full name
ribosomal protein S6

synonyms
S6, RPS6, ENSG00000137154

HGNC
HGNC:10429

Entrez Gene
Gene:6194

ENSEMBL
ENSG00000137154

location
chr: 9
start: 19376253
stop: 19380272
strand: -

transcripts
NM_001010.2

pathways
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S [NCBI:1268683] [REACTOME:R-HSA-72662] [PUBMED:9732867] [PUBMED:592399] [PUBMED:641056] [PUBMED:6853548]
Apelin signaling pathway [NCBI:1492886] [KEGG:hsa04371] [PUBMED:23973488] [PUBMED:16182514] [PUBMED:21725702] [PUBMED:22842084] [PUBMED:27825851] [PUBMED:27650065] [PUBMED:22140623] [PUBMED:23943882] [PUBMED:26944568] [PUBMED:24055369] [PUBMED:26385179] [PUBMED:26143239] [PUBMED:22028387] [PUBMED:26254105] [PUBMED:26756969] [PUBMED:22995518] [PUBMED:27979574] [PUBMED:23924696] [PUBMED:21464822] [PUBMED:25914650] [PUBMED:24990699] [PUBMED:26607438] [PUBMED:25164121] [PUBMED:25275559] [PUBMED:25139773] [PUBMED:25931124] [PUBMED:19093215] [PUBMED:20539939] [PUBMED:25652330] [PUBMED:18272138] [PUBMED:23603510]
Cap-dependent Translation Initiation [NCBI:1268680] [REACTOME:R-HSA-72737]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
EGFR tyrosine kinase inhibitor resistance [NCBI:1404798] [KEGG:hsa01521] [PUBMED:16843264] [PUBMED:23401451] [PUBMED:20966921] [PUBMED:24307395] [PUBMED:22956644] [PUBMED:25232485] [PUBMED:24493829] [PUBMED:23071030] [PUBMED:18483355] [PUBMED:24202392] [PUBMED:19632948] [PUBMED:23361103] [PUBMED:26579470] [PUBMED:22970367] [PUBMED:23358468] [PUBMED:17554333] [PUBMED:25337673] [PUBMED:22474259] [PUBMED:20551942]
ErbB1 downstream signaling [NCBI:138057] [Pathway Interaction Database:erbb1_downstream_pathway] [PUBMED:1330321] [PUBMED:7939666] [PUBMED:9448004] [PUBMED:3497813] [PUBMED:7680434] [PUBMED:18567582] [PUBMED:12503606] [PUBMED:12183455] [PUBMED:8073291] [PUBMED:17563371] [PUBMED:8378775] [PUBMED:19219045] [PUBMED:1990291] [PUBMED:15550174] [PUBMED:16508002] [PUBMED:17881733] [PUBMED:11278353] [PUBMED:9889102] [PUBMED:14699061] [PUBMED:8248196] [PUBMED:8262053] [PUBMED:11319218] [PUBMED:19595761] [PUBMED:17360704] [PUBMED:15048123] [PUBMED:19341767] [PUBMED:9837959] [PUBMED:14993287] [PUBMED:19710016] [PUBMED:18516090] [PUBMED:9733714] [PUBMED:8052307] [PUBMED:10567369] [PUBMED:9335504] [PUBMED:9580112] [PUBMED:11018520] [PUBMED:10499589] [PUBMED:19706684] [PUBMED:8910287] [PUBMED:10469645] [PUBMED:11073940] [PUBMED:9315636] [PUBMED:2189103] [PUBMED:14765121] [PUBMED:14970219] [PUBMED:8332195] [PUBMED:16239230] [PUBMED:8621729] [PUBMED:11889038] [PUBMED:11029289] [PUBMED:11152283] [PUBMED:8071311] [PUBMED:12932319] [PUBMED:19541618] [PUBMED:2123453] [PUBMED:9384584] [PUBMED:8140422] [PUBMED:10644690] [PUBMED:18156174] [PUBMED:15718470] [PUBMED:12172553] [