Logo
full name
proteasome 26S subunit, non-ATPase 5

synonyms
S5B, PSMD5, ENSG00000095261

HGNC
HGNC:9563

Entrez Gene
Gene:5711

ENSEMBL
ENSG00000095261

location
chr: 9
start: 123578331
stop: 123605299
strand: -

transcripts
NM_001270427.1
NM_005047.3

pathways
ABC transporter disorders [NCBI:1268933] [REACTOME:R-HSA-5619084] [PUBMED:21740521] [PUBMED:16399363] [PUBMED:23415156] [PUBMED:21389634] [PUBMED:21488864] [PUBMED:21554546]
ABC-family proteins mediated transport [NCBI:1269904] [REACTOME:R-HSA-382556] [PUBMED:11435397] [PUBMED:12045106] [PUBMED:19234479]
APC/C-mediated degradation of cell cycle proteins [NCBI:1269838] [REACTOME:R-HSA-174143] [PUBMED:15678131] [PUBMED:12049731]
APC/C:Cdc20 mediated degradation of Securin [NCBI:1269849] [REACTOME:R-HSA-174154] [PUBMED:12070128] [PUBMED:10827941]
APC/C:Cdc20 mediated degradation of mitotic proteins [NCBI:1269844] [REACTOME:R-HSA-176409] [PUBMED:15949434] [PUBMED:10465783]
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 [NCBI:1269851] [REACTOME:R-HSA-174178] [PUBMED:16413484] [PUBMED:15678131]
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint [NCBI:1269845] [REACTOME:R-HSA-179419]
ARMS-mediated activation [NCBI:1269471] [REACTOME:R-HSA-170984] [PUBMED:9069267]
AUF1 (hnRNP D0) binds and destabilizes mRNA [NCBI:1269726] [REACTOME:R-HSA-450408] [PUBMED:16391004] [PUBMED:12704645] [PUBMED:10205060] [PUBMED:12440953] [PUBMED:18573886] [PUBMED:12819195]
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins [NCBI:1269842] [REACTOME:R-HSA-176814] [PUBMED:15678131]
Activation of NF-kappaB in B cells [NCBI:1269186] [REACTOME:R-HSA-1169091] [PUBMED:10593898] [PUBMED:3129195] [PUBMED:7479848] [PUBMED:7809113] [PUBMED:9721103] [PUBMED:18462924] [PUBMED:8387275] [PUBMED:7628694] [PUBMED:7862124] [PUBMED:7831327] [PUBMED:7575604] [PUBMED:16356855] [PUBMED:16301747] [PUBMED:7957109] [PUBMED:11460167] [PUBMED:9914500] [PUBMED:19066035] [PUBMED:17428801] [PUBMED:7479976] [PUBMED:1756723]
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Antigen processing-Cross presentation [NCBI:1269195] [REACTOME:R-HSA-1236975] [PUBMED:17157489] [PUBMED:20171863] [PUBMED:16181333] [PUBMED:15761154] [PUBMED:16181335] [PUBMED:19218463]
Antigen processing: Ubiquitination & Proteasome degradation [NCBI:1269193] [REACTOME:R-HSA-983168] [PUBMED:12648452] [PUBMED:11917093] [PUBMED:19489725] [PUBMED:14734113] [PUBMED:20351195] [PUBMED:17145306]
