Logo
full name
arachidonate 5-lipoxygenase

synonyms
5-LO, 5-LOX, 5LPG, LOG5, ALOX5, ENSG00000012779

HGNC
HGNC:435

Entrez Gene
Gene:240

ENSEMBL
ENSG00000012779
ENSG00000262552

location
chr: 10
start: 45869624
stop: 45941569
strand: +

OMIM
OMIM:152390: ALOX5
OMIM:600807: {Asthma, diminished response to antileukotriene treatment in}

transcripts
NM_000698.3
NM_001256154.1
NM_001256153.1

pathways
Arachidonic acid metabolism [NCBI:82991] [KEGG:hsa00590] [NCBI:1270087] [REACTOME:R-HSA-2142753] [PUBMED:14622984] [PUBMED:15292194] [PUBMED:10908295] [PUBMED:15205388] [PUBMED:9812980] [PUBMED:14660610] [PUBMED:11328810] [PUBMED:14636671] [PUBMED:14626496] [PUBMED:11679404] [PUBMED:19244215]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
Fc epsilon RI signaling pathway [NCBI:83082] [KEGG:hsa04664] [PUBMED:16470226] [PUBMED:12145654] [PUBMED:11079101] [PUBMED:10586892] [PUBMED:14630197] [PUBMED:12360215] [PUBMED:11449275]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Interleukin-4 and 13 signaling [NCBI:1470923] [REACTOME:R-HSA-6785807] [PUBMED:12704343] [PUBMED:10358772]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Neutrophil degranulation [NCBI:1457780] [REACTOME:R-HSA-6798695] [PUBMED:20338884] [PUBMED:1378856] [PUBMED:17627888] [PUBMED:23650620] [PUBMED:8692836]
Ovarian steroidogenesis [NCBI:790011] [KEGG:hsa04913] [PUBMED:11883103] [PUBMED:11408113] [PUBMED:16603089] [PUBMED:15831519] [PUBMED:11447221] [PUBMED:20628033] [PUBMED:10630400] [PUBMED:18440223] [PUBMED:20937107] [PUBMED:11704115] [PUBMED:17003287] [PUBMED:17008391] [PUBMED:15541573] [PUBMED:21862696] [PUBMED:16414178] [PUBMED:14769828]
Serotonergic synapse [NCBI:525336] [KEGG:hsa04726] [PUBMED:9658404] [PUBMED:15034221] [PUBMED:11043573] [PUBMED:9651340] [PUBMED:9542727] [PUBMED:18676031] [PUBMED:12543273] [PUBMED:15710402] [PUBMED:16826372] [PUBMED:19545642] [PUBMED:11916537] [PUBMED:11701344] [PUBMED:12676358] [PUBMED:20561690] [PUBMED:16896947]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
Synthesis of 5-eicosatetraenoic acids [NCBI:1270090] [REACTOME:R-HSA-2142688] [PUBMED:19244215]
Synthesis of Leukotrienes (LT) and Eoxins (EX) [NCBI:1270089] [REACTOME:R-HSA-2142691] [PUBMED:6311078] [PUBMED:19130894] [PUBMED:17623009] [PUBMED:19244215]
Synthesis of Lipoxins (LX) [NCBI:1270093] [REACTOME:R-HSA-2142700] [PUBMED:19244215] [PUBMED:16968948]
Toxoplasmosis [NCBI:169642] [KEGG:hsa05145] [PUBMED:18617274] [PUBMED:19400868] [PUBMED:17024357] [PUBMED:19744886] [PUBMED:19891610] [PUBMED:17110955] [PUBMED:12106793] [PUBMED:12580944] [PUBMED:12857995] [PUBMED:10234174] [PUBMED:18327664] [PUBMED:10525166] [PUBMED:18059289] [PUBMED:18775432] [PUBMED:14642303] [PUBMED:15361242] [PUBMED:16339966] [PUBMED:14987366] [PUBMED:15639739]
aspirin triggered resolvin D biosynthesis [NCBI:782385] [BIOCYC:HUMAN_PWY66-395] [PUBMED:15726828] [PUBMED:12590139]
aspirin triggered resolvin E biosynthesis [NCBI:782386] [BIOCYC:HUMAN_PWY66-394] [PUBMED:16112645] [PUBMED:21206090] [PUBMED:15753205] [PUBMED:16757471] [PUBMED:22450811] [PUBMED:17114001] [PUBMED:15726828] [PUBMED:15890784]
aspirin-triggered lipoxin biosynthesis [NCBI:782387] [BIOCYC:HUMAN_PWY66-393] [PUBMED:7568157] [PUBMED:16968948] [PUBMED:21071715]
leukotriene biosynthesis [NCBI:545300] [BIOCYC:HUMAN_PWY66-375] [PUBMED:20097252] [PUBMED:14770184] [PUBMED:11729303]
lipoxin biosynthesis [NCBI:835386] [BIOCYC:HUMAN_PWY66-392] [PUBMED:10657608] [PUBMED:16968948] [PUBMED:2548801] [PUBMED:8376607] [PUBMED:8326019] [PUBMED:9112289] [PUBMED:1381961]
resolvin D biosynthesis [NCBI:782384] [BIOCYC:HUMAN_PWY66-397] [PUBMED:15726828] [PUBMED:12590139]