full name
glutamate ionotropic receptor NMDA type subunit 1
synonyms
GluN1, MRD8, NMDA1, NMDAR1, NR1, GRIN1, ENSG00000176884
HGNC
HGNC:4584
Entrez Gene
Gene:2902
ENSEMBL
ENSG00000176884
location
chr: 9
start: 140033609
stop: 140063214
strand: +
OMIM
OMIM:138249:
GRIN1
(Autosomal dominant inheritance)
OMIM:614254:
Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant
OMIM:617820:
Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive
transcripts
NM_001185090.1
NM_001185091.1
NM_007327.3
NM_021569.3
NM_000832.6
pathways
ARMS-mediated activation
[NCBI:1269471]
[REACTOME:R-HSA-170984]
[PUBMED:9069267]
Activation of NMDA receptor upon glutamate binding and postsynaptic events
[NCBI:1268798]
[REACTOME:R-HSA-442755]
[PUBMED:18616423]
Alcoholism
[NCBI:585563]
[KEGG:hsa05034]
[PUBMED:16764827]
[PUBMED:18616668]
[PUBMED:19077056]
[PUBMED:18991950]
[PUBMED:19756388]
[PUBMED:12068305]
[PUBMED:16102840]
[PUBMED:20947635]
[PUBMED:20729980]
[PUBMED:16278489]
[PUBMED:17270154]
[PUBMED:20626732]
[PUBMED:18310464]
[PUBMED:10774721]
[PUBMED:19342616]
[PUBMED:12605085]
[PUBMED:15500908]
[PUBMED:14729391]
[PUBMED:12085089]
[PUBMED:16776597]
Alzheimer's disease
[NCBI:83097]
[KEGG:hsa05010]
[PUBMED:18782350]
[PUBMED:18035450]
[PUBMED:15177383]
[PUBMED:10527810]
[PUBMED:15363492]
[PUBMED:16677790]
[PUBMED:15295589]
[PUBMED:17055782]
[PUBMED:15864339]
[PUBMED:15750290]
[PUBMED:18675468]
[PUBMED:15232608]
[PUBMED:9848086]
[PUBMED:11484003]
[PUBMED:10830966]
[PUBMED:16529745]
[PUBMED:17568632]
Amphetamine addiction
[NCBI:547607]
[KEGG:hsa05031]
[PUBMED:16776597]
[PUBMED:18617632]
[PUBMED:16724157]
[PUBMED:19222557]
[PUBMED:14746512]
[PUBMED:18632938]
[PUBMED:8630246]
[PUBMED:14622123]
[PUBMED:21338876]
[PUBMED:8753884]
[PUBMED:10774721]
[PUBMED:14529709]
[PUBMED:17728700]
[PUBMED:21989194]
[PUBMED:16151049]
[PUBMED:18440072]
[PUBMED:19199083]
[PUBMED:10414964]
Amyotrophic lateral sclerosis (ALS)
[NCBI:83099]
[KEGG:hsa05014]
[PUBMED:16026864]
[PUBMED:16924260]
[PUBMED:11513882]
[PUBMED:17015226]
[PUBMED:16723044]
[PUBMED:10970056]
[PUBMED:16909020]
[PUBMED:12531867]
[PUBMED:16713195]
[PUBMED:16603792]
[PUBMED:11870681]
[PUBMED:16050975]
[PUBMED:17409386]
[PUBMED:11239414]
[PUBMED:18519638]
[PUBMED:14569202]
[PUBMED:12728264]
[PUBMED:11715057]
[PUBMED:17566607]
[PUBMED:17434459]
[PUBMED:16909017]
[PUBMED:12595144]
[PUBMED:15310460]
[PUBMED:14739060]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
CREB phosphorylation through the activation of CaMKII
[NCBI:1268805]
[REACTOME:R-HSA-442729]
[PUBMED:16799259]
CREB phosphorylation through the activation of Ras
[NCBI:1268801]
[REACTOME:R-HSA-442742]
[PUBMED:12819448]
Calcium signaling pathway
[NCBI:83050]
[KEGG:hsa04020]
[PUBMED:11080247]
[PUBMED:14572802]
[PUBMED:11413485]
[PUBMED:22129055]
[PUBMED:10508738]
[PUBMED:15000521]
[PUBMED:9235901]
[PUBMED:7861177]
[PUBMED:9149541]
[PUBMED:14517314]
[PUBMED:15111104]
[PUBMED:11698232]
[PUBMED:10331643]
[PUBMED:12838335]
[PUBMED:8125957]
[PUBMED:19172794]
[PUBMED:10997573]
[PUBMED:21338471]
[PUBMED:11299192]
[PUBMED:22002090]
[PUBMED:12972622]
Circadian entrainment
[NCBI:698773]
[KEGG:hsa04713]
[PUBMED:15016477]
