full name
nerve growth factor

synonyms
Beta-NGF, HSAN5, NGFB, NGF, ENSG00000134259

HGNC
HGNC:7808

Entrez Gene
Gene:4803

ENSEMBL
ENSG00000134259

location
chr: 1
start: 115828537
stop: 115880857
strand: -

OMIM
OMIM:162030: NGF (Autosomal recessive inheritance)
OMIM:608654: Neuropathy, hereditary sensory and autonomic, type V

transcripts
NM_002506.2

pathways
ARMS-mediated activation [NCBI:1269471] [REACTOME:R-HSA-170984] [PUBMED:9069267]
Activation of TRKA receptors [NCBI:1269461] [REACTOME:R-HSA-187015] [PUBMED:16939974]
Apoptosis [NCBI:83060] [KEGG:hsa04210] [NCBI:1270262] [REACTOME:R-HSA-109581] [PUBMED:12189384] [PUBMED:20533903] [PUBMED:18208375] [PUBMED:22429822] [PUBMED:15218528] [PUBMED:24769728] [PUBMED:18023214] [PUBMED:25526085] [PUBMED:23070002] [PUBMED:15654015] [PUBMED:15601572] [PUBMED:14561771] [PUBMED:24278747] [PUBMED:21914490] [PUBMED:22465226] [PUBMED:21145844] [PUBMED:12838338] [PUBMED:18238895] [PUBMED:12949498] [PUBMED:18304445] [PUBMED:14737178] [PUBMED:26231733] [PUBMED:9916983] [PUBMED:14634621] [PUBMED:19770840] [PUBMED:22075987] [PUBMED:4561027] [PUBMED:20075940] [PUBMED:9894605] [PUBMED:26615431] [PUBMED:12505355] [PUBMED:11520933] [PUBMED:19148180] [PUBMED:16397578] [PUBMED:15719025] [PUBMED:15322527] [PUBMED:15725726] [PUBMED:12209154] [PUBMED:23803157]
Axonal growth stimulation [NCBI:1269457] [REACTOME:R-HSA-209563] [PUBMED:16215275]
Cell death signalling via NRAGE, NRIF and NADE [NCBI:1269447] [REACTOME:R-HSA-204998] [PUBMED:12787561]
Ceramide signalling [NCBI:1269455] [REACTOME:R-HSA-193681] [PUBMED:12676795]
Frs2-mediated activation [NCBI:1269470] [REACTOME:R-HSA-170968] [PUBMED:9069267]
Inflammatory mediator regulation of TRP channels [NCBI:948277] [KEGG:hsa04750] [PUBMED:21841075] [PUBMED:15820689] [PUBMED:16776582] [PUBMED:12838328] [PUBMED:17548207] [PUBMED:16319926] [PUBMED:18427980] [PUBMED:20932256] [PUBMED:18615141] [PUBMED:17124270] [PUBMED:17684094] [PUBMED:22470230] [PUBMED:19074743] [PUBMED:23000387] [PUBMED:24099085] [PUBMED:17321113]
MAPK signaling pathway [NCBI:83048] [KEGG:hsa04010] [PUBMED:11749383] [PUBMED:12566928] [PUBMED:12849693] [PUBMED:12676795] [PUBMED:12947395] [PUBMED:14597384] [PUBMED:11369511] [PUBMED:12191611] [PUBMED:12390245]
NADE modulates death signalling [NCBI:1269450] [REACTOME:R-HSA-205025] [PUBMED:11278287]
NF-kB is activated and signals survival [NCBI:1269454] [REACTOME:R-HSA-209560] [PUBMED:16187223]
NFG and proNGF binds to p75NTR [NCBI:1269446] [REACTOME:R-HSA-205017]
NGF processing [NCBI:1269444] [REACTOME:R-HSA-167060] [PUBMED:12787574]
NGF signalling via TRKA from the plasma membrane [NCBI:1269460] [REACTOME:R-HSA-187037] [PUBMED:11520933] [PUBMED:12676795] [PUBMED:10851172] [PUBMED:10579918]
NRAGE signals death through JNK [NCBI:1269448] [REACTOME:R-HSA-193648] [PUBMED:12376548]
