full name
exosome component 3
synonyms
bA3J10.7, CGI-102, hRrp-40, p10, PCH1B, RP11-3J10.8, RRP40, Rrp40p, EXOSC3, ENSG00000107371
HGNC
HGNC:17944
Entrez Gene
Gene:51010
ENSEMBL
ENSG00000107371
location
chr: 9
start: 37779711
stop: 37785089
strand: -
OMIM
OMIM:606489:
EXOSC3
(Autosomal recessive inheritance)
OMIM:614678:
Pontocerebellar hypoplasia, type 1B
transcripts
NM_001002269.2
NM_016042.3
pathways
ATF4 activates genes
[NCBI:1268762]
[REACTOME:R-HSA-380994]
[PUBMED:18840095]
[PUBMED:16931790]
[PUBMED:14742429]
[PUBMED:16687408]
[PUBMED:20022965]
[PUBMED:18426796]
[PUBMED:14630918]
[PUBMED:16912112]
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
[NCBI:1269727]
[REACTOME:R-HSA-450385]
[PUBMED:12440953]
[PUBMED:12704645]
[PUBMED:11719186]
[PUBMED:15687258]
[PUBMED:16391004]
Deadenylation-dependent mRNA decay
[NCBI:1269712]
[REACTOME:R-HSA-429914]
[PUBMED:19239894]
[PUBMED:14749774]
[PUBMED:17245413]
[PUBMED:15475613]
[PUBMED:16141059]
[PUBMED:11283721]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
KSRP (KHSRP) binds and destabilizes mRNA
[NCBI:1269729]
[REACTOME:R-HSA-450604]
[PUBMED:16391004]
[PUBMED:12704645]
[PUBMED:12440953]
Major pathway of rRNA processing in the nucleolus and cytosol
[NCBI:1383086]
[REACTOME:R-HSA-6791226]
[PUBMED:25346433]
[PUBMED:11862453]
[PUBMED:23973377]
[PUBMED:21318072]
[PUBMED:23412654]
[PUBMED:12150911]
[PUBMED:25877921]
[PUBMED:21956940]
[PUBMED:22342225]
[PUBMED:12068309]
Metabolism of proteins
[NCBI:1268677]
[REACTOME:R-HSA-392499]
PERK regulates gene expression
[NCBI:1268761]
[REACTOME:R-HSA-381042]
[PUBMED:18048764]
[PUBMED:17956313]
[PUBMED:18038217]
[PUBMED:18436705]
RNA degradation
[NCBI:117291]
[KEGG:hsa03018]
[PUBMED:16939780]
[PUBMED:17560162]
[PUBMED:17471261]
[PUBMED:16968219]
[PUBMED:16766188]
[PUBMED:17447862]
[PUBMED:19239894]
Regulation of mRNA stability by proteins that bind AU-rich elements
[NCBI:1269725]
[REACTOME:R-HSA-450531]
[PUBMED:12440953]
[PUBMED:12704645]
[PUBMED:15460540]
[PUBMED:16391004]
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
[NCBI:1269728]
[REACTOME:R-HSA-450513]
[PUBMED:18481987]
[PUBMED:16391004]
[PUBMED:12440953]
[PUBMED:12704645]
Unfolded Protein Response (UPR)
[NCBI:1268756]
[REACTOME:R-HSA-381119]
[PUBMED:18436705]
[PUBMED:18038217]
[PUBMED:27067637]
[PUBMED:16365312]
[PUBMED:18048764]
[PUBMED:15952902]
mRNA decay by 3' to 5' exoribonuclease
[NCBI:1269714]
[REACTOME:R-HSA-429958]
[PUBMED:14749774]
[PUBMED:19239894]
[PUBMED:15475613]
[PUBMED:16141059]
[PUBMED:17245413]
[PUBMED:11283721]
rRNA processing
[NCBI:1383085]
[REACTOME:R-HSA-72312]
[PUBMED:20174677]
[PUBMED:21956940]
[PUBMED:25346433]
[PUBMED:25590339]
[PUBMED:15193314]
[PUBMED:11862453]
[PUBMED:19917616]
[PUBMED:24490730]
rRNA processing in the nucleus and cytosol
[NCBI:1427846]
[REACTOME:R-HSA-8868773]
[PUBMED:24490730]
[PUBMED:21956940]
[PUBMED:25346433]