PUBMED:10082559] [PUBMED:17079732] [PUBMED:12446727] [PUBMED:9989263] [PUBMED:12551925] [PUBMED:10856237] [PUBMED:8013650] [PUBMED:7600581] [PUBMED:8688081] [PUBMED:8397445] [PUBMED:16135787] [PUBMED:7637810] [PUBMED:9438848] [PUBMED:12515821] [PUBMED:12881422] [PUBMED:9305638] [PUBMED:15284024] [PUBMED:3136398] [PUBMED:10597268] [PUBMED:10648629] [PUBMED:9790194] [PUBMED:9797479] [PUBMED:16093354] [PUBMED:7741752] [PUBMED:10891480] [PUBMED:17052213] [PUBMED:8221888] [PUBMED:9593664] [PUBMED:16892053] [PUBMED:8413226] [PUBMED:9407138] [PUBMED:9710644] [PUBMED:8248197] [PUBMED:12414794] [PUBMED:1653949] [PUBMED:12181570] [PUBMED:9550702] [PUBMED:12110590] [PUBMED:10400627] [PUBMED:9927426] [PUBMED:12242303] [PUBMED:10480933] [PUBMED:9665134] [PUBMED:11238956] [PUBMED:16984645] [PUBMED:7761091] [PUBMED:17322878] [PUBMED:12640115] [PUBMED:14963038] [PUBMED:17486115] [PUBMED:8503013] [PUBMED:16155590] [PUBMED:16628218] [PUBMED:1406636] [PUBMED:9430728] [PUBMED:19401591] [PUBMED:17053785] [PUBMED:7992057] [PUBMED:14609431] [PUBMED:9346240] [PUBMED:8626780] [PUBMED:8940018] [PUBMED:12454019] [PUBMED:10441128] [PUBMED:14747473] [PUBMED:11777939] [PUBMED:8614832] [PUBMED:8378774] [PUBMED:19121340] [PUBMED:18775988] [PUBMED:15039778] [PUBMED:9770464] [PUBMED:10567531] [PUBMED:8180183] [PUBMED:10675331] [PUBMED:1545823] [PUBMED:7958858] [PUBMED:11948693] [PUBMED:2109185] [PUBMED:8942998] [PUBMED:1637333] [PUBMED:14690430] [PUBMED:11134016] [PUBMED:12429840] [PUBMED:8621573] [PUBMED:7600582] [PUBMED:8226933] [PUBMED:10201527] [PUBMED:12832467] [PUBMED:3492494] [PUBMED:15034142] [PUBMED:9596579] [PUBMED:7889942] [PUBMED:8524316] [PUBMED:7731720] [PUBMED:8386592] [PUBMED:16407412] [PUBMED:6334806] [PUBMED:11703925] [PUBMED:11099046] [PUBMED:7876145] [PUBMED:14498832]
Eukaryotic Translation Elongation [NCBI:1268690] [REACTOME:R-HSA-156842] [PUBMED:15189156]
Eukaryotic Translation Initiation [NCBI:1268679] [REACTOME:R-HSA-72613] [PUBMED:20444697]
Eukaryotic Translation Termination [NCBI:1268692] [REACTOME:R-HSA-72764] [PUBMED:15314182] [PUBMED:2684966]
Formation of a pool of free 40S subunits [NCBI:1268681] [REACTOME:R-HSA-72689]
Formation of the ternary complex, and subsequently, the 43S complex [NCBI:1268682] [REACTOME:R-HSA-72695] [PUBMED:641056] [PUBMED:1104615] [PUBMED:592399] [PUBMED:429297]
GTP hydrolysis and joining of the 60S ribosomal subunit [NCBI:1268686] [REACTOME:R-HSA-72706] [PUBMED:11018020] [PUBMED:1095581] [PUBMED:429297] [PUBMED:641056] [PUBMED:1856230] [PUBMED:592398] [PUBMED:10659855] [PUBMED:592399]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
