full name
heat shock protein family A (Hsp70) member 5

synonyms
BIP, GRP78, MIF2, HSPA5, ENSG00000044574

HGNC
HGNC:5238

Entrez Gene
Gene:3309

ENSEMBL
ENSG00000044574

location
chr: 9
start: 127997127
stop: 128003666
strand: -

transcripts
NM_005347.4

pathways
ATF6 (ATF6-alpha) activates chaperone genes [NCBI:1268758] [REACTOME:R-HSA-381183] [PUBMED:10866666] [PUBMED:14973138] [PUBMED:12014989] [PUBMED:25821458] [PUBMED:10856300] [PUBMED:10958673]
ATF6 (ATF6-alpha) activates chaperones [NCBI:1268757] [REACTOME:R-HSA-381033] [PUBMED:25821458] [PUBMED:18048764] [PUBMED:18038217] [PUBMED:18436705]
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Antigen Presentation: Folding, assembly and peptide loading of class I MHC [NCBI:1269194] [REACTOME:R-HSA-983170] [PUBMED:19178136] [PUBMED:18926908] [PUBMED:12495737] [PUBMED:15224092] [PUBMED:18641646]
Antigen processing and presentation [NCBI:83074] [KEGG:hsa04612] [PUBMED:12776207] [PUBMED:15653315] [PUBMED:15814328] [PUBMED:20010787] [PUBMED:15224094] [PUBMED:15745856] [PUBMED:11244040] [PUBMED:15304636] [PUBMED:11905820] [PUBMED:16181333] [PUBMED:16200082] [PUBMED:15653312] [PUBMED:15224093] [PUBMED:15771591] [PUBMED:12974477]
Cellular response to heat stress [NCBI:1270421] [REACTOME:R-HSA-3371556] [PUBMED:8455624] [PUBMED:8441385]
Cellular responses to stress [NCBI:1270414] [REACTOME:R-HSA-2262752] [PUBMED:15709958]
Class I MHC mediated antigen processing & presentation [NCBI:1269192] [REACTOME:R-HSA-983169] [PUBMED:8717519] [PUBMED:17145306] [PUBMED:18926908] [PUBMED:17055423] [PUBMED:12495737] [PUBMED:18641646] [PUBMED:18243674]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
IRE1alpha activates chaperones [NCBI:1268759] [REACTOME:R-HSA-381070] [PUBMED:18048764] [PUBMED:18038217] [PUBMED:18436705]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
PERK regulates gene expression [NCBI:1268761] [REACTOME:R-HSA-381042] [PUBMED:18048764] [PUBMED:17956313] [PUBMED:18038217] [PUBMED:18436705]
Platelet activation, signaling and aggregation [NCBI:1269350] [REACTOME:R-HSA-76002] [PUBMED:16543958] [PUBMED:8704248] [PUBMED:2018971] [PUBMED:1672265] [PUBMED:17059469] [PUBMED:12681240] [PUBMED:12411949] [PUBMED:11511514]
Platelet degranulation [NCBI:1269367] [REACTOME:R-HSA-114608] [PUBMED:14630798]
Prion diseases [NCBI:101144] [KEGG:hsa05020] [PUBMED:15695097] [PUBMED:18558863] [PUBMED:11592845] [PUBMED:15528202] [PUBMED:17051207] [PUBMED:18245809] [PUBMED:14705136] [PUBMED:10398674] [PUBMED:15890824] [PUBMED:14661267] [PUBMED:15611724] [PUBMED:15342004] [PUBMED:18391177] [PUBMED:17085779] [PUBMED:12850426]
Protein export [NCBI:83041] [KEGG:hsa03060] [PUBMED:10652088] [PUBMED:12475201] [PUBMED:15063851] [PUBMED:10924740] [PUBMED:17368028] [PUBMED:10087917] [PUBMED:16212506] [PUBMED:19299134] [PUBMED:17259602] [PUBMED:18046402] [PUBMED:10747959] [PUBMED:11007775]
Protein processing in endoplasmic reticulum [NCBI:167325] [KEGG:hsa04141] [PUBMED:20347046] [PUBMED:18023214] [PUBMED:20219571] [PUBMED:19491040] [PUBMED:20112977]
Regulation of HSF1-mediated heat shock response [NCBI:1270425] [REACTOME:R-HSA-3371453] [PUBMED:7623826]
Response to elevated platelet cytosolic Ca2+ [NCBI:1269365] [REACTOME:R-HSA-76005] [PUBMED:8424766]
Thyroid hormone synthesis [NCBI:835410] [KEGG:hsa04918] [PUBMED:21448409] [PUBMED:9086577] [PUBMED:21986207] [PUBMED:11137035] [PUBMED:17666482] [PUBMED:20407074] [PUBMED:20093166] [PUBMED:20122987] [PUBMED:15611820] [PUBMED:20378719] [PUBMED:23438835] [PUBMED:11717564] [PUBMED:16870170] [PUBMED:19196800] [PUBMED:9538302] [PUBMED:11029276] [PUBMED:20167242] [PUBMED:10893432] [PUBMED:21683758]
Unfolded Protein Response (UPR) [NCBI:1268756] [REACTOME:R-HSA-381119] [PUBMED:18436705] [PUBMED:18038217] [PUBMED:27067637] [PUBMED:16365312] [PUBMED:18048764] [PUBMED:15952902]