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Genes
SHC3
Gene - SHC3
full name
SHC adaptor protein 3
synonyms
N-Shc, NSHC, RAI, SHCC, SHC3, ENSG00000148082
HGNC
HGNC:18181
Entrez Gene
Gene:53358
ENSEMBL
ENSG00000148082
location
chr: 9
start: 91620686
stop: 91793682
strand: -
transcripts
NM_016848.5
pathways
ARMS-mediated activation
[NCBI:1269471]
[REACTOME:R-HSA-170984]
[PUBMED:9069267]
Alcoholism
[NCBI:585563]
[KEGG:hsa05034]
[PUBMED:16764827]
[PUBMED:18616668]
[PUBMED:19077056]
[PUBMED:18991950]
[PUBMED:19756388]
[PUBMED:12068305]
[PUBMED:16102840]
[PUBMED:20947635]
[PUBMED:20729980]
[PUBMED:16278489]
[PUBMED:17270154]
[PUBMED:20626732]
[PUBMED:18310464]
[PUBMED:10774721]
[PUBMED:19342616]
[PUBMED:12605085]
[PUBMED:15500908]
[PUBMED:14729391]
[PUBMED:12085089]
[PUBMED:16776597]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
Bacterial invasion of epithelial cells
[NCBI:149807]
[KEGG:hsa05100]
[PUBMED:17298394]
[PUBMED:16406780]
[PUBMED:19185531]
[PUBMED:19157959]
[PUBMED:17719540]
[PUBMED:19296488]
Breast cancer
[NCBI:1435207]
[KEGG:hsa05224]
[PUBMED:24649067]
[PUBMED:26040571]
[PUBMED:11879567]
[PUBMED:22722193]
[PUBMED:26028978]
[PUBMED:25013431]
[PUBMED:11737884]
[PUBMED:23702927]
[PUBMED:21076461]
[PUBMED:21898546]
[PUBMED:27390604]
[PUBMED:24291072]
[PUBMED:26968398]
[PUBMED:20087430]
[PUBMED:23000897]
[PUBMED:25544707]
[PUBMED:24596345]
[PUBMED:23988612]
[PUBMED:24111892]
[PUBMED:25907219]
[PUBMED:15343273]
[PUBMED:21965336]
[PUBMED:23881035]
[PUBMED:23196196]
[PUBMED:22178455]
[PUBMED:20436504]
[PUBMED:19088017]
[PUBMED:16113099]
[PUBMED:20971825]
Chemokine signaling pathway
[NCBI:99051]
[KEGG:hsa04062]
[PUBMED:17371236]
[PUBMED:19159344]
[PUBMED:17169327]
[PUBMED:10852130]
[PUBMED:9765254]
[PUBMED:15771581]
[PUBMED:14607270]
[PUBMED:18662984]
[PUBMED:12495636]
[PUBMED:15803148]
[PUBMED:15046611]
[PUBMED:12069927]
[PUBMED:18711432]
[PUBMED:17675482]
[PUBMED:16144840]
[PUBMED:17496928]
[PUBMED:17537990]
[PUBMED:11872087]
[PUBMED:12051620]
[PUBMED:14625285]
[PUBMED:8576262]
[PUBMED:11244042]
Chronic myeloid leukemia
[NCBI:83116]
[KEGG:hsa05220]
[PUBMED:22286129]
[PUBMED:12801837]
[PUBMED:11160144]
[PUBMED:15719031]
[PUBMED:10403855]
[PUBMED:9834202]
[PUBMED:11071626]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16484590]
[PUBMED:14982876]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
DAP12 interactions
[NCBI:1269283]
[REACTOME:R-HSA-2172127]
[PUBMED:19120482]
[PUBMED:17220916]
[PUBMED:9490415]
[PUBMED:18192027]
[PUBMED:15884055]
DAP12 signaling
[NCBI:1269284]
[REACTOME:R-HSA-2424491]
[PUBMED:15884055]
[PUBMED:17110943]
[PUBMED:17220916]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