[PUBMED:12700026]
[PUBMED:20605968]
[PUBMED:15813931]
[PUBMED:15930378]
[PUBMED:12573527]
[PUBMED:17586087]
[PUBMED:20664079]
[PUBMED:17646042]
[PUBMED:17167088]
[PUBMED:16217123]
[PUBMED:11294753]
[PUBMED:19109992]
[PUBMED:10446325]
[PUBMED:10208575]
[PUBMED:11086993]
[PUBMED:19449447]
Cocaine addiction
[NCBI:546258]
[KEGG:hsa05030]
[PUBMED:15091342]
[PUBMED:16278489]
[PUBMED:14566342]
[PUBMED:12064476]
[PUBMED:16251986]
[PUBMED:18440072]
[PUBMED:19403004]
[PUBMED:11595774]
[PUBMED:11268215]
[PUBMED:15582154]
[PUBMED:12818179]
[PUBMED:14746512]
[PUBMED:10234039]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
DAP12 interactions
[NCBI:1269283]
[REACTOME:R-HSA-2172127]
[PUBMED:19120482]
[PUBMED:17220916]
[PUBMED:9490415]
[PUBMED:18192027]
[PUBMED:15884055]
DAP12 signaling
[NCBI:1269284]
[REACTOME:R-HSA-2424491]
[PUBMED:15884055]
[PUBMED:17110943]
[PUBMED:17220916]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
Downstream signal transduction
[NCBI:1269479]
[REACTOME:R-HSA-186763]
[PUBMED:10508235]
[PUBMED:9739761]
EPH-Ephrin signaling
[NCBI:1270330]
[REACTOME:R-HSA-2682334]
[PUBMED:18281458]
[PUBMED:22120527]
EPHB-mediated forward signaling
[NCBI:1270332]
[REACTOME:R-HSA-3928662]
[PUBMED:12808016]
FCERI mediated MAPK activation
[NCBI:1269299]
[REACTOME:R-HSA-2871796]
[PUBMED:19290926]
[PUBMED:19909365]
[PUBMED:17122878]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
Frs2-mediated activation
[NCBI:1269470]
[REACTOME:R-HSA-170968]
[PUBMED:9069267]
GRB2 events in EGFR signaling
[NCBI:1269382]
[REACTOME:R-HSA-179812]
[PUBMED:11706405]
[PUBMED:11498013]
Gastrin-CREB signalling pathway via PKC and MAPK
[NCBI:1269592]
[REACTOME:R-HSA-881907]
[PUBMED:10413847]
[PUBMED:7491953]
[PUBMED:17698287]
Glutamatergic synapse
[NCBI:213818]
[KEGG:hsa04724]
[PUBMED:10481192]
[PUBMED:11561058]
[PUBMED:18425072]
[PUBMED:17706608]
[PUBMED:20055706]
[PUBMED:19112153]
[PUBMED:17663464]
[PUBMED:19110202]
[PUBMED:19559598]
[PUBMED:9665875]
[PUBMED:11672421]
[PUBMED:18464791]
[PUBMED:12399578]
[PUBMED:14684436]
Huntington's disease
[NCBI:83100]
[KEGG:hsa05016]
[PUBMED:15336977]
[PUBMED:11738471]
[PUBMED:11807533]
[PUBMED:15996546]
[PUBMED:14526190]
[PUBMED:15242639]
[PUBMED:17041811]
[PUBMED:15996541]
[PUBMED:18951640]
[PUBMED:15459747]
[PUBMED:16288298]
[PUBMED:17081970]
[PUBMED:15695335]
[PUBMED:12372277]
[PUBMED:11839795]
IGF1R signaling cascade
[NCBI:1269618]
[REACTOME:R-HSA-2428924]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
IRS-mediated signalling
[NCBI:1269431]
[REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R
[NCBI:1269620]
[REACTOME:R-HSA-2428928]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:18927274]
[PUBMED:21042815]
[PUBMED:20098959]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Insulin receptor signalling cascade
[NCBI:1269429]
[REACTOME:R-HSA-74751]
[PUBMED:9677303]
[PUBMED:11282018]
Interactions of neurexins and neuroligins at synapses
[NCBI:1427850]
[REACTOME:R-HSA-6794361]
[PUBMED:22424845]
[PUBMED:23559421]
[PUBMED:21155806]
[PUBMED:17299456]
[PUBMED:17275284]
Interleukin receptor SHC signaling
[NCBI:1269322]
[REACTOME:R-HSA-912526]
[PUBMED:8294403]
