full name
Janus kinase 2
synonyms
JTK10, THCYT3, JAK2, ENSG00000096968
HGNC
HGNC:6192
Entrez Gene
Gene:3717
ENSEMBL
ENSG00000096968
location
chr: 9
start: 4985245
stop: 5129948
strand: +
OMIM
OMIM:147796:
JAK2
(Autosomal dominant inheritance)
OMIM:133100:
Erythrocytosis, somatic
OMIM:601626:
Leukemia, acute myeloid, somatic
OMIM:254450:
Myelofibrosis, somatic
OMIM:263300:
Polycythemia vera, somatic
OMIM:614521:
Thrombocythemia 3
OMIM:600880:
{Budd-Chiari syndrome, somatic}
transcripts
NM_004972.3
pathways
AGE-RAGE signaling pathway in diabetic complications
[NCBI:1319988]
[KEGG:hsa04933]
[PUBMED:23776698]
[PUBMED:15569303]
[PUBMED:16894049]
[PUBMED:18323529]
[PUBMED:11375353]
[PUBMED:21111800]
[PUBMED:19404313]
[PUBMED:20470857]
[PUBMED:17005604]
[PUBMED:23961320]
[PUBMED:21261520]
[PUBMED:11180401]
[PUBMED:18922799]
[PUBMED:21680901]
[PUBMED:11684565]
[PUBMED:21590515]
[PUBMED:12709399]
[PUBMED:20300563]
[PUBMED:21440603]
[PUBMED:22558488]
ARMS-mediated activation
[NCBI:1269471]
[REACTOME:R-HSA-170984]
[PUBMED:9069267]
Adipocytokine signaling pathway
[NCBI:83093]
[KEGG:hsa04920]
[PUBMED:12829246]
[PUBMED:10905472]
[PUBMED:15980064]
[PUBMED:12754525]
[PUBMED:12368907]
[PUBMED:11557972]
[PUBMED:15856064]
[PUBMED:9671776]
[PUBMED:10766253]
[PUBMED:15733744]
[PUBMED:15058305]
[PUBMED:14716305]
[PUBMED:11479627]
[PUBMED:14679176]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
CXCR4-mediated signaling events
[NCBI:137910]
[Pathway Interaction Database:cxcr4_pathway]
[PUBMED:18799424]
[PUBMED:17537990]
[PUBMED:10881171]
[PUBMED:17675482]
[PUBMED:11157475]
[PUBMED:12077227]
[PUBMED:11544290]
[PUBMED:8752280]
[PUBMED:12535795]
[PUBMED:19380820]
[PUBMED:10952719]
[PUBMED:16230460]
[PUBMED:12682230]
[PUBMED:16503409]
[PUBMED:10644702]
[PUBMED:9722546]
[PUBMED:11784854]
[PUBMED:10491003]
[PUBMED:10521508]
[PUBMED:10606629]
[PUBMED:15615703]
[PUBMED:17568820]
[PUBMED:10753828]
[PUBMED:12519755]
[PUBMED:12032308]
[PUBMED:8752281]
[PUBMED:10570282]
[PUBMED:11369622]
[PUBMED:15728464]
[PUBMED:12590707]
[PUBMED:16038794]
[PUBMED:14662753]
[PUBMED:18596232]
[PUBMED:17056591]
[PUBMED:14602072]
[PUBMED:15994292]
[PUBMED:16919488]
[PUBMED:15872091]
[PUBMED:10506573]
[PUBMED:12036857]
[PUBMED:15618472]
[PUBMED:14704365]
[PUBMED:18227351]
[PUBMED:11641392]
[PUBMED:18319399]
[PUBMED:12133960]
[PUBMED:15630457]
Chemokine signaling pathway
[NCBI:99051]
[KEGG:hsa04062]
[PUBMED:17371236]
[PUBMED:19159344]
[PUBMED:17169327]
[PUBMED:10852130]
[PUBMED:9765254]
[PUBMED:15771581]
[PUBMED:14607270]
[PUBMED:18662984]
[PUBMED:12495636]
[PUBMED:15803148]
[PUBMED:15046611]
[PUBMED:12069927]
[PUBMED:18711432]
[PUBMED:17675482]
[PUBMED:16144840]
[PUBMED:17496928]
[PUBMED:17537990]
[PUBMED:11872087]
[PUBMED:12051620]
[PUBMED:14625285]
[PUBMED:8576262]
[PUBMED:11244042]
Cholinergic synapse
[NCBI:217716]
[KEGG:hsa04725]
[PUBMED:20060019]
[PUBMED:11283752]
[PUBMED:15165747]
[PUBMED:12893537]
[PUBMED:11738031]
[PUBMED:21550798]
[PUBMED:19712465]
[PUBMED:12690458]
[PUBMED:12436417]
[PUBMED:19378880]
[PUBMED:11923408]
[PUBMED:20446119]
Chromatin modifying enzymes
[NCBI:1270434]
[REACTOME:R-HSA-3247509]
Chromatin organization
[NCBI:1270433]
[REACTOME:R-HSA-4839726]
[PUBMED:21342762]
[PUBMED:15598472]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
DAP12 interactions
[NCBI:1269283]
[REACTOME:R-HSA-2172127]
[PUBMED:19120482]
[PUBMED:17220916]
[PUBMED:9490415]
[PUBMED:18192027]
[PUBMED:15884055]
DAP12 signaling
[NCBI:1269284]
[REACTOME:R-HSA-2424491]
[PUBMED:15884055]
[PUBMED:17110943]
[PUBMED:17220916]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