Downstream signal transduction
[NCBI:1269479]
[REACTOME:R-HSA-186763]
[PUBMED:10508235]
[PUBMED:9739761]
EGFR tyrosine kinase inhibitor resistance
[NCBI:1404798]
[KEGG:hsa01521]
[PUBMED:16843264]
[PUBMED:23401451]
[PUBMED:20966921]
[PUBMED:24307395]
[PUBMED:22956644]
[PUBMED:25232485]
[PUBMED:24493829]
[PUBMED:23071030]
[PUBMED:18483355]
[PUBMED:24202392]
[PUBMED:19632948]
[PUBMED:23361103]
[PUBMED:26579470]
[PUBMED:22970367]
[PUBMED:23358468]
[PUBMED:17554333]
[PUBMED:25337673]
[PUBMED:22474259]
[PUBMED:20551942]
Endocrine resistance
[NCBI:1404799]
[KEGG:hsa01522]
[PUBMED:24415977]
[PUBMED:23625614]
[PUBMED:24841429]
[PUBMED:15613444]
[PUBMED:23714450]
[PUBMED:20960099]
[PUBMED:22771991]
[PUBMED:19701242]
[PUBMED:24289103]
[PUBMED:24130921]
[PUBMED:23344024]
[PUBMED:22015292]
[PUBMED:26122181]
[PUBMED:26473850]
[PUBMED:18804516]
[PUBMED:24565562]
[PUBMED:26849149]
[PUBMED:25907219]
[PUBMED:20887199]
ErbB signaling pathway
[NCBI:83049]
[KEGG:hsa04012]
[PUBMED:16377102]
[PUBMED:14967450]
[PUBMED:9642287]
[PUBMED:9872057]
[PUBMED:10880430]
[PUBMED:12851486]
[PUBMED:16729045]
[PUBMED:15863494]
[PUBMED:15864276]
[PUBMED:17000658]
[PUBMED:16729043]
[PUBMED:10490623]
[PUBMED:11252954]
[PUBMED:14744244]
[PUBMED:16829981]
Estrogen signaling pathway
[NCBI:799177]
[KEGG:hsa04915]
[PUBMED:15695368]
[PUBMED:16112267]
[PUBMED:9278514]
[PUBMED:19187465]
[PUBMED:12421825]
[PUBMED:12650715]
[PUBMED:18253054]
[PUBMED:16516516]
[PUBMED:14573532]
[PUBMED:18755790]
[PUBMED:18538919]
[PUBMED:19767412]
[PUBMED:14993035]
[PUBMED:19549587]
[PUBMED:15862823]
[PUBMED:20694192]
[PUBMED:19464786]
[PUBMED:21779010]
[PUBMED:16270355]
[PUBMED:21742056]
[PUBMED:19700741]
[PUBMED:21844907]
FCERI mediated MAPK activation
[NCBI:1269299]
[REACTOME:R-HSA-2871796]
[PUBMED:19290926]
[PUBMED:19909365]
[PUBMED:17122878]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
Focal adhesion
[NCBI:83067]
[KEGG:hsa04510]
[PUBMED:10698680]
[PUBMED:15459662]
[PUBMED:14756624]
[PUBMED:11573199]
[PUBMED:12640026]
[PUBMED:15179030]
[PUBMED:15108811]
[PUBMED:15053919]
[PUBMED:11082269]
[PUBMED:15034601]
[PUBMED:12235283]
[PUBMED:14519391]
[PUBMED:11146675]
[PUBMED:11229600]
[PUBMED:15688067]
[PUBMED:14744429]
[PUBMED:11882383]
Frs2-mediated activation
[NCBI:1269470]
[REACTOME:R-HSA-170968]
[PUBMED:9069267]
GRB2 events in EGFR signaling
[NCBI:1269382]
[REACTOME:R-HSA-179812]
[PUBMED:11706405]
[PUBMED:11498013]
Gastrin-CREB signalling pathway via PKC and MAPK
[NCBI:1269592]
[REACTOME:R-HSA-881907]
[PUBMED:10413847]
[PUBMED:7491953]
[PUBMED:17698287]
Glioma
[NCBI:83110]
[KEGG:hsa05214]
[PUBMED:11057895]
[PUBMED:11253051]