Interleukin-2 signaling
[NCBI:1269321]
[REACTOME:R-HSA-451927]
[PUBMED:17936914]
[PUBMED:18817510]
[PUBMED:19543225]
[PUBMED:18062768]
Interleukin-3, 5 and GM-CSF signaling
[NCBI:1269323]
[REACTOME:R-HSA-512988]
[PUBMED:10450743]
[PUBMED:9766809]
Long-term potentiation
[NCBI:83085]
[KEGG:hsa04720]
[PUBMED:9697848]
[PUBMED:15652868]
[PUBMED:15803158]
[PUBMED:11378299]
[PUBMED:10652548]
[PUBMED:15857686]
[PUBMED:14715912]
MAPK family signaling cascades
[NCBI:1269501]
[REACTOME:R-HSA-5683057]
[PUBMED:21167873]
[PUBMED:17161475]
[PUBMED:22535895]
[PUBMED:21372320]
MAPK1/MAPK3 signaling
[NCBI:1269502]
[REACTOME:R-HSA-5684996]
[PUBMED:25378393]
[PUBMED:18199641]
[PUBMED:17496909]
[PUBMED:21779496]
[PUBMED:15520807]
[PUBMED:16393692]
[PUBMED:19520853]
[PUBMED:17496910]
[PUBMED:22569528]
NCAM signaling for neurite out-growth
[NCBI:1270312]
[REACTOME:R-HSA-375165]
[PUBMED:18760361]
[PUBMED:12587671]
[PUBMED:15662836]
[PUBMED:17975827]
[PUBMED:15153429]
[PUBMED:12700044]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
Neuroactive ligand-receptor interaction
[NCBI:83053]
[KEGG:hsa04080]
Neuronal System
[NCBI:1268763]
[REACTOME:R-HSA-112316]
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
[NCBI:1268786]
[REACTOME:R-HSA-112314]
Nicotine addiction
[NCBI:583255]
[KEGG:hsa05033]
[PUBMED:19498417]
[PUBMED:15661626]
[PUBMED:12436424]
[PUBMED:19669944]
[PUBMED:19434058]
[PUBMED:19184650]
[PUBMED:15165747]
[PUBMED:12716925]
[PUBMED:18723034]
[PUBMED:18640919]
[PUBMED:11906697]
[PUBMED:14708004]
[PUBMED:17009926]
[PUBMED:14747518]
[PUBMED:20485364]
[PUBMED:16251989]
[PUBMED:20833261]
Post NMDA receptor activation events
[NCBI:1268800]
[REACTOME:R-HSA-438064]
[PUBMED:18616423]
Prolonged ERK activation events
[NCBI:1269469]
[REACTOME:R-HSA-169893]
[PUBMED:12765839]
[PUBMED:9069267]
Protein-protein interactions at synapses
[NCBI:1427849]
[REACTOME:R-HSA-6794362]
[PUBMED:18923512]
[PUBMED:16337696]
[PUBMED:17299456]
RAF/MAP kinase cascade
[NCBI:1269285]
[REACTOME:R-HSA-5673001]
[PUBMED:21167873]
[PUBMED:24937142]
[PUBMED:20674547]
[PUBMED:17496910]
[PUBMED:22177953]
[PUBMED:17496919]
[PUBMED:22569528]
[PUBMED:22535895]
[PUBMED:12068308]
[PUBMED:17496923]
[PUBMED:19091303]
[PUBMED:21372320]
[PUBMED:21388974]
[PUBMED:15520807]
RET signaling
[NCBI:1427866]
[REACTOME:R-HSA-8853659]
[PUBMED:15013219]
[PUBMED:17036197]
Rap1 signaling pathway
[NCBI:868086]
[KEGG:hsa04015]
[PUBMED:17624944]
[PUBMED:12351703]
[PUBMED:10579920]
[PUBMED:19159611]
[PUBMED:18363565]
[PUBMED:12765839]
[PUBMED:12508104]
[PUBMED:11331911]
[PUBMED:17182900]
[PUBMED:15803158]
[PUBMED:19615876]
[PUBMED:21402149]
[PUBMED:17624948]
[PUBMED:17383543]
[PUBMED:14607972]
[PUBMED:15780587]
[PUBMED:19710505]
Ras activation uopn Ca2+ infux through NMDA receptor
[NCBI:1268802]
[REACTOME:R-HSA-442982]
[PUBMED:14622581]
Ras signaling pathway
[NCBI:868085]
[KEGG:hsa04014]
[PUBMED:23506953]
[PUBMED:18437264]
[PUBMED:15062121]
[PUBMED:22189424]
[PUBMED:22233291]
[PUBMED:12778136]
[PUBMED:11313946]
[PUBMED:17428555]
[PUBMED:19091743]
[PUBMED:18568040]
[PUBMED:20420946]
[PUBMED:12217381]
[PUBMED:14663478]
[PUBMED:21686117]
[PUBMED:12642680]