Disease
[NCBI:1268854]
[REACTOME:R-HSA-1643685]
Diseases of signal transduction
[NCBI:1268855]
[REACTOME:R-HSA-5663202]
[PUBMED:12509752]
Downstream signal transduction
[NCBI:1269479]
[REACTOME:R-HSA-186763]
[PUBMED:10508235]
[PUBMED:9739761]
EGFR tyrosine kinase inhibitor resistance
[NCBI:1404798]
[KEGG:hsa01521]
[PUBMED:16843264]
[PUBMED:23401451]
[PUBMED:20966921]
[PUBMED:24307395]
[PUBMED:22956644]
[PUBMED:25232485]
[PUBMED:24493829]
[PUBMED:23071030]
[PUBMED:18483355]
[PUBMED:24202392]
[PUBMED:19632948]
[PUBMED:23361103]
[PUBMED:26579470]
[PUBMED:22970367]
[PUBMED:23358468]
[PUBMED:17554333]
[PUBMED:25337673]
[PUBMED:22474259]
[PUBMED:20551942]
EPO signaling pathway
[NCBI:138051]
[Pathway Interaction Database:epopathway]
[PUBMED:14699131]
[PUBMED:7889566]
[PUBMED:8537396]
[PUBMED:11124936]
[PUBMED:9344843]
[PUBMED:12504103]
[PUBMED:7528577]
[PUBMED:15329338]
[PUBMED:15254422]
[PUBMED:7537740]
[PUBMED:9334184]
[PUBMED:10882725]
[PUBMED:15007095]
[PUBMED:15705783]
[PUBMED:10910907]
[PUBMED:8343951]
[PUBMED:8034732]
Endothelins
[NCBI:137958]
[Pathway Interaction Database:endothelinpathway]
[PUBMED:1319997]
[PUBMED:12719447]
[PUBMED:15047866]
[PUBMED:1905483]
[PUBMED:3144974]
[PUBMED:12922939]
[PUBMED:9595433]
[PUBMED:2558572]
[PUBMED:10364236]
[PUBMED:11231316]
[PUBMED:17569879]
[PUBMED:11078350]
[PUBMED:17535295]
[PUBMED:17533154]
[PUBMED:8764613]
[PUBMED:8617878]
[PUBMED:17526654]
[PUBMED:8843717]
[PUBMED:12606754]
[PUBMED:15200122]
[PUBMED:8319594]
[PUBMED:17627891]
[PUBMED:8940174]
[PUBMED:12397581]
[PUBMED:2545198]
ErbB2/ErbB3 signaling events
[NCBI:137955]
[Pathway Interaction Database:erbb2erbb3pathway]
[PUBMED:9677338]
[PUBMED:11546794]
[PUBMED:9710588]
[PUBMED:11984589]
[PUBMED:19474313]
[PUBMED:12072561]
[PUBMED:18760695]
[PUBMED:18614687]
[PUBMED:11027222]
[PUBMED:12466964]
[PUBMED:10704452]
[PUBMED:19535578]
[PUBMED:7556067]
[PUBMED:16481445]
[PUBMED:10493750]
[PUBMED:17998937]
[PUBMED:17210635]
[PUBMED:18799465]
[PUBMED:12411582]
[PUBMED:15520002]
[PUBMED:10531446]
[PUBMED:10101228]
[PUBMED:10399934]
[PUBMED:8815893]
[PUBMED:19179536]
[PUBMED:7877996]
[PUBMED:11173924]
[PUBMED:12651161]
[PUBMED:9362461]
[PUBMED:18426980]
[PUBMED:19019207]
[PUBMED:9338783]
[PUBMED:11312610]
[PUBMED:11940572]
[PUBMED:8707830]
[PUBMED:11564761]
[PUBMED:9049301]
[PUBMED:9694850]
[PUBMED:10582594]
[PUBMED:9637684]
[PUBMED:8702681]
ErbB4 signaling events
[NCBI:137991]
[Pathway Interaction Database:erbb4_pathway]
[PUBMED:16815842]
[PUBMED:8617750]
[PUBMED:9663464]
[PUBMED:12466964]
[PUBMED:15345710]
[PUBMED:16061658]
[PUBMED:12954715]
[PUBMED:17463226]
[PUBMED:17646177]
[PUBMED:17085783]
[PUBMED:18721752]
[PUBMED:15023535]
[PUBMED:9556621]
[PUBMED:12807903]
[PUBMED:17486069]
[PUBMED:10358079]
[PUBMED:12454007]
[PUBMED:8702723]
[PUBMED:10693928]
[PUBMED:18334649]
[PUBMED:10725395]
[PUBMED:11731109]
[PUBMED:7477376]
[PUBMED:16837552]
[PUBMED:15863494]
[PUBMED:19047365]
[PUBMED:10722704]
[PUBMED:19193720]
[PUBMED:10348342]
[PUBMED:17018285]
[PUBMED:9135143]
[PUBMED:9618494]
[PUBMED:12716924]
[PUBMED:18819924]
[PUBMED:10867024]
[PUBMED:15985438]
[PUBMED:7559778]
[PUBMED:7759543]
[PUBMED:12824469]
[PUBMED:10744726]
[PUBMED:15746097]
[PUBMED:18653779]
[PUBMED:15534001]
[PUBMED:17460065]
[PUBMED:10508857]
[PUBMED:15282549]
[PUBMED:9362517]
[PUBMED:9685416]
[PUBMED:11679632]
[PUBMED:10839362]
[PUBMED:10353604]
FCERI mediated MAPK activation
[NCBI:1269299]
[REACTOME:R-HSA-2871796]
[PUBMED:19290926]
[PUBMED:19909365]
[PUBMED:17122878]
