full name
cyclin dependent kinase inhibitor 2A
synonyms
ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, CDKN2A, ENSG00000147889
HGNC
HGNC:1787
Entrez Gene
Gene:1029
ENSEMBL
ENSG00000147889
location
chr: 9
start: 21967751
stop: 21994490
strand: -
OMIM
OMIM:600160:
CDKN2A
(Autosomal dominant inheritance)
OMIM:155755:
{Melanoma and neural system tumor syndrome}
OMIM:155601:
{Melanoma, cutaneous malignant, 2}
OMIM:606719:
{Melanoma-pancreatic cancer syndrome}
transcripts
NM_058195.3
NM_000077.4
NM_001195132.1
NM_058197.4
pathways
Bladder cancer
[NCBI:83115]
[KEGG:hsa05219]
[PUBMED:15551095]
[PUBMED:15746962]
[PUBMED:11103787]
[PUBMED:16474624]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:17149381]
[PUBMED:16110317]
Cell Cycle
[NCBI:1269741]
[REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic
[NCBI:1269763]
[REACTOME:R-HSA-69278]
Cell cycle
[NCBI:83054]
[KEGG:hsa04110]
[PUBMED:7973727]
[PUBMED:17568790]
[PUBMED:9832503]
[PUBMED:16936746]
[PUBMED:9029154]
[PUBMED:12573239]
[PUBMED:19020303]
[PUBMED:9618481]
[PUBMED:12809600]
[PUBMED:8242749]
[PUBMED:10385618]
[PUBMED:17426725]
[PUBMED:17018296]
[PUBMED:16212951]
[PUBMED:12925736]
[PUBMED:11099028]
[PUBMED:15568976]
[PUBMED:15838516]
[PUBMED:15838523]
[PUBMED:15876871]
[PUBMED:7908906]
[PUBMED:9889196]
Cellular Senescence
[NCBI:1270426]
[REACTOME:R-HSA-2559583]
[PUBMED:21078816]
[PUBMED:18711403]
[PUBMED:22048312]
[PUBMED:19818705]
[PUBMED:17662938]
[PUBMED:23746838]
[PUBMED:9282108]
[PUBMED:17667954]
[PUBMED:13905658]
Cellular responses to stress
[NCBI:1270414]
[REACTOME:R-HSA-2262752]
[PUBMED:15709958]
Chronic myeloid leukemia
[NCBI:83116]
[KEGG:hsa05220]
[PUBMED:22286129]
[PUBMED:12801837]
[PUBMED:11160144]
[PUBMED:15719031]
[PUBMED:10403855]
[PUBMED:9834202]
[PUBMED:11071626]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16484590]
[PUBMED:14982876]
Cyclin D associated events in G1
[NCBI:1269767]
[REACTOME:R-HSA-69231]
Endocrine resistance
[NCBI:1404799]
[KEGG:hsa01522]
[PUBMED:24415977]
[PUBMED:23625614]
[PUBMED:24841429]
[PUBMED:15613444]
[PUBMED:23714450]
[PUBMED:20960099]
[PUBMED:22771991]
[PUBMED:19701242]
[PUBMED:24289103]
[PUBMED:24130921]
[PUBMED:23344024]
[PUBMED:22015292]
[PUBMED:26122181]
[PUBMED:26473850]
[PUBMED:18804516]
[PUBMED:24565562]
[PUBMED:26849149]
[PUBMED:25907219]
[PUBMED:20887199]
G1 Phase
[NCBI:1269766]
[REACTOME:R-HSA-69236]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
Glioma
[NCBI:83110]
[KEGG:hsa05214]
[PUBMED:11057895]
[PUBMED:11253051]
[PUBMED:12154354]
[PUBMED:12084351]
[PUBMED:15639402]
[PUBMED:9643506]
[PUBMED:16095998]
