full name
poly(A) binding protein cytoplasmic 1

synonyms
PAB1, PABP, PABP1, PABPC2, PABPL1, PABPC1, ENSG00000070756

HGNC
HGNC:8554

Entrez Gene
Gene:26986

ENSEMBL
ENSG00000070756

location
chr: 8
start: 101715144
stop: 101734969
strand: -

transcripts
NM_002568.3

pathways
AUF1 (hnRNP D0) binds and destabilizes mRNA [NCBI:1269726] [REACTOME:R-HSA-450408] [PUBMED:16391004] [PUBMED:12704645] [PUBMED:10205060] [PUBMED:12440953] [PUBMED:18573886] [PUBMED:12819195]
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S [NCBI:1268683] [REACTOME:R-HSA-72662] [PUBMED:9732867] [PUBMED:592399] [PUBMED:641056] [PUBMED:6853548]
Cap-dependent Translation Initiation [NCBI:1268680] [REACTOME:R-HSA-72737]
Deadenylation of mRNA [NCBI:1269713] [REACTOME:R-HSA-429947] [PUBMED:17245413] [PUBMED:17052452] [PUBMED:15475613] [PUBMED:18608124] [PUBMED:11283721] [PUBMED:16141059] [PUBMED:19239894] [PUBMED:14749774]
Deadenylation-dependent mRNA decay [NCBI:1269712] [REACTOME:R-HSA-429914] [PUBMED:19239894] [PUBMED:14749774] [PUBMED:17245413] [PUBMED:15475613] [PUBMED:16141059] [PUBMED:11283721]
Eukaryotic Translation Initiation [NCBI:1268679] [REACTOME:R-HSA-72613] [PUBMED:20444697]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
L13a-mediated translational silencing of Ceruloplasmin expression [NCBI:1268688] [REACTOME:R-HSA-156827] [PUBMED:14567916]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) [NCBI:1269717] [REACTOME:R-HSA-975957] [PUBMED:19859661] [PUBMED:21496649] [PUBMED:17352659] [PUBMED:20795950] [PUBMED:19359157] [PUBMED:17531985] [PUBMED:17671086] [PUBMED:19410547]
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) [NCBI:1269718] [REACTOME:R-HSA-975956] [PUBMED:20795950] [PUBMED:18447580] [PUBMED:17671086] [PUBMED:17531985] [PUBMED:19359157] [PUBMED:19859661] [PUBMED:17352659] [PUBMED:18447585] [PUBMED:18256688]
Nonsense-Mediated Decay (NMD) [NCBI:1269716] [REACTOME:R-HSA-927802] [PUBMED:18524595] [PUBMED:17671086] [PUBMED:19359157] [PUBMED:17531985] [PUBMED:17352659] [PUBMED:21496649] [PUBMED:19859661] [PUBMED:20795950] [PUBMED:19010255]
RNA degradation [NCBI:117291] [KEGG:hsa03018] [PUBMED:16939780] [PUBMED:17560162] [PUBMED:17471261] [PUBMED:16968219] [PUBMED:16766188] [PUBMED:17447862] [PUBMED:19239894]
RNA transport [NCBI:177876] [KEGG:hsa03013] [PUBMED:10872469] [PUBMED:17401408] [PUBMED:20733056] [PUBMED:11018020] [PUBMED:15519698] [PUBMED:16314458] [PUBMED:15901496] [PUBMED:9548260] [PUBMED:18313922]
Regulation of mRNA stability by proteins that bind AU-rich elements [NCBI:1269725] [REACTOME:R-HSA-450531] [PUBMED:12440953] [PUBMED:12704645] [PUBMED:15460540] [PUBMED:16391004]
Translation [NCBI:1268678] [REACTOME:R-HSA-72766]
Translation initiation complex formation [NCBI:1268684] [REACTOME:R-HSA-72649] [PUBMED:6853548] [PUBMED:641056] [PUBMED:9732867] [PUBMED:592399]
mRNA surveillance pathway [NCBI:193328] [KEGG:hsa03015] [PUBMED:16723977] [PUBMED:18158581] [PUBMED:16715045] [PUBMED:17183357] [PUBMED:15040442]