Factors involved in megakaryocyte development and platelet production
[NCBI:1269377]
[REACTOME:R-HSA-983231]
[PUBMED:16856888]
[PUBMED:17635743]
[PUBMED:17934486]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
Frs2-mediated activation
[NCBI:1269470]
[REACTOME:R-HSA-170968]
[PUBMED:9069267]
G beta:gamma signalling through PI3Kgamma
[NCBI:1269581]
[REACTOME:R-HSA-392451]
[PUBMED:17916723]
[PUBMED:17041586]
G-protein beta:gamma signalling
[NCBI:1269580]
[REACTOME:R-HSA-397795]
[PUBMED:18834311]
GPCR downstream signaling
[NCBI:1269574]
[REACTOME:R-HSA-388396]
[PUBMED:12040175]
GPVI-mediated activation cascade
[NCBI:1269357]
[REACTOME:R-HSA-114604]
[PUBMED:16102042]
[PUBMED:11943772]
GRB2 events in EGFR signaling
[NCBI:1269382]
[REACTOME:R-HSA-179812]
[PUBMED:11706405]
[PUBMED:11498013]
Gastrin-CREB signalling pathway via PKC and MAPK
[NCBI:1269592]
[REACTOME:R-HSA-881907]
[PUBMED:10413847]
[PUBMED:7491953]
[PUBMED:17698287]
Growth hormone receptor signaling
[NCBI:1269327]
[REACTOME:R-HSA-982772]
[PUBMED:15601831]
[PUBMED:8548048]
[PUBMED:17488973]
[PUBMED:20664532]
Hemostasis
[NCBI:1269340]
[REACTOME:R-HSA-109582]
Herpes simplex infection
[NCBI:377873]
[KEGG:hsa05168]
[PUBMED:12224518]
[PUBMED:17913820]
[PUBMED:12844494]
[PUBMED:10998601]
[PUBMED:15163721]
[PUBMED:19694546]
[PUBMED:16297150]
[PUBMED:14747533]
[PUBMED:12826401]
[PUBMED:14963113]
[PUBMED:15056211]
[PUBMED:12797447]
[PUBMED:21107701]
[PUBMED:10918307]
[PUBMED:10696424]
[PUBMED:16076403]
[PUBMED:10364308]
[PUBMED:17222692]
[PUBMED:9621021]
[PUBMED:12224508]
[PUBMED:19879619]
[PUBMED:11070032]
[PUBMED:9499021]
[PUBMED:18596690]
[PUBMED:12525427]
[PUBMED:12224517]
[PUBMED:10196275]
[PUBMED:15047834]
[PUBMED:18508584]
[PUBMED:20036979]
IFN-gamma pathway
[NCBI:138040]
[Pathway Interaction Database:ifngpathway]
[PUBMED:9724754]
[PUBMED:10657627]
[PUBMED:10067896]
[PUBMED:9271410]
[PUBMED:8608598]
[PUBMED:15878863]
[PUBMED:11971965]
[PUBMED:11438544]
[PUBMED:15051500]
[PUBMED:17032168]
[PUBMED:11909529]
[PUBMED:11171987]
[PUBMED:7514165]
[PUBMED:12817007]
[PUBMED:8232552]
[PUBMED:10485906]
[PUBMED:8755534]
[PUBMED:10490100]
[PUBMED:8156998]
[PUBMED:11972023]
[PUBMED:8986769]
[PUBMED:12438563]
[PUBMED:10022928]
[PUBMED:12270932]
[PUBMED:7510216]
[PUBMED:15311277]
[PUBMED:14670297]
[PUBMED:12048245]
[PUBMED:10777554]
[PUBMED:12138178]
[PUBMED:9336467]
[PUBMED:7690989]
[PUBMED:1281555]
[PUBMED:17606919]
[PUBMED:10805787]
[PUBMED:12050152]
[PUBMED:8608597]
[PUBMED:15879117]
[PUBMED:12855578]
[PUBMED:10995751]
[PUBMED:10490099]
[PUBMED:7777519]
IGF1R signaling cascade
[NCBI:1269618]
[REACTOME:R-HSA-2428924]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
IL-6-type cytokine receptor ligand interactions
[NCBI:1339143]
[REACTOME:R-HSA-6788467]
[PUBMED:9716487]
[PUBMED:12773095]
IL12-mediated signaling events
[NCBI:137922]
[Pathway Interaction Database:il12_2pathway]
[PUBMED:12874225]
[PUBMED:12221108]
[PUBMED:16380506]
[PUBMED:9768751]
[PUBMED:17114419]
[PUBMED:10358173]
[PUBMED:9890938]
[PUBMED:12213961]
[PUBMED:11120802]
[PUBMED:9202126]
[PUBMED:16641133]
[PUBMED:10198225]
[PUBMED:16763563]
[PUBMED:15728489]
[PUBMED:8103068]
[PUBMED:10903740]
[PUBMED:10201984]
[PUBMED:7638186]
[PUBMED:11894097]
[PUBMED:16220539]
[PUBMED:10961885]
[PUBMED:7594594]
[PUBMED:17110450]
[PUBMED:9582275]
[PUBMED:10320373]
[PUBMED:7528775]
[PUBMED:11207258]
[PUBMED:9038232]
[PUBMED:15522880]
[PUBMED:11175814]
[PUBMED:9531298]
[PUBMED:7722452]
[PUBMED:8943050]
[PUBMED:7553885]
[PUBMED:9454765]
IL23-mediated signaling events
[NCBI:138000]
[Pathway Interaction Database:il23pathway]
