full name
ubiquitin conjugating enzyme E2 D1

synonyms
E2%2817%29KB1, SFT, UBC4%2F5, UBCH5, UBCH5A, UBE2D1, ENSG00000072401

HGNC
HGNC:12474

Entrez Gene
Gene:7321

ENSEMBL
ENSG00000072401

location
chr: 10
start: 60094739
stop: 60130513
strand: +

transcripts
NM_003338.4
NM_001204880.1

pathways
APC-Cdc20 mediated degradation of Nek2A [NCBI:1269847] [REACTOME:R-HSA-179409] [PUBMED:11742988] [PUBMED:16648845]
APC/C-mediated degradation of cell cycle proteins [NCBI:1269838] [REACTOME:R-HSA-174143] [PUBMED:15678131] [PUBMED:12049731]
APC/C:Cdc20 mediated degradation of Cyclin B [NCBI:1269848] [REACTOME:R-HSA-174048] [PUBMED:11285280]
APC/C:Cdc20 mediated degradation of Securin [NCBI:1269849] [REACTOME:R-HSA-174154] [PUBMED:12070128] [PUBMED:10827941]
APC/C:Cdc20 mediated degradation of mitotic proteins [NCBI:1269844] [REACTOME:R-HSA-176409] [PUBMED:15949434] [PUBMED:10465783]
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 [NCBI:1269851] [REACTOME:R-HSA-174178] [PUBMED:16413484] [PUBMED:15678131]
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint [NCBI:1269845] [REACTOME:R-HSA-179419]
Activated TLR4 signalling [NCBI:1269236] [REACTOME:R-HSA-166054] [PUBMED:15276183] [PUBMED:15588429] [PUBMED:15845500] [PUBMED:15596121]
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins [NCBI:1269842] [REACTOME:R-HSA-176814] [PUBMED:15678131]
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Antigen processing: Ubiquitination & Proteasome degradation [NCBI:1269193] [REACTOME:R-HSA-983168] [PUBMED:12648452] [PUBMED:11917093] [PUBMED:19489725] [PUBMED:14734113] [PUBMED:20351195] [PUBMED:17145306]
Autodegradation of Cdh1 by Cdh1:APC/C [NCBI:1269852] [REACTOME:R-HSA-174084] [PUBMED:15029244]
C-type lectin receptors (CLRs) [NCBI:1269303] [REACTOME:R-HSA-5621481] [PUBMED:19521399] [PUBMED:24330199]
CLEC7A (Dectin-1) signaling [NCBI:1269304] [REACTOME:R-HSA-5607764] [PUBMED:12719478] [PUBMED:19223162]
Cdc20:Phospho-APC/C mediated degradation of Cyclin A [NCBI:1269846] [REACTOME:R-HSA-174184] [PUBMED:11285280]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints [NCBI:1269742] [REACTOME:R-HSA-69620]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Cellular Senescence [NCBI:1270426] [REACTOME:R-HSA-2559583] [PUBMED:21078816] [PUBMED:18711403] [PUBMED:22048312] [PUBMED:19818705] [PUBMED:17662938] [PUBMED:23746838] [PUBMED:9282108] [PUBMED:17667954] [PUBMED:13905658]
Cellular response to hypoxia [NCBI:1270415] [REACTOME:R-HSA-2262749] [PUBMED:15304631]
Cellular responses to stress [NCBI:1270414] [REACTOME:R-HSA-2262752] [PUBMED:15709958]
Class I MHC mediated antigen processing & presentation [NCBI:1269192] [REACTOME:R-HSA-983169] [PUBMED:8717519] [PUBMED:17145306] [PUBMED:18926908] [PUBMED:17055423] [PUBMED:12495737] [PUBMED:18641646] [PUBMED:18243674]
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase [NCBI:1269850] [REACTOME:R-HSA-176407] [PUBMED:15678131]
