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Genes
PRF1
Gene - PRF1
full name
perforin 1
synonyms
FLH2, HPLH2, P1, PFN1, PFP, PRF1, ENSG00000180644
HGNC
HGNC:9360
Entrez Gene
Gene:5551
ENSEMBL
ENSG00000180644
location
chr: 10
start: 72357104
stop: 72362531
strand: -
OMIM
OMIM:170280
: PRF1
OMIM:609135
: Aplastic anemia
OMIM:603553
: Hemophagocytic lymphohistiocytosis, familial, 2
OMIM:605027
: Lymphoma, non-Hodgkin
transcripts
NM_005041.4
NM_001083116.1
pathways
Allograft rejection
[NCBI:83123]
[KEGG:hsa05330]
[PUBMED:8835634]
[PUBMED:12023610]
[PUBMED:12563298]
[PUBMED:17445565]
[PUBMED:12216939]
[PUBMED:14710779]
[PUBMED:10746853]
[PUBMED:10571983]
[PUBMED:10331992]
[PUBMED:10667806]
Apoptosis
[NCBI:83060]
[KEGG:hsa04210]
[NCBI:1270262]
[REACTOME:R-HSA-109581]
[PUBMED:12189384]
[PUBMED:20533903]
[PUBMED:18208375]
[PUBMED:22429822]
[PUBMED:15218528]
[PUBMED:24769728]
[PUBMED:18023214]
[PUBMED:25526085]
[PUBMED:23070002]
[PUBMED:15654015]
[PUBMED:15601572]
[PUBMED:14561771]
[PUBMED:24278747]
[PUBMED:21914490]
[PUBMED:22465226]
[PUBMED:21145844]
[PUBMED:12838338]
[PUBMED:18238895]
[PUBMED:12949498]
[PUBMED:18304445]
[PUBMED:14737178]
[PUBMED:26231733]
[PUBMED:9916983]
[PUBMED:14634621]
[PUBMED:19770840]
[PUBMED:22075987]
[PUBMED:4561027]
[PUBMED:20075940]
[PUBMED:9894605]
[PUBMED:26615431]
[PUBMED:12505355]
[PUBMED:11520933]
[PUBMED:19148180]
[PUBMED:16397578]
[PUBMED:15719025]
[PUBMED:15322527]
[PUBMED:15725726]
[PUBMED:12209154]
[PUBMED:23803157]
Autoimmune thyroid disease
[NCBI:83121]
[KEGG:hsa05320]
[PUBMED:15132715]
[PUBMED:12192541]
[PUBMED:17192582]
[PUBMED:9534029]
[PUBMED:11396701]
[PUBMED:11913070]
[PUBMED:15049952]
[PUBMED:11577986]
[PUBMED:15762980]
Caspase cascade in apoptosis
[NCBI:137974]
[Pathway Interaction Database:caspase_pathway]
[PUBMED:7774019]
[PUBMED:8626669]
[PUBMED:9850096]
[PUBMED:11803376]
[PUBMED:15189451]
[PUBMED:10564664]
[PUBMED:9642276]
[PUBMED:10567584]
[PUBMED:12419244]
[PUBMED:11423904]
[PUBMED:9422506]
[PUBMED:11438643]
[PUBMED:9070648]
[PUBMED:9588194]
[PUBMED:11085743]
[PUBMED:9298992]
[PUBMED:9933635]
[PUBMED:9528810]
[PUBMED:9323209]
[PUBMED:10809769]
[PUBMED:8700869]
[PUBMED:9463409]
[PUBMED:10497198]
[PUBMED:11953316]
[PUBMED:9422513]
[PUBMED:10409650]
[PUBMED:11463840]
[PUBMED:10611247]
[PUBMED:8605870]
Downstream signaling in naive CD8+ T cells
[NCBI:138018]
[Pathway Interaction Database:cd8tcrdownstreampathway]
[PUBMED:293720]
[PUBMED:7935374]
[PUBMED:12065418]
[PUBMED:8566027]
[PUBMED:12917261]
[PUBMED:8394352]
[PUBMED:8441422]
[PUBMED:1386920]
[PUBMED:8617294]
[PUBMED:12732656]
[PUBMED:7889942]
[PUBMED:1737937]
[PUBMED:1381507]
[PUBMED:16210616]
[PUBMED:11927626]
[PUBMED:10477579]
[PUBMED:10206983]
[PUBMED:8376940]
[PUBMED:9395475]
[PUBMED:12972619]
[PUBMED:8394845]
[PUBMED:11485747]
[PUBMED:15814665]
[PUBMED:14645153]
[PUBMED:2119889]
[PUBMED:8208531]
[PUBMED:10970869]
[PUBMED:8612134]
[PUBMED:8623163]
[PUBMED:16237086]
[PUBMED:16585578]
[PUBMED:10544201]
[PUBMED:8397339]
[PUBMED:14605368]
[PUBMED:12560487]
[PUBMED:7982959]
Graft-versus-host disease
[NCBI:83124]
[KEGG:hsa05332]
[PUBMED:14556773]
[PUBMED:17784964]
[PUBMED:14735553]
[PUBMED:16412784]
[PUBMED:17900507]
[PUBMED:15372473]
[PUBMED:16147539]
[PUBMED:12359826]
[PUBMED:15882431]
IL12 signaling mediated by STAT4
[NCBI:137936]