Apoptosis [NCBI:83060] [KEGG:hsa04210] [NCBI:1270262] [REACTOME:R-HSA-109581] [PUBMED:12189384] [PUBMED:20533903] [PUBMED:18208375] [PUBMED:22429822] [PUBMED:15218528] [PUBMED:24769728] [PUBMED:18023214] [PUBMED:25526085] [PUBMED:23070002] [PUBMED:15654015] [PUBMED:15601572] [PUBMED:14561771] [PUBMED:24278747] [PUBMED:21914490] [PUBMED:22465226] [PUBMED:21145844] [PUBMED:12838338] [PUBMED:18238895] [PUBMED:12949498] [PUBMED:18304445] [PUBMED:14737178] [PUBMED:26231733] [PUBMED:9916983] [PUBMED:14634621] [PUBMED:19770840] [PUBMED:22075987] [PUBMED:4561027] [PUBMED:20075940] [PUBMED:9894605] [PUBMED:26615431] [PUBMED:12505355] [PUBMED:11520933] [PUBMED:19148180] [PUBMED:16397578] [PUBMED:15719025] [PUBMED:15322527] [PUBMED:15725726] [PUBMED:12209154] [PUBMED:23803157]
Assembly of the pre-replicative complex [NCBI:1269833] [REACTOME:R-HSA-68867] [PUBMED:11801723] [PUBMED:9829972] [PUBMED:9288745] [PUBMED:9407030] [PUBMED:9927482] [PUBMED:9335335] [PUBMED:11046155]
Asymmetric localization of PCP proteins [NCBI:1269612] [REACTOME:R-HSA-4608870] [PUBMED:16687519] [PUBMED:16495441] [PUBMED:12724779] [PUBMED:17230199] [PUBMED:19379695]
Autodegradation of Cdh1 by Cdh1:APC/C [NCBI:1269852] [REACTOME:R-HSA-174084] [PUBMED:15029244]
Autodegradation of the E3 ubiquitin ligase COP1 [NCBI:1269747] [REACTOME:R-HSA-349425] [PUBMED:16931761]
Axon guidance [NCBI:83065] [KEGG:hsa04360] [NCBI:1270303] [REACTOME:R-HSA-422475] [PUBMED:14682358] [PUBMED:15084255] [PUBMED:11687826] [PUBMED:15818466] [PUBMED:15363605] [PUBMED:12471249] [PUBMED:15630019] [PUBMED:11891122] [PUBMED:15960985] [PUBMED:12677003]
Beta-catenin independent WNT signaling [NCBI:1269610] [REACTOME:R-HSA-3858494] [PUBMED:22935904] [PUBMED:21903638] [PUBMED:23256519] [PUBMED:8065359] [PUBMED:7739543] [PUBMED:23140633]
C-type lectin receptors (CLRs) [NCBI:1269303] [REACTOME:R-HSA-5621481] [PUBMED:19521399] [PUBMED:24330199]
CDK-mediated phosphorylation and removal of Cdc6 [NCBI:1269783] [REACTOME:R-HSA-69017] [PUBMED:12045100] [PUBMED:11046155]
CDT1 association with the CDC6:ORC:origin complex [NCBI:1269836] [REACTOME:R-HSA-68827] [PUBMED:11125146] [PUBMED:11836525] [PUBMED:10766247] [PUBMED:11175741] [PUBMED:10898791] [PUBMED:10766248] [PUBMED:9442876] [PUBMED:9635433]
CLEC7A (Dectin-1) signaling [NCBI:1269304] [REACTOME:R-HSA-5607764] [PUBMED:12719478] [PUBMED:19223162]
Cdc20:Phospho-APC/C mediated degradation of Cyclin A [NCBI:1269846] [REACTOME:R-HSA-174184] [PUBMED:11285280]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints [NCBI:1269742] [REACTOME:R-HSA-69620]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Cellular response to hypoxia [NCBI:1270415] [REACTOME:R-HSA-2262749] [PUBMED:15304631]
Cellular responses to stress [NCBI:1270414] [REACTOME:R-HSA-2262752] [PUBMED:15709958]
Class I MHC mediated antigen processing & presentation [NCBI:1269192] [REACTOME:R-HSA-983169] [PUBMED:8717519] [PUBMED:17145306] [PUBMED:18926908] [PUBMED:17055423] [PUBMED:12495737] [PUBMED:18641646] [PUBMED:18243674]