[PUBMED:16200068]
[PUBMED:12023338]
[PUBMED:17030949]
[PUBMED:16670770]
[PUBMED:17074928]
[PUBMED:15583831]
[PUBMED:16919486]
[PUBMED:12417590]
[PUBMED:16622035]
[PUBMED:16698929]
[PUBMED:14978083]
[PUBMED:12610626]
[PUBMED:15308705]
[PUBMED:16200070]
[PUBMED:15657292]
[PUBMED:16648837]
[PUBMED:11114383]
[PUBMED:12023369]
[PUBMED:9038232]
IL27-mediated signaling events
[NCBI:137929]
[Pathway Interaction Database:il27pathway]
[PUBMED:11672539]
[PUBMED:16365415]
[PUBMED:16906167]
[PUBMED:15356135]
[PUBMED:14657353]
[PUBMED:15944269]
[PUBMED:14764690]
[PUBMED:14614852]
[PUBMED:15308705]
[PUBMED:15004160]
[PUBMED:12734330]
[PUBMED:11057672]
[PUBMED:15494513]
[PUBMED:14614853]
[PUBMED:12121660]
[PUBMED:16906166]
[PUBMED:15749890]
IL4-mediated signaling events
[NCBI:137933]
[Pathway Interaction Database:il4_2pathway]
[PUBMED:8602263]
[PUBMED:15199062]
[PUBMED:7705411]
[PUBMED:11160325]
[PUBMED:8557643]
[PUBMED:8134361]
[PUBMED:1948049]
[PUBMED:10843732]
[PUBMED:11034397]
[PUBMED:8624802]
[PUBMED:14557412]
[PUBMED:1997653]
[PUBMED:10586089]
[PUBMED:14634100]
[PUBMED:17541284]
[PUBMED:8124718]
[PUBMED:16210622]
[PUBMED:7822337]
[PUBMED:11572871]
[PUBMED:2147202]
[PUBMED:10228008]
[PUBMED:7675087]
[PUBMED:12574343]
[PUBMED:14603527]
[PUBMED:15659391]
[PUBMED:11160269]
[PUBMED:7760829]
[PUBMED:7973658]
[PUBMED:10072514]
[PUBMED:9013879]
[PUBMED:8624803]
[PUBMED:10490661]
[PUBMED:14978013]
[PUBMED:10364072]
[PUBMED:12459556]
[PUBMED:11714803]
[PUBMED:8602264]
[PUBMED:9811885]
[PUBMED:12776189]
[PUBMED:15728454]
[PUBMED:10601358]
[PUBMED:11739727]
[PUBMED:11160275]
[PUBMED:9852037]
[PUBMED:9670964]
[PUBMED:15004182]
[PUBMED:8266078]
[PUBMED:3144043]
[PUBMED:8992992]
[PUBMED:8089482]
[PUBMED:9651359]
[PUBMED:16810739]
[PUBMED:7499365]
[PUBMED:7721786]
[PUBMED:9065461]
[PUBMED:11241672]
[PUBMED:10950967]
[PUBMED:8810328]
[PUBMED:8624821]
[PUBMED:9110977]
[PUBMED:8609418]
[PUBMED:15187136]
[PUBMED:9414268]
[PUBMED:8916957]
[PUBMED:10201892]
[PUBMED:17200144]
[PUBMED:8458387]
[PUBMED:11544308]
[PUBMED:10657944]
[PUBMED:15153491]
[PUBMED:7544011]
[PUBMED:8266076]
[PUBMED:11801631]
[PUBMED:12044779]
[PUBMED:8621475]
[PUBMED:9697832]
[PUBMED:12242343]
[PUBMED:7694370]
[PUBMED:9380721]
[PUBMED:9541585]
[PUBMED:7807002]
[PUBMED:16537510]
[PUBMED:8258319]
[PUBMED:9799097]
[PUBMED:12023955]
[PUBMED:8085155]
IL6-mediated signaling events
[NCBI:137932]
[Pathway Interaction Database:il6_7pathway]
[PUBMED:8559663]
[PUBMED:8662591]
[PUBMED:11689697]
[PUBMED:11727828]
[PUBMED:10383440]
[PUBMED:10777583]
[PUBMED:16774741]
[PUBMED:12754507]
[PUBMED:9295319]
[PUBMED:15722452]
[PUBMED:10859312]
[PUBMED:9590172]
[PUBMED:9880505]
[PUBMED:12445202]
[PUBMED:8134389]
[PUBMED:10409724]
[PUBMED:8164674]
[PUBMED:8272872]
[PUBMED:9794795]
[PUBMED:7678052]
[PUBMED:8511589]
[PUBMED:8668165]
[PUBMED:9724754]
[PUBMED:8083235]
[PUBMED:12754505]
[PUBMED:8621622]
[PUBMED:16254248]
[PUBMED:12361954]
[PUBMED:10605021]
[PUBMED:9388184]
[PUBMED:15935617]
[PUBMED:11120832]
[PUBMED:7875298]
[PUBMED:9973404]
[PUBMED:11335711]
[PUBMED:9632795]
[PUBMED:11468294]
[PUBMED:7898939]
[PUBMED:8626374]
[PUBMED:8670868]
[PUBMED:7537214]
[PUBMED:15677447]
[PUBMED:2261637]
[PUBMED:9874564]
[PUBMED:12829785]
[PUBMED:8537375]
[PUBMED:8272873]
[PUBMED:7523403]
[PUBMED:11251120]
[PUBMED:9163525]
[PUBMED:3136546]
[PUBMED:10727406]
[PUBMED:10023775]
[PUBMED:12754506]
[PUBMED:12456685]
[PUBMED:2788034]
[PUBMED:10446219]
[PUBMED:15572665]
[PUBMED:1662392]
[PUBMED:15010462]
[PUBMED:8140422]
[PUBMED:8467812]
IRS-mediated signalling
[NCBI:1269431]
[REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R
[NCBI:1269620]
[REACTOME:R-HSA-2428928]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:18927274]
[PUBMED:21042815]
[PUBMED:20098959]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Influenza A
[NCBI:217173]
[KEGG:hsa05164]
[PUBMED:17267598]
[PUBMED:18049471]
[PUBMED:16882036]
[PUBMED:11907320]
[PUBMED:17944269]
[PUBMED:20629046]
[PUBMED:17072332]
[PUBMED:18588994]
[PUBMED:19864182]
[PUBMED:19290913]
[PUBMED:19420020]
[PUBMED:17213831]
[PUBMED:9060654]
[PUBMED:19481124]
[PUBMED:16494716]
[PUBMED:21147034]
[PUBMED:18980544]
[PUBMED:20020828]
[PUBMED:15502848]
[PUBMED:19782761]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Insulin receptor signalling cascade
[NCBI:1269429]
[REACTOME:R-HSA-74751]
[PUBMED:9677303]
[PUBMED:11282018]
Interferon Signaling
[NCBI:1269311]
[REACTOME:R-HSA-913531]
[PUBMED:18929502]
[PUBMED:15607020]
[PUBMED:15864272]
[PUBMED:14525967]
[PUBMED:19059436]
Interferon gamma signaling
[NCBI:1269314]
[REACTOME:R-HSA-877300]
[PUBMED:9462485]
[PUBMED:18929502]
[PUBMED:9143700]
[PUBMED:14525967]
Interleukin receptor SHC signaling
[NCBI:1269322]
[REACTOME:R-HSA-912526]
[PUBMED:8294403]
Interleukin-2 signaling
[NCBI:1269321]
[REACTOME:R-HSA-451927]
[PUBMED:17936914]
[PUBMED:18817510]
[PUBMED:19543225]
[PUBMED:18062768]
Interleukin-3, 5 and GM-CSF signaling
[NCBI:1269323]
[REACTOME:R-HSA-512988]
[PUBMED:10450743]
[PUBMED:9766809]
Interleukin-4 and 13 signaling
[NCBI:1470923]
[REACTOME:R-HSA-6785807]
[PUBMED:12704343]
[PUBMED:10358772]
Interleukin-6 family signaling
[NCBI:1339142]
[REACTOME:R-HSA-6783589]
[PUBMED:9685167]
[PUBMED:8666978]
[PUBMED:12773095]
[PUBMED:9143707]
[PUBMED:9716487]
[PUBMED:7632928]
Interleukin-6 signaling
[NCBI:1269325]
[REACTOME:R-HSA-1059683]
[PUBMED:20410258]
Jak-STAT signaling pathway
[NCBI:83077]
[KEGG:hsa04630]
[PUBMED:21034406]
[PUBMED:22339650]
[PUBMED:16204702]
[PUBMED:25587654]
[PUBMED:24069565]
[PUBMED:22383755]
[PUBMED:24606160]
[PUBMED:10851053]
[PUBMED:23735217]
[PUBMED:25217450]
[PUBMED:21372217]
Leishmaniasis
[NCBI:144181]
[KEGG:hsa05140]
[PUBMED:11890722]
[PUBMED:7916951]
[PUBMED:10417174]
[PUBMED:11298294]
[PUBMED:10586030]
[PUBMED:15322192]
[PUBMED:15831826]
[PUBMED:11728310]
[PUBMED:15039466]
[PUBMED:10462516]
[PUBMED:10608501]
[PUBMED:15721837]
[PUBMED:15639739]
[PUBMED:14762510]
[PUBMED:18793215]
[PUBMED:7591091]
[PUBMED:12438359]
[PUBMED:18070909]
[PUBMED:17543969]
[PUBMED:15983048]
[PUBMED:16848789]
[PUBMED:10770277]
[PUBMED:9504340]
MAPK family signaling cascades
[NCBI:1269501]
[REACTOME:R-HSA-5683057]
[PUBMED:21167873]
[PUBMED:17161475]
[PUBMED:22535895]
[PUBMED:21372320]
MAPK1 (ERK2) activation
[NCBI:1269505]
[REACTOME:R-HSA-112411]
[PUBMED:22177953]
[PUBMED:8131746]
MAPK1/MAPK3 signaling
[NCBI:1269502]
[REACTOME:R-HSA-5684996]
[PUBMED:25378393]
[PUBMED:18199641]
[PUBMED:17496909]
[PUBMED:21779496]
[PUBMED:15520807]
[PUBMED:16393692]
[PUBMED:19520853]
[PUBMED:17496910]
[PUBMED:22569528]
MAPK3 (ERK1) activation
[NCBI:1269504]
[REACTOME:R-HSA-110056]
Measles
[NCBI:213306]
[KEGG:hsa05162]
[PUBMED:16237742]
[PUBMED:12804771]
[PUBMED:19198562]
[PUBMED:20376484]
[PUBMED:11385511]
[PUBMED:16963735]
[PUBMED:19198566]
[PUBMED:18922877]
[PUBMED:19203114]
[PUBMED:12620806]
[PUBMED:16690907]
[PUBMED:17720800]
[PUBMED:20636817]
[PUBMED:12410527]
[PUBMED:11582511]
[PUBMED:19203109]
[PUBMED:19203113]
[PUBMED:14585342]
[PUBMED:12805463]
NCAM signaling for neurite out-growth
[NCBI:1270312]
[REACTOME:R-HSA-375165]
[PUBMED:18760361]
[PUBMED:12587671]
[PUBMED:15662836]
[PUBMED:17975827]
