full name
plasminogen activator, urokinase

synonyms
ATF, BDPLT5, QPD, u-PA, UPA, URK, PLAU, ENSG00000122861

HGNC
HGNC:9052

Entrez Gene
Gene:5328

ENSEMBL
ENSG00000122861

location
chr: 10
start: 75670862
stop: 75677259
strand: +

OMIM
OMIM:191840: PLAU (Autosomal dominant inheritance)
OMIM:601709: Quebec platelet disorder
OMIM:104300: {Alzheimer disease, late-onset, susceptibility to}

transcripts
ENST00000446342.1
ENST00000372764.3

pathways
ATF-2 transcription factor network [NCBI:138006] [Pathway Interaction Database:atf2_pathway] [PUBMED:12048217] [PUBMED:19255142] [PUBMED:11739785] [PUBMED:7624151] [PUBMED:19822663] [PUBMED:17590016] [PUBMED:7535770] [PUBMED:18396163] [PUBMED:20507983] [PUBMED:19422799] [PUBMED:7824938] [PUBMED:11713276] [PUBMED:17258390] [PUBMED:10454570] [PUBMED:20067572] [PUBMED:10364225] [PUBMED:12121977] [PUBMED:12110590] [PUBMED:19176525] [PUBMED:16511568] [PUBMED:17079470] [PUBMED:17267404] [PUBMED:10777595] [PUBMED:2516827] [PUBMED:18397884] [PUBMED:10207054] [PUBMED:9436983] [PUBMED:7737130] [PUBMED:10982836] [PUBMED:9006914] [PUBMED:19592489] [PUBMED:17158955] [PUBMED:17189429] [PUBMED:11566021] [PUBMED:17626013] [PUBMED:17036053] [PUBMED:20702711] [PUBMED:10085140] [PUBMED:20032511] [PUBMED:17219413] [PUBMED:17337306] [PUBMED:9511728] [PUBMED:12196528] [PUBMED:19304750] [PUBMED:17700520] [PUBMED:16373341] [PUBMED:12833146] [PUBMED:1827203] [PUBMED:17699753] [PUBMED:9990041] [PUBMED:15304344] [PUBMED:11231009] [PUBMED:18385943] [PUBMED:18387947] [PUBMED:18638549] [PUBMED:15767263] [PUBMED:10777545] [PUBMED:14630918] [PUBMED:18802055] [PUBMED:10037779] [PUBMED:12052888] [PUBMED:8943243] [PUBMED:20181929] [PUBMED:19647037] [PUBMED:8382609] [PUBMED:16405968] [PUBMED:1641004]
Complement and coagulation cascades [NCBI:83073] [KEGG:hsa04610] [PUBMED:23564577] [PUBMED:25309880] [PUBMED:26082779] [PUBMED:23110467] [PUBMED:20027185] [PUBMED:25568220] [PUBMED:26324800] [PUBMED:25705421] [PUBMED:21811895] [PUBMED:23911436] [PUBMED:23564578] [PUBMED:24924409] [PUBMED:26489954] [PUBMED:17635716]
Dissolution of Fibrin Clot [NCBI:1269372] [REACTOME:R-HSA-75205] [PUBMED:10853003] [PUBMED:11460480] [PUBMED:9330876]
E2F transcription factor network [NCBI:137934] [Pathway Interaction Database:e2f_pathway] [PUBMED:15175242] [PUBMED:11034215] [PUBMED:8832394] [PUBMED:7479977] [PUBMED:12077144] [PUBMED:11274364] [PUBMED:8618861] [PUBMED:11857079] [PUBMED:7958837] [PUBMED:15014447] [PUBMED:9774682] [PUBMED:9704927] [PUBMED:9271400] [PUBMED:8334989] [PUBMED:16288221] [PUBMED:10766737] [PUBMED:8657141] [PUBMED:8552092] [PUBMED:11101847] [PUBMED:12757710] [PUBMED:17704056] [PUBMED:7705662] [PUBMED:15897886] [PUBMED:9192872] [PUBMED:9778043] [PUBMED:12766778] [PUBMED:15510213] [PUBMED:11418595] [PUBMED:10454584] [PUBMED:10783242] [PUBMED:11904439] [PUBMED:16179649] [PUBMED:7791762] [PUBMED:11719808] [PUBMED:12389032] [PUBMED:8264596] [PUBMED:19491197] [PUBMED:15713665] [PUBMED:16357170] [PUBMED:9689056] [PUBMED:12748276] [PUBMED:2524830] [PUBMED:14633988] [PUBMED:12697828] [PUBMED:12101096] [PUBMED:11799067] [PUBMED:15133492] [PUBMED:16892051] [PUBMED:8943353] [PUBMED:9724731] [PUBMED:10030670] [PUBMED:11459832] [PUBMED:8114719] [PUBMED:9520412] [PUBMED:18348985] [PUBMED:9020173] [PUBMED:11389439] [PUBMED:16211008] [PUBMED:12411495] [PUBMED:7958836] [PUBMED:12909625] [PUBMED:15306814] [PUBMED:10688648] [PUBMED:12611887] [PUBMED:9191053] [PUBMED:10373518] [PUBMED:10187822]