Deubiquitination [NCBI:1427860] [REACTOME:R-HSA-5688426] [PUBMED:19243136] [PUBMED:20074029] [PUBMED:15571815] [PUBMED:20418328] [PUBMED:16325574] [PUBMED:12944365] [PUBMED:23845989] [PUBMED:22201797]
Downregulation of SMAD2/3:SMAD4 transcriptional activity [NCBI:1269529] [REACTOME:R-HSA-2173795] [PUBMED:19917253] [PUBMED:11389444] [PUBMED:10535941] [PUBMED:10199400] [PUBMED:16751101] [PUBMED:17591695] [PUBMED:10485843] [PUBMED:21095583] [PUBMED:11427533] [PUBMED:19135894] [PUBMED:10531062] [PUBMED:22045334] [PUBMED:10549282]
Downstream TCR signaling [NCBI:1269176] [REACTOME:R-HSA-202424] [PUBMED:15084594]
E3 ubiquitin ligases ubiquitinate target proteins [NCBI:1470927] [REACTOME:R-HSA-8866654] [PUBMED:23747565] [PUBMED:27312108] [PUBMED:24699078] [PUBMED:19489725] [PUBMED:23912815] [PUBMED:22389392] [PUBMED:17588513] [PUBMED:19436320] [PUBMED:23732108] [PUBMED:19754430] [PUBMED:23624913] [PUBMED:23657496] [PUBMED:26085183]
FCERI mediated NF-kB activation [NCBI:1269301] [REACTOME:R-HSA-2871837] [PUBMED:17336609] [PUBMED:16432253]
Fc epsilon receptor (FCERI) signaling [NCBI:1269298] [REACTOME:R-HSA-2454202] [PUBMED:15099567] [PUBMED:21799019]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
IKK complex recruitment mediated by RIP1 [NCBI:1269223] [REACTOME:R-HSA-937041] [PUBMED:16603398] [PUBMED:16115877] [PUBMED:14530355]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Inactivation of APC/C via direct inhibition of the APC/C complex [NCBI:1269762] [REACTOME:R-HSA-141430] [PUBMED:14593737] [PUBMED:11535616] [PUBMED:9637688]
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components [NCBI:1269761] [REACTOME:R-HSA-141405] [PUBMED:14593737]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Internalization of ErbB1 [NCBI:138013] [Pathway Interaction Database:erbb1_internalization_pathway] [PUBMED:9733512] [PUBMED:9950686] [PUBMED:12839496] [PUBMED:10953014] [PUBMED:17052190] [PUBMED:15212941] [PUBMED:19460345] [PUBMED:18316398] [PUBMED:11823423] [PUBMED:18657070] [PUBMED:12242303] [PUBMED:17940017] [PUBMED:15465819] [PUBMED:17121848] [PUBMED:15772153] [PUBMED:18508924] [PUBMED:18031739] [PUBMED:16914641] [PUBMED:11408594] [PUBMED:11099046] [PUBMED:16543144] [PUBMED:11703925] [PUBMED:11894095] [PUBMED:15282549] [PUBMED:9851973] [PUBMED:16554368] [PUBMED:12897150] [PUBMED:11983899] [PUBMED:18362181] [PUBMED:15475003] [PUBMED:12631709] [PUBMED:15701692] [PUBMED:16862145] [PUBMED:16735510] [PUBMED:18694561] [PUBMED:14505571] [PUBMED:10567412] [PUBMED:15635092] [PUBMED:15210722] [PUBMED:16892055] [PUBMED:1645724] [PUBMED:16407834] [PUBMED:17363458] [PUBMED:16382132] [PUBMED:10428778] [PUBMED:15314065] [PUBMED:16120644] [PUBMED:7925272] [PUBMED:12234920] [PUBMED:8175702] [PUBMED:10085141] [PUBMED:11375397] [PUBMED:10635327] [PUBMED:19723633] [PUBMED:10788520] [PUBMED:12218189] [PUBMED:19054389]
M Phase [NCBI:1269810] [REACTOME:R-HSA-68886]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Mitotic Anaphase [NCBI:1269825] [REACTOME:R-HSA-68882]