Cross-presentation of soluble exogenous antigens (endosomes) [NCBI:1269199] [REACTOME:R-HSA-1236978] [PUBMED:15592474] [PUBMED:20171863] [PUBMED:17157489]
Cyclin A:Cdk2-associated events at S phase entry [NCBI:1269778] [REACTOME:R-HSA-69656] [PUBMED:7629134] [PUBMED:11231585] [PUBMED:1396589] [PUBMED:15014502] [PUBMED:10454565] [PUBMED:11907280]
Cyclin E associated events during G1/S transition [NCBI:1269769] [REACTOME:R-HSA-69202]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
DAP12 interactions [NCBI:1269283] [REACTOME:R-HSA-2172127] [PUBMED:19120482] [PUBMED:17220916] [PUBMED:9490415] [PUBMED:18192027] [PUBMED:15884055]
DAP12 signaling [NCBI:1269284] [REACTOME:R-HSA-2424491] [PUBMED:15884055] [PUBMED:17110943] [PUBMED:17220916]
DNA Replication [NCBI:1269875] [REACTOME:R-HSA-69306] [PUBMED:11257218] [PUBMED:12045100] [PUBMED:1536007] [PUBMED:10966477] [PUBMED:1579437] [PUBMED:8223461]
DNA Replication Pre-Initiation [NCBI:1269832] [REACTOME:R-HSA-69002]
Dectin-1 mediated noncanonical NF-kB signaling [NCBI:1269306] [REACTOME:R-HSA-5607761] [PUBMED:19521399] [PUBMED:19302050] [PUBMED:23570314]
Defective CFTR causes cystic fibrosis [NCBI:1268934] [REACTOME:R-HSA-5678895] [PUBMED:16126935] [PUBMED:22650116] [PUBMED:2570460] [PUBMED:21652558]
Degradation of AXIN [NCBI:1269606] [REACTOME:R-HSA-4641257] [PUBMED:21478859] [PUBMED:14551908] [PUBMED:22363759] [PUBMED:20858899] [PUBMED:21799911]
Degradation of DVL [NCBI:1269605] [REACTOME:R-HSA-4641258] [PUBMED:14684739] [PUBMED:20006983] [PUBMED:22826439] [PUBMED:11970895] [PUBMED:16547521] [PUBMED:16446366]
Degradation of GLI1 by the proteasome [NCBI:1269639] [REACTOME:R-HSA-5610780] [PUBMED:17283082] [PUBMED:10075717] [PUBMED:10725236] [PUBMED:21921029] [PUBMED:12361967]
Degradation of GLI2 by the proteasome [NCBI:1269638] [REACTOME:R-HSA-5610783] [PUBMED:19056373] [PUBMED:17283082] [PUBMED:23719536] [PUBMED:16611981]
Degradation of beta-catenin by the destruction complex [NCBI:1269596] [REACTOME:R-HSA-195253] [PUBMED:17143292]
Deubiquitination [NCBI:1427860] [REACTOME:R-HSA-5688426] [PUBMED:19243136] [PUBMED:20074029] [PUBMED:15571815] [PUBMED:20418328] [PUBMED:16325574] [PUBMED:12944365] [PUBMED:23845989] [PUBMED:22201797]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases of signal transduction [NCBI:1268855] [REACTOME:R-HSA-5663202] [PUBMED:12509752]
Disorders of transmembrane transporters [NCBI:1268932] [REACTOME:R-HSA-5619115] [PUBMED:16399363]
Downstream TCR signaling [NCBI:1269176] [REACTOME:R-HSA-202424] [PUBMED:15084594]
Downstream signal transduction [NCBI:1269479] [REACTOME:R-HSA-186763] [PUBMED:10508235] [PUBMED:9739761]
Downstream signaling events of B Cell Receptor (BCR) [NCBI:1269185] [REACTOME:R-HSA-1168372] [PUBMED:17052215] [PUBMED:19909372]