[PUBMED:12762887]
[PUBMED:16700615]
HTLV-I infection
[NCBI:373901]
[KEGG:hsa05166]
[PUBMED:17446673]
[PUBMED:16436385]
[PUBMED:14686485]
[PUBMED:19861996]
[PUBMED:19092975]
[PUBMED:11325603]
[PUBMED:16155602]
[PUBMED:12910251]
[PUBMED:16155605]
[PUBMED:16036567]
[PUBMED:11244044]
[PUBMED:18702816]
[PUBMED:15569630]
[PUBMED:21114861]
[PUBMED:16155611]
[PUBMED:17384582]
[PUBMED:16155608]
[PUBMED:10602469]
[PUBMED:19014483]
[PUBMED:9325311]
Melanoma
[NCBI:83114]
[KEGG:hsa05218]
[PUBMED:16822996]
[PUBMED:14695152]
[PUBMED:11224709]
[PUBMED:10843728]
[PUBMED:12894244]
[PUBMED:16899407]
[PUBMED:16001072]
[PUBMED:15721476]
[PUBMED:15557758]
[PUBMED:15009714]
[PUBMED:16001050]
[PUBMED:15841168]
[PUBMED:16750612]
Metabolism of proteins
[NCBI:1268677]
[REACTOME:R-HSA-392499]
MicroRNAs in cancer
[NCBI:852705]
[KEGG:hsa05206]
[PUBMED:23075324]
[PUBMED:21742789]
[PUBMED:22351564]
[PUBMED:18817506]
[PUBMED:22345301]
[PUBMED:21402473]
[PUBMED:22926415]
[PUBMED:23165235]
[PUBMED:19630570]
[PUBMED:21565290]
[PUBMED:23091478]
[PUBMED:23462054]
[PUBMED:23316212]
[PUBMED:19773200]
[PUBMED:22035854]
[PUBMED:20221895]
[PUBMED:20345848]
[PUBMED:22580099]
[PUBMED:20128019]
Mitotic G1-G1/S phases
[NCBI:1269764]
[REACTOME:R-HSA-453279]
Non-small cell lung cancer
[NCBI:83119]
[KEGG:hsa05223]
[PUBMED:11895903]
[PUBMED:21753699]
[PUBMED:23733083]
[PUBMED:11902573]
[PUBMED:19629074]
[PUBMED:12867060]
[PUBMED:22154278]
[PUBMED:10944551]
[PUBMED:16112428]
[PUBMED:15942304]
[PUBMED:12407699]
[PUBMED:15948711]
[PUBMED:18593892]
[PUBMED:23201355]
[PUBMED:21855164]
[PUBMED:12379883]
[PUBMED:17625570]
[PUBMED:12741677]
[PUBMED:22736493]
[PUBMED:21850578]
[PUBMED:16870043]
[PUBMED:16189154]
Oncogene Induced Senescence
[NCBI:1270427]
[REACTOME:R-HSA-2559585]
[PUBMED:10722742]
[PUBMED:20583212]
[PUBMED:8521522]
[PUBMED:20534573]
[PUBMED:11234019]
[PUBMED:14729966]
[PUBMED:12839923]
[PUBMED:8319905]
[PUBMED:18365017]
[PUBMED:15572696]
[PUBMED:9529249]
[PUBMED:10733595]
[PUBMED:9824166]
[PUBMED:11782450]
[PUBMED:8259215]
[PUBMED:7588608]
[PUBMED:8552081]
[PUBMED:9704925]
[PUBMED:22336108]
[PUBMED:11883935]
Oxidative Stress Induced Senescence
[NCBI:1270428]
[REACTOME:R-HSA-2559580]
[PUBMED:17344414]
[PUBMED:17332741]
[PUBMED:8622688]
[PUBMED:7588633]
[PUBMED:15563468]
[PUBMED:15287722]
[PUBMED:11062067]
[PUBMED:16337592]
[PUBMED:14532106]
[PUBMED:17254968]
[PUBMED:15866172]
[PUBMED:9628874]
[PUBMED:12171911]
[PUBMED:7816143]
[PUBMED:22020331]
[PUBMED:11564866]
[PUBMED:9162092]
[PUBMED:8974401]
[PUBMED:19451217]
[PUBMED:12808055]
[PUBMED:17210787]
[PUBMED:8846784]
[PUBMED:19462008]
[PUBMED:12134156]
