full name
cytochrome P450 family 11 subfamily B member 2

synonyms
ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18, P450aldo, P450C18, CYP11B2, ENSG00000179142

HGNC
HGNC:2592

Entrez Gene
Gene:1585

ENSEMBL
ENSG00000179142

location
chr: 8
start: 143991975
stop: 143999259
strand: -

OMIM
OMIM:124080: CYP11B2
OMIM:203400: Hypoaldosteronism, congenital, due to CMO I deficiency
OMIM:610600: Hypoaldosteronism, congenital, due to CMO II deficiency

transcripts
NM_000498.3

pathways
Aldosterone synthesis and secretion [NCBI:1272485] [KEGG:hsa04925] [PUBMED:15044681] [PUBMED:10536682] [PUBMED:24944029] [PUBMED:25788893] [PUBMED:15026188] [PUBMED:22689262] [PUBMED:22364774] [PUBMED:18406824] [PUBMED:14645496] [PUBMED:21839803] [PUBMED:22395411] [PUBMED:23628605] [PUBMED:21962440]
Biological oxidations [NCBI:1270189] [REACTOME:R-HSA-211859]
C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone [NCBI:413394] [KEGG:hsa_M00108]
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone [NCBI:413395] [KEGG:hsa_M00109]
Cytochrome P450 - arranged by substrate type [NCBI:1270191] [REACTOME:R-HSA-211897] [PUBMED:16584116] [PUBMED:15102545] [PUBMED:12369887]
Endogenous sterols [NCBI:1270192] [REACTOME:R-HSA-211976] [PUBMED:16872679] [PUBMED:15102545] [PUBMED:16584116]
Glucocorticoid biosynthesis [NCBI:1270048] [REACTOME:R-HSA-194002] [PUBMED:15583024]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Metabolism of steroid hormones [NCBI:1270046] [REACTOME:R-HSA-196071] [PUBMED:15583024]
Mineralocorticoid biosynthesis [NCBI:1270049] [REACTOME:R-HSA-193993] [PUBMED:15583024]
Phase 1 - Functionalization of compounds [NCBI:1270190] [REACTOME:R-HSA-211945] [PUBMED:12369887] [PUBMED:17125408] [PUBMED:16584116]
Steroid hormone biosynthesis [NCBI:82940] [KEGG:hsa00140] [PUBMED:15642792] [PUBMED:16413106] [PUBMED:12832414] [PUBMED:17475203] [PUBMED:12604236] [PUBMED:10998348] [PUBMED:11469811] [PUBMED:16547389] [PUBMED:17926129] [PUBMED:17459698]
mineralocorticoid biosynthesis [NCBI:545305] [BIOCYC:HUMAN_PWY66-382] [PUBMED:3487786] [PUBMED:7673125] [PUBMED:1741400]
superpathway of steroid hormone biosynthesis [NCBI:907943] [BIOCYC:HUMAN_PWY-7305] [PUBMED:16973755]