[PUBMED:15153429]
[PUBMED:12700044]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
Notch-mediated HES/HEY network
[NCBI:169347]
[Pathway Interaction Database:hes_heypathway]
[PUBMED:15546612]
[PUBMED:11038350]
[PUBMED:12065598]
[PUBMED:11741889]
[PUBMED:10851137]
[PUBMED:10205173]
[PUBMED:10747963]
[PUBMED:10913198]
[PUBMED:11101851]
[PUBMED:16201968]
[PUBMED:12488457]
[PUBMED:12370315]
[PUBMED:19116245]
[PUBMED:16025100]
[PUBMED:11486044]
[PUBMED:15607978]
[PUBMED:15467735]
[PUBMED:14739937]
[PUBMED:9694793]
[PUBMED:8749394]
[PUBMED:16782059]
[PUBMED:12972610]
[PUBMED:17392792]
[PUBMED:11334435]
[PUBMED:11486045]
[PUBMED:16753023]
[PUBMED:15485867]
[PUBMED:15866158]
[PUBMED:16199874]
[PUBMED:12374742]
[PUBMED:9570950]
[PUBMED:10964718]
[PUBMED:16682003]
[PUBMED:16287852]
[PUBMED:10692439]
[PUBMED:11095750]
[PUBMED:11287612]
[PUBMED:15314183]
[PUBMED:15156153]
[PUBMED:15684393]
[PUBMED:7566092]
[PUBMED:11604511]
[PUBMED:9819403]
[PUBMED:15563463]
[PUBMED:15870295]
Oncogenic MAPK signaling
[NCBI:1457781]
[REACTOME:R-HSA-6802957]
[PUBMED:25907612]
[PUBMED:24651010]
[PUBMED:24202393]
[PUBMED:25435214]
[PUBMED:21993244]
[PUBMED:24814062]
[PUBMED:22589270]
PI3K-Akt signaling pathway
[NCBI:692234]
[KEGG:hsa04151]
[PUBMED:12048182]
[PUBMED:11357143]
[PUBMED:21440011]
[PUBMED:15209374]
[PUBMED:12669022]
[PUBMED:18842113]
[PUBMED:16847462]
[PUBMED:12660731]
[PUBMED:17360849]
[PUBMED:9838078]
[PUBMED:15505410]
[PUBMED:16248975]
[PUBMED:12531180]
[PUBMED:21779440]
[PUBMED:16187290]
[PUBMED:15784165]
[PUBMED:21620960]
Paradoxical activation of RAF signaling by kinase inactive BRAF
[NCBI:1457785]
[REACTOME:R-HSA-6802955]
[PUBMED:25435214]
[PUBMED:20674547]
[PUBMED:24957944]
[PUBMED:23352452]
[PUBMED:20130576]
[PUBMED:23680146]
[PUBMED:16364920]
[PUBMED:25907612]
[PUBMED:15035987]
[PUBMED:20179705]
[PUBMED:19727074]
[PUBMED:20141835]
[PUBMED:22510884]
Paxillin-independent events mediated by a4b1 and a4b7
[NCBI:137971]
[Pathway Interaction Database:a4b1_paxindep_pathway]
[PUBMED:16670268]
[PUBMED:16227616]
[PUBMED:9655832]
[PUBMED:9233649]
[PUBMED:10508262]
[PUBMED:7511642]
[PUBMED:8634433]
[PUBMED:11238661]
[PUBMED:12589802]
[PUBMED:15793570]
[PUBMED:1377605]
[PUBMED:8912000]
[PUBMED:7687523]
[PUBMED:9041197]
Platelet activation, signaling and aggregation
[NCBI:1269350]
[REACTOME:R-HSA-76002]
[PUBMED:16543958]
[PUBMED:8704248]
[PUBMED:2018971]
[PUBMED:1672265]
[PUBMED:17059469]
[PUBMED:12681240]
[PUBMED:12411949]
[PUBMED:11511514]
Prolactin receptor signaling
[NCBI:1269328]
[REACTOME:R-HSA-1170546]
[PUBMED:9626554]
[PUBMED:11356125]
[PUBMED:11826263]
Prolactin signaling pathway
[NCBI:814182]
[KEGG:hsa04917]
[PUBMED:17519353]
[PUBMED:17535875]
[PUBMED:20149678]
[PUBMED:12670737]
[PUBMED:17307904]
[PUBMED:18601698]
[PUBMED:17975019]
[PUBMED:16231422]
[PUBMED:18219564]
[PUBMED:9475379]
[PUBMED:16677418]
[PUBMED:9626554]
[PUBMED:21664429]
[PUBMED:11606470]
Prolonged ERK activation events
[NCBI:1269469]
[REACTOME:R-HSA-169893]
[PUBMED:12765839]
[PUBMED:9069267]
RAF activation
[NCBI:1269286]
[REACTOME:R-HSA-5673000]
[PUBMED:9689060]
[PUBMED:16364920]
[PUBMED:23993095]
[PUBMED:17555829]
[PUBMED:12865432]
[PUBMED:11782426]
[PUBMED:11296227]
[PUBMED:12068308]
[PUBMED:11447113]
[PUBMED:11950876]
[PUBMED:21779496]
[PUBMED:20141835]
[PUBMED:11296228]
[PUBMED:15710605]
[PUBMED:2993863]
[PUBMED:11821947]
[PUBMED:24937142]
[PUBMED:11579234]
RAF-independent MAPK1/3 activation
[NCBI:1269503]
[REACTOME:R-HSA-112409]
[PUBMED:21135874]
[PUBMED:22569528]
[PUBMED:23954936]
RAF/MAP kinase cascade
[NCBI:1269285]