ER-Phagosome pathway [NCBI:1269197] [REACTOME:R-HSA-1236974] [PUBMED:16213220] [PUBMED:20171863] [PUBMED:14508490] [PUBMED:17027300] [PUBMED:14561893] [PUBMED:15845646] [PUBMED:22915823] [PUBMED:18006660] [PUBMED:14508489] [PUBMED:12151002] [PUBMED:15728715]
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis [NCBI:1457807] [REACTOME:R-HSA-8854050] [PUBMED:25654763] [PUBMED:22306998]
FCERI mediated MAPK activation [NCBI:1269299] [REACTOME:R-HSA-2871796] [PUBMED:19290926] [PUBMED:19909365] [PUBMED:17122878]
FCERI mediated NF-kB activation [NCBI:1269301] [REACTOME:R-HSA-2871837] [PUBMED:17336609] [PUBMED:16432253]
Fc epsilon receptor (FCERI) signaling [NCBI:1269298] [REACTOME:R-HSA-2454202] [PUBMED:15099567] [PUBMED:21799019]
Frs2-mediated activation [NCBI:1269470] [REACTOME:R-HSA-170968] [PUBMED:9069267]
G1/S DNA Damage Checkpoints [NCBI:1269743] [REACTOME:R-HSA-69615]
G1/S Transition [NCBI:1269768] [REACTOME:R-HSA-69206]
G2/M Checkpoints [NCBI:1269753] [REACTOME:R-HSA-69481]
G2/M Transition [NCBI:1269799] [REACTOME:R-HSA-69275]
GLI3 is processed to GLI3R by the proteasome [NCBI:1269637] [REACTOME:R-HSA-5610785] [PUBMED:21921029] [PUBMED:20154143] [PUBMED:16371461] [PUBMED:10693759] [PUBMED:16705181] [PUBMED:17283082]
GRB2 events in EGFR signaling [NCBI:1269382] [REACTOME:R-HSA-179812] [PUBMED:11706405] [PUBMED:11498013]
Gastrin-CREB signalling pathway via PKC and MAPK [NCBI:1269592] [REACTOME:R-HSA-881907] [PUBMED:10413847] [PUBMED:7491953] [PUBMED:17698287]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
HIV Infection [NCBI:1269057] [REACTOME:R-HSA-162906] [PUBMED:16354571] [PUBMED:9759480]
Hedgehog 'off' state [NCBI:1269636] [REACTOME:R-HSA-5610787] [PUBMED:21801010] [PUBMED:20395968] [PUBMED:23719536] [PUBMED:21502959]
Hedgehog 'on' state [NCBI:1269640] [REACTOME:R-HSA-5632684] [PUBMED:23719536] [PUBMED:21502959] [PUBMED:21801010] [PUBMED:20395968]
Hedgehog ligand biogenesis [NCBI:1269634] [REACTOME:R-HSA-5358346] [PUBMED:8824192] [PUBMED:11486055] [PUBMED:18585355] [PUBMED:23719536] [PUBMED:9593755] [PUBMED:21357747] [PUBMED:22902404] [PUBMED:23565096] [PUBMED:15163793] [PUBMED:11395778] [PUBMED:21257310] [PUBMED:16396909] [PUBMED:15075292]
Hh mutants abrogate ligand secretion [NCBI:1268927] [REACTOME:R-HSA-5387390] [PUBMED:19603532] [PUBMED:24784881] [PUBMED:23565096] [PUBMED:20104595]
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD [NCBI:1268928] [REACTOME:R-HSA-5362768] [PUBMED:23565096] [PUBMED:20104595] [PUBMED:19603532]
Host Interactions of HIV factors [NCBI:1269091] [REACTOME:R-HSA-162909]
IGF1R signaling cascade [NCBI:1269618] [REACTOME:R-HSA-2428924] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959]