Mitotic Metaphase and Anaphase [NCBI:1269823] [REACTOME:R-HSA-2555396]
Mitotic Spindle Checkpoint [NCBI:1269758] [REACTOME:R-HSA-69618] [PUBMED:14593737] [PUBMED:12360190]
MyD88-independent TLR3/TLR4 cascade [NCBI:1269220] [REACTOME:R-HSA-166166] [PUBMED:15276183]
Negative regulators of RIG-I/MDA5 signaling [NCBI:1269264] [REACTOME:R-HSA-936440] [PUBMED:18703349] [PUBMED:18549796]
Ovarian tumor domain proteases [NCBI:1427863] [REACTOME:R-HSA-5689896] [PUBMED:23827681]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha [NCBI:1270418] [REACTOME:R-HSA-1234176] [PUBMED:15247232] [PUBMED:15474027] [PUBMED:12788921] [PUBMED:18184961] [PUBMED:12351678] [PUBMED:11292861] [PUBMED:17434750] [PUBMED:19208626] [PUBMED:12538644] [PUBMED:12615973] [PUBMED:11598268] [PUBMED:21335549] [PUBMED:12912907] [PUBMED:11292862]
Phosphorylation of the APC/C [NCBI:1269843] [REACTOME:R-HSA-176412] [PUBMED:10793135]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Protein processing in endoplasmic reticulum [NCBI:167325] [KEGG:hsa04141] [PUBMED:20347046] [PUBMED:18023214] [PUBMED:20219571] [PUBMED:19491040] [PUBMED:20112977]
Protein ubiquitination [NCBI:1457808] [REACTOME:R-HSA-8852135] [PUBMED:23912815] [PUBMED:17588513] [PUBMED:25175772] [PUBMED:19940261] [PUBMED:19775879] [PUBMED:23624913] [PUBMED:23657496] [PUBMED:23800009] [PUBMED:22708562] [PUBMED:26235645] [PUBMED:25833379] [PUBMED:26187467] [PUBMED:24699078] [PUBMED:26085183] [PUBMED:21883762] [PUBMED:23747565] [PUBMED:27002219] [PUBMED:27312108] [PUBMED:19436320] [PUBMED:23061719] [PUBMED:24457024] [PUBMED:24652853] [PUBMED:23732108] [PUBMED:22389392] [PUBMED:19754430] [PUBMED:19489725] [PUBMED:25815272]
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways [NCBI:1269259] [REACTOME:R-HSA-168928] [PUBMED:17395582] [PUBMED:17942531] [PUBMED:18701081] [PUBMED:17683970] [PUBMED:18989317] [PUBMED:16214811]
Regulation of APC/C activators between G1/S and early anaphase [NCBI:1269839] [REACTOME:R-HSA-176408] [PUBMED:16508672] [PUBMED:12049731] [PUBMED:12208841] [PUBMED:15678131]
Regulation of Hypoxia-inducible Factor (HIF) by oxygen [NCBI:1270416] [REACTOME:R-HSA-1234174] [PUBMED:19704417] [PUBMED:20728359] [PUBMED:21335549] [PUBMED:19339544] [PUBMED:17916722] [PUBMED:18498744] [PUBMED:16724055] [PUBMED:20965423]
Regulation of mitotic cell cycle [NCBI:1269837] [REACTOME:R-HSA-453276]
Senescence-Associated Secretory Phenotype (SASP) [NCBI:1270431] [REACTOME:R-HSA-2559582] [PUBMED:18411265] [PUBMED:21979375] [PUBMED:18267069] [PUBMED:19597488] [PUBMED:19218920] [PUBMED:20818427] [PUBMED:11114305] [PUBMED:8617720] [PUBMED:22178396] [PUBMED:19805069] [PUBMED:23770676] [PUBMED:8384717] [PUBMED:18555777] [PUBMED:21686281] [PUBMED:20351173] [PUBMED:8688489] [PUBMED:19053174] [PUBMED:8234276] [PUBMED:18555778]
Separation of Sister Chromatids [NCBI:1269826] [REACTOME:R-HSA-2467813] [PUBMED:11081627] [PUBMED:10411507] [PUBMED:12070128] [PUBMED:12194817] [PUBMED:11509732]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by BMP [NCBI:1269522] [REACTOME:R-HSA-201451] [PUBMED:19762341]