[PUBMED:12154354]
[PUBMED:12084351]
[PUBMED:15639402]
[PUBMED:9643506]
[PUBMED:16095998]
[PUBMED:12762887]
[PUBMED:16700615]
IGF1R signaling cascade
[NCBI:1269618]
[REACTOME:R-HSA-2428924]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
IRS-mediated signalling
[NCBI:1269431]
[REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R
[NCBI:1269620]
[REACTOME:R-HSA-2428928]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:18927274]
[PUBMED:21042815]
[PUBMED:20098959]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Insulin receptor signalling cascade
[NCBI:1269429]
[REACTOME:R-HSA-74751]
[PUBMED:9677303]
[PUBMED:11282018]
Insulin signaling pathway
[NCBI:83090]
[KEGG:hsa04910]
[PUBMED:11742412]
[PUBMED:11343120]
[PUBMED:15733744]
[PUBMED:11282018]
[PUBMED:10196204]
[PUBMED:18291668]
[PUBMED:9609110]
[PUBMED:10567225]
[PUBMED:12791379]
[PUBMED:9748166]
[PUBMED:15624019]
[PUBMED:9445476]
[PUBMED:9346240]
[PUBMED:14635525]
[PUBMED:16288289]
[PUBMED:12867054]
[PUBMED:15229476]
[PUBMED:17344645]
[PUBMED:9609111]
Interleukin receptor SHC signaling
[NCBI:1269322]
[REACTOME:R-HSA-912526]
[PUBMED:8294403]
Interleukin-2 signaling
[NCBI:1269321]
[REACTOME:R-HSA-451927]
[PUBMED:17936914]
[PUBMED:18817510]
[PUBMED:19543225]
[PUBMED:18062768]
Interleukin-3, 5 and GM-CSF signaling
[NCBI:1269323]
[REACTOME:R-HSA-512988]
[PUBMED:10450743]
[PUBMED:9766809]
MAPK family signaling cascades
[NCBI:1269501]
[REACTOME:R-HSA-5683057]
[PUBMED:21167873]
[PUBMED:17161475]
[PUBMED:22535895]
[PUBMED:21372320]
MAPK1/MAPK3 signaling
[NCBI:1269502]
[REACTOME:R-HSA-5684996]
[PUBMED:25378393]
[PUBMED:18199641]
[PUBMED:17496909]
[PUBMED:21779496]
[PUBMED:15520807]
[PUBMED:16393692]
[PUBMED:19520853]
[PUBMED:17496910]
[PUBMED:22569528]
NCAM signaling for neurite out-growth
[NCBI:1270312]
[REACTOME:R-HSA-375165]
[PUBMED:18760361]
[PUBMED:12587671]
[PUBMED:15662836]
[PUBMED:17975827]
[PUBMED:15153429]
[PUBMED:12700044]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
Natural killer cell mediated cytotoxicity
[NCBI:83079]
[KEGG:hsa04650]
[PUBMED:12530970]
[PUBMED:15567854]
[PUBMED:8942070]
[PUBMED:11905813]
[PUBMED:9143705]
[PUBMED:9862693]
[PUBMED:11895890]
[PUBMED:12205470]
[PUBMED:11836514]
[PUBMED:15607806]
[PUBMED:16002670]
[PUBMED:15618404]
[PUBMED:11390470]
[PUBMED:11062493]
[PUBMED:14710949]
[PUBMED:12752668]
[PUBMED:15607802]
[PUBMED:16109839]
[PUBMED:12766758]
[PUBMED:16177799]
Neurotrophic factor-mediated Trk receptor signaling
[NCBI:137977]
[Pathway Interaction Database:trkrpathway]
[PUBMED:1849459]
[PUBMED:8226808]
[PUBMED:11163269]
[PUBMED:7510697]
[PUBMED:11027277]
[PUBMED:15758069]
[PUBMED:11425862]
