full name
protein tyrosine phosphatase, non-receptor type 22

synonyms
LYP, LYP1, LYP2, PEP, PTPN8, PTPN22, ENSG00000134242

HGNC
HGNC:9652

Entrez Gene
Gene:26191

ENSEMBL
ENSG00000134242

location
chr: 1
start: 114356433
stop: 114414375
strand: -

OMIM
OMIM:600716: PTPN22
OMIM:222100: {Diabetes, type 1, susceptibility to}
OMIM:180300: {Rheumatoid arthritis, susceptibility to}
OMIM:152700: {Systemic lupus erythematosus susceptibility to}

transcripts
ENST00000528414.1
ENST00000359785.5

pathways
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Phosphorylation of CD3 and TCR zeta chains [NCBI:1269173] [REACTOME:R-HSA-202427] [PUBMED:10375551]
TCR signaling [NCBI:1269172] [REACTOME:R-HSA-202403] [PUBMED:10375551] [PUBMED:12876557] [PUBMED:9989491]
Translocation of ZAP-70 to Immunological synapse [NCBI:1269174] [REACTOME:R-HSA-202430] [PUBMED:10375551]