IRS-mediated signalling [NCBI:1269431] [REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R [NCBI:1269620] [REACTOME:R-HSA-2428928] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:18927274] [PUBMED:21042815] [PUBMED:20098959]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Infectious disease [NCBI:1269056] [REACTOME:R-HSA-5663205]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Insulin receptor signalling cascade [NCBI:1269429] [REACTOME:R-HSA-74751] [PUBMED:9677303] [PUBMED:11282018]
Interleukin receptor SHC signaling [NCBI:1269322] [REACTOME:R-HSA-912526] [PUBMED:8294403]
Interleukin-2 signaling [NCBI:1269321] [REACTOME:R-HSA-451927] [PUBMED:17936914] [PUBMED:18817510] [PUBMED:19543225] [PUBMED:18062768]
Interleukin-3, 5 and GM-CSF signaling [NCBI:1269323] [REACTOME:R-HSA-512988] [PUBMED:10450743] [PUBMED:9766809]
M Phase [NCBI:1269810] [REACTOME:R-HSA-68886]
M/G1 Transition [NCBI:1269831] [REACTOME:R-HSA-68874]
MAPK family signaling cascades [NCBI:1269501] [REACTOME:R-HSA-5683057] [PUBMED:21167873] [PUBMED:17161475] [PUBMED:22535895] [PUBMED:21372320]
MAPK1/MAPK3 signaling [NCBI:1269502] [REACTOME:R-HSA-5684996] [PUBMED:25378393] [PUBMED:18199641] [PUBMED:17496909] [PUBMED:21779496] [PUBMED:15520807] [PUBMED:16393692] [PUBMED:19520853] [PUBMED:17496910] [PUBMED:22569528]
MAPK6/MAPK4 signaling [NCBI:1269506] [REACTOME:R-HSA-5687128] [PUBMED:18644862] [PUBMED:22800433] [PUBMED:19166925] [PUBMED:12808096] [PUBMED:18248330] [PUBMED:20849292] [PUBMED:21329875] [PUBMED:21177870] [PUBMED:17161475] [PUBMED:18593949] [PUBMED:21372320] [PUBMED:18720373] [PUBMED:17947239] [PUBMED:15226418] [PUBMED:22505454]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of amino acids and derivatives [NCBI:1270158] [REACTOME:R-HSA-71291]
Metabolism of polyamines [NCBI:1270170] [REACTOME:R-HSA-351202] [PUBMED:11564948] [PUBMED:12686127] [PUBMED:15784477]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Mitotic Anaphase [NCBI:1269825] [REACTOME:R-HSA-68882]
Mitotic G1-G1/S phases [NCBI:1269764] [REACTOME:R-HSA-453279]
Mitotic G2-G2/M phases [NCBI:1269797] [REACTOME:R-HSA-453274]
Mitotic Metaphase and Anaphase [NCBI:1269823] [REACTOME:R-HSA-2555396]
NCAM signaling for neurite out-growth [NCBI:1270312] [REACTOME:R-HSA-375165] [PUBMED:18760361] [PUBMED:12587671] [PUBMED:15662836] [PUBMED:17975827] [PUBMED:15153429] [PUBMED:12700044]
NGF signalling via TRKA from the plasma membrane [NCBI:1269460] [REACTOME:R-HSA-187037] [PUBMED:11520933] [PUBMED:12676795] [PUBMED:10851172] [PUBMED:10579918]
NIK-->noncanonical NF-kB signaling [NCBI:1269331] [REACTOME:R-HSA-5676590] [PUBMED:22017430] [PUBMED:18322009] [PUBMED:19302050] [PUBMED:21173796]