[PUBMED:21196257]
[PUBMED:16869784]
[PUBMED:21111786]
[PUBMED:16966426]
[PUBMED:10712923]
[PUBMED:22020205]
[PUBMED:17384584]
[PUBMED:15572660]
[PUBMED:18413813]
SALM protein interactions at the synapses
[NCBI:1383059]
[REACTOME:R-HSA-8849932]
[PUBMED:22046028]
[PUBMED:16630835]
[PUBMED:21736948]
SHC1 events in EGFR signaling
[NCBI:1269383]
[REACTOME:R-HSA-180336]
[PUBMED:11498013]
[PUBMED:8755247]
SOS-mediated signalling
[NCBI:1269440]
[REACTOME:R-HSA-112412]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by EGFR
[NCBI:1269380]
[REACTOME:R-HSA-177929]
[PUBMED:10459005]
[PUBMED:10404636]
[PUBMED:12297041]
[PUBMED:15142631]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signaling by Insulin receptor
[NCBI:1269428]
[REACTOME:R-HSA-74752]
[PUBMED:8276779]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signaling by Leptin
[NCBI:1269632]
[REACTOME:R-HSA-2586552]
[PUBMED:22211890]
[PUBMED:23562747]
[PUBMED:20600241]
[PUBMED:21622208]
[PUBMED:23579596]
[PUBMED:22458591]
[PUBMED:21489811]
[PUBMED:19724019]
[PUBMED:21331644]
[PUBMED:22448029]
[PUBMED:21147620]
[PUBMED:20198122]
[PUBMED:21677426]
[PUBMED:20029269]
[PUBMED:22249808]
[PUBMED:22991412]
[PUBMED:21527729]
[PUBMED:17937601]
[PUBMED:20553370]
[PUBMED:21713385]
[PUBMED:23565489]
[PUBMED:22289780]
Signaling by PDGF
[NCBI:1269478]
[REACTOME:R-HSA-186797]
[PUBMED:15207811]
[PUBMED:10508235]
[PUBMED:9739761]
Signaling by SCF-KIT
[NCBI:1269487]
[REACTOME:R-HSA-1433557]
[PUBMED:17350321]
[PUBMED:16483568]
[PUBMED:7688988]
[PUBMED:19540337]
[PUBMED:16475976]
[PUBMED:15526160]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
[NCBI:1269617]
[REACTOME:R-HSA-2404192]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22044904]
[PUBMED:22649417]
Signaling by VEGF
[NCBI:1269480]
[REACTOME:R-HSA-194138]
[PUBMED:15585754]
[PUBMED:13678960]
[PUBMED:16336962]
[PUBMED:16835467]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Signalling to ERKs
[NCBI:1269464]
[REACTOME:R-HSA-187687]
[PUBMED:10508738]
Signalling to RAS
[NCBI:1269465]
[REACTOME:R-HSA-167044]
[PUBMED:11520933]
Signalling to p38 via RIT and RIN
[NCBI:1269468]
[REACTOME:R-HSA-187706]
[PUBMED:10712923]
Transmission across Chemical Synapses
[NCBI:1268766]
[REACTOME:R-HSA-112315]
Unblocking of NMDA receptor, glutamate binding and activation
[NCBI:1268799]
[REACTOME:R-HSA-438066]
[PUBMED:9481670]
VEGFA-VEGFR2 Pathway
[NCBI:1269483]
[REACTOME:R-HSA-4420097]
[PUBMED:17344076]
[PUBMED:16633338]
[PUBMED:19230644]
[PUBMED:13678960]
VEGFR2 mediated cell proliferation
[NCBI:1269485]
[REACTOME:R-HSA-5218921]
[PUBMED:22866201]
[PUBMED:22180219]
[PUBMED:22762016]
cAMP signaling pathway
[NCBI:1017634]
[KEGG:hsa04024]
[PUBMED:10880354]
[PUBMED:9204709]
[PUBMED:21693691]
[PUBMED:24062645]
[PUBMED:24450633]
[PUBMED:21346730]
[PUBMED:24613710]
[PUBMED:21744067]
[PUBMED:22082266]
[PUBMED:16460276]
[PUBMED:18176800]
[PUBMED:14715909]
[PUBMED:7688165]
[PUBMED:24281338]
[PUBMED:11117527]
[PUBMED:16765984]
[PUBMED:18323530]
[PUBMED:18064650]
[PUBMED:21852968]
[PUBMED:11493633]
[PUBMED:21212391]
[PUBMED:15142747]
[PUBMED:17077866]
[PUBMED:19460777]
[PUBMED:19874988]
[PUBMED:16571352]
[PUBMED:22022314]