NRIF signals cell death from the nucleus [NCBI:1269449] [REACTOME:R-HSA-205043] [PUBMED:15721744]
Neurotrophic factor-mediated Trk receptor signaling [NCBI:137977] [Pathway Interaction Database:trkrpathway] [PUBMED:1849459] [PUBMED:8226808] [PUBMED:11163269] [PUBMED:7510697] [PUBMED:11027277] [PUBMED:15758069] [PUBMED:11425862] [PUBMED:11238898] [PUBMED:11251075] [PUBMED:8344249] [PUBMED:9356464] [PUBMED:11150291] [PUBMED:10092678] [PUBMED:1280261] [PUBMED:11150334] [PUBMED:11244088] [PUBMED:10985348] [PUBMED:15753086] [PUBMED:1653651] [PUBMED:11466412] [PUBMED:15167895] [PUBMED:1831195] [PUBMED:10490030] [PUBMED:8384556] [PUBMED:16697063] [PUBMED:17003042] [PUBMED:15520226] [PUBMED:15632082] [PUBMED:16611639] [PUBMED:16187212] [PUBMED:9182757] [PUBMED:1604323] [PUBMED:16284401] [PUBMED:8356095] [PUBMED:10329710] [PUBMED:9927421] [PUBMED:9856458] [PUBMED:10691301] [PUBMED:1375038] [PUBMED:10679771] [PUBMED:15122257] [PUBMED:15513915] [PUBMED:16701206] [PUBMED:1710174] [PUBMED:8155326] [PUBMED:8288573] [PUBMED:7972023] [PUBMED:7512734] [PUBMED:10601297] [PUBMED:16203995] [PUBMED:12510192] [PUBMED:16481401] [PUBMED:8106527] [PUBMED:11278445] [PUBMED:9099755] [PUBMED:1850821] [PUBMED:9632781] [PUBMED:10235685] [PUBMED:15917464] [PUBMED:9285826] [PUBMED:12446789] [PUBMED:7657612] [PUBMED:1850549] [PUBMED:12879077] [PUBMED:16157584] [PUBMED:10207144] [PUBMED:12006576] [PUBMED:8052307] [PUBMED:8382740] [PUBMED:10629055]
Neurotrophin signaling pathway [NCBI:101143] [KEGG:hsa04722] [PUBMED:16699811] [PUBMED:10812966] [PUBMED:12676795] [PUBMED:16939974] [PUBMED:10851172] [PUBMED:15499580] [PUBMED:14704852] [PUBMED:11399424] [PUBMED:10764727] [PUBMED:10985348] [PUBMED:16856873] [PUBMED:11529497]
PI3K-Akt signaling pathway [NCBI:692234] [KEGG:hsa04151] [PUBMED:12048182] [PUBMED:11357143] [PUBMED:21440011] [PUBMED:15209374] [PUBMED:12669022] [PUBMED:18842113] [PUBMED:16847462] [PUBMED:12660731] [PUBMED:17360849] [PUBMED:9838078] [PUBMED:15505410] [PUBMED:16248975] [PUBMED:12531180] [PUBMED:21779440] [PUBMED:16187290] [PUBMED:15784165] [PUBMED:21620960]
PI3K/AKT activation [NCBI:1269473] [REACTOME:R-HSA-198203] [PUBMED:10579926] [PUBMED:12123609]
PLC-gamma1 signalling [NCBI:1269472] [REACTOME:R-HSA-167021] [PUBMED:12676795] [PUBMED:10579907]
Prolonged ERK activation events [NCBI:1269469] [REACTOME:R-HSA-169893] [PUBMED:12765839] [PUBMED:9069267]
Rap1 signaling pathway [NCBI:868086] [KEGG:hsa04015] [PUBMED:17624944] [PUBMED:12351703] [PUBMED:10579920] [PUBMED:19159611] [PUBMED:18363565] [PUBMED:12765839] [PUBMED:12508104] [PUBMED:11331911] [PUBMED:17182900] [PUBMED:15803158] [PUBMED:19615876] [PUBMED:21402149] [PUBMED:17624948] [PUBMED:17383543] [PUBMED:14607972] [PUBMED:15780587] [PUBMED:19710505]