Orc1 removal from chromatin [NCBI:1269782] [REACTOME:R-HSA-68949] [PUBMED:11931757] [PUBMED:11739726] [PUBMED:11809796] [PUBMED:1110244]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha [NCBI:1270418] [REACTOME:R-HSA-1234176] [PUBMED:15247232] [PUBMED:15474027] [PUBMED:12788921] [PUBMED:18184961] [PUBMED:12351678] [PUBMED:11292861] [PUBMED:17434750] [PUBMED:19208626] [PUBMED:12538644] [PUBMED:12615973] [PUBMED:11598268] [PUBMED:21335549] [PUBMED:12912907] [PUBMED:11292862]
PCP/CE pathway [NCBI:1269611] [REACTOME:R-HSA-4086400] [PUBMED:23140633] [PUBMED:18848778] [PUBMED:10811221] [PUBMED:19365405] [PUBMED:9598355] [PUBMED:21983142] [PUBMED:17433286] [PUBMED:20004982] [PUBMED:19204114]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Programmed Cell Death [NCBI:1270261] [REACTOME:R-HSA-5357801] [PUBMED:25236395]
Prolonged ERK activation events [NCBI:1269469] [REACTOME:R-HSA-169893] [PUBMED:12765839] [PUBMED:9069267]
RAF/MAP kinase cascade [NCBI:1269285] [REACTOME:R-HSA-5673001] [PUBMED:21167873] [PUBMED:24937142] [PUBMED:20674547] [PUBMED:17496910] [PUBMED:22177953] [PUBMED:17496919] [PUBMED:22569528] [PUBMED:22535895] [PUBMED:12068308] [PUBMED:17496923] [PUBMED:19091303] [PUBMED:21372320] [PUBMED:21388974] [PUBMED:15520807]
RET signaling [NCBI:1427866] [REACTOME:R-HSA-8853659] [PUBMED:15013219] [PUBMED:17036197]
Regulation of APC/C activators between G1/S and early anaphase [NCBI:1269839] [REACTOME:R-HSA-176408] [PUBMED:16508672] [PUBMED:12049731] [PUBMED:12208841] [PUBMED:15678131]
Regulation of Apoptosis [NCBI:1270295] [REACTOME:R-HSA-169911] [PUBMED:12724336] [PUBMED:11432772]
Regulation of DNA replication [NCBI:1269794] [REACTOME:R-HSA-69304]
Regulation of Hypoxia-inducible Factor (HIF) by oxygen [NCBI:1270416] [REACTOME:R-HSA-1234174] [PUBMED:19704417] [PUBMED:20728359] [PUBMED:21335549] [PUBMED:19339544] [PUBMED:17916722] [PUBMED:18498744] [PUBMED:16724055] [PUBMED:20965423]
Regulation of RAS by GAPs [NCBI:1269290] [REACTOME:R-HSA-5658442] [PUBMED:23443682]
Regulation of activated PAK-2p34 by proteasome mediated degradation [NCBI:1270296] [REACTOME:R-HSA-211733] [PUBMED:12853446] [PUBMED:9786869]
Regulation of mRNA stability by proteins that bind AU-rich elements [NCBI:1269725] [REACTOME:R-HSA-450531] [PUBMED:12440953] [PUBMED:12704645] [PUBMED:15460540] [PUBMED:16391004]
Regulation of mitotic cell cycle [NCBI:1269837] [REACTOME:R-HSA-453276]
Regulation of ornithine decarboxylase (ODC) [NCBI:1270174] [REACTOME:R-HSA-350562] [PUBMED:16459331] [PUBMED:16205122] [PUBMED:10623564]
Removal of licensing factors from origins [NCBI:1269796] [REACTOME:R-HSA-69300]
S Phase [NCBI:1269777] [REACTOME:R-HSA-69242]
SCF(Skp2)-mediated degradation of p27/p21 [NCBI:1269770] [REACTOME:R-HSA-187577] [PUBMED:7624798] [PUBMED:14532004] [PUBMED:12730199]
SCF-beta-TrCP mediated degradation of Emi1 [NCBI:1269841] [REACTOME:R-HSA-174113] [PUBMED:12791267]