HIF-1 signaling pathway [NCBI:695200] [KEGG:hsa04066] [PUBMED:11902584] [PUBMED:20965423] [PUBMED:20679415] [PUBMED:15031665] [PUBMED:18259201] [PUBMED:22205687] [PUBMED:19364912] [PUBMED:19147540] [PUBMED:15448722] [PUBMED:16234508] [PUBMED:18505681] [PUBMED:20836033] [PUBMED:19861159] [PUBMED:17955264] [PUBMED:22562152]
IGF1R signaling cascade [NCBI:1269618] [REACTOME:R-HSA-2428924] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959]
IL2 signaling events mediated by PI3K [NCBI:137938] [Pathway Interaction Database:il2_pi3kpathway] [PUBMED:15271800] [PUBMED:8617294] [PUBMED:7543780] [PUBMED:9092570] [PUBMED:9162082] [PUBMED:7737351] [PUBMED:9108028] [PUBMED:11486019] [PUBMED:1614535] [PUBMED:15843522] [PUBMED:7760801] [PUBMED:9029085] [PUBMED:1652056] [PUBMED:11994454] [PUBMED:12393431] [PUBMED:9771966] [PUBMED:10373522] [PUBMED:12525482] [PUBMED:3523754] [PUBMED:7736574] [PUBMED:10982827] [PUBMED:7589144] [PUBMED:7528328]
IRS-mediated signalling [NCBI:1269431] [REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R [NCBI:1269620] [REACTOME:R-HSA-2428928] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:18927274] [PUBMED:21042815] [PUBMED:20098959]
Infectious disease [NCBI:1269056] [REACTOME:R-HSA-5663205]
Influenza Infection [NCBI:1269108] [REACTOME:R-HSA-168254]
Influenza Life Cycle [NCBI:1269109] [REACTOME:R-HSA-168255]
Influenza Viral RNA Transcription and Replication [NCBI:1269115] [REACTOME:R-HSA-168273] [PUBMED:2214032] [PUBMED:6863242] [PUBMED:6616622] [PUBMED:6269803]
Insulin receptor signalling cascade [NCBI:1269429] [REACTOME:R-HSA-74751] [PUBMED:9677303] [PUBMED:11282018]
Insulin signaling pathway [NCBI:83090] [KEGG:hsa04910] [PUBMED:11742412] [PUBMED:11343120] [PUBMED:15733744] [PUBMED:11282018] [PUBMED:10196204] [PUBMED:18291668] [PUBMED:9609110] [PUBMED:10567225] [PUBMED:12791379] [PUBMED:9748166] [PUBMED:15624019] [PUBMED:9445476] [PUBMED:9346240] [PUBMED:14635525] [PUBMED:16288289] [PUBMED:12867054] [PUBMED:15229476] [PUBMED:17344645] [PUBMED:9609111]
L13a-mediated translational silencing of Ceruloplasmin expression [NCBI:1268688] [REACTOME:R-HSA-156827] [PUBMED:14567916]
Major pathway of rRNA processing in the nucleolus and cytosol [NCBI:1383086] [REACTOME:R-HSA-6791226] [PUBMED:25346433] [PUBMED:11862453] [PUBMED:23973377] [PUBMED:21318072] [PUBMED:23412654] [PUBMED:12150911] [PUBMED:25877921] [PUBMED:21956940] [PUBMED:22342225] [PUBMED:12068309]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of amino acids and derivatives [NCBI:1270158] [REACTOME:R-HSA-71291]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) [NCBI:1269717] [REACTOME:R-HSA-975957] [PUBMED:19859661] [PUBMED:21496649] [PUBMED:17352659] [PUBMED:20795950] [PUBMED:19359157] [PUBMED:17531985] [PUBMED:17671086] [PUBMED:19410547]