[PUBMED:11238898]
[PUBMED:11251075]
[PUBMED:8344249]
[PUBMED:9356464]
[PUBMED:11150291]
[PUBMED:10092678]
[PUBMED:1280261]
[PUBMED:11150334]
[PUBMED:11244088]
[PUBMED:10985348]
[PUBMED:15753086]
[PUBMED:1653651]
[PUBMED:11466412]
[PUBMED:15167895]
[PUBMED:1831195]
[PUBMED:10490030]
[PUBMED:8384556]
[PUBMED:16697063]
[PUBMED:17003042]
[PUBMED:15520226]
[PUBMED:15632082]
[PUBMED:16611639]
[PUBMED:16187212]
[PUBMED:9182757]
[PUBMED:1604323]
[PUBMED:16284401]
[PUBMED:8356095]
[PUBMED:10329710]
[PUBMED:9927421]
[PUBMED:9856458]
[PUBMED:10691301]
[PUBMED:1375038]
[PUBMED:10679771]
[PUBMED:15122257]
[PUBMED:15513915]
[PUBMED:16701206]
[PUBMED:1710174]
[PUBMED:8155326]
[PUBMED:8288573]
[PUBMED:7972023]
[PUBMED:7512734]
[PUBMED:10601297]
[PUBMED:16203995]
[PUBMED:12510192]
[PUBMED:16481401]
[PUBMED:8106527]
[PUBMED:11278445]
[PUBMED:9099755]
[PUBMED:1850821]
[PUBMED:9632781]
[PUBMED:10235685]
[PUBMED:15917464]
[PUBMED:9285826]
[PUBMED:12446789]
[PUBMED:7657612]
[PUBMED:1850549]
[PUBMED:12879077]
[PUBMED:16157584]
[PUBMED:10207144]
[PUBMED:12006576]
[PUBMED:8052307]
[PUBMED:8382740]
[PUBMED:10629055]
Neurotrophin signaling pathway
[NCBI:101143]
[KEGG:hsa04722]
[PUBMED:16699811]
[PUBMED:10812966]
[PUBMED:12676795]
[PUBMED:16939974]
[PUBMED:10851172]
[PUBMED:15499580]
[PUBMED:14704852]
[PUBMED:11399424]
[PUBMED:10764727]
[PUBMED:10985348]
[PUBMED:16856873]
[PUBMED:11529497]
Phospholipase D signaling pathway
[NCBI:1311074]
[KEGG:hsa04072]
[PUBMED:9310372]
[PUBMED:9119890]
[PUBMED:15310762]
[PUBMED:18936782]
[PUBMED:24990952]
[PUBMED:14769825]
[PUBMED:21936578]
[PUBMED:10666319]
[PUBMED:17210675]
[PUBMED:19264150]
[PUBMED:23076158]
[PUBMED:17054901]
[PUBMED:16622417]
[PUBMED:10807766]
[PUBMED:12217395]
[PUBMED:11042115]
[PUBMED:19815110]
[PUBMED:24995811]
[PUBMED:16143829]
[PUBMED:8135758]
[PUBMED:11991733]
[PUBMED:19410013]
[PUBMED:17245604]
Prolactin signaling pathway
[NCBI:814182]
[KEGG:hsa04917]
[PUBMED:17519353]
[PUBMED:17535875]
[PUBMED:20149678]
[PUBMED:12670737]
[PUBMED:17307904]
[PUBMED:18601698]
[PUBMED:17975019]
[PUBMED:16231422]
[PUBMED:18219564]
[PUBMED:9475379]
[PUBMED:16677418]
[PUBMED:9626554]
[PUBMED:21664429]
[PUBMED:11606470]
Prolonged ERK activation events
[NCBI:1269469]
[REACTOME:R-HSA-169893]
[PUBMED:12765839]
[PUBMED:9069267]
RAF/MAP kinase cascade
[NCBI:1269285]
[REACTOME:R-HSA-5673001]
[PUBMED:21167873]
[PUBMED:24937142]
[PUBMED:20674547]
[PUBMED:17496910]
[PUBMED:22177953]
[PUBMED:17496919]
[PUBMED:22569528]
[PUBMED:22535895]
[PUBMED:12068308]
[PUBMED:17496923]
[PUBMED:19091303]
[PUBMED:21372320]
[PUBMED:21388974]
[PUBMED:15520807]
RET signaling
[NCBI:1427866]
[REACTOME:R-HSA-8853659]