SHC1 events in EGFR signaling [NCBI:1269383] [REACTOME:R-HSA-180336] [PUBMED:11498013] [PUBMED:8755247]
SOS-mediated signalling [NCBI:1269440] [REACTOME:R-HSA-112412]
Separation of Sister Chromatids [NCBI:1269826] [REACTOME:R-HSA-2467813] [PUBMED:11081627] [PUBMED:10411507] [PUBMED:12070128] [PUBMED:12194817] [PUBMED:11509732]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by EGFR [NCBI:1269380] [REACTOME:R-HSA-177929] [PUBMED:10459005] [PUBMED:10404636] [PUBMED:12297041] [PUBMED:15142631]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Signaling by Hedgehog [NCBI:1269633] [REACTOME:R-HSA-5358351] [PUBMED:19081070] [PUBMED:21801010] [PUBMED:15549094] [PUBMED:23719536]
Signaling by Insulin receptor [NCBI:1269428] [REACTOME:R-HSA-74752] [PUBMED:8276779]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
Signaling by Leptin [NCBI:1269632] [REACTOME:R-HSA-2586552] [PUBMED:22211890] [PUBMED:23562747] [PUBMED:20600241] [PUBMED:21622208] [PUBMED:23579596] [PUBMED:22458591] [PUBMED:21489811] [PUBMED:19724019] [PUBMED:21331644] [PUBMED:22448029] [PUBMED:21147620] [PUBMED:20198122] [PUBMED:21677426] [PUBMED:20029269] [PUBMED:22249808] [PUBMED:22991412] [PUBMED:21527729] [PUBMED:17937601] [PUBMED:20553370] [PUBMED:21713385] [PUBMED:23565489] [PUBMED:22289780]
Signaling by PDGF [NCBI:1269478] [REACTOME:R-HSA-186797] [PUBMED:15207811] [PUBMED:10508235] [PUBMED:9739761]
Signaling by SCF-KIT [NCBI:1269487] [REACTOME:R-HSA-1433557] [PUBMED:17350321] [PUBMED:16483568] [PUBMED:7688988] [PUBMED:19540337] [PUBMED:16475976] [PUBMED:15526160]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) [NCBI:1269617] [REACTOME:R-HSA-2404192] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22044904] [PUBMED:22649417]
Signaling by VEGF [NCBI:1269480] [REACTOME:R-HSA-194138] [PUBMED:15585754] [PUBMED:13678960] [PUBMED:16336962] [PUBMED:16835467]
Signaling by Wnt [NCBI:1269594] [REACTOME:R-HSA-195721] [PUBMED:19530173] [PUBMED:23256519] [PUBMED:22952392] [PUBMED:19204114] [PUBMED:19365405] [PUBMED:19619488] [PUBMED:17143292] [PUBMED:17230199] [PUBMED:18710302] [PUBMED:16099039] [PUBMED:20576942] [PUBMED:10858654] [PUBMED:12967557]
Signaling by the B Cell Receptor (BCR) [NCBI:1269183] [REACTOME:R-HSA-983705] [PUBMED:1702903] [PUBMED:2011584] [PUBMED:1081164] [PUBMED:19065780] [PUBMED:16849466] [PUBMED:1375264] [PUBMED:7538118] [PUBMED:11901194] [PUBMED:8580068] [PUBMED:19249086] [PUBMED:18596693] [PUBMED:10648173] [PUBMED:4589993] [PUBMED:8163536] [PUBMED:1376928] [PUBMED:7688784] [PUBMED:6335036] [PUBMED:17052215] [PUBMED:18818202] [PUBMED:20206686] [PUBMED:7592958] [PUBMED:7524079] [PUBMED:15489917] [PUBMED:15509800] [PUBMED:18187424] [PUBMED:7927516] [PUBMED:803528] [PUBMED:19909372] [PUBMED:20192804] [PUBMED:8306975]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Signalling to ERKs [NCBI:1269464] [REACTOME:R-HSA-187687] [PUBMED:10508738]
