replication [NCBI:1269875] [REACTOME:R-HSA-69306] [PUBMED:11257218] [PUBMED:12045100] [PUBMED:1536007] [PUBMED:10966477] [PUBMED:1579437] [PUBMED:8223461]
DNA Replication Pre-Initiation [NCBI:1269832] [REACTOME:R-HSA-69002]
DNA replication [NCBI:83039] [KEGG:hsa03030] [PUBMED:9759502] [PUBMED:8087839]
DNA strand elongation [NCBI:1269784] [REACTOME:R-HSA-69190] [PUBMED:9081985] [PUBMED:1976634] [PUBMED:7623835] [PUBMED:1536007] [PUBMED:8594377]
G1/S Transition [NCBI:1269768] [REACTOME:R-HSA-69206]
G2/M Checkpoints [NCBI:1269753] [REACTOME:R-HSA-69481]
M/G1 Transition [NCBI:1269831] [REACTOME:R-HSA-68874]
Mitotic G1-G1/S phases [NCBI:1269764] [REACTOME:R-HSA-453279]
Orc1 removal from chromatin [NCBI:1269782] [REACTOME:R-HSA-68949] [PUBMED:11931757] [PUBMED:11739726] [PUBMED:11809796] [PUBMED:1110244]
Regulation of DNA replication [NCBI:1269794] [REACTOME:R-HSA-69304]
Removal of licensing factors from origins [NCBI:1269796] [REACTOME:R-HSA-69300]
S Phase [NCBI:1269777] [REACTOME:R-HSA-69242]
Switching of origins to a post-replicative state [NCBI:1269781] [REACTOME:R-HSA-69052]
Synthesis of DNA [NCBI:1269779] [REACTOME:R-HSA-69239]
Unwinding of DNA [NCBI:1269785] [REACTOME:R-HSA-176974] [PUBMED:10834843] [PUBMED:15707891]