Ras signaling pathway [NCBI:868085] [KEGG:hsa04014] [PUBMED:23506953] [PUBMED:18437264] [PUBMED:15062121] [PUBMED:22189424] [PUBMED:22233291] [PUBMED:12778136] [PUBMED:11313946] [PUBMED:17428555] [PUBMED:19091743] [PUBMED:18568040] [PUBMED:20420946] [PUBMED:12217381] [PUBMED:14663478] [PUBMED:21686117] [PUBMED:12642680] [PUBMED:21196257] [PUBMED:16869784] [PUBMED:21111786] [PUBMED:16966426] [PUBMED:10712923] [PUBMED:22020205] [PUBMED:17384584] [PUBMED:15572660] [PUBMED:18413813]
Retrograde neurotrophin signalling [NCBI:1269476] [REACTOME:R-HSA-177504]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Signalling to ERKs [NCBI:1269464] [REACTOME:R-HSA-187687] [PUBMED:10508738]
Signalling to RAS [NCBI:1269465] [REACTOME:R-HSA-167044] [PUBMED:11520933]
Signalling to STAT3 [NCBI:1269474] [REACTOME:R-HSA-198745]
Signalling to p38 via RIT and RIN [NCBI:1269468] [REACTOME:R-HSA-187706] [PUBMED:10712923]
TRKA activation by NGF [NCBI:1269462] [REACTOME:R-HSA-187042] [PUBMED:1844238] [PUBMED:1315923]
Trk receptor signaling mediated by PI3K and PLC-gamma [NCBI:137967] [Pathway Interaction Database:pi3kplctrkpathway] [PUBMED:11136977] [PUBMED:11864996] [PUBMED:8663990] [PUBMED:12367511] [PUBMED:9094314] [PUBMED:10330161] [PUBMED:11953455] [PUBMED:7886457] [PUBMED:16319926] [PUBMED:10102273] [PUBMED:11418861] [PUBMED:10729337] [PUBMED:9346240] [PUBMED:10677043] [PUBMED:15702476] [PUBMED:15207235] [PUBMED:9637919]
p75 NTR receptor-mediated signalling [NCBI:1269445] [REACTOME:R-HSA-193704] [PUBMED:16699811] [PUBMED:16939974] [PUBMED:12671646]
p75(NTR)-mediated signaling [NCBI:138019] [Pathway Interaction Database:p75ntrpathway] [PUBMED:14673001] [PUBMED:14593116] [PUBMED:10545116] [PUBMED:11729324] [PUBMED:16252010] [PUBMED:11756426] [PUBMED:12414813] [PUBMED:2157470] [PUBMED:11777929] [PUBMED:1547788] [PUBMED:10764727] [PUBMED:8614802] [PUBMED:14960584] [PUBMED:12376548] [PUBMED:11756498] [PUBMED:8079174] [PUBMED:16498402] [PUBMED:15051733] [PUBMED:12682012] [PUBMED:14638693] [PUBMED:14966521] [PUBMED:9915784] [PUBMED:11487608] [PUBMED:10485890] [PUBMED:16630834] [PUBMED:11312266] [PUBMED:10985348] [PUBMED:11244088] [PUBMED:6093111] [PUBMED:10595511] [PUBMED:14985763] [PUBMED:12097334] [PUBMED:15548667] [PUBMED:15470142] [PUBMED:11279271] [PUBMED:8878481] [PUBMED:12422217] [PUBMED:15987945] [PUBMED:15668238] [PUBMED:10433815] [PUBMED:12692556] [PUBMED:2025430] [PUBMED:15930396] [PUBMED:11278287] [PUBMED:12034707]
p75NTR negatively regulates cell cycle via SC1 [NCBI:1269451] [REACTOME:R-HSA-193670] [PUBMED:12371150]
p75NTR recruits signalling complexes [NCBI:1269453] [REACTOME:R-HSA-209543]
p75NTR regulates axonogenesis [NCBI:1269456] [REACTOME:R-HSA-193697] [PUBMED:17335080]
p75NTR signals via NF-kB [NCBI:1269452] [REACTOME:R-HSA-193639] [PUBMED:16997282]