Signaling by TGF-beta Receptor Complex [NCBI:1269523] [REACTOME:R-HSA-170834] [PUBMED:19648010]
Synthesis of active ubiquitin: roles of E1 and E2 enzymes [NCBI:1457809] [REACTOME:R-HSA-8866652] [PUBMED:26235645] [PUBMED:24457024] [PUBMED:27002219] [PUBMED:17597759] [PUBMED:19940261] [PUBMED:6277905] [PUBMED:6305978]
TCR signaling [NCBI:1269172] [REACTOME:R-HSA-202403] [PUBMED:10375551] [PUBMED:12876557] [PUBMED:9989491]
TRIF-mediated TLR3/TLR4 signaling [NCBI:1269221] [REACTOME:R-HSA-937061] [PUBMED:15814722] [PUBMED:12855817] [PUBMED:14739303]
Toll Like Receptor 3 (TLR3) Cascade [NCBI:1269219] [REACTOME:R-HSA-168164] [PUBMED:19627256] [PUBMED:15733829] [PUBMED:18202435]
Toll Like Receptor 4 (TLR4) Cascade [NCBI:1269234] [REACTOME:R-HSA-166016]
Toll-Like Receptors Cascades [NCBI:1269204] [REACTOME:R-HSA-168898] [PUBMED:15950447] [PUBMED:12893815] [PUBMED:15976490] [PUBMED:15585605] [PUBMED:14751757]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer [NCBI:1269527] [REACTOME:R-HSA-2173793] [PUBMED:12150994] [PUBMED:16751101] [PUBMED:10199400] [PUBMED:18568018] [PUBMED:19135894] [PUBMED:10531062]
Ubiquitin mediated proteolysis [NCBI:83056] [KEGG:hsa04120] [PUBMED:16405856] [PUBMED:12944364] [PUBMED:16922408] [PUBMED:17588513] [PUBMED:16922367] [PUBMED:16922370] [PUBMED:16816840]
p53 pathway [NCBI:138067] [Pathway Interaction Database:p53regulationpathway] [PUBMED:9153395] [PUBMED:15448695] [PUBMED:10734067] [PUBMED:11340074] [PUBMED:15525938] [PUBMED:17189186] [PUBMED:18454141] [PUBMED:11715018] [PUBMED:9733514] [PUBMED:12963717] [PUBMED:15989956] [PUBMED:10581258] [PUBMED:18566590] [PUBMED:15029243] [PUBMED:14612427] [PUBMED:19011621] [PUBMED:12842086] [PUBMED:16377624] [PUBMED:17268548] [PUBMED:16845383] [PUBMED:17534149] [PUBMED:12397361] [PUBMED:11740489] [PUBMED:12110584] [PUBMED:11713287] [PUBMED:17646389] [PUBMED:14654783] [PUBMED:9153396] [PUBMED:18243116] [PUBMED:10673501] [PUBMED:17719542] [PUBMED:11983168] [PUBMED:12397362] [PUBMED:17189187] [PUBMED:16757976] [PUBMED:12667443] [PUBMED:9733515] [PUBMED:9878046] [PUBMED:9363941] [PUBMED:11504915] [PUBMED:11359766] [PUBMED:9529248] [PUBMED:17936559] [PUBMED:15210108] [PUBMED:17293853] [PUBMED:16107876] [PUBMED:9724636] [PUBMED:17707234] [PUBMED:10606744] [PUBMED:11780126] [PUBMED:10821866] [PUBMED:18485870] [PUBMED:17110336] [PUBMED:11046142] [PUBMED:11331603] [PUBMED:19597489] [PUBMED:16163388] [PUBMED:14671306] [PUBMED:17108971] [PUBMED:15242646] [PUBMED:15314173] [PUBMED:12654245] [PUBMED:15308643] [PUBMED:9744860] [PUBMED:17906639] [PUBMED:9891054] [PUBMED:17098746] [PUBMED:17349958] [PUBMED:11030628] [PUBMED:15103385] [PUBMED:14744935] [PUBMED:9529249] [PUBMED:11283254] [PUBMED:11606419] [PUBMED:11078726] [PUBMED:10611322] [PUBMED:9288740] [PUBMED:11127820] [PUBMED:19357310] [PUBMED:9450543]
protein ubiquitylation [NCBI:1208955] [BIOCYC:HUMAN_PWY-7511]