[PUBMED:15013219]
[PUBMED:17036197]
Ras signaling pathway
[NCBI:868085]
[KEGG:hsa04014]
[PUBMED:23506953]
[PUBMED:18437264]
[PUBMED:15062121]
[PUBMED:22189424]
[PUBMED:22233291]
[PUBMED:12778136]
[PUBMED:11313946]
[PUBMED:17428555]
[PUBMED:19091743]
[PUBMED:18568040]
[PUBMED:20420946]
[PUBMED:12217381]
[PUBMED:14663478]
[PUBMED:21686117]
[PUBMED:12642680]
[PUBMED:21196257]
[PUBMED:16869784]
[PUBMED:21111786]
[PUBMED:16966426]
[PUBMED:10712923]
[PUBMED:22020205]
[PUBMED:17384584]
[PUBMED:15572660]
[PUBMED:18413813]
SHC1 events in EGFR signaling
[NCBI:1269383]
[REACTOME:R-HSA-180336]
[PUBMED:11498013]
[PUBMED:8755247]
SOS-mediated signalling
[NCBI:1269440]
[REACTOME:R-HSA-112412]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by EGFR
[NCBI:1269380]
[REACTOME:R-HSA-177929]
[PUBMED:10459005]
[PUBMED:10404636]
[PUBMED:12297041]
[PUBMED:15142631]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signaling by Insulin receptor
[NCBI:1269428]
[REACTOME:R-HSA-74752]
[PUBMED:8276779]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signaling by Leptin
[NCBI:1269632]
[REACTOME:R-HSA-2586552]
[PUBMED:22211890]
[PUBMED:23562747]
[PUBMED:20600241]
[PUBMED:21622208]
[PUBMED:23579596]
[PUBMED:22458591]
[PUBMED:21489811]
[PUBMED:19724019]
[PUBMED:21331644]
[PUBMED:22448029]
[PUBMED:21147620]
[PUBMED:20198122]
[PUBMED:21677426]
[PUBMED:20029269]
[PUBMED:22249808]
[PUBMED:22991412]
[PUBMED:21527729]
[PUBMED:17937601]
[PUBMED:20553370]
[PUBMED:21713385]
[PUBMED:23565489]
[PUBMED:22289780]
Signaling by PDGF
[NCBI:1269478]
[REACTOME:R-HSA-186797]
[PUBMED:15207811]
[PUBMED:10508235]
[PUBMED:9739761]
Signaling by SCF-KIT
[NCBI:1269487]
[REACTOME:R-HSA-1433557]
[PUBMED:17350321]
[PUBMED:16483568]
[PUBMED:7688988]
[PUBMED:19540337]
[PUBMED:16475976]
[PUBMED:15526160]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
[NCBI:1269617]
[REACTOME:R-HSA-2404192]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22044904]
[PUBMED:22649417]
Signaling by VEGF
[NCBI:1269480]
[REACTOME:R-HSA-194138]
[PUBMED:15585754]
[PUBMED:13678960]
[PUBMED:16336962]
[PUBMED:16835467]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Signalling to ERKs
[NCBI:1269464]
[REACTOME:R-HSA-187687]
[PUBMED:10508738]
Signalling to RAS
[NCBI:1269465]
[REACTOME:R-HSA-167044]
[PUBMED:11520933]
Signalling to p38 via RIT and RIN
[NCBI:1269468]
[REACTOME:R-HSA-187706]
[PUBMED:10712923]
VEGFA-VEGFR2 Pathway
[NCBI:1269483]
[REACTOME:R-HSA-4420097]
[PUBMED:17344076]
[PUBMED:16633338]
[PUBMED:19230644]
[PUBMED:13678960]
VEGFR2 mediated cell proliferation
[NCBI:1269485]
[REACTOME:R-HSA-5218921]
[PUBMED:22866201]
[PUBMED:22180219]
[PUBMED:22762016]