FGF signaling pathway [NCBI:137989] [Pathway Interaction Database:fgf_pathway] [PUBMED:12419216] [PUBMED:16775459] [PUBMED:1656221] [PUBMED:16857743] [PUBMED:8707855] [PUBMED:17545628] [PUBMED:17623664] [PUBMED:16893902] [PUBMED:15105428] [PUBMED:16436388] [PUBMED:12370824] [PUBMED:9707175] [PUBMED:1380001] [PUBMED:15569927] [PUBMED:11241670] [PUBMED:11433297] [PUBMED:16709412] [PUBMED:12815057] [PUBMED:14966081] [PUBMED:17086194] [PUBMED:17311277] [PUBMED:14534538] [PUBMED:12398894] [PUBMED:8940113] [PUBMED:17266935] [PUBMED:10652257] [PUBMED:12604616] [PUBMED:14666721] [PUBMED:9045692] [PUBMED:15509650] [PUBMED:11353842] [PUBMED:12791257] [PUBMED:15564375] [PUBMED:12529371] [PUBMED:17409417] [PUBMED:17005551] [PUBMED:12815619] [PUBMED:11997436] [PUBMED:12110689] [PUBMED:17627937]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
MicroRNAs in cancer [NCBI:852705] [KEGG:hsa05206] [PUBMED:23075324] [PUBMED:21742789] [PUBMED:22351564] [PUBMED:18817506] [PUBMED:22345301] [PUBMED:21402473] [PUBMED:22926415] [PUBMED:23165235] [PUBMED:19630570] [PUBMED:21565290] [PUBMED:23091478] [PUBMED:23462054] [PUBMED:23316212] [PUBMED:19773200] [PUBMED:22035854] [PUBMED:20221895] [PUBMED:20345848] [PUBMED:22580099] [PUBMED:20128019]
NF-kappa B signaling pathway [NCBI:634527] [KEGG:hsa04064] [PUBMED:22119011] [PUBMED:16264088] [PUBMED:21187855] [PUBMED:15546385] [PUBMED:17607554] [PUBMED:21135871] [PUBMED:16984817] [PUBMED:17047224] [PUBMED:19203223] [PUBMED:20300215] [PUBMED:14657271] [PUBMED:17431096] [PUBMED:15134788] [PUBMED:16356770] [PUBMED:21772278] [PUBMED:12654254] [PUBMED:22390971] [PUBMED:22017435] [PUBMED:17183360] [PUBMED:21173796] [PUBMED:15905862] [PUBMED:19302050] [PUBMED:17098202] [PUBMED:21872579] [PUBMED:22152226] [PUBMED:18613837] [PUBMED:19489733] [PUBMED:11875461] [PUBMED:19726767] [PUBMED:22017430] [PUBMED:21232019] [PUBMED:18832076]
Neutrophil degranulation [NCBI:1457780] [REACTOME:R-HSA-6798695] [PUBMED:20338884] [PUBMED:1378856] [PUBMED:17627888] [PUBMED:23650620] [PUBMED:8692836]
Osteopontin-mediated events [NCBI:137960] [Pathway Interaction Database:avb3_opn_pathway] [PUBMED:9727056] [PUBMED:9585425] [PUBMED:16888388] [PUBMED:16474180] [PUBMED:15757900] [PUBMED:9682033] [PUBMED:12529435] [PUBMED:15142256] [PUBMED:14624447] [PUBMED:15711558] [PUBMED:9988732] [PUBMED:12730217] [PUBMED:11600576] [PUBMED:8744948] [PUBMED:16691505] [PUBMED:11940607] [PUBMED:16006560] [PUBMED:10766830] [PUBMED:10559185]
Proteoglycans in cancer [NCBI:782000] [KEGG:hsa05205] [PUBMED:19433454] [PUBMED:20655987] [PUBMED:18798267] [PUBMED:10633082] [PUBMED:10687947] [PUBMED:22735579] [PUBMED:24412155] [PUBMED:9346940] [PUBMED:22087031] [PUBMED:22194599] [PUBMED:14711376] [PUBMED:19255147] [PUBMED:15655247] [PUBMED:11717317] [PUBMED:17971838] [PUBMED:18413366] [PUBMED:20974860] [PUBMED:11830493] [PUBMED:23058688] [PUBMED:18450475] [PUBMED:12748184] [PUBMED:19733083] [PUBMED:18812315] [PUBMED:12509413] [PUBMED:21155971] [PUBMED:11931647] [PUBMED:18949819] [PUBMED:12729888] [PUBMED:15994311] [PUBMED:23305321] [PUBMED:18505598] [PUBMED:22563565] [PUBMED:22033227]