[REACTOME:R-HSA-5673001]
[PUBMED:21167873]
[PUBMED:24937142]
[PUBMED:20674547]
[PUBMED:17496910]
[PUBMED:22177953]
[PUBMED:17496919]
[PUBMED:22569528]
[PUBMED:22535895]
[PUBMED:12068308]
[PUBMED:17496923]
[PUBMED:19091303]
[PUBMED:21372320]
[PUBMED:21388974]
[PUBMED:15520807]
RET signaling
[NCBI:1427866]
[REACTOME:R-HSA-8853659]
[PUBMED:15013219]
[PUBMED:17036197]
RMTs methylate histone arginines
[NCBI:1270439]
[REACTOME:R-HSA-3214858]
[PUBMED:19150423]
[PUBMED:23235912]
Regulation of IFNG signaling
[NCBI:1269315]
[REACTOME:R-HSA-877312]
[PUBMED:10526574]
[PUBMED:18031232]
[PUBMED:12645661]
S1P3 pathway
[NCBI:138063]
[Pathway Interaction Database:s1p_s1p3_pathway]
[PUBMED:12577307]
[PUBMED:11853542]
[PUBMED:17158356]
[PUBMED:15138255]
[PUBMED:14732717]
[PUBMED:11150298]
[PUBMED:14657000]
[PUBMED:9854026]
[PUBMED:10617617]
[PUBMED:16527273]
SHC1 events in EGFR signaling
[NCBI:1269383]
[REACTOME:R-HSA-180336]
[PUBMED:11498013]
[PUBMED:8755247]
SOS-mediated signalling
[NCBI:1269440]
[REACTOME:R-HSA-112412]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by BRAF and RAF fusions
[NCBI:1457786]
[REACTOME:R-HSA-6802952]
[PUBMED:18974108]
[PUBMED:24135138]
[PUBMED:22745804]
[PUBMED:25907612]
[PUBMED:20526349]
[PUBMED:15630448]
[PUBMED:25204415]
[PUBMED:24345920]
[PUBMED:21424530]
[PUBMED:23583981]
Signaling by EGFR
[NCBI:1269380]
[REACTOME:R-HSA-177929]
[PUBMED:10459005]
[PUBMED:10404636]
[PUBMED:12297041]
[PUBMED:15142631]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signaling by Insulin receptor
[NCBI:1269428]
[REACTOME:R-HSA-74752]
[PUBMED:8276779]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signaling by Leptin
[NCBI:1269632]
[REACTOME:R-HSA-2586552]
[PUBMED:22211890]
[PUBMED:23562747]
[PUBMED:20600241]
[PUBMED:21622208]
[PUBMED:23579596]
[PUBMED:22458591]
[PUBMED:21489811]
[PUBMED:19724019]
[PUBMED:21331644]
[PUBMED:22448029]
[PUBMED:21147620]
[PUBMED:20198122]
[PUBMED:21677426]
[PUBMED:20029269]
[PUBMED:22249808]
[PUBMED:22991412]
[PUBMED:21527729]
[PUBMED:17937601]
[PUBMED:20553370]
[PUBMED:21713385]
[PUBMED:23565489]
[PUBMED:22289780]
Signaling by PDGF
[NCBI:1269478]
[REACTOME:R-HSA-186797]
[PUBMED:15207811]
[PUBMED:10508235]
[PUBMED:9739761]
Signaling by RAS mutants
[NCBI:1457782]
[REACTOME:R-HSA-6802949]
[PUBMED:21993244]
[PUBMED:22589270]
[PUBMED:24651010]
Signaling by SCF-KIT
[NCBI:1269487]
[REACTOME:R-HSA-1433557]
[PUBMED:17350321]
[PUBMED:16483568]
[PUBMED:7688988]
[PUBMED:19540337]
[PUBMED:16475976]
[PUBMED:15526160]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
[NCBI:1269617]
[REACTOME:R-HSA-2404192]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22044904]
[PUBMED:22649417]
Signaling by VEGF
[NCBI:1269480]
[REACTOME:R-HSA-194138]
[PUBMED:15585754]
[PUBMED:13678960]
[PUBMED:16336962]
[PUBMED:16835467]
Signaling by moderate kinase activity BRAF mutants
[NCBI:1457784]
[REACTOME:R-HSA-6802946]
[PUBMED:25907612]
[PUBMED:15035987]
[PUBMED:24202393]
[PUBMED:22510884]
[PUBMED:25355519]
[PUBMED:23352452]
Signaling events mediated by PTP1B
[NCBI:138017]
[Pathway Interaction Database:ptp1bpathway]
[PUBMED:12414790]
[PUBMED:8223493]
[PUBMED:12857726]
[PUBMED:8999839]
[PUBMED:14766979]
[PUBMED:9355745]
[PUBMED:11579209]
[PUBMED:8940134]
[PUBMED:12802338]
[PUBMED:10807907]
[PUBMED:15866871]
[PUBMED:10751417]
[PUBMED:11346638]
[PUBMED:11970899]
[PUBMED:9083103]
[PUBMED:7693694]
[PUBMED:11900546]
[PUBMED:7983051]
[PUBMED:11694501]
[PUBMED:10514492]
[PUBMED:12176037]
[PUBMED:16644720]
[PUBMED:16388599]
[PUBMED:9624118]
[PUBMED:9786960]
[PUBMED:14966267]
[PUBMED:15894168]