[PUBMED:8626550]
[PUBMED:8774846]
[PUBMED:12189133]
[PUBMED:9195981]
[PUBMED:8622669]
[PUBMED:8259215]
[PUBMED:19528227]
[PUBMED:9564042]
[PUBMED:9529249]
[PUBMED:16436515]
[PUBMED:19451218]
[PUBMED:17395714]
[PUBMED:9030721]
[PUBMED:12435631]
[PUBMED:22325352]
Pancreatic cancer
[NCBI:83108]
[KEGG:hsa05212]
[PUBMED:12079267]
[PUBMED:14967450]
[PUBMED:15774796]
[PUBMED:10740269]
[PUBMED:12946833]
[PUBMED:16702400]
[PUBMED:14586404]
[PUBMED:15823750]
[PUBMED:12648469]
[PUBMED:11407945]
[PUBMED:12459728]
[PUBMED:14580692]
[PUBMED:11707511]
[PUBMED:12545153]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Platinum drug resistance
[NCBI:1404797]
[KEGG:hsa01524]
[PUBMED:24074238]
[PUBMED:26867799]
[PUBMED:14609433]
[PUBMED:26184483]
[PUBMED:24874729]
[PUBMED:15607932]
[PUBMED:25546083]
[PUBMED:25058905]
[PUBMED:19190080]
[PUBMED:14576837]
[PUBMED:20811617]
[PUBMED:21892204]
[PUBMED:20647037]
[PUBMED:17336087]
[PUBMED:26886018]
[PUBMED:23442359]
[PUBMED:17625587]
Post-translational protein modification
[NCBI:1268701]
[REACTOME:R-HSA-597592]
Regulation of TP53 Activity
[NCBI:1383076]
[REACTOME:R-HSA-5633007]
[PUBMED:19450511]
[PUBMED:20457558]
[PUBMED:23825024]
[PUBMED:25641576]
Regulation of TP53 Degradation
[NCBI:1383079]
[REACTOME:R-HSA-6804757]
[PUBMED:21730132]
[PUBMED:10570149]
[PUBMED:15563468]
[PUBMED:16845383]
[PUBMED:11923872]
[PUBMED:11883935]
[PUBMED:17290220]
[PUBMED:17121812]
[PUBMED:10673500]
[PUBMED:9843217]
[PUBMED:9529249]
[PUBMED:21730163]
[PUBMED:11715018]
[PUBMED:9733514]
[PUBMED:19838211]
[PUBMED:10608892]
[PUBMED:16474402]
[PUBMED:19450511]
[PUBMED:16163388]
[PUBMED:10722742]
[PUBMED:21986495]
[PUBMED:15788536]
[PUBMED:19816404]
[PUBMED:11359766]
[PUBMED:11504915]
[PUBMED:9733515]
[PUBMED:19756449]
[PUBMED:11983168]
[PUBMED:8319905]
[PUBMED:20438709]
Regulation of TP53 Expression and Degradation
[NCBI:1383077]
[REACTOME:R-HSA-6806003]
[PUBMED:11883935]
[PUBMED:11923872]
[PUBMED:19293287]
[PUBMED:23303139]
[PUBMED:17499002]
[PUBMED:15563468]
[PUBMED:17121812]
[PUBMED:21986495]
[PUBMED:15103385]
[PUBMED:9529249]
[PUBMED:21814038]
[PUBMED:19250907]
[PUBMED:8319905]
[PUBMED:7878469]
[PUBMED:12654245]
[PUBMED:16213212]
SUMO E3 ligases SUMOylate target proteins
[NCBI:1268743]
[REACTOME:R-HSA-3108232]
[PUBMED:20674646]
[PUBMED:17763827]
[PUBMED:19471022]
[PUBMED:23746258]
[PUBMED:24016193]
[PUBMED:23503365]
[PUBMED:21252943]
[PUBMED:17000644]
[PUBMED:24273646]
[PUBMED:22811915]
[PUBMED:21693764]
[PUBMED:23277067]
[PUBMED:21102611]
SUMOylation
[NCBI:1268738]
[REACTOME:R-HSA-2990846]
[PUBMED:21102611]
[PUBMED:20674646]
[PUBMED:23514139]