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) [NCBI:1269718] [REACTOME:R-HSA-975956] [PUBMED:20795950] [PUBMED:18447580] [PUBMED:17671086] [PUBMED:17531985] [PUBMED:19359157] [PUBMED:19859661] [PUBMED:17352659] [PUBMED:18447585] [PUBMED:18256688]
Nonsense-Mediated Decay (NMD) [NCBI:1269716] [REACTOME:R-HSA-927802] [PUBMED:18524595] [PUBMED:17671086] [PUBMED:19359157] [PUBMED:17531985] [PUBMED:17352659] [PUBMED:21496649] [PUBMED:19859661] [PUBMED:20795950] [PUBMED:19010255]
PI3K Cascade [NCBI:1269432] [REACTOME:R-HSA-109704]
PI3K-Akt signaling pathway [NCBI:692234] [KEGG:hsa04151] [PUBMED:12048182] [PUBMED:11357143] [PUBMED:21440011] [PUBMED:15209374] [PUBMED:12669022] [PUBMED:18842113] [PUBMED:16847462] [PUBMED:12660731] [PUBMED:17360849] [PUBMED:9838078] [PUBMED:15505410] [PUBMED:16248975] [PUBMED:12531180] [PUBMED:21779440] [PUBMED:16187290] [PUBMED:15784165] [PUBMED:21620960]
PKB-mediated events [NCBI:1269434] [REACTOME:R-HSA-109703]
Peptide chain elongation [NCBI:1268691] [REACTOME:R-HSA-156902] [PUBMED:12297040]
Proteoglycans in cancer [NCBI:782000] [KEGG:hsa05205] [PUBMED:19433454] [PUBMED:20655987] [PUBMED:18798267] [PUBMED:10633082] [PUBMED:10687947] [PUBMED:22735579] [PUBMED:24412155] [PUBMED:9346940] [PUBMED:22087031] [PUBMED:22194599] [PUBMED:14711376] [PUBMED:19255147] [PUBMED:15655247] [PUBMED:11717317] [PUBMED:17971838] [PUBMED:18413366] [PUBMED:20974860] [PUBMED:11830493] [PUBMED:23058688] [PUBMED:18450475] [PUBMED:12748184] [PUBMED:19733083] [PUBMED:18812315] [PUBMED:12509413] [PUBMED:21155971] [PUBMED:11931647] [PUBMED:18949819] [PUBMED:12729888] [PUBMED:15994311] [PUBMED:23305321] [PUBMED:18505598] [PUBMED:22563565] [PUBMED:22033227]
Ribosomal scanning and start codon recognition [NCBI:1268685] [REACTOME:R-HSA-72702] [PUBMED:9732867] [PUBMED:7000367] [PUBMED:592399] [PUBMED:641056]
Ribosome [NCBI:83036] [KEGG:hsa03010] [PUBMED:10476960] [PUBMED:11014182] [PUBMED:10937989] [PUBMED:10937990] [PUBMED:11014183] [PUBMED:10476961] [PUBMED:10497122]
SRP-dependent cotranslational protein targeting to membrane [NCBI:1268689] [REACTOME:R-HSA-1799339]
Selenoamino acid metabolism [NCBI:1339149] [REACTOME:R-HSA-2408522] [PUBMED:20812787]
Selenocysteine synthesis [NCBI:1339156] [REACTOME:R-HSA-2408557] [PUBMED:19747061] [PUBMED:20623998] [PUBMED:18252769]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Insulin receptor [NCBI:1269428] [REACTOME:R-HSA-74752] [PUBMED:8276779]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) [NCBI:1269617] [REACTOME:R-HSA-2404192] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22044904] [PUBMED:22649417]
Translation [NCBI:1268678] [REACTOME:R-HSA-72766]
Translation initiation complex formation [NCBI:1268684] [REACTOME:R-HSA-72649] [PUBMED:6853548] [PUBMED:641056] [PUBMED:9732867] [PUBMED:592399]