[Pathway Interaction Database:il12_stat4pathway]
[PUBMED:2504877]
[PUBMED:7722452]
[PUBMED:16365415]
[PUBMED:9558063]
[PUBMED:8700209]
[PUBMED:9325300]
[PUBMED:12213961]
[PUBMED:10037767]
[PUBMED:7737303]
[PUBMED:10358173]
[PUBMED:16641133]
[PUBMED:12372421]
[PUBMED:10946290]
[PUBMED:11046021]
[PUBMED:14660657]
[PUBMED:15728489]
[PUBMED:10097133]
[PUBMED:11207258]
[PUBMED:11801649]
[PUBMED:11786644]
[PUBMED:10229825]
[PUBMED:11466347]
[PUBMED:12716907]
[PUBMED:8700208]
[PUBMED:15522880]
IL2 signaling events mediated by STAT5
[NCBI:137988]
[Pathway Interaction Database:il2_stat5pathway]
[PUBMED:11160217]
[PUBMED:16645171]
[PUBMED:9121484]
[PUBMED:17182565]
[PUBMED:14607901]
[PUBMED:9104808]
[PUBMED:11485747]
[PUBMED:14614860]
[PUBMED:10679091]
[PUBMED:12196288]
[PUBMED:10072077]
[PUBMED:10544201]
[PUBMED:15004274]
[PUBMED:9390691]
[PUBMED:9395528]
[PUBMED:10514006]
[PUBMED:14500638]
[PUBMED:16757175]
[PUBMED:9541574]
[PUBMED:8617294]
Natural killer cell mediated cytotoxicity
[NCBI:83079]
[KEGG:hsa04650]
[PUBMED:12530970]
[PUBMED:15567854]
[PUBMED:8942070]
[PUBMED:11905813]
[PUBMED:9143705]
[PUBMED:9862693]
[PUBMED:11895890]
[PUBMED:12205470]
[PUBMED:11836514]
[PUBMED:15607806]
[PUBMED:16002670]
[PUBMED:15618404]
[PUBMED:11390470]
[PUBMED:11062493]
[PUBMED:14710949]
[PUBMED:12752668]
[PUBMED:15607802]
[PUBMED:16109839]
[PUBMED:12766758]
[PUBMED:16177799]
TCR signaling in naive CD8+ T cells
[NCBI:138055]
[Pathway Interaction Database:cd8tcrpathway]
[PUBMED:9094314]
[PUBMED:15125833]
[PUBMED:11994416]
[PUBMED:7509360]
[PUBMED:12755691]
[PUBMED:8642247]
[PUBMED:12361955]
[PUBMED:11956228]
[PUBMED:10072079]
[PUBMED:8977171]
[PUBMED:2141684]
[PUBMED:8700169]
[PUBMED:8164687]
[PUBMED:9489702]
[PUBMED:8702662]
[PUBMED:2548204]
[PUBMED:11175263]
[PUBMED:8114715]
[PUBMED:10209031]
[PUBMED:15536066]
[PUBMED:7678351]
[PUBMED:8673703]
[PUBMED:7830771]
[PUBMED:7509083]
[PUBMED:16733527]
[PUBMED:9438848]
[PUBMED:8790380]
[PUBMED:1639064]
[PUBMED:15980863]
[PUBMED:8084588]
[PUBMED:14702343]
[PUBMED:10790433]
[PUBMED:10807788]
[PUBMED:16169499]
[PUBMED:15802604]
[PUBMED:8892604]
[PUBMED:2114552]
[PUBMED:12421919]
[PUBMED:12917261]
[PUBMED:8146197]
[PUBMED:1335364]
[PUBMED:10021361]
[PUBMED:8183372]
[PUBMED:8627172]
[PUBMED:8898939]
[PUBMED:2190221]
[PUBMED:9710204]
[PUBMED:11287959]
[PUBMED:14764585]
[PUBMED:12954628]
[PUBMED:10209041]
[PUBMED:1464315]
[PUBMED:12507424]
[PUBMED:12732656]
[PUBMED:8195151]
[PUBMED:12138205]
[PUBMED:16005298]
[PUBMED:9312149]
[PUBMED:7544353]
[PUBMED:16906149]
[PUBMED:9637919]
[PUBMED:12845325]
[PUBMED:2470098]
[PUBMED:10918068]
[PUBMED:16116204]
[PUBMED:16921383]
[PUBMED:10562325]
[PUBMED:9819387]
[PUBMED:16582901]
[PUBMED:8034711]
[PUBMED:8479536]
[PUBMED:10640739]
[PUBMED:3919143]
[PUBMED:10224278]
[PUBMED:10811865]
Type I diabetes mellitus
[NCBI:83095]
[KEGG:hsa04940]
[PUBMED:11507694]
[PUBMED:8072542]
[PUBMED:15889095]
[PUBMED:15889096]
[PUBMED:12796471]
[PUBMED:14617043]
[PUBMED:8786033]
[PUBMED:9719467]
[PUBMED:12752668]
Viral myocarditis
[NCBI:125138]
[KEGG:hsa05416]
[PUBMED:19357408]
[PUBMED:18545064]
[PUBMED:18357777]
[PUBMED:11524405]
[PUBMED:12920582]
[PUBMED:14522402]
[PUBMED:17200452]
[PUBMED:18039131]
[PUBMED:16413486]
[PUBMED:12439638]
[PUBMED:16817756]
[PUBMED:16845885]
[PUBMED:10051305]
[PUBMED:10904843]