full name
complement C5

synonyms
C5a, C5b, CPAMD4, C5, ENSG00000106804

HGNC
HGNC:1331

Entrez Gene
Gene:727

ENSEMBL
ENSG00000106804

location
chr: 9
start: 123714613
stop: 123812554
strand: -

OMIM
OMIM:120900: C5 (Autosomal recessive inheritance)
OMIM:609536: C5 deficiency
OMIM:615749: [Eculizumab, poor response to]

transcripts
NM_001735.2

pathways
Activation of C3 and C5 [NCBI:1269248] [REACTOME:R-HSA-174577] [PUBMED:15199963] [PUBMED:458145]
Class A/1 (Rhodopsin-like receptors) [NCBI:1269545] [REACTOME:R-HSA-373076] [PUBMED:16902930]
Complement and coagulation cascades [NCBI:83073] [KEGG:hsa04610] [PUBMED:23564577] [PUBMED:25309880] [PUBMED:26082779] [PUBMED:23110467] [PUBMED:20027185] [PUBMED:25568220] [PUBMED:26324800] [PUBMED:25705421] [PUBMED:21811895] [PUBMED:23911436] [PUBMED:23564578] [PUBMED:24924409] [PUBMED:26489954] [PUBMED:17635716]
Complement cascade [NCBI:1269241] [REACTOME:R-HSA-166658] [PUBMED:3052276] [PUBMED:11044372] [PUBMED:11213801] [PUBMED:15476920] [PUBMED:14698228]
G alpha (i) signalling events [NCBI:1269576] [REACTOME:R-HSA-418594] [PUBMED:3113327] [PUBMED:9278091]
GPCR downstream signaling [NCBI:1269574] [REACTOME:R-HSA-388396] [PUBMED:12040175]
GPCR ligand binding [NCBI:1269544] [REACTOME:R-HSA-500792] [PUBMED:15251227]
Herpes simplex infection [NCBI:377873] [KEGG:hsa05168] [PUBMED:12224518] [PUBMED:17913820] [PUBMED:12844494] [PUBMED:10998601] [PUBMED:15163721] [PUBMED:19694546] [PUBMED:16297150] [PUBMED:14747533] [PUBMED:12826401] [PUBMED:14963113] [PUBMED:15056211] [PUBMED:12797447] [PUBMED:21107701] [PUBMED:10918307] [PUBMED:10696424] [PUBMED:16076403] [PUBMED:10364308] [PUBMED:17222692] [PUBMED:9621021] [PUBMED:12224508] [PUBMED:19879619] [PUBMED:11070032] [PUBMED:9499021] [PUBMED:18596690] [PUBMED:12525427] [PUBMED:12224517] [PUBMED:10196275] [PUBMED:15047834] [PUBMED:18508584] [PUBMED:20036979]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Peptide ligand-binding receptors [NCBI:1269546] [REACTOME:R-HSA-375276] [PUBMED:14576899] [PUBMED:10977869] [PUBMED:16918325] [PUBMED:16847439] [PUBMED:17293890] [PUBMED:15734727] [PUBMED:12895595] [PUBMED:17604107] [PUBMED:14507421] [PUBMED:12432945] [PUBMED:16612131]
Pertussis [NCBI:218111] [KEGG:hsa05133] [PUBMED:20610650] [PUBMED:12701623] [PUBMED:15201703] [PUBMED:18401006] [PUBMED:20210554] [PUBMED:16622221] [PUBMED:17148436] [PUBMED:21204863] [PUBMED:20404851] [PUBMED:10540218] [PUBMED:16999837] [PUBMED:16481212] [PUBMED:16863919] [PUBMED:16390441] [PUBMED:21423776] [PUBMED:17328678] [PUBMED:12915094]
Prion diseases [NCBI:101144] [KEGG:hsa05020] [PUBMED:15695097] [PUBMED:18558863] [PUBMED:11592845] [PUBMED:15528202] [PUBMED:17051207] [PUBMED:18245809] [PUBMED:14705136] [PUBMED:10398674] [PUBMED:15890824] [PUBMED:14661267] [PUBMED:15611724] [PUBMED:15342004] [PUBMED:18391177] [PUBMED:17085779] [PUBMED:12850426]
Regulation of Complement cascade [NCBI:1269250] [REACTOME:R-HSA-977606] [PUBMED:19730437] [PUBMED:20720586] [PUBMED:15476920]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Staphylococcus aureus infection [NCBI:172846] [KEGG:hsa05150] [PUBMED:18837785] [PUBMED:16679003] [PUBMED:18544012] [PUBMED:15372083] [PUBMED:19112495] [PUBMED:16640587] [PUBMED:15561843] [PUBMED:16322743] [PUBMED:16710608] [PUBMED:16111912] [PUBMED:11361034] [PUBMED:12091905] [PUBMED:16724100] [PUBMED:16242332] [PUBMED:17132726] [PUBMED:20178484] [PUBMED:16086019] [PUBMED:12228315] [PUBMED:19503103] [PUBMED:14993252] [PUBMED:18061675] [PUBMED:17114475] [PUBMED:17848512] [PUBMED:17517597] [PUBMED:20133685] [PUBMED:18045383] [PUBMED:16184199] [PUBMED:17893203] [PUBMED:20062962] [PUBMED:15273292]
Systemic lupus erythematosus [NCBI:83122] [KEGG:hsa05322] [PUBMED:12835292] [PUBMED:12965173] [PUBMED:16932712] [PUBMED:10025913] [PUBMED:15972354] [PUBMED:17943287] [PUBMED:10430616] [PUBMED:18305268] [PUBMED:15380523] [PUBMED:8048228] [PUBMED:15459673]
Terminal pathway of complement [NCBI:1269249] [REACTOME:R-HSA-166665]