[PUBMED:19923268]
[PUBMED:20462400]
[PUBMED:17768054]
SUMOylation of DNA damage response and repair proteins
[NCBI:1268744]
[REACTOME:R-HSA-3108214]
[PUBMED:22018829]
[PUBMED:24926426]
[PUBMED:23122649]
[PUBMED:23781231]
[PUBMED:23416108]
[PUBMED:21486569]
[PUBMED:23746258]
[PUBMED:21896653]
[PUBMED:22357966]
[PUBMED:21664912]
SUMOylation of transcription factors
[NCBI:1339110]
[REACTOME:R-HSA-3232118]
[PUBMED:16095902]
[PUBMED:21892772]
[PUBMED:19107415]
[PUBMED:19616654]
[PUBMED:15209380]
[PUBMED:18031228]
Senescence-Associated Secretory Phenotype (SASP)
[NCBI:1270431]
[REACTOME:R-HSA-2559582]
[PUBMED:18411265]
[PUBMED:21979375]
[PUBMED:18267069]
[PUBMED:19597488]
[PUBMED:19218920]
[PUBMED:20818427]
[PUBMED:11114305]
[PUBMED:8617720]
[PUBMED:22178396]
[PUBMED:19805069]
[PUBMED:23770676]
[PUBMED:8384717]
[PUBMED:18555777]
[PUBMED:21686281]
[PUBMED:20351173]
[PUBMED:8688489]
[PUBMED:19053174]
[PUBMED:8234276]
[PUBMED:18555778]
Transcriptional Regulation by TP53
[NCBI:1269654]
[REACTOME:R-HSA-3700989]
[PUBMED:26122615]
[PUBMED:19410540]
Viral carcinogenesis
[NCBI:658418]
[KEGG:hsa05203]
[PUBMED:9990017]
[PUBMED:15173177]
[PUBMED:16036567]
[PUBMED:16581947]
[PUBMED:9060639]
[PUBMED:17457345]
[PUBMED:15956361]
[PUBMED:21421561]
[PUBMED:18391203]
[PUBMED:21040832]
[PUBMED:9837909]
[PUBMED:17645777]
[PUBMED:15967719]
[PUBMED:12686421]
[PUBMED:17049016]
[PUBMED:21152115]
[PUBMED:11160754]
[PUBMED:21966251]
[PUBMED:17979705]
[PUBMED:8617242]
[PUBMED:12925958]
[PUBMED:10873631]
[PUBMED:21250384]
[PUBMED:15614436]
[PUBMED:10354594]
[PUBMED:20494113]
[PUBMED:18702816]
[PUBMED:9651361]
[PUBMED:16459163]
[PUBMED:11278402]
[PUBMED:15510157]
[PUBMED:19956178]
[PUBMED:18251977]
[PUBMED:11766888]
[PUBMED:10824878]
[PUBMED:21372216]
[PUBMED:11244044]
[PUBMED:17894800]
[PUBMED:11905817]
[PUBMED:21347341]
[PUBMED:12186904]
[PUBMED:9374493]
[PUBMED:16352731]
[PUBMED:12770701]
[PUBMED:17384582]
[PUBMED:14506283]
[PUBMED:11091847]
[PUBMED:17267064]
[PUBMED:11886269]
[PUBMED:21177815]
[PUBMED:10400746]
[PUBMED:19156753]
[PUBMED:9882379]
[PUBMED:14559998]
[PUBMED:15767449]
[PUBMED:22110506]
[PUBMED:20534855]
[PUBMED:15542638]
[PUBMED:9343405]
[PUBMED:10405893]
[PUBMED:19400863]
[PUBMED:9349482]
[PUBMED:14747563]
[PUBMED:21647825]
[PUBMED:12970441]
[PUBMED:11669605]
[PUBMED:15795286]
[PUBMED:21994562]
[PUBMED:14530271]
[PUBMED:9594662]
[PUBMED:22566809]
[PUBMED:19651473]
[PUBMED:8756622]
[PUBMED:15105524]
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p53 signaling pathway
[NCBI:83055]
[KEGG:hsa04115]
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