Viral mRNA Translation [NCBI:1269120] [REACTOME:R-HSA-192823] [PUBMED:16630668]
mTOR signaling pathway [NCBI:83059] [KEGG:hsa04150] [NCBI:138001] [Pathway Interaction Database:mtor_4pathway] [PUBMED:17277771] [PUBMED:15341740] [PUBMED:12172553] [PUBMED:15718470] [PUBMED:14651849] [PUBMED:15268862] [PUBMED:15306821] [PUBMED:26046644] [PUBMED:12869586] [PUBMED:24556838] [PUBMED:17928295] [PUBMED:9427642] [PUBMED:18046414] [PUBMED:12912918] [PUBMED:16286006] [PUBMED:26658722] [PUBMED:24842496] [PUBMED:23465396] [PUBMED:17709744] [PUBMED:17599906] [PUBMED:16919458] [PUBMED:10364159] [PUBMED:15342917] [PUBMED:11500364] [PUBMED:19812304] [PUBMED:12482958] [PUBMED:11729323] [PUBMED:16962653] [PUBMED:18952604] [PUBMED:9465032] [PUBMED:1496022] [PUBMED:10567431] [PUBMED:19114562] [PUBMED:17510057] [PUBMED:18604198] [PUBMED:15545625] [PUBMED:11914378] [PUBMED:17461779] [PUBMED:9445476] [PUBMED:18497260] [PUBMED:12604610] [PUBMED:15071500] [PUBMED:18925875] [PUBMED:12906785] [PUBMED:11287630] [PUBMED:15004009] [PUBMED:16756488] [PUBMED:17043309] [PUBMED:18198340] [PUBMED:12820960] [PUBMED:12747827] [PUBMED:17053147] [PUBMED:15851026] [PUBMED:15467718] [PUBMED:18762023] [PUBMED:25242279] [PUBMED:24698685] [PUBMED:11175345] [PUBMED:27304501] [PUBMED:18411301] [PUBMED:11500365] [PUBMED:17693255] [PUBMED:23694989] [PUBMED:12231510] [PUBMED:19446321] [PUBMED:11418588] [PUBMED:19258318] [PUBMED:18439900] [PUBMED:19225151] [PUBMED:26185979] [PUBMED:10357815] [PUBMED:26269525] [PUBMED:23421405] [PUBMED:9271440] [PUBMED:16915281] [PUBMED:17141160] [PUBMED:15249583] [PUBMED:12912989] [PUBMED:27027448] [PUBMED:18423201] [PUBMED:19211835] [PUBMED:9204908] [PUBMED:26700098] [PUBMED:18566587] [PUBMED:17386266]
mTOR signalling [NCBI:1269436] [REACTOME:R-HSA-165159] [PUBMED:21157483]
mTORC1-mediated signalling [NCBI:1269438] [REACTOME:R-HSA-166208] [PUBMED:23641065] [PUBMED:22500797]
rRNA modification in the nucleus and cytosol [NCBI:1383087] [REACTOME:R-HSA-6790901] [PUBMED:25590339] [PUBMED:15193314] [PUBMED:20347423] [PUBMED:25775268] [PUBMED:21956940] [PUBMED:24490730] [PUBMED:19917616] [PUBMED:25176256] [PUBMED:3418702] [PUBMED:26410597] [PUBMED:22122054] [PUBMED:23391857] [PUBMED:8674114] [PUBMED:12114023] [PUBMED:17894445] [PUBMED:24121435] [PUBMED:412496] [PUBMED:9211966] [PUBMED:22065625] [PUBMED:24369424]
rRNA processing [NCBI:1383085] [REACTOME:R-HSA-72312] [PUBMED:20174677] [PUBMED:21956940] [PUBMED:25346433] [PUBMED:25590339] [PUBMED:15193314] [PUBMED:11862453] [PUBMED:19917616] [PUBMED:24490730]
rRNA processing in the nucleus and cytosol [NCBI:1427846] [REACTOME:R-HSA-8868773] [PUBMED:24490730] [PUBMED:21956940] [PUBMED:25346433]