[PUBMED:11773439]
[PUBMED:11864611]
[PUBMED:8548812]
[PUBMED:16477024]
[PUBMED:9418872]
[PUBMED:9050838]
[PUBMED:12424235]
[PUBMED:12748279]
[PUBMED:1383688]
[PUBMED:8782827]
[PUBMED:8626723]
[PUBMED:11007774]
[PUBMED:10993888]
[PUBMED:15226396]
[PUBMED:10066179]
[PUBMED:10660596]
[PUBMED:12554649]
[PUBMED:11970898]
[PUBMED:9566916]
Signaling events mediated by Stem cell factor receptor (c-Kit)
[NCBI:138068]
[Pathway Interaction Database:kitpathway]
[PUBMED:12909618]
[PUBMED:10364466]
[PUBMED:10673502]
[PUBMED:15315962]
[PUBMED:12192036]
[PUBMED:12444928]
[PUBMED:15504549]
[PUBMED:8950973]
[PUBMED:11071635]
[PUBMED:12149208]
[PUBMED:11369651]
[PUBMED:9038210]
[PUBMED:10679268]
[PUBMED:15465815]
[PUBMED:10523831]
[PUBMED:8611693]
[PUBMED:15676208]
[PUBMED:11805142]
[PUBMED:10637471]
[PUBMED:9872323]
[PUBMED:11809791]
[PUBMED:11520784]
[PUBMED:12691919]
[PUBMED:10397721]
[PUBMED:15611091]
[PUBMED:12356726]
[PUBMED:9528781]
[PUBMED:1381360]
[PUBMED:9651683]
[PUBMED:10849422]
[PUBMED:9355737]
Signaling pathways regulating pluripotency of stem cells
[NCBI:1026136]
[KEGG:hsa04550]
[PUBMED:20705693]
[PUBMED:23653415]
[PUBMED:16518401]
[PUBMED:17211451]
[PUBMED:22649650]
[PUBMED:24910449]
[PUBMED:19551525]
[PUBMED:22298652]
[PUBMED:23370346]
[PUBMED:24315442]
[PUBMED:18414030]
[PUBMED:17647265]
[PUBMED:18295576]
[PUBMED:24957798]
[PUBMED:24147644]
[PUBMED:16153702]
[PUBMED:19427042]
[PUBMED:18220859]
[PUBMED:19571885]
[PUBMED:23585347]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Signalling to ERKs
[NCBI:1269464]
[REACTOME:R-HSA-187687]
[PUBMED:10508738]
Signalling to RAS
[NCBI:1269465]
[REACTOME:R-HSA-167044]
[PUBMED:11520933]
Signalling to p38 via RIT and RIN
[NCBI:1269468]
[REACTOME:R-HSA-187706]
[PUBMED:10712923]
Th1 and Th2 cell differentiation
[NCBI:1458885]
[KEGG:hsa04658]
[PUBMED:15819694]
[PUBMED:12171942]
[PUBMED:19165228]
[PUBMED:23336087]
[PUBMED:26044597]
[PUBMED:19151746]
[PUBMED:19362457]
[PUBMED:22044277]
[PUBMED:11752608]
[PUBMED:23405903]
[PUBMED:19375293]
[PUBMED:24113868]
[PUBMED:19151747]
[PUBMED:23624818]
[PUBMED:22566933]
[PUBMED:11121747]
[PUBMED:20969597]
[PUBMED:20065998]
Th17 cell differentiation
[NCBI:1469482]
[KEGG:hsa04659]
[PUBMED:23325835]
[PUBMED:23036716]
[PUBMED:20488727]
[PUBMED:21151104]
[PUBMED:21084214]
[PUBMED:20054607]
[PUBMED:22754770]
[PUBMED:22640807]
[PUBMED:19379825]
[PUBMED:22133865]
[PUBMED:22324470]
[PUBMED:17768419]
[PUBMED:18408735]
[PUBMED:21776333]
[PUBMED:26253381]
[PUBMED:16200068]
[PUBMED:18362914]
[PUBMED:24325586]
[PUBMED:19381306]
[PUBMED:18166487]
Toxoplasmosis
[NCBI:169642]
[KEGG:hsa05145]
[PUBMED:18617274]
[PUBMED:19400868]
[PUBMED:17024357]
[PUBMED:19744886]
[PUBMED:19891610]
[PUBMED:17110955]
[PUBMED:12106793]
[PUBMED:12580944]
[PUBMED:12857995]
[PUBMED:10234174]
[PUBMED:18327664]
[PUBMED:10525166]
[PUBMED:18059289]
[PUBMED:18775432]
[PUBMED:14642303]
[PUBMED:15361242]
[PUBMED:16339966]
[PUBMED:14987366]
[PUBMED:15639739]
Tuberculosis
[NCBI:213780]
[KEGG:hsa05152]
[PUBMED:20199890]
[PUBMED:21274449]
[PUBMED:17359235]
[PUBMED:20415982]
[PUBMED:18541216]
[PUBMED:19369951]
[PUBMED:15083155]
[PUBMED:11378475]
[PUBMED:15228522]
[PUBMED:19634703]
[PUBMED:21274433]
[PUBMED:19563525]
[PUBMED:18407066]
[PUBMED:18288961]
[PUBMED:16200082]
[PUBMED:17785780]
[PUBMED:11932234]
VEGFA-VEGFR2 Pathway
[NCBI:1269483]
[REACTOME:R-HSA-4420097]
[PUBMED:17344076]
[PUBMED:16633338]
[PUBMED:19230644]
[PUBMED:13678960]
VEGFR2 mediated cell proliferation
[NCBI:1269485]
[REACTOME:R-HSA-5218921]
[PUBMED:22866201]
[PUBMED:22180219]
[PUBMED:22762016]