Transcriptional misregulation in cancer [NCBI:523016] [KEGG:hsa05202] [PUBMED:17327229] [PUBMED:20190806] [PUBMED:20145147] [PUBMED:11313274] [PUBMED:11863357] [PUBMED:19472090] [PUBMED:18330902] [PUBMED:19738075] [PUBMED:15024077] [PUBMED:12032780] [PUBMED:14630078] [PUBMED:21765642] [PUBMED:19564705] [PUBMED:17101797] [PUBMED:15160934] [PUBMED:15688424] [PUBMED:15985538] [PUBMED:12527902] [PUBMED:12511414] [PUBMED:11607818] [PUBMED:17222504] [PUBMED:15826838] [PUBMED:21747944] [PUBMED:19406209] [PUBMED:10350329] [PUBMED:21779514] [PUBMED:18563191] [PUBMED:16946003] [PUBMED:17250957] [PUBMED:12670461] [PUBMED:12529654] [PUBMED:18855877] [PUBMED:17505060] [PUBMED:20153925] [PUBMED:20490326] [PUBMED:12130514] [PUBMED:18648544] [PUBMED:19855079] [PUBMED:10717473] [PUBMED:20478527] [PUBMED:11340171] [PUBMED:16169901] [PUBMED:14998494] [PUBMED:19233641] [PUBMED:19133982] [PUBMED:12393465] [PUBMED:19059936] [PUBMED:18172298] [PUBMED:10500199] [PUBMED:19141473] [PUBMED:10537274] [PUBMED:15156184] [PUBMED:14701735] [PUBMED:19422821] [PUBMED:21518926] [PUBMED:18850010] [PUBMED:19075677] [PUBMED:18457914] [PUBMED:12527906] [PUBMED:15644444] [PUBMED:10784387] [PUBMED:17024155] [PUBMED:19075268] [PUBMED:15826834] [PUBMED:21849159] [PUBMED:21123453] [PUBMED:20974671] [PUBMED:20863376]
Validated transcriptional targets of AP1 family members Fra1 and Fra2 [NCBI:169349] [Pathway Interaction Database:fra_pathway] [PUBMED:20386569] [PUBMED:1827665] [PUBMED:17510314] [PUBMED:17001307] [PUBMED:19419315] [PUBMED:12121977] [PUBMED:15790882] [PUBMED:18435914] [PUBMED:1406676] [PUBMED:20543861] [PUBMED:19687301] [PUBMED:9651314] [PUBMED:20392257] [PUBMED:20472895] [PUBMED:16554298] [PUBMED:17496887] [PUBMED:19995753] [PUBMED:8058317] [PUBMED:2497053] [PUBMED:8798756] [PUBMED:17347653] [PUBMED:18331200] [PUBMED:19966854] [PUBMED:17882273] [PUBMED:9858556] [PUBMED:3130660] [PUBMED:19289495] [PUBMED:11756554] [PUBMED:1945831] [PUBMED:15688012] [PUBMED:8441422] [PUBMED:17371847] [PUBMED:10421804] [PUBMED:2110368] [PUBMED:18548006] [PUBMED:20353950] [PUBMED:15229648] [PUBMED:11425864] [PUBMED:15601844] [PUBMED:10918580] [PUBMED:9858557] [PUBMED:19716794] [PUBMED:9819396] [PUBMED:17052890] [PUBMED:20398633] [PUBMED:20371606] [PUBMED:10359014] [PUBMED:15143165] [PUBMED:15618352] [PUBMED:9160889] [PUBMED:12052899] [PUBMED:9409785] [PUBMED:15291758] [PUBMED:1923525] [PUBMED:7759510] [PUBMED:15608675] [PUBMED:14519134] [PUBMED:20053986] [PUBMED:15256456] [PUBMED:19923172] [PUBMED:15558021] [PUBMED:12773579]
amb2 Integrin signaling [NCBI:137945] [Pathway Interaction Database:amb2_neutrophils_pathway] [PUBMED:15004192] [PUBMED:16260637] [PUBMED:8874219] [PUBMED:12736251] [PUBMED:12824186] [PUBMED:17202407] [PUBMED:15458976] [PUBMED:12208882] [PUBMED:10985384] [PUBMED:8598477] [PUBMED:8157977] [PUBMED:14530377] [PUBMED:16567504] [PUBMED:7836767] [PUBMED:17003381] [PUBMED:10899906] [PUBMED:15741160] [PUBMED:9920836] [PUBMED:12941957] [PUBMED:12773513] [PUBMED:15283855] [PUBMED:16854414] [PUBMED:15217824] [PUBMED:15090462] [PUBMED:14769799] [PUBMED:16905120] [PUBMED:9831565] [PUBMED:12194823] [PUBMED:17268551] [PUBMED:17133598] [PUBMED:15153528] [PUBMED:11418469] [PUBMED:14623906] [PUBMED:12036876] [PUBMED:16391519] [PUBMED:15304494] [PUBMED:16093349] [PUBMED:16403785]