Signalling to RAS [NCBI:1269465] [REACTOME:R-HSA-167044] [PUBMED:11520933]
Signalling to p38 via RIT and RIN [NCBI:1269468] [REACTOME:R-HSA-187706] [PUBMED:10712923]
Stabilization of p53 [NCBI:1269746] [REACTOME:R-HSA-69541] [PUBMED:11331603] [PUBMED:10673500] [PUBMED:10673501] [PUBMED:10710310]
Switching of origins to a post-replicative state [NCBI:1269781] [REACTOME:R-HSA-69052]
Synthesis of DNA [NCBI:1269779] [REACTOME:R-HSA-69239]
TCF dependent signaling in response to WNT [NCBI:1269599] [REACTOME:R-HSA-201681] [PUBMED:19619488] [PUBMED:23256519] [PUBMED:23343194]
TCR signaling [NCBI:1269172] [REACTOME:R-HSA-202403] [PUBMED:10375551] [PUBMED:12876557] [PUBMED:9989491]
TNFR2 non-canonical NF-kB pathway [NCBI:1269329] [REACTOME:R-HSA-5668541] [PUBMED:19680262] [PUBMED:24298274] [PUBMED:21173796] [PUBMED:20489699] [PUBMED:24432023] [PUBMED:21232019] [PUBMED:22017430]
The role of GTSE1 in G2/M progression after G2 checkpoint [NCBI:1383017] [REACTOME:R-HSA-8852276] [PUBMED:10984615] [PUBMED:9724637] [PUBMED:20577264] [PUBMED:14707141] [PUBMED:23236459] [PUBMED:20018861] [PUBMED:12750368]
Transmembrane transport of small molecules [NCBI:1269903] [REACTOME:R-HSA-382551]
UCH proteinases [NCBI:1427861] [REACTOME:R-HSA-5689603] [PUBMED:16325574] [PUBMED:19243136]
Ub-specific processing proteases [NCBI:1427862] [REACTOME:R-HSA-5689880] [PUBMED:16325574]
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A [NCBI:1269752] [REACTOME:R-HSA-69601] [PUBMED:10828887]
Ubiquitin-dependent degradation of Cyclin D [NCBI:1269791] [REACTOME:R-HSA-75815] [PUBMED:9136925]
Ubiquitin-dependent degradation of Cyclin D1 [NCBI:1269792] [REACTOME:R-HSA-69229]
VEGFA-VEGFR2 Pathway [NCBI:1269483] [REACTOME:R-HSA-4420097] [PUBMED:17344076] [PUBMED:16633338] [PUBMED:19230644] [PUBMED:13678960]
VEGFR2 mediated cell proliferation [NCBI:1269485] [REACTOME:R-HSA-5218921] [PUBMED:22866201] [PUBMED:22180219] [PUBMED:22762016]
Vif-mediated degradation of APOBEC3G [NCBI:1269098] [REACTOME:R-HSA-180585] [PUBMED:15781449] [PUBMED:14564014] [PUBMED:14528300]
Vpu mediated degradation of CD4 [NCBI:1269107] [REACTOME:R-HSA-180534] [PUBMED:16354571] [PUBMED:15578980]
p53-Dependent G1 DNA Damage Response [NCBI:1269745] [REACTOME:R-HSA-69563] [PUBMED:9153396] [PUBMED:8247533] [PUBMED:1423616] [PUBMED:9153395]
p53-Dependent G1/S DNA damage checkpoint [NCBI:1269744] [REACTOME:R-HSA-69580] [PUBMED:1323840]
p53-Independent DNA Damage Response [NCBI:1269751] [REACTOME:R-HSA-69610] [PUBMED:11298456]
p53-Independent G1/S DNA damage checkpoint [NCBI:1269750] [REACTOME:R-HSA-69